Patents Assigned to University Hospital of Basel
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Publication number: 20230019870Abstract: The present invention relates to a reliable method of prediction of lower respiratory tract infection or inflammation in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development and the severity of the disease, allowing the classification of patients according to risk.Type: ApplicationFiled: June 23, 2022Publication date: January 19, 2023Applicant: UNIVERSITY HOSPITAL OF BASELInventors: Daiana Stolz, Frederic Lajaunias
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Patent number: 11402390Abstract: The present invention relates to a reliable method of prediction of lower respiratory tract infection or inflammation in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development and the severity of the disease, allowing the classification of patients according to risk.Type: GrantFiled: March 5, 2018Date of Patent: August 2, 2022Assignees: UNIVERSITY HOSPITAL OF BASEL, Lascco SAInventors: Daiana Stolz, Frederic Lajaunias
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Publication number: 20180259532Abstract: The present invention relates to a reliable method of prediction of lower respiratory tract infection or inflammation in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development and the severity of the disease, allowing the classification of patients according to risk.Type: ApplicationFiled: March 5, 2018Publication date: September 13, 2018Applicants: UNIVERSITY HOSPITAL OF BASEL, STEPSTONE DIAGNOSTICS SARLInventors: Daiana Stolz, Frederic Lajaunias
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Patent number: 9765292Abstract: A bioreactor for preferably three-dimensional cell culturing comprises a scaffold chamber, a first tube, a second tube and a first valve with a scaffold adapter, a tube adapter and a medium adapter. The first valve has a housing with a longitudinal female portion ending in an opening and a longitudinal actuator being arranged through the opening of the female portion of the housing such that the actuator is arranged partially inside the housing and partially outside the housing, wherein the actuator of the first valve is axially moveable relative to the housing of the first valve between a first position in which the first valve is in the operation position and a second position in which the first valve is in the medium change position. By providing the actuators in the first valve which is applied by axial movements, operation of the bioreactor can be comparably simple and safe.Type: GrantFiled: June 4, 2013Date of Patent: September 19, 2017Assignees: University Hospital of Basel, Cellec Biotek AGInventors: Elia Piccinini, David Wendt, Adam Papadimitropoulos, Laura Spinelli, Stefania Adele Riboldi, Francesco Giovanni Greco, Peter Iwatschenko
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Patent number: 8497680Abstract: Disclosed is a magnetic resonance method for the quantification of molecular diffusion. The method uses a diffusion-weighted (dw) double echo steady state sequence (DESS). In particular, the method allows direct quantification of molecular diffusion from two steady state scans with differing diffusion weighting such as one with diffusion-weighting and preferably one without diffusion weighting. Such a quantification of molecular diffusion allows for rapid and/or quantitative measurements of physiological and/or functional parameters of living tissue. Quantitative measurements are often a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research performed at different sites. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR promises to have a very significant impact.Type: GrantFiled: March 24, 2011Date of Patent: July 30, 2013Assignee: University Hospital of BaselInventors: Oliver Bieri, Klaus Scheffler
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Publication number: 20130079296Abstract: The present invention relates to a reliable method of prediction of lower respiratory tract infection or inflammation in humans, wherein the level of pancreatic stone protein/regenerating protein (PSP/reg) is determined in serum, and a high level is indicative of the development and the severity of the disease, allowing the classification of patients according to risk.Type: ApplicationFiled: May 31, 2011Publication date: March 28, 2013Applicants: SEPSTONE DIAGNOSTICS SARL, UNIVERSITY HOSPITAL OF BASELInventors: Daiana Stolz, Frederic Lajaunias
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Patent number: 8314618Abstract: Apparatus and methods for quantification of transverse relaxation times (T2) using steady-state free precession sequences (generally known as fast imaging sequences) and their sensitivity to a quadratic increase of the RF pulse phase, also known as RF spoiling. Using at least two image acquisitions with different partial RF spoiling increments, T2 can be assessed with high precision and with short acquisition times in the limit of large excitation angles being independent on the longitudinal relaxation time (T1) and magnetization transfer effects as compared to other SSFP based quantitative T2 methods. This invention is not restricted to any kind of target and may be applied in 3D as well as in 2D.Type: GrantFiled: March 26, 2010Date of Patent: November 20, 2012Assignee: University Hospital of BaselInventors: Oliver Bieri, Klaus Scheffler
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Publication number: 20120242334Abstract: Disclosed is a magnetic resonance method for the quantification of molecular diffusion. The method uses a diffusion-weighted (dw) double echo steady state sequence (DESS). In particular, the method allows direct quantification of molecular diffusion from two steady state scans with differing diffusion weighting such as one with diffusion-weighting and preferably one without diffusion weighting. Such a quantification of molecular diffusion allows for rapid and/or quantitative measurements of physiological and/or functional parameters of living tissue. Quantitative measurements are often a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research performed at different sites. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR promises to have a very significant impact.Type: ApplicationFiled: March 24, 2011Publication date: September 27, 2012Applicant: UNIVERSITY HOSPITAL OF BASELInventors: Oliver BIERI, Klaus SCHEFFLER
