Abstract: The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethyl-ethanamin) (Captodiamine).

Abstract: A scanning ophthalmoscope focuses coherent light to a target area in which a subject's eye is located. One or more scanning stages direct the light in a scanning pattern within the target area, and an imaging detector receives a reflected light signal returned following retinal reflection in the subject's eye. Adaptive optics compensate for aberrations in the wavefront. The light is provided as an annular beam at a plane which is conjugate with the pupil of a subject whose eye is located in the target area, whereby the annular beam is focused from an annulus at the pupil of the eye to a spot at the fundus of the eye. The spot size resulting from using an annular beam in this way is significantly reduced providing enhanced resolution.

Abstract: The invention broadly relates to the use of the Active in the causal treatment of a disease caused by axonal demyelination, in which the Active maintains the integrity of myelination (for example by promoting remyelination, and/or preventing demyelination, of the axonal sheaths). The invention is particularly directed to the causal treatment of CNS demyelination diseases, for example MS, especially primary progressive MS and/or relapse remitting MS, and PNS demyelination diseases, for example Charcot-Marie-Tooth Disease. The Active of the invention may be suitably administered when a patient is in relapse (i.e. upon relapse), and be continued while the patient is in relapse, with a view to attenuating the severity of the relapse, and/or accelerating disease remission. Alternatively, the Active may be administered continuously with a view to prolonging the remission period, and/or attenuating the severity of the relapse, and/or preventing relapse.

Abstract: A method for generating product recommendations comprises analyzing a database of messages, comprising a set of messages posted by users of a micro-blogging service to generate a user index and a product index. The user index comprises for each of a plurality of users of the system, a ranked set of terms included by the user in their posted messages. The product index comprises for each product which is to be potentially recommended, a ranked set of terms derived from messages posted by users and referencing the product. Responsive to a query identifying a user, the user index for the user is compared to the product indices to return a limited set of product identifiers corresponding to product indices most similar to the user index. The set of product identifiers are provided as recommendations to a service provider.

Abstract: Provided herein is a method for the isolation or removal of a cellular component from a cell that comprises the steps of applying a pulse of nanoparticles to the cell, allowing the nanoparticles to traffic through the cell for a period of time sufficient to allow the nanoparticles locate to and interact with the cellular component to be isolated, and separation of the nanoparticles and isolated cellular component from the cell.

Abstract: A method is disclosed for analysing a computing device including a non-volatile storage medium in which a set of snapshots is stored. Each snapshot comprises at least one most recently used, MRU, key for an application, at least one MRU key having a plurality of elements. The method comprises comparing a first MRU key from a first snapshot for a first time and a corresponding second MRU key for a second snapshot for a second time temporally following said first time. If the second MRU key has a second element identified as less recently used than a first element of the second MRU key and the second element of the first MRU key is identified as not being less recently used than the first element of the first MRU key, the first element is labelled as having been newly modified between the first and second times.

Abstract: A method of and apparatus for stimulating pelvic floor muscles in a patient comprises applying at least one electrode externally to each side of the patient's body in the region of the pelvis, and energising the electrodes to apply a muscular stimulation current which flows laterally across the patient through the patient's pelvic floor. Preferably a plurality of electrodes are applied symmetrically on each side of the body. The electrodes may be incorporated in a garment.

Abstract: Methods of identifying gene targets associated with learning and memory and with memory consolidation, as well as to specific nucleic acid molecules that have been discovered to be associated with memory consolidation are provided. Accordingly, the invention also relates to methods of modulating learning and memory function, methods of diagnosing learning and memory disorders, and methods of identifying compounds that modulate learning and memory function via manipulations of the nucleic acid molecules and their products.

Abstract: Methods of identifying gene targets associated with schizophrenia or the symptoms thereof, as well as to specific nucleic acid molecules that have been discovered to be associated with schizophrenia are provided. Accordingly, the invention also relates to methods of modulating schizophrenia or the symptoms thereof, methods of diagnosing schizophrenia or the symptoms thereof, methods for predicting the susceptibility to schizophrenia or the symptoms thereof, and methods of identifying compounds that modulate schizophrenia or the symptoms thereof via manipulations of the nucleic acid molecules and their products.

Abstract: A computer program product comprising a non-transitory computer readable medium for storing or recording instructions in machine readable form. The instructions, when executed in a motion sensor enabled smart phone, record target data associated with a response of the motion sensor to a desired sequence of movements of a user performing a therapeutic exercise while wearing the smart phone, map the target data to run-time target parameters of a software application, receive performance data associated with a response of the motion sensor to a subsequent sequence of movements of the user performing the therapeutic exercise while wearing the smart phone, map the performance data to the target parameters of the software application to determine the operation of the software application and provide information for display on a remote monitor visible to the user indicating the quality of the user's performance of the exercise.

