Patents Assigned to University College London
  • Publication number: 20200170956
    Abstract: The present invention relates to the therapeutic uses of compositions containing antibody molecules and functional fragments thereof e.g antibody molecules and functional fragments capable of binding to tumor necrosis factor alpha (TNF?), in the topical treatment of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis.
    Type: Application
    Filed: April 26, 2018
    Publication date: June 4, 2020
    Applicants: Tillotts Pharma AG, University College London
    Inventors: Vipul YADAV, Abdul Waseh BASIT, Felipe José OLIVEIRA VARUM, Roberto Carlos BRAVO GONZALÉZ, Esther Maria FURRER
  • Patent number: 10668023
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 2, 2020
    Assignee: University College London
    Inventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
  • Patent number: 10639474
    Abstract: According to an embodiment, a hearing aid system is disclosed. The system includes a speech processor communicatively coupled to a microphone. The speech processor is configured to process a microphone signal received at the speech processor for producing an electrical stimulation signal and an acoustic stimulation signal. The speech processor is also configured to generate a modified acoustic stimulation signal by modifying the acoustic stimulation signal at least for a part of a residual frequency range of a patient in dependence on effect of an implantable electrode array on mechanical properties of cochlea of the patient. The system also includes a first unit and a second unit.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: May 5, 2020
    Assignees: OTICON MEDICAL A/S, UNIVERSITY COLLEGE LONDON
    Inventors: Søren Kamaric Riis, Attila Frater, Torsten Marquardt
  • Patent number: 10610163
    Abstract: Assessing Susceptibility to Epilepsy and Epileptic Seizures A method and system adapted to assist with assessing susceptibility to epilepsy and/or epileptic seizures in a patient receives (202) patient brain data and generates (204) a network model from the received patient brain data. The system further generates (206) synthetic brain activity data in at least some of the nodes of the network model and computes (208) seizure frequency from the synthetic brain activity data by monitoring transitions from non-seizure states to seizures states in at least some of the nodes over time. The system further includes a device (104, 110) configured to use the seizure frequency to compute (210) a likelihood of susceptibility to epilepsy and/or epileptic seizures in the patient, and a device (104, 110) configured to compare (212) the computed likelihood with another likelihood of susceptibility to epilepsy and/or epileptic seizures in order to assess whether the likelihood has increased or decreased.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 7, 2020
    Assignees: UNIVERSITY OF EXETER, KINGS COLLEGE LONDON
    Inventors: John Robert Terry, Mark Richardson, Oscar Benjamin
  • Patent number: 10513773
    Abstract: A process for depositing an inorganic material on a substrate, the process comprising, providing a substrate having a surface, providing a precursor mixture comprising a metal sulfonate, and delivering the precursor mixture to the surface of the substrate, wherein the surface of the substrate is at a substrate temperature of above 450° C. and is sufficient to effect decomposition of the metal sulfonate. The inorganic material may include a metal or a metal oxide. The preferred metal sulfonate is metal triflate.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: December 24, 2019
    Assignees: Pilkington Group Limited, University College London
    Inventors: Deborah Raisbeck, Simon James Hurst, Ivan P. Parkin, Claire J. Carmalt, Joe A. Manzi
  • Patent number: 10401453
    Abstract: A method of acquiring magnetic resonance imaging (MRI) data from an MRI scan of an object includes generating a number of excitation sequences by, in order: generating an excitation pulse, generating an imaging magnetic field gradient, and generating a spoiler magnetic field gradient. MRI data is acquired during the generation of the spoiler magnetic field gradients. The spoiler magnetic field gradients are selected such that, during each excitation sequence, substantially the same k-space trajectory is traversed during the generation of the spoiler magnetic field gradient.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: September 3, 2019
    Assignees: Siemens Healthcare Limited, Siemens Healthcare GmbH, University College, London
    Inventors: Iulius Dragonu, Craig Buckley, Heiko Meyer, Nikolaus Weiskopf, Martina Callaghan, Daniel Papp
  • Publication number: 20190254980
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Application
    Filed: March 15, 2019
    Publication date: August 22, 2019
    Applicant: UNIVERSITY COLLEGE LONDON
    Inventors: Abdul Waseh BASIT, Valentine Chidi Ibekwe
  • Patent number: 10369112
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: August 6, 2019
    Assignee: UNIVERSITY COLLEGE LONDON
    Inventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
  • Publication number: 20190094319
    Abstract: A method of acquiring magnetic resonance imaging (MRI) data from an MRI scan of an object includes generating a number of excitation sequences by, in order: generating an excitation pulse, generating an imaging magnetic field gradient, and generating a spoiler magnetic field gradient. MRI data is acquired during the generation of the spoiler magnetic field gradients. The spoiler magnetic field gradients are selected such that, during each excitation sequence, substantially the same k-space trajectory is traversed during the generation of the spoiler magnetic field gradient.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 28, 2019
    Applicants: Siemens Healthcare Limited, Siemens Healthcare GmbH, University College London
    Inventors: Iulius Dragonu, Craig Buckley, Heiko Meyer, Nikolaus Weiskopf, Martina Callaghan, Daniel Papp
  • Publication number: 20180172435
    Abstract: The present invention provides a measuring apparatus (200) for measuring properties of a surface (101, 103), the apparatus (200) comprising a mounting structure (210) comprising a plurality of segments (211-216) moveably mounted (217) with respect to each other, an actuation mechanism to move the segments of the mounting structure with respect to each other, and a plurality of sensors (220), each sensor being mounted to a segment of the mounting structure (210). The invention also provides a method of measuring properties of a surface (101, 103). The surface (102, 103) to be measured may be an aerodynamic surface of an aircraft.
