Patents Assigned to University College London
-
Publication number: 20240000714Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof, e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.Type: ApplicationFiled: June 12, 2023Publication date: January 4, 2024Applicants: Tillotts Pharma AG, University College LondonInventors: Vipul YADAV, Abdul Waseh BASIT, Felipe José OLIVEIRA VARUM, Roberto Carlos BRAVO GONZALÉZ, Esther Maria FURRER
-
Patent number: 11717484Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof, e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.Type: GrantFiled: April 26, 2018Date of Patent: August 8, 2023Assignees: Tillotts Pharma AG, University College LondonInventors: Vipul Yadav, Abdul Waseh Basit, Felipe José Oliveira Varum, Roberto Carlos Bravo Gonzaléz, Esther Maria Furrer
-
Patent number: 11634773Abstract: The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.Type: GrantFiled: July 13, 2018Date of Patent: April 25, 2023Assignees: THE FRANCIS CRICK INSTITUTE LIMITED, UNIVERSITY COLLEGE LONDON, CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Charles Swanton, Nicholas McGranahan, Rachel Rosenthal
-
Patent number: 11235113Abstract: A device for monitoring adherence of a patient to a prescribed regimen is provided. The device has a pulmonary delivery device fluid, an adapter in communication with the delivery device and a dispenser in fluid communication with the adapter. A pressurized drug, contained in the pulmonary delivery device, can be delivered from the pulmonary delivery device to the patient through the adapter and the dispenser. A sensor is mounted to the adapter or the dispenser for detecting a temperature or pressure change caused by the movement of the drug from the pulmonary delivery device to the patient and generating a feedback signal based on the change. The feedback signal is further processed for generating a signal indicating a successful deliver of the drug to the patient.Type: GrantFiled: April 7, 2017Date of Patent: February 1, 2022Assignees: UNIVERSITY COLLEGE LONDON, UCL BUSINESS PLCInventors: Chris L. O'Callaghan, Xiao Liu
-
Publication number: 20210318239Abstract: A device is disclosed for detecting time-resolved optical data, the device comprising a sensor comprising a number of detection elements configured to detect a light signal in a single photon regime, a timing circuit connected to said number of detection elements though a common line, and a control module connected to the sensor, the control module being configured to selectively enable the detection elements of the sensor according to a set of enabling patterns. The timing circuit is configured to measure a time of arrival of an output signal from the detection elements on the common line, the output signal being indicative of the detection of a photon of the light signal by any of the enabled detection elements.Type: ApplicationFiled: July 22, 2019Publication date: October 14, 2021Applicants: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE - CNR, UNIVERSITY COLLEGE LONDONInventors: Cosimo D'ANDREA, Gianluca VALENTINI, Andrea FARINA, Simon ARRIDGE
-
Patent number: 10857103Abstract: A delayed release drug formulation includes a core and a coating. The coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release drug formulation is used to target release of a drug from a core to the intestine, particularly the colon.Type: GrantFiled: April 17, 2020Date of Patent: December 8, 2020Assignee: UNIVERSITY COLLEGE LONDONInventors: Abdul Basit, Valentine Ibekwe
-
Patent number: 10758491Abstract: A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.Type: GrantFiled: February 24, 2020Date of Patent: September 1, 2020Assignee: University College LondonInventors: Abdul Basit, Valentine Ibekwe
-
Publication number: 20200237676Abstract: A delayed release drug formulation includes a core and a coating. The coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release drug formulation is used to target release of a drug from a core to the intestine, particularly the colon.Type: ApplicationFiled: April 17, 2020Publication date: July 30, 2020Applicant: University College LondonInventors: Abdul BASIT, Valentine Ibekwe
-
Publication number: 20200206142Abstract: A delayed release coating includes a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above. The delayed release coating is used to target release of a drug from a core to the intestine, particularly the colon.Type: ApplicationFiled: February 24, 2020Publication date: July 2, 2020Applicant: UNIVERSITY COLLEGE LONDONInventors: Abdul Basit, Valentine Ibekwe
-
Publication number: 20200170956Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.Type: ApplicationFiled: April 26, 2018Publication date: June 4, 2020Applicants: Tillotts Pharma AG, University College LondonInventors: Vipul YADAV, Abdul Waseh BASIT, Felipe José OLIVEIRA VARUM, Roberto Carlos BRAVO GONZALÉZ, Esther Maria FURRER
-
Patent number: 10668023Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.Type: GrantFiled: March 15, 2019Date of Patent: June 2, 2020Assignee: University College LondonInventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
-
