Abstract: Disclosed are screening methods and sequences related thereto. Disclosed are methods for detecting mutations in the MYH gene of an individual. Also disclosed are methods of genotyping and methods of predicting for an individual the likelihood of developing certain cancers, such as colorectal cancer.

Abstract: The invention relates to self-contained assay cassette for detecting a ligand in a sample. The assay cassette provides for turbulent flow and mixing of the sample with assay components, including receptors that bind to a ligand, optional microspheres capable of binding the receptors or to which other secondary receptors are attached, and liquid crystalline materials. The assay cassette also provides for laminar flow of the mixed sample into a detection chamber where complexes between a receptor, ligand, and optional microspheres, is detected as transmission of polarized light through the detection chambers. The invention also relates to methods for detecting a ligand in a sample using turbulent flow to mix the sample with assay components, including liquid crystalline materials, and laminar flow of the mixed sample such that the liquid crystalline material assumes an ordered conformation in absence of a ligand.

Abstract: The present invention relates generally to a method for determining the level of expression of one or more candidate objects of interest in a biological sample. In particular, the present invention relates to a method for determining the level of expression of one or more candidate objects of interest using image analysis. More specifically, the present invention relates to a method and a system for determining the level of expression of one or more candidate objects of interest using an automated (computer-aided) image analysis system.

Abstract: In an information retrieval method a meta search engine receives a user information query in the form of key words; and submits the query to a search engine, and also submits the query to a snippet database storing previously selected results, indexed by a snippet index of terms included in snippets of the results when they were previously selected. The meta search engine then receives results from the search engine; and receives a response from the snippet database. It merges the results from the search engine with those from the snippet database; and submits re-ranked results to the user. The snippet database processes in parallel with the underlying search engine. The meta search engine also monitors which results of the returned re-ranked results are selected by the user, and updates the snippet index accordingly.

Abstract: The invention provides for an apparatus (1) for growing aquatic animals comprising at least two securing members (3, 6) adapted to be removably fixed together such that a feed substrate (7) can be reversibly sandwiched between the securing members. The invention also provides for modular assemblies of the apparatus, and further provides methods of culturing aquatic animals and methods of increasing roe content of aquatic animals.

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.

Abstract: Soluble amphiphilic macrocycle analogues having lipophilic groups attached to one side of the units making up the macrocycle and hydrophilic groups attached to the other side. These amphiphilic macrocyclic derivatives have the ability to self-assemble in aqueous solvent forming micelles or vesicles and can be used as hosts for the solubilization and/or stabilization of various compounds. Embodiments of the present invention utilize macrocyclic oligosaccharides and preferably cyclodextrin as the macrocyclic derivatives to be modified.

Abstract: The invention provides a peptide triazole conjugate and derivatives thereof, and methods of its use.

Abstract: An apparatus for characterising a subject's visual response, comprising a data processor, a display and an input device, wherein the data processor is arranged to present evaluation images at different positions on the display such that they occur at different positions within the subject's field of view, and wherein each evaluation image comprises a contribution of at least two items selected from a list comprising: a base image, a test image, and a noise image, and wherein the data processor is responsive to the input device such that the subject can indicate whether they can see the test image in the evaluation image, and the data processor is further arranged to evaluate the subject's responses so as to give an indication of one or more of visual efficiency, internal noise and visual sensitivity as a function of position within the subjects field of view.

Abstract: There is disclosed a method of creating an LDPC code that is defined by a parity-check matrix H. The parity-check matrix H is derived from a (0,1)-geometry which is induced by a finite inversive space. This inversive space has an order q where every circle in the inversive space contains exactly q+1 points, q is preferably even, and most preferably equal to 2. Where the inversive space has a dimension n. Where the (0,1)-geometry is formed as a derived geometric structure based on pencils of degree m?n in the inversive space. The method includes construction of a binary K by N matrix H labelled by K circles and N pencils of the inversive space, wherein the (i, j)-entry of the matrix is 1 if circle i belongs to pencil j, and 0 otherwise. If the degree of the pencil is given by 2 then the parity-check matrix H needs to be transposed, i.e. HT is used instead of H. A method of transmitting a message, a coder, a decoder and a data transmission system using such codes are also disclosed.