Abstract: A method of processing an Orthogonal Frequency-Division Multiplex (OFDM) signal having a plurality of data carriers and a plurality of unused carriers is disclosed. The method comprises transforming an original frequency-domain OFDM signal into a time domain signal and simulating the effect of a non-linear amplifier on the time-domain signal to provide a potentially distorted time domain signal. The potentially distorted time domain signal is transformed into a potentially distorted frequency domain signal and at least some of any values of the data carriers in the potentially distorted frequency domain signal are restored with corresponding values from the original frequency domain signal. At least some of the unused carriers in the at least partially restored frequency domain signal are scaled with a scaling factor.

Abstract: A method of wetting a surface of a solid substrate with a liquid metal, comprises activating said surface with a high energy beam; and introducing the liquid metal to the surface while in the active state, the temperature of the surface being above the melting point of the liquid metal.

Abstract: The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethyl-ethanamin) (Captodiamine).

Abstract: The invention provides a compound for use in the treatment of symptoms associated with psychosis, schizophrenia, a cognitive impairment disorder, a mood disorder, a nervous system disorder and/or a behavioral disorder. The compound has the formula ? and is administered to a subject in need thereof in an effective amount. The compound Meparfynol (3-methylpent-1-yn-3-ol) has been found to be effective.

Abstract: A method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium containing a substrate comprising one or more monoaromatic hydrocarbons selected from the group consisting of benzene, toluene, ethylbenzene, ortho-xylene, meta-xylene, para-xylene and styrene, one or more strains of Pseudomonas putida selected from the group consisting of F1, mt-2 and CA-3 having the respective accession numbers DSM 6899, NCIMB10432 and NCIMB41162; and (ii) recovering the PHA produced from the culture medium; with the proviso that the substrate cannot comprise styrene in the absence of at least one of benzene, toluene, ethyl benzene and ortho-, meta- or para-xylene.

Abstract: This invention relates to heat-expanded synthetic cheese products, heat-expandable precursors for forming same, the preparation of the precursor and the cheese products, and the use of a sugar alcohol for improving the organoleptic properties and/or the volume expansion % of the heat-expandable precursors and/or heat-expanded synthetic cheese products. The invention provides a heat-expanded synthetic cheese product, comprising: —from about 20% to about 59% by weight of a milk protein or a source thereof; from about 10% to about 50% by weight of a starch; from about 2% to about 24% by weight of a sugar alcohol; from about 3% to about 15% by weight of water; wherein the heat-expanded synthetic cheese product comprises no more than 10% by weight of fat, the percentages being percentages by weight of the total product, and wherein the heat-expanded synthetic cheese product is a microwave-expanded synthetic cheese product or a radiofrequency (RP)-expanded synthetic cheese product.

Abstract: In an information retrieval method a meta search engine receives a user information query in the form of key words; and submits the query to a search engine, and also submits the query to a snippet database storing previously selected results, indexed by a snippet index of terms included in snippets of the results when they were previously selected. The meta search engine then receives results from the search engine; and receives a response from the snippet database. It merges the results from the search engine with those from the snippet database; and submits re-ranked results to the user. The snippet database processes in parallel with the underlying search engine. The meta search engine also monitors which results of the returned re-ranked results are selected by the user, and updates the snippet index accordingly.

Abstract: A system for providing extreme ultraviolet (EUV) radiation comprises a laser source arranged to produce a laser beam having a focus; and a carrier movable relative to the laser source for carrying a surface material, the surface material when carried by the carrier providing a renewable target edge. The focussed beam is arranged to impinge on the target edge to produce an EUV radiation emitting plasma. The system is cooperable with a mirror for harnessing the EUV radiation by reflecting EUV radiation impinging thereon. The mirror comprises a substantially aspheric surface and means for supplying a reflecting liquid to at least partially coat the aspheric surface, the mirror being rotatable to centrifugally confine the liquid to the aspheric surface.

Abstract: The present invention relates to stereoselective methods for the preparation of ?-glycosyl thiols and ?-S-linked glycosylceramides.

Abstract: A method for determining clock skew in a packet-based telephony session is disclosed. A telephony device receives RTCP SR packets from a remote telephony device transmitting RTP packets in a telephony session. Each control packet includes an NTP time-stamp and a RTP time-stamp. The device determines from two or more of the received SR packets a first relative rate of a remote media card clock to the remote system clock rate. Further, the device determines from two or more transmitted RTCP SR packets, a second relative rate of a local media card clock to the local system clock rate. The device can then be adjusted to take into account the first and second relative rates for optimum buffer management and to more accurately adjust the quality of a session based on one-way packet delay.