Patents Assigned to University Health Network
  • Publication number: 20200277361
    Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
    Type: Application
    Filed: February 12, 2020
    Publication date: September 3, 2020
    Applicants: PROTHENA BIOSCIENCES LIMITED, UNIVERSITY HEALTH NETWORK
    Inventors: Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
  • Patent number: 10745760
    Abstract: There is provided herein, systems, devices and methods for determining a risk of recurrence of cancer following a cancer therapy of a patient by determining genomic instability of a tumour. There is further provided systems, devices and methods for categorizing a patient into a prognostic cancer sub-group by using copy number alterations.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: August 18, 2020
    Assignees: University Health Network, Ontario Institute for Cancer Research
    Inventors: Paul Boutros, Robert G. Bristow, Emilie Lalonde
  • Patent number: 10736923
    Abstract: A method for generating chondrocytes and/or cartilage, optionally articular like non-hypertrophic chondrocyte cells and/or cartilage like tissue and/or hypertrophic chondrocyte like cells and/or cartilage like tissue, the method comprising: a. culturing a primitive streak-like mesoderm population, optionally a CD56+, PDGFRalpha+ KDR? primitive streak-like mesoderm population, with a paraxial mesoderm specifying cocktail comprising: i. a FGF agonist; ii. a BMP inhibitor; optionally Noggin, LDN-193189, Dorsomorphin; and iii. optionally one or more of a TGFbeta inhibitor, optionally SB431524; and a Wnt inhibitor, optionally DKK1, IWP2, or XAV939; ?to specify a paraxial mesoderm population expressing cell surface CD73, CD105 and/or PDGFR-beta; b. generating a chondrocyte precursor population comprising: i. culturing the paraxial mesoderm population expressing CD73, CD105 and/or PDGFR-beta at a high cell density optionally in serum free or serum containing media; ii.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: August 11, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Gordon Keller, April M. Craft
  • Patent number: 10729792
    Abstract: There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 4, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Gang Zheng, Joseph Keca
  • Patent number: 10716791
    Abstract: The present application relates to a-substituted amino acid compounds of the Formula (I), compositions comprising these compounds and their use, in particular for the treatment of diseases, disorders or conditions characterized by or associated with the hypercitrullination of proteins by peptidyl arginine deiminase (PAD) enzymes.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: July 21, 2020
    Assignee: University Health Network
    Inventors: Lakshmi P. Kotra, Ewa Wasilewski
  • Patent number: 10711246
    Abstract: Provided are methods and products for obtaining cardiovascular lineage cells from hPSCs.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: July 14, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Gordon Keller, Alec Drake Witty, Steven James Kattman
  • Publication number: 20200207861
    Abstract: A method for inhibition of leukemic stem cells expressing IL-3R? (CD123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3R? (CD123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.
    Type: Application
    Filed: July 19, 2019
    Publication date: July 2, 2020
    Applicants: CSL Limited, University Health Network
    Inventors: John Edgar DICK, Liqing Jin, Gino Luigi VAIRO, David Paul Gearing, Samantha Jane Busfield
  • Publication number: 20200202588
    Abstract: A method and apparatus is provided to iteratively reconstruct a computed tomography (CT) image using a spatially-varying content-oriented regularization parameter, thereby achieving uniform statistical properties within respective organs/regions and different statistical properties (e.g., degree of smoothing and noise level) among the respective organs/regions. For example, less smoothing and sharper features/resolution can be applied within a lung region than within a soft-tissue region by using a smaller regularization parameter value in the lung region than in the soft-tissue region. This can be achieved, e.g., using a minimum intensity projection to suppress/eliminate sub-solid nodules in the lung region. The content-oriented regularization parameter can be generated by reconstructing an initial CT image, which is then segmented/classified according to organs and/or tissue type.
    Type: Application
    Filed: December 20, 2018
    Publication date: June 25, 2020
    Applicants: CANON MEDICAL SYSTEMS CORPORATION, UNIVERSITY HEALTH NETWORK
    Inventors: Chung CHAN, Zhou YU, Jian ZHOU, Patrik ROGALLA, Bernice HOPPEL, Kurt Walter SCHULTZ
  • Patent number: 10685461
    Abstract: A method and apparatus is provided to iteratively reconstruct a computed tomography (CT) image using a spatially-varying content-oriented regularization parameter, thereby achieving uniform statistical properties within respective organs/regions and different statistical properties (e.g., degree of smoothing and noise level) among the respective organs/regions. For example, less smoothing and sharper features/resolution can be applied within a lung region than within a soft-tissue region by using a smaller regularization parameter value in the lung region than in the soft-tissue region. This can be achieved, e.g., using a minimum intensity projection to suppress/eliminate sub-solid nodules in the lung region. The content-oriented regularization parameter can be generated by reconstructing an initial CT image, which is then segmented/classified according to organs and/or tissue type.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 16, 2020
    Assignees: CANON MEDICAL SYSTEMS CORPORATION, UNIVERSITY HEALTH NETWORK
    Inventors: Chung Chan, Zhou Yu, Jian Zhou, Patrik Rogalla, Bernice Hoppel, Kurt Walter Schultz
  • Patent number: 10669330
    Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: June 2, 2020
    Assignees: PROTHENA BIOSCIENCES LIMITED, UNIVERSITY HEALTH NETWORK
    Inventors: Yue Liu, Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
  • Publication number: 20200157494
    Abstract: Methods for producing hepatocyte and/or cholangiocyte lineage cells from pluripotent stem cells, the method comprising (a) specifying the extended nodal agonist treated induced endodermal cell population to obtain a cell population comprising hepatocyte and/or cholangiocyte progenitors by contacting the extended nodal agonist treated induced endodermal cell population with specification media comprising a FGF agonist and a BMP4 agonist and/or active conjugates and/or fragments thereof; (b) inducing maturation, and optionally further lineage specification and/or expansion of the hepatocyte and/or cholangiocyte progenitors of the cell population to obtain a population comprising hepatocyte lineage cells such as hepatoblasts, hepatocytes and/or cholangiocytes, the inducing maturation step comprising generating aggregates of the cell population. Optionally, the method also comprises activating the cAMP pathway within the aggregates and forming co-aggregates.