Abstract: A system for providing extreme ultraviolet (EUV) radiation comprises a laser source arranged to produce a laser beam having a focus; and a carrier movable relative to the laser source for carrying a surface material, the surface material when carried by the carrier providing a renewable target edge. The focussed beam is arranged to impinge on the target edge to produce an EUV radiation emitting plasma. The system is cooperable with a mirror for harnessing the EUV radiation by reflecting EUV radiation impinging thereon. The mirror comprises a substantially aspheric surface and means for supplying a reflecting liquid to at least partially coat the aspheric surface, the mirror being rotatable to centrifugally confine the liquid to the aspheric surface.

Abstract: A conversational recommender system retrieves k cases (3) and generates a structure for user feedback (4). The structure includes a list of critique units for each of which the user can specify a value range. It also generates compound critiques, each being a combination of features and value ranges presented together. An explanation of a compound critique can be generated in response to a user request. The system determines (7), from one cycle of a session to the next, if a preference has been carried. If so, a re-focus function implementing diversity is used for retrieval in the next cycle. If not, a refine function implementary similarity-based retrieval is used for the next cycle of the session.

Abstract: The invention provides isolated liver stage Plasmodium polypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-48 and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the liver stage Plasmodium polypeptides of the invention, compositions comprising one or more liver stage Plasmodium polypeptides of the invention, methods for inducing an immune response against the liver stage Plasmodium polypeptides, and methods for treating and diagnosing liver stage malaria.

Abstract: Apparatus and method for measuring the deformation of a tethered or untethered cantilever by projecting a radiation beam onto the cantilever, detecting an interference pattern reflected from or transmitted through the cantilever, and calculating the deformation of the cantilever by measuring the intensity variation within at least a portion of the interference pattern.

Abstract: The present invention provides a system and method for creating a coherent optical comb comprising a plurality of lasers, each laser providing an optical output channel; means for combining each optical channel output; a modulator for modulating the combined optical channel outputs, to provide a modulated signal; means for feeding back said modulated signal to said plurality of lasers, such that each laser output channel is phase and/or frequency locked with respect to at least one other of said plurality of lasers. A discrete optical comb is obtained without the need for excessively high power laser outputs and only employs a single (optional) wavelength locker for all channels.

Abstract: The invention relates to materials and methods for evaluating the prognosis of a patient presenting with chronic myelogenous leukaemia (CLL) and for CLL therapy.

Abstract: A device for providing extracorporeal cardiac pacing. The device includes an ultrasound transducer mountable to the external thorax of a patient and an ultrasound generator for transmitting ultrasound pulses to the ultrasound transducer. The heart rate of a patient is monitored by the device. A controller evaluates the heartbeat as compared with threshold criteria for stimulation of the heart and causes the ultrasound generator to deliver ultrasound pulses to the ultrasound transducer at a prescribed intensity, frequency, and pulse duration.

Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR1 or NR1R2 wherein each of R1 and R2 is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO2-alkyl, alkenyl, CN, NH2, hydroxy, halo, alkoxy, CF3 and nitro; Y is a polar functional group selected from OH, NO2, CN, COR3, COOR3, NR3R4, CONR3R4, SO3H, SO2—R3, SO2NR3R4 and CF3, where each of R3 and R4 is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X—Y is other than meta-C?—C—(CH2)2CO2H, meta-C?—C—(CH2)2OH, meta-C?C—(CH2)2CO2Me, meta-(CH2)4CO2H, ortho-CH2CO2H, ortho-(CH2)2CO2H and ortho-(CH2)4CO2H; and (ii) when A is phenyl, n is 0, and Z is OMe, X—Y is other than meta-C?

Abstract: An animation tool which is configured to enable a user to generate one or more animations for subsequent execution on a computer platform is described. The animation tool provides a plurality of graphical integers which a user can use to generate an animation. The graphical integers are divisible into graphical elements and graphical element effects, the effects being applied by a user onto an element and defining the viewing properties of that element.

Abstract: Disclosed are screening methods and sequences related thereto. Disclosed are methods for detecting mutations in the MYH gene of an individual. Also disclosed are methods of genotyping and methods of predicting for an individual the likelihood of developing certain cancers, such as colorectal cancer.