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Patent number: 8274285Abstract: Apparatus and methods for modification of the frequency response profile of steady-state free precession (SSFP) type of magnetic resonance imaging (MRI) sequences. Using alternating dephasing moments within succeeding radiofrequency (RF) excitation pulses, the frequency response function of SSFP sequences can be modified to different shapes such as near triangular or bell shaped. The particular response function as produced by alternating dephasing moments can be used, among others, for functional brain MRI, MR spectroscopy or spatial encoding.Type: GrantFiled: March 26, 2010Date of Patent: September 25, 2012Assignee: University Hospital of BaselInventors: Oliver Bieri, Klaus Scheffler
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Patent number: 8153610Abstract: The present invention relates to compounds of the following general formula: (I) wherein R1 and R2 are fatty acyl groups, a process to extract them from Mycobacterium tuberculosis, and their use in the treatment or the prophylaxis of tuberculosis.Type: GrantFiled: April 9, 2004Date of Patent: April 10, 2012Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), University Hospital of Basel, University of ErlangenInventors: Germain Puzo, Martine Gilleron, Steffen Stenger, Gennaro De Libero
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Publication number: 20110280886Abstract: The present invention relates to a method for treating cancer in a subject using a mTOR inhibitor in combination with a therapeutically effective amount of a modulator of a MNK.Type: ApplicationFiled: November 11, 2009Publication date: November 17, 2011Applicants: UNIVERSITY HOSPITAL BASEL, NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG, F RIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARInventors: Michal Grzmil, Brian Arthur Hemmings, Adrian Merlo, Pier Jr Morin
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Publication number: 20110234225Abstract: Apparatus and methods for quantification of transverse relaxation times (T2) using steady-state free precession sequences (generally known as fast imaging sequences) and their sensitivity to a quadratic increase of the RF pulse phase, also known as RF spoiling. Using at least two image acquisitions with different partial RF spoiling increments, T2 can be assessed with high precision and with short acquisition times in the limit of large excitation angles being independent on the longitudinal relaxation time (T1) and magnetization transfer effects as compared to other SSFP based quantitative T2 methods. This invention is not restricted to any kind of target and may be applied in 3D as well as in 2D.Type: ApplicationFiled: March 26, 2010Publication date: September 29, 2011Applicant: University Hospital of BaselInventors: Oliver Bieri, Klaus Scheffler
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Publication number: 20110234224Abstract: Apparatus and methods for modification of the frequency response profile of steady-state free precession (SSFP) type of magnetic resonance imaging (MRI) sequences. Using alternating dephasing moments within succeeding radiofrequency (RF) excitation pulses, the frequency response function of SSFP sequences can be modified to different shapes such as near triangular or bell shaped. The particular response function as produced by alternating dephasing moments can be used, among others, for functional brain MRI, MR spectroscopy or spatial encoding.Type: ApplicationFiled: March 26, 2010Publication date: September 29, 2011Applicant: UNIVERSITY HOSPITAL OF BASELInventors: Oliver Bieri, Klaus Scheffler
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Patent number: 7960342Abstract: SRIF peptide antagonists, which are selective for SSTR2 in contrast to the other cloned SRIF receptors and which bind with high affinity to the cloned human receptor SSTR2 but do not activate the receptor, have many useful functions. Because they do not bind with significant affinity to SSTR1, SSTR3, SSTR4 or SSTR5, their administration avoids potential undesirable side effects. Because they block the receptor function, they can be used therapeutically to block certain physiological effects which SSTR2 mediates. By incorporating radioiodine or the like in these SSTR2-selective SRIF antagonists, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, highly radioactive moieties can be N-terminally coupled, complexed or chelated thereto.Type: GrantFiled: October 15, 2007Date of Patent: June 14, 2011Assignees: The Salk Institute for Biological Studies, Universitat Bern, University Hospital BaselInventors: Jean E. F. Rivier, Judit Erchegyi, Jean Claude Reubi, Helmut R. Maecke
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Publication number: 20080311650Abstract: The present invention relates to a method and apparatus for growing cells in a three-dimensional scaffold. Relative movement of the scaffold and an end cap of the culture chamber results in circulation of the growth medium through the scaffold. The invention is also suited for introduction of cells into a scaffold. The scaffold may be any sort of natural or synthetic material that will support cellular life, including a tissue.Type: ApplicationFiled: May 4, 2005Publication date: December 18, 2008Applicant: UNIVERSITY HOSPITAL OF BASELInventors: Marcel Jakob, Karl Jakob, Ivan Martin, Nicholas Eion Timmins
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Publication number: 20070292528Abstract: The present invention pertains to a treatment of cancer, particularly prostate cancer, by blocking the large conductance, Ca2+-activated potassium channel KCNMA1 Embodiments of the invention include methods of detecting the level of expression of KCNMA1, methods for treating patients with prostate cancer, and methods of discovering drugs for treating cancer.Type: ApplicationFiled: May 5, 2004Publication date: December 20, 2007Applicant: University Hospital of BaselInventors: Lukas Bubendorf, Michael Bloch