Patent number: 10639474Abstract: According to an embodiment, a hearing aid system is disclosed. The system includes a speech processor communicatively coupled to a microphone. The speech processor is configured to process a microphone signal received at the speech processor for producing an electrical stimulation signal and an acoustic stimulation signal. The speech processor is also configured to generate a modified acoustic stimulation signal by modifying the acoustic stimulation signal at least for a part of a residual frequency range of a patient in dependence on effect of an implantable electrode array on mechanical properties of cochlea of the patient. The system also includes a first unit and a second unit.Type: GrantFiled: May 11, 2017Date of Patent: May 5, 2020Assignees: OTICON MEDICAL A/S, UNIVERSITY COLLEGE LONDONInventors: Søren Kamaric Riis, Attila Frater, Torsten Marquardt
-
Patent number: 10513773Abstract: A process for depositing an inorganic material on a substrate, the process comprising, providing a substrate having a surface, providing a precursor mixture comprising a metal sulfonate, and delivering the precursor mixture to the surface of the substrate, wherein the surface of the substrate is at a substrate temperature of above 450° C. and is sufficient to effect decomposition of the metal sulfonate. The inorganic material may include a metal or a metal oxide. The preferred metal sulfonate is metal triflate.Type: GrantFiled: February 10, 2016Date of Patent: December 24, 2019Assignees: Pilkington Group Limited, University College LondonInventors: Deborah Raisbeck, Simon James Hurst, Ivan P. Parkin, Claire J. Carmalt, Joe A. Manzi
-
Patent number: 10401453Abstract: A method of acquiring magnetic resonance imaging (MRI) data from an MRI scan of an object includes generating a number of excitation sequences by, in order: generating an excitation pulse, generating an imaging magnetic field gradient, and generating a spoiler magnetic field gradient. MRI data is acquired during the generation of the spoiler magnetic field gradients. The spoiler magnetic field gradients are selected such that, during each excitation sequence, substantially the same k-space trajectory is traversed during the generation of the spoiler magnetic field gradient.Type: GrantFiled: September 22, 2017Date of Patent: September 3, 2019Assignees: Siemens Healthcare Limited, Siemens Healthcare GmbH, University College, LondonInventors: Iulius Dragonu, Craig Buckley, Heiko Meyer, Nikolaus Weiskopf, Martina Callaghan, Daniel Papp
-
Publication number: 20190254980Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.Type: ApplicationFiled: March 15, 2019Publication date: August 22, 2019Applicant: UNIVERSITY COLLEGE LONDONInventors: Abdul Waseh BASIT, Valentine Chidi Ibekwe
-
Patent number: 10369112Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.Type: GrantFiled: December 7, 2017Date of Patent: August 6, 2019Assignee: UNIVERSITY COLLEGE LONDONInventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
-
Publication number: 20190094319Abstract: A method of acquiring magnetic resonance imaging (MRI) data from an MRI scan of an object includes generating a number of excitation sequences by, in order: generating an excitation pulse, generating an imaging magnetic field gradient, and generating a spoiler magnetic field gradient. MRI data is acquired during the generation of the spoiler magnetic field gradients. The spoiler magnetic field gradients are selected such that, during each excitation sequence, substantially the same k-space trajectory is traversed during the generation of the spoiler magnetic field gradient.Type: ApplicationFiled: September 22, 2017Publication date: March 28, 2019Applicants: Siemens Healthcare Limited, Siemens Healthcare GmbH, University College LondonInventors: Iulius Dragonu, Craig Buckley, Heiko Meyer, Nikolaus Weiskopf, Martina Callaghan, Daniel Papp
-
Publication number: 20180172435Abstract: The present invention provides a measuring apparatus (200) for measuring properties of a surface (101, 103), the apparatus (200) comprising a mounting structure (210) comprising a plurality of segments (211-216) moveably mounted (217) with respect to each other, an actuation mechanism to move the segments of the mounting structure with respect to each other, and a plurality of sensors (220), each sensor being mounted to a segment of the mounting structure (210). The invention also provides a method of measuring properties of a surface (101, 103). The surface (102, 103) to be measured may be an aerodynamic surface of an aircraft.Type: ApplicationFiled: May 27, 2016Publication date: June 21, 2018Applicants: University College London, Airbus Operations LimitedInventors: Stuart Robson, Ben Sargeant, Abdul Rahman El-Nounu
-
Patent number: 9993435Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.Type: GrantFiled: April 1, 2015Date of Patent: June 12, 2018Assignee: UNIVERSITY COLLEGE LONDONInventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
-
Publication number: 20180098944Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.Type: ApplicationFiled: December 7, 2017Publication date: April 12, 2018Applicant: UNIVERSITY COLLEGE LONDONInventors: Abdul Waseh BASIT, Valentine Chidi IBEKWE