Patents Assigned to University Health Network
-
Patent number: 11662315Abstract: A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.Type: GrantFiled: November 1, 2021Date of Patent: May 30, 2023Assignees: THE TRUSTEES OF DARTMOUTH COLLEGE, UNIVERSITY HEALTH NETWORKInventors: Keith D. Paulsen, David W. Roberts, Dennis Wirth, Brian C. Wilson, Mira Sibai
-
Publication number: 20230148588Abstract: An organ perfusion solution includes a colloid component, a salt mixture, a buffer system, and a glutamine compound in a physiologically acceptable medium.Type: ApplicationFiled: March 26, 2021Publication date: May 18, 2023Applicant: University Health NetworkInventors: Mingyao LIU, Shafique KESHAVJEE
-
Publication number: 20230128394Abstract: There is provided herein a method for expanding human CD4?CD8? regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR+CD56? or alternatively ??-TCR+.Type: ApplicationFiled: December 23, 2022Publication date: April 27, 2023Applicant: UNIVERSITY HEALTH NETWORKInventors: Li ZHANG, Paulina ACHITA, Jongbok LEE, Dalam LY, Dzana DERVOVIC
-
Patent number: 11636288Abstract: Embodiments described herein provide a platform, device and process for digital pathology that enable multi-level annotation and visualization of histopathologic slides using a modular arrangement of deep convolutional neural networks (CNNs). The CNNs can be trained using pathology images (e.g., in some cases increasing the base of data by breaking larger fields of view into smaller ones) to learn features consistent with certain pathologies. The platform can use the CNNs to visually annotate pathology slides at an interface tool of a display device. The platform can automate the process of selection, as well as provide an opportunity for the pathologist to see a depiction of predicted results. The platform can use the CNNs to identify regions of interest on pathology slides. The interface tool can enable a predicted region of interest (ROI) type to be visually presented on a surface map showing the basis of the prediction.Type: GrantFiled: November 6, 2018Date of Patent: April 25, 2023Assignee: UNIVERSITY HEALTH NETWORKInventors: Kevin Faust, Zoya Volynskaya, Ugljesa Djuric, Phedias Diamandis
-
Patent number: 11629185Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.Type: GrantFiled: December 18, 2020Date of Patent: April 18, 2023Assignees: NOVO NORDISK A/S, UNIVERSITY HEALTH NETWORKInventors: Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
-
Patent number: 11607454Abstract: Devices, materials, compounds, systems, and processes for Cherenkov-Activated Nuclear-Targeted Photodynamic Therapy that involves generating Cherenkov light within the tissue of a target volume and using this light to activate photosensitizing material that is located in the nucleus of cells of the target volume.Type: GrantFiled: May 19, 2017Date of Patent: March 21, 2023Assignee: UNIVERSITY HEALTH NETWORKInventors: Brian Wilson, Christine Allen
-
Patent number: 11597917Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.Type: GrantFiled: June 6, 2018Date of Patent: March 7, 2023Assignees: The Medical College of Wisconsin, Inc., University Health Network, Washington University in St. LouisInventors: Jeffrey A. Medin, John F. Dipersio, Murtaza S. Nagree
-
Patent number: 11572354Abstract: Inhibition of indoleamine 2,3-dioxygenase (IDO1) is an attractive immunotherapeutic approach for the treatment of a variety of cancers. Dysregulation of this enzyme has also been implicated in other severe diseases such as Alzheimer's disease and arthritis. Small molecule inhibitors of Formula (Ia) and (Ib) of IDO, their synthesis, and uses thereof are provided.Type: GrantFiled: January 9, 2019Date of Patent: February 7, 2023Assignee: University Health NetworkInventors: Donald Weaver, Michael G. Brant, Stephanie Wohnig, Fan Wu, Jake Goodwin-Tindall, Autumn Meek, Paolo Schiavini
-
Patent number: 11560558Abstract: There is described herein, a method of capturing cell-free methylated DNA from a sample having less than 100 mg of cell-free DNA, comprising the steps of: subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA; adding a first amount of filler DNA to the sample, wherein at least a portion of the filler DNA is methylated; denaturing the sample; and capturing cell-free methylated DNA using a binder selective for methylated polynucleotides.Type: GrantFiled: November 4, 2021Date of Patent: January 24, 2023Assignees: UNIVERSITY HEALTH NETWORK, SINAI HEALTH SYSTEMInventors: Daniel Diniz De Carvalho, Shu Yi Shen, Rajat Singhania
