Abstract: New pyridinic sulfonamide derivatives represented by a general formula (I), wherein R1, represents a mono- or polyhalogenated C1–12-alkyl or a mono- or poly-halogenated C3–8-cycloalkyl group. The method of production of such derivatives and their use as active therapeutic substance in the treatment of diseases such as inflammation, arthrosis, cancer, angiogenesis and asthma are also reported.
Type:
Grant
Filed:
September 19, 2002
Date of Patent:
June 5, 2007
Assignee:
University De Liege
Inventors:
Jacques Delarge, Bernard Pirotte, Jean-Michel Dogne, Xavier de Leval, Fabien Julemont
Abstract: The present invention relates, for example, to an isolated DNA comprising a sequence which encodes a cold-active beta galatosidase that is specific for lactose and has a stable enzymatic activity at a temperature below 8° C. In embodiments of the invention, the DNA is isolated from the psychrophilic bacterium Pseudoalteromonas haloplanktis.
Type:
Application
Filed:
March 18, 2004
Publication date:
September 8, 2005
Applicant:
University de Liege
Inventors:
Charles Gerday, Anne Hoyoux, Jean-Marie Francois, Phillip Dubois, Etienne Baise, Isabell Jennes, Sabine Genicot