    Type: Application
    Filed: August 22, 2018
    Publication date: May 21, 2020
    Applicants: UNIVERSITY HEALTH NETWORK, THE HOSPITAL FOR SICK CHILDREN
    Inventors: Gordon KELLER, Shinichiro OGAWA, Anand GHANEKAR, Christine BEAR, Binita M. KAMATH, Mina OGAWA, James SURAPISITCHAT
  • Publication number: 20200155004
    Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.
    Type: Application
    Filed: December 23, 2019
    Publication date: May 21, 2020
    Applicant: University Health Network
    Inventors: Anthony Taywon Kim, Brian Campbell WILSON
  • Patent number: 10654907
    Abstract: Provided is a method for determining a TCR polypeptide chain that can form a TCR specific for a peptide of interest. Also provided are methods and compositions for producing a cell expressing a T cell receptor (TCR) specific for a peptide of interest, methods and compositions for producing a TCR chain nucleic acid and/or pair of TCR chain polypeptides and/or nucleic acids encoding a TCR, a cell population comprising the cell harboring the nucleic acids encoding a TCR obtained by said method, and a method for treating a disorder comprising administering to the subject said cell population.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: May 19, 2020
    Assignee: University Health Network
    Inventors: Naoto Hirano, Munehide Nakatsugawa, Toshiki Ochi
  • Patent number: 10633433
    Abstract: The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
    Type: Grant
    Filed: July 2, 2016
    Date of Patent: April 28, 2020
    Assignees: PROTHENA BIOSCIENCES LIMITED, UNIVERSITY HEALTH NETWORK
    Inventors: Tarlochan S. Nijjar, Avijit Chakrabartty, Jeffrey N. Higaki
  • Publication number: 20200104998
    Abstract: Systems and methods for obtaining diagnostic data of a target are disclosed. The systems include an imaging device and a drape. The imaging device includes at least one excitation light source for fluorescent imaging, and an optical sensor configured to detect signals responsive to illumination of the target with the excitation light. The drape is configured to reduce ambient light surrounding the target during imaging.
    Type: Application
    Filed: October 4, 2019
    Publication date: April 2, 2020
    Applicant: UNIVERSITY HEALTH NETWORK
    Inventor: Ralph DACOSTA
  • Patent number: 10607738
    Abstract: Various embodiments are described herein for a system and a method for treatment planning for providing ablative therapy to a patient. The treatment planning may involve segmenting images of the patient to define areas to receive treatment, defining trial parameters, simulating treatment of ablative therapy to the patient according to the trial parameters; analyzing a thermal dose distribution resulting from the simulated treatment to determine treatment effectiveness; determining when the treatment effectiveness meets a treatment effectiveness criteria; and providing an indication of the trial parameters when the treatment effectiveness meets the treatment effectiveness criteria.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 31, 2020
    Assignees: University Health Network, Sunnybrook Research Institute
    Inventors: Sean Davidson, Michael D. Sherar, Kieran Murphy, Claire McCann, Robert Weersink
  • Patent number: 10596393
    Abstract: A Radio-Therapy (RT) system includes an integrated radiation source and a Magnetic Resonance Imaging (MRI) system that implements a method for providing a variable imaging Field Of View (FOV). The FOV can be tailored for various RT-specific applications such as, but not limited to, patient setup verification and real-time tumor tracking, for example, as well as for various imaging volumes of interest.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: March 24, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Teodor Marius Stanescu, David Anthony Jaffray
  • Publication number: 20200087386
    Abstract: The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, among other applications.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 19, 2020
    Applicants: PROTHENA BIOSCIENCES LIMITED, UNIVERSITY HEALTH NETWORK
    Inventors: YUE LIU, TARLOCHAN S. NIJJAR, AVIJIT CHAKRABARTTY, JEFFREY N. HIGAKI
  • Patent number: 10584130
    Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: March 10, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Sze-Wan Li, Heinz W. Pauls, Peter Brent Sampson
  • Patent number: 10570143
    Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: February 25, 2020
    Assignee: UNIVERSITY HEALTH NETWORK
    Inventors: Yong Liu, Heinz W. Pauls, Radoslaw Laufer, Sze-Wan Li, Peter Brent Sampson, Miklos Feher, Grace Ng, Narendra Kumar B. Patel, Yunhui Lang