-
Patent number: 11547725Abstract: There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the population of CD8+ T cells with Coenzyme A.Type: GrantFiled: December 21, 2017Date of Patent: January 10, 2023Assignee: UNIVERSITY HEALTH NETWORKInventors: Pamela S. Ohashi, Michael St. Paul, Sam Saibil
-
Publication number: 20230000356Abstract: A system for outputting a representation of a wound in tissue comprises a housing configured to removably receive at least a portion of a wireless communication device. At least one light source coupled to the housing is configured to emit excitation light to illuminate a target which includes at least a portion of the wound. A power supply contained in the housing is configured to provide power to the light source. A non-transitory computer-readable medium stores a program executable to cause the performance of operations comprising detecting signals responsive to illumination of the target, outputting the representation of the target based thereon, storing data relative to one or more target surface parameter based on the detected signals, and displaying the representation. The signals correspond to at least one of endogenous or exogeneous fluorescence, absorbance, and reflectance from at least one biological component in and/or on the target.Type: ApplicationFiled: July 1, 2022Publication date: January 5, 2023Applicant: UNIVERSITY HEALTH NETWORKInventors: Ralph Sebastian Dacosta, Brian C. Wilson, Kai Zhang
-
Patent number: 11534460Abstract: There is provided herein a method for expanding human CD4-CD8- regulatory T cells (DN Tregs) from a population of cells comprising DN Tregs, comprising: culturing the population of cells with artificial antigen presenting cells (APCs), preferably the DN Tregs are ??-TCR-CD56- or alternatively ?8-TCR+.Type: GrantFiled: May 11, 2016Date of Patent: December 27, 2022Assignee: University Health NetworkInventors: Li Zhang, Paulina Achita, Jong Lee, Dalam Ly, Dzana Dervovic
-
Patent number: 11504075Abstract: Uptake of hypoxia-sensitive PET tracers is dependent on tissue transport properties, specifically, distribution volume. Variability in tissue transport properties reduces the sensitivity of static PET imaging to hypoxia. When tissue transport (vd) effects are substantial, correlations between the two methods of determining hypoxic fractions are greatly reduced—that is, trapping rates k3 are only modestly correlated with tumour-to-blood ratio (TBR). In other words, the usefulness of dynamic- and static-PET based hypoxia surrogates, trapping rate k3 and TBR, in determining hypoxic fractions is reduced in regions where diffusive equilibrium is achieved slowly. A process is provided for quantifying hypoxic fractions using a novel biomarker for hypoxia, hypoxia-sensitive tracer binding rate kb, based on PET imaging data. The same formalism can be applied to model the kinetics of non-binding CT and MT contrast agents, giving histopathological information about the imaged tissue.Type: GrantFiled: December 20, 2018Date of Patent: November 22, 2022Assignee: UNIVERSITY HEALTH NETWORKInventors: Edward Taylor, David A. Jaffray, Ivan Wai Tong Yeung
-
Patent number: 11499195Abstract: There is described herein a method of prognosing and/or predicting disease progression and/or in subject with prostate cancer, the method comprising: a) providing a sample containing mitochondrial genetic material from prostate cancer cells; b) sequencing the mitochondrial genetic material with respect to at least 1 patient biomarker selected from CSB1, OHR, ATP8 and HV1 (hypervariable region 1); c) comparing the sequence of the patient biomarkers to control or reference biomarkers to determine mitochondrial single nucleotide variations (mtSNVs); and d) determining the a prostate cancer prognosis; wherein a relatively worse outcome is associated with the presence of mtSNVs in CSB1, OHR, ATP8 and a relatively better outcome is associated with the presence of mtSNVs in HV1.Type: GrantFiled: June 2, 2017Date of Patent: November 15, 2022Assignees: Ontario Institute for Cancer Research, University Health NetworkInventors: Julia A. Hopkins, Paul Boutros, Robert G. Bristow
-
