Abstract: The invention is a crystallization cassette and associated method for growing and analyzing macromolecular crystals in situ by X-ray crystallography. The cassette allows proteins (as well as other macromolecules) to be crystallized by the counter-diffusion method in a restricted geometry. Using this procedure, crystals can be adequately prepared for direct X-ray data analysis such that the protein's three-dimesional structure can be solved without crystal manipulation.

Abstract: A handheld system for collecting and storing radiation data and position data includes both a radiation detector and a position detector interfaced to a handheld computer. The handheld computer retrieves and time correlates position data and radiation data for storage in a computer storage medium. A computer program code is also stored in the storage medium and includes executable portions adapted to retrieve both radiation data and position data and also adapted to time correlate radiation data and position data for storage in the storage medium. Methods of using a handheld system are provided that include carrying the handheld system to radiation areas for collecting and storing radiation data and position data for universal mapping. A method of training personnel for using a handheld system provides radiation data and a computer storage medium that simulates higher radiation readings correlated to position data for simulating a radiation area.

Abstract: A handheld system for collecting and storing radiation data and position data includes both a radiation detector and a position detector interfaced to a handheld computer. The handheld computer retrieves and time correlates position data and radiation data for storage in a computer storage medium. A computer program code is also stored in the storage medium and includes executable portions adapted to retrieve both radiation data and position data and also adapted to time correlate radiation data and position data for storage in the storage medium. Methods of using a handheld system are provided that include carrying the handheld system to radiation areas for collecting and storing radiation data and position data for universal mapping. A method of training personnel for using a handheld system provides radiation data and a computer storage medium that simulates higher radiation readings correlated to position data for simulating a radiation area.

Abstract: A method and apparatus are provided for accurately measuring the blood oxygen saturation with a retinal vessel. The apparatus includes an optical source for illuminating the retinal vessel with optical signals. The apparatus also includes a filter, such as an aperture, disposed within the path of the optical signals returning from the eye. The filter preferentially passes single pass optical signals that have diffused through the retinal layer and/or the choroidal layer of the eye while traversing the retinal vessel only once, while blocking or otherwise redirecting the other optical signals. The apparatus also includes a detector for separately detecting at least the single pass optical signals and, in some instances, the other optical signals as well. The apparatus can also include a processing element for determining the blood oxygen saturation in the retinal vessel based upon the optical signals that have been detected.

Abstract: A waveguide assembly is provided that includes a waveguide region and at least one photonic crystal (PhC) region. The waveguide region includes a longitudinally extending core that has an input channel and at least one output channel, and a cladding at least partially surrounding the core for confining signals within the core. The PhC region(s), in turn, extend laterally through at least a portion of the core to at least partially direct signals propagating through the core. The PhC region(s) can extend through at least a portion of the core to thereby form, for example, a bend, beamsplitter, polarizing beamsplitter, Mach-Zender interferometer or ring resonator for signals propagating through the core.

Abstract: A liquid crystal adaptive lens (LCAL) includes a reference plate, a liquid crystal layer disposed in electrical communication with the reference plate, and a plurality of closed-loop electrodes disposed in electrical communication with the liquid crystal layer. The closed-loop electrodes are adapted to receive a variable control voltage such that the refractive index of at least a portion of the liquid crystal layer is adjustable such that light passing through the liquid crystal layer is capable of being redirected. By including closed-loop electrodes, the liquid crystal layer of the LCAL is capable of having a radially varying refractive index.

Abstract: A nucleic acid detector and a method of using the detector are disclosed for detecting the presence of target nucleic acid sequences within a sample. The nucleic acid detector comprises a substrate-bound, hairpin-shaped nucleic acid captor in conjunction with a labeled universal nucleic acid detector probe. The captor has a segment that is complementary to at least a portion of the target nucleic acid and is denatured and hybridized to the target under test conditions. Hybridization of the captor to the target maintains the captor in an open conformation which exposes an end portion of the captor to the universal detector probe. The detector probe is able to hybridize with the exposed end portion of the captor if the captor has hybridized with a target. The labeled detector probe is detectable by external detection methods. Detector probes having identical universal detector probe sequences may be used to identify the presence of multiple targets having various target sequences within a sample.

Abstract: Methods, apparatus and computer program products are provided for more accurately determining the percent transmittance of a vessel, such as a retinal vessel, at each of a number of different wavelengths and, in turn, for more accurately determining the blood oxygen saturation within the vessel. The blood oxygen saturation is determined based upon a plurality of images of the vessel obtained with illumination of different wavelengths. Background images are generated based upon respective images of the vessel in order to approximate the tissue bed underlying the vessel, such as the background fundus underlying the retinal vessel. Thereafter, a plurality of transmittance images are determined based upon respective pairs of the background images and the images of the vessel, such as by dividing the image of the vessel by the respective background image. Based upon a plurality of transmittance images, the blood oxygen saturation in the vessel may be determined.

