Abstract: The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.

Abstract: The present invention relates to compounds which activate the p53 response, and find use in, for example, hyperproliferative diseases such as cancer treatment and potentially other diseases/conditions involving sirtuin function.

Abstract: A computer processor based method for controlling a plurality of computer displays in response to user behavior, the method comprising identifying at least one display that is unattended by the user by determining the user's visual focus, and applying an overlay window to the unattended display to control visualization of the identified unattended display.

Abstract: A dendrimer of formula (I): [DENDRON1]x-CORE-[B-[X]b]a (I) wherein: CORE is a metal ion or a group containing a metal ion, or is a non-polymeric organic group; B is a phenyl ring; a is an integer of from 1 to 8; b is an integer of from 3 to 5; x is zero or an integer of from 1 to 7; each X is an aryl or heteroaryl ring, or is an at least partially conjugated dendritic molecular structure; each DENDRON1 is an at least partially conjugated dendritic molecular structure; and wherein the dendrimer further comprises one or more surface groups; with the proviso that where CORE is a non-metallic core, then X is an at least partially conjugated dendritic molecular structure comprising at least one linking group.

Abstract: An ambulatory device for use in a therapeutic and/or cosmetic treatment, the device comprises an organic light-emitting semiconductor which, in use, covers an area to be treated and emits electromagnetic radiation to cause said therapeutic and/or cosmetic treatment of the area. The light source may be extensive to provide uniform irradiation of the area to be treated and may be pulsed. The device may also include a photopharmaceutical.

Abstract: The present invention provides compounds, compositions, medicaments and methods comprising or using carbohydrate binding molecules. More specifically, the invention provides a means of treating diseases and/or conditions caused or contributed to by pathogens, particularly microbial pathogens and methods of screening, identifying, detecting tagging and/or labelling carbohydrates.

Abstract: The present invention relates to the synthesis of a variety of metal organic frameworks (MOFs) using low temperature and solvents which are considered to be not particularly harmful to the environment. There is also provided novel MOFs which may be made by the desired processes.

Abstract: A method for sorting particles, in particular cells A and B. The method uses a single channel with only one input and only one output. A particle mix A and B in a fluid is introduced into the channel and particles within the channel are sorted.

Abstract: An optoelectronic semiconductor component includes a semiconductor layer sequence having at least one active layer, and a photonic crystal that couples radiation having a peak wavelength out of or into the semiconductor layer sequence, wherein the photonic crystal is at a distance from the active layer and formed by superimposition of at least two lattices having mutually different reciprocal lattice constants normalized to the peak wavelength.

Abstract: A pulse generator is disclosed. The pulse generator can include an ac source for providing an ac signal. A pulsed switch can be connected to an ac output of the ac source that is adapted or configured to generate a pulsed output from the ac signal and a non-linear frequency multiplier adapted or configured to shorten the pulses of the pulsed output. The pulsed switch can include a mixer.

Abstract: An apparatus and method for mineralising demineralised and hypo-mineralised biological material such as tooth or bone. The apparatus has a probe electrode for receiving a mineralisation agent and a counter electrode. It is also provided with a controller to control the electrical signal provided to the probe such that the extent of mineralisation of the biological material is controlled by modulating or changing the electrical signal provided by the probe based upon the measured output of the circuit formed from the probe, counter electrode and biological material. The electrical output provides a measure of the extent of mineralisation of the biological material which is compared with data from a reference technique which gives 3D structural information on an area of interest in the biological material.

Abstract: A micro-fluidic system comprising means for optically trapping a particle and a Raman excitation source for causing Raman scatter from the particle while it is in the optical trap.

Abstract: The resolution of conventional imaging devices is restricted by the diffraction limit ‘Perfect’ imaging devices which can achieve a resolution beyond the diffraction limit have been considered impossible to implement. However, the present disclosure provides an imaging device which can achieve improved resolution beyond the diffraction limit and which can be implemented in practice. Said imaging device comprises: a. a lens having a refractive index that varies according to a predetermined refractive index profile; b. a source; c. an outlet for decoupling waves from the device; and d. a reflector provided around the lens, the source and the outlet, wherein the reflector and the refractive index profile of the lens are together arranged to direct waves transmitted in any of a plurality of directions from the source to the outlet.

Abstract: An optical parametric oscillator comprising: an optical cavity; a semiconductor gain-medium located within the optical cavity, such that together they form a semiconductor laser, and a nonlinear material located within the cavity such that the nonlinear material continuously generates down-converted idler- and signal-waves in response to a pump-wave continuously generated by the semiconductor gain-medium, wherein the pump wave is resonant within the optical cavity and one or other but not both of the down-converted waves is resonant within the pump wave cavity or a further optical cavity. Brewster plates ensure singly resonant optical parametric oscillators and a birefringent filer is used for frequency setting. Coupled cavities allow for setting the photon lifetime in the cavity that relaxation oscillations are prevented.

Abstract: An optical parametric device comprising a slant-stripe periodically poled nonlinear material that is operable to generate signal in response to interaction with a pump wave, the non-linear interaction being such that the pump and idler waves are collinear and the signal wave is non-collinear relative to the pump and idler waves, wherein the slant-stripe non-linear material is able to generate two idler waves and two signal waves, and the device is adapted to allow for the selection and output coupling of a required one of the two signal waves.

Abstract: A method of screening compounds or molecules comprising the steps of: translating a sequence encoding the amino acid sequence comprising SEQ ID No. 29 in a translation system in the presence of a test compound or molecule; and analysing the translation product(s) for the presence of one or more of (a) a peptide comprising the amino acids Pro-Gly at the C terminus and a peptide comprising the amino acid Pro at the N terminus: or (b) a peptide comprising the amino acid sequence of SEQ ID No. 29.

Abstract: A solar cell that has a thin film of active material in which is defined a series or array of diffraction cells, wherein each diffraction unit-cell has a non-periodic series of diffraction features and is adapted to suppress at least one low order diffraction mode.

Abstract: An intra-cavity optical parametric oscillator. The oscillator includes means for providing a non-linear loss for suppressing relaxation oscillations.

Abstract: A direct carbon fuel cell DCFC system (5), the system comprising an electrochemical cell, the electrochemical cell (10) comprising a cathode (30), a solid state first electrolyte (25) and an anode (20), wherein, the system further comprises an anode chamber containing a second electrolyte (125) and a fuel (120). The system, when using molten carbonate as second electrolyte, is preferably purged with CO2 via purge gas inlet (60).

Abstract: Methods for controlling light transmission through a medium by transmitting light from a single spatial portion of an input optical field through the medium creating an output optical field, superposing the output optical field with a reference optical field creating an optical interference field, detecting an intensity of a spatial portion of a polarization component of the optical interference field and using the detected intensity to determine a value of an optical field amplitude and of an optical field phase for each of a plurality of spatial portions of the input optical field and for each of first and second orthogonal input polarization states of transmitted light entering the medium. The method may be used in the control of the transmission of light 1) through a medium, which is randomizing in amplitude, phase and/or polarization or 2) through a multi-mode fiber or for beam shaping, optical trapping and/or optical manipulation.