Patent number: 11497796Abstract: Disclosed herein is an agent that modulates a cis interaction between Repulsive Guidance Molecule A (RGMa) and Neogenin or lipid rafts. Modulation by the agent may include blocking the cis interaction between RGMa and Neogenin and/or disrupting lipid rafts. In turn, this promotes neuronal cell survival and axon growth and/or regeneration. Also disclosed herein is a method of treating a disease in a subject in need thereof. The method may include administering the agent to the subject. Further disclosed herein is a method of identifying an agent that modulates the cis interaction between RGMa and Neogenin.Type: GrantFiled: February 15, 2019Date of Patent: November 15, 2022Assignee: UNIVERSITY HEALTH NETWORKInventors: Philippe P. Monnier, Nardos G. Tassew
-
Patent number: 11491180Abstract: There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.Type: GrantFiled: June 25, 2021Date of Patent: November 8, 2022Assignees: UNIVERSITY HEALTH NETWORK, NOTOGEN. INC.Inventors: William Mark Erwin, Bjorn C. J. Eek
-
Patent number: 11485057Abstract: The present invention provides a method of producing the composite comprising: a) melt blending the matrix with the fibers to produce a melted composite, b) injecting the melted composite into a mold and allowing the melted composite to solidify and, c) removing at least a portion of the outermost layer of a composite such that the fibers protrude from the surface of the composite. Also provided is composite produced by the methods of the invention comprising soft and hard fibers embedded in a soft rubber-like matrix, wherein the fibers protrude from the composite's surface. In specific embodiments, the composite comprises carbon fibers and poly(p-phenylene-2,6-benzobisoxazole) (PBO) fibers in a thermoplastic polyurethane (TPU) matrix, wherein the fibers protrude from the composite's surface. Slip-resistant product comprising the composite are also provided.Type: GrantFiled: April 9, 2019Date of Patent: November 1, 2022Assignee: University Health NetworkInventors: Zahra S. Bagheri, Ali O. Anwer, Reza Rizvi, Hani E. Naguib, Tilak Dutta, Geoffrey Roy Fernie
-
Patent number: 11471480Abstract: There is disclosed herein compositions, methods, uses and systems for reducing pain in a patient that emanates from a body area, preferably spine or joint. Methods of treatment or prevention are described for a disease or condition selected from degenerative disc disease, disc injury, pain, arthritis, or suspected arthritis.Type: GrantFiled: June 25, 2021Date of Patent: October 18, 2022Assignees: UNIVERSITY HEALTH NETWORK, NOTOGEN, INC.Inventors: William Mark Erwin, Bjorn C. J. Eek
-
Publication number: 20220324938Abstract: The present disclosure is directed recombinant T cell receptors capable of binding a tyrosinase epitope, a MAGA-A1 epitope, a MART1 epitope, a MAGE-A3 epitope, or an SSX2 epitope and nucleic acid molecules encoding the same. In some embodiments, the nucleic acid molecules further comprise a second nucleotide sequence, wherein the second nucleotide sequence or the polypeptide encoded by the second nucleotide sequence inhibits the expression of an endogenous TCR. Other aspects of the disclosure are directed to vectors comprising the nucleic acid molecule and cells comprising the recombinant TCR, the nucleic acid molecule, or the vector. Still other aspects of the disclosure are directed to methods of using the same. In some embodiments, the methods comprise treating a cancer in a subject in need thereof.Type: ApplicationFiled: March 24, 2020Publication date: October 13, 2022Applicant: University Health NetworkInventors: Naoto HIRANO, Kenji MURATA, Kayoko SASO
-
Publication number: 20220291215Abstract: The present disclosure is directed to methods of identifying MHC class II-specific T cell receptors (TCRs). In certain aspects, the method comprises contacting a T cell with a complex comprising an (i) MHC class II molecule having a higher affinity for CD4 than naturally occurring MHC class II molecules and (ii) a peptide, e.g., an epitope. In certain aspects, the HLA class II molecule comprises a beta chain having one or more mutations relative to a wild-type beta chain sequence.Type: ApplicationFiled: July 29, 2020Publication date: September 15, 2022Applicant: University Health NetworkInventors: Naoto HIRANO, Munehide NAKATSUGAWA, Yuki YAMASHITA, Kenji SUGATA, Muhammed Aashiq RAHMAN