    Type: Application
    Filed: May 27, 2016
    Publication date: June 21, 2018
    Applicants: University College London, Airbus Operations Limited
    Inventors: Stuart Robson, Ben Sargeant, Abdul Rahman El-Nounu
  • Patent number: 9993435
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: June 12, 2018
    Assignee: UNIVERSITY COLLEGE LONDON
    Inventors: Abdul Waseh Basit, Valentine Chidi Ibekwe
  • Publication number: 20180098944
    Abstract: A delayed release coating comprising a mixture of a first material selected from starch; amylose; amylopectin; chitosan; chondroitin sulfate; cyclodextrin; dextran; pullulan; carrageenan; scleroglucan; chitin; curdulan and levan, and a second material which has a pH threshold at about pH 5 or above, is used to target release of a drug from a core to the intestine, particularly the colon.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 12, 2018
    Applicant: UNIVERSITY COLLEGE LONDON
    Inventors: Abdul Waseh BASIT, Valentine Chidi IBEKWE
  • Publication number: 20170326366
    Abstract: According to an embodiment, a hearing aid system is disclosed. The system includes a speech processor communicatively coupled to a microphone. The speech processor is configured to process a microphone signal received at the speech processor for producing an electrical stimulation signal and an acoustic stimulation signal. The speech processor is also configured to generate a modified acoustic stimulation signal by modifying the acoustic stimulation signal at least for a part of a residual frequency range of a patient in dependence on effect of an implantable electrode array on mechanical properties of cochlea of the patient. The system also includes a first unit and a second unit.
    Type: Application
    Filed: May 11, 2017
    Publication date: November 16, 2017
    Applicants: Oticon Medical A/S, University College London
    Inventors: Søren Kamaric RIIS, Attila FRATER, Torsten MARQUARDT
  • Patent number: 9805496
    Abstract: The disclosure provides an approach for generating virtual terrains. A terrain editing application is configured to receive assets of various types, including a blank canvas, two-dimensional (2D) sketches, real-world elevation maps, authored heightfields, etc. The assets specify characteristics of a terrain, and provide starting points for creating the virtual terrain. The editing application further provides a set of tools allowing a user to modify the virtual terrain. In one embodiment, the set of tools may include a copy-and-paste tool, a peak creation tool, a ridge creation tool, a ridge tracing tool, and a resynthesis tool. The editing application generates a new layer for each edit, as well as 2D and three-dimensional (3D) previews of the edited terrain. The editing application also provides a user-adjustable frequency decomposition of each layer. The editing application combines layers using Laplacian blending to produce the final virtual terrain.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: October 31, 2017
    Assignees: Disney Enterprises, Inc., University College London
    Inventors: Kenneth Mitchell, Gwyneth Bradbury, Tim Weyrich
  • Patent number: 9702900
    Abstract: A method for performing sub-nanometer three-dimensional magnetic resonance imaging of a sample under ambient conditions using a diamond having at least one shallowly planted nitrogen-vacancy (NV) center. A driving radio-frequency (RF) signal and a microwave signal are applied to provide independent control of the NV spin and the target dark spins. A magnetic-field gradient is applied to the sample with a scanning magnetic tip to provide a narrow spatial volume in which the target dark electronic spins are on resonance with the driving RF field. The sample is controllably scanned by moving the magnetic tip to systematically bring non-resonant target dark spins into resonance with RF signal. The dark spins are measured and mapped by detecting magnetic resonance of said nitrogen-vacancy center at each of said different magnetic tip positions. The dark-spin point-spread-function for imaging the dark spins is directly measured by the NV center.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: July 11, 2017
    Assignees: President and Fellows of Harvard College, University College London
    Inventors: Amir Yacoby, Michael Grinolds, Marc Warner, Kristiaan De Greve, Yuliya Dovzhenko
  • Patent number: 9584928
    Abstract: The application relates to a bilateral hearing assistance system comprising first and second hearing assistance devices a processing unit, which in a NORMAL mode of operation processes an input audio signal based on configurable processing parameters and provides a processed electric stimulation signal. The system further includes one or more stimulation units for—in a TEST mode delivers first and second electric TEST stimulation signals to output units of said first and second devices respectively. The application further relates to a method of fitting a bilateral hearing assistance system to a particular user. The disclosure provides a measure allowing an improved fitting of bilaterally implanted Cochlear Implant users. The system further includes an evaluation unit configured to analyze the recorded physiological response of the user and to provide an objective measure of the user's perception of said TEST stimulation signals.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: February 28, 2017
    Assignees: OTICON MEDICAL A/S, UNIVERSITY COLLEGE LONDON
    Inventors: Jonathan Laudanski, Jamie A. Undurraga, Nick Haywood, Torsten Marquardt, David McAlpine
  • Patent number: 9452066
    Abstract: A transcutaneous prosthesis which includes a first component shaped for implantation into a bone, a second component intended for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells, and a third component intended for location exterior to the skin surface having a low surface energy which deters bacterial adhesion.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: September 27, 2016
    Assignee: University College London
    Inventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
  • Patent number: 9402944
    Abstract: The present invention relates to the field of extracorporeal liver perfusion and, more particularly, to the design of a chamber in which a biological component can be housed to form e.g. a bio-artificial liver (BAL). It also relates to a bio-artificial liver per se, it's components and methodological steps associated with its development and use. The chamber (10) for the biological component (100) of a bio-artificial liver (200) is configured to allow: • Proliferation of the biological component, in situ; • Cryopreservation of the biological component, in situ, and • Perfusion of the biological component, in situ.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: August 2, 2016
    Assignee: University College London
    Inventors: Clare Selden, Humphrey Hodgson, Sam Coward
  • Patent number: 9145377
    Abstract: A compound of formula I wherein Ar1 is a bicyclic aryl or heteroaryl, which may be optionally substituted; X and Y are each independently a group of formula II: -L1-Ar2-L2-Ar3-Q-(CH2)n-NR1R2 L1 and L2 are each independently selected from NR3, C2H2, CH2, —O—, —S— and a bond; Ar2 and Ar3 are independently optionally substituted C5 or C6 aryl or heteroaryl; Q is selected from NH(C?O), NR3, S, O; n is an integer from 1 to 5; R1 and R2 are optionally substituted and are independently hydrogen, C1-7 alkyl, C3-20 heterocyclyl, or C5-20 aryl, or R1 and R2, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 3 to 8 ring atoms; R3 is H or C1-7 alkyl.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: September 29, 2015
    Assignee: University College London
    Inventors: Stephen Neidle, Caterina Maria Lombardo, Sarah Welsh
  • Publication number: 20150264492
    Abstract: The application relates to a bilateral hearing assistance system comprising first and second hearing assistance devices a processing unit, which in a NORMAL mode of operation processes an input audio signal based on configurable processing parameters and provides a processed electric stimulation signal. The system further includes one or more stimulation units for—in a TEST mode delivers first and second electric TEST stimulation signals to output units of said first and second devices respectively. The application further relates to a method of fitting a bilateral hearing assistance system to a particular user. The disclosure provides a measure allowing an improved fitting of bilaterally implanted Cochlear Implant users. The system further includes an evaluation unit configured to analyze the recorded physiological response of the user and to provide an objective measure of the user's perception of said TEST stimulation signals.
    Type: Application
    Filed: March 10, 2015
    Publication date: September 17, 2015
    Applicants: University College London, Oticon Medical A/S
    Inventors: Jonathan LAUDANSKI, Jamie A. UNDURRAGA, Nick HAYWOOD, Torsten MARQUARDT, David McALPINE