Abstract: A passive thermal control enclosure for transporting and storing payloads in earth orbit includes an inner box-like enclosure surrounded by an outer box-like enclosure with insulation in the space between the enclosures. The walls of the inner enclosure are fiber-matrix composite skins with honeycomb sandwiched therebetween. Each enclosure has its own door latched closed by releasable latches formed in opposed pairs that can be operated without any net force on the operator. Packs of phase change material (PCM) are placed into the inner enclosure with the payload. The PCM is contained in flexible packages. The packs of PCM are removed when they melt and replaced with fresh packs, and the melted packs preferably are re-frozen on-board the orbiting spacecraft. Freezing preferably is carried out such that the freeze front moves substantially in only one direction from one end of the pack to the other.

Abstract: Methods, apparatus and computer program products are provided for more accurately determining the percent transmittance of a vessel, such as a retinal vessel, at each of a number of different wavelengths and, in turn, for more accurately determining the blood oxygen saturation within the vessel. The blood oxygen saturation is determined based upon a plurality of images of the vessel obtained with illumination of different wavelengths. Background images are generated based upon respective images of the vessel in order to approximate the tissue bed underlying the vessel, such as the background fundus underlying the retinal vessel. Thereafter, a plurality of transmittance images are determined based upon respective pairs of the background images and the images of the vessel, such as by dividing the image of the vessel by the respective background image. Based upon a plurality of transmittance images, the blood oxygen saturation in the vessel may be determined.

Abstract: A passive thermal control enclosure for transporting and storing payloads in earth orbit includes an inner box-like enclosure surrounded by an outer box-like enclosure with insulation in the space between the enclosures. The walls of the inner enclosure are fiber-matrix composite skins with honeycomb sandwiched therebetween. Each enclosure has its own door latched closed by releasable latches formed in opposed pairs that can be operated without any net force on the operator. Packs of phase change material (PCM) are placed into the inner enclosure with the payload. The PCM is contained in flexible packages. The packs of PCM are removed when they melt and replaced with fresh packs, and the melted packs preferably are re-frozen on-board the orbiting spacecraft. Freezing preferably is carried out such that the freeze front moves substantially in only one direction from one end of the pack to the other.

Abstract: An electrolytic plating process is provided for electrodepositing a nickel or nickel cobalt alloy which contains at least about 2% to 25% by atomic volume of phosphorous. The process solutions contains nickel and optionally cobalt sulfate, hypophosphorous acid or a salt thereof, boric acid or a salt thereof, a monodentate organic acid or a salt thereof, and a multidentate organic acid or a salt thereof. The pH of the plating bath is from about 3.0 to about 4.5. An electroplating process is also provided which includes electroplating from the bath a nickel or nickel cobalt phosphorous alloy. This process can achieve a deposit with high microyield of at least about 84 kg/mm2 (120 ksi) and a density lower than pure nickel of about 8.0 gm/cc. This process can be used to plate a deposit of essentially zero stress at plating temperatures from ambient to 70° C.

Abstract: A liquid crystal adaptive lens (LCAL) includes a reference plate, a liquid crystal layer disposed in electrical communication with the reference plate, and a plurality of closed-loop electrodes disposed in electrical communication with the liquid crystal layer. The closed-loop electrodes are adapted to receive a variable control voltage such that the refractive index of at least a portion of the liquid crystal layer is adjustable such that light passing through the liquid crystal layer is capable of being redirected. By including closed-loop electrodes, the liquid crystal layer of the LCAL is capable of having a radially varying refractive index.

Abstract: A valve for controlling the flow of a fluid comprises a housing, a flow-control element disposed within the housing, at least one seat operably engaging the flow-control element, and a biasing device for urging the seat and the flow-control element relative toward each other. In some embodiments, the valve also includes an actuating device operably engaging the flow-control element. The flow-control element, the seat, and the biasing device are comprised of a refractory material, and at least the biasing device is formed of a toughened refractory or ceramic material that is fully annealed so that porosity in the material is substantially eliminated and such that the material is substantially homogenous. In some embodiments, the seat, the flow-control element, the biasing device, and/or other components may be advantageously fabricated together as a unitary structure. An associated fabrication method is also provided.

Abstract: An electrolytic plating process is provided for electrodepositing a nickel or nickel cobalt alloy which contains at least about 2% to 25% by atomic volume of phosphorous. The process solutions contains nickel and optionally cobalt sulfate, hypophosphorous acid or a salt thereof, boric acid or a salt thereof, a monodentate organic acid or a salt thereof, and a multidentate organic acid or a salt thereof. The pH of the plating bath is from about 3.0 to about 4.5. An electroplating process is also provided which includes electroplating from the bath a nickel or nickel cobalt phosphorous alloy. This process can achieve a deposit with high microyield of at least about 84 kg/mm2 (120 ksi) and a density lower than pure nickel of about 8.0 gm/cc. This process can be used to plate a deposit of essentially zero stress at plating temperatures from ambient to 70° C.

Abstract: The present invention provides optical systems and methods that use a plurality of optical reflectors to fold the optical path of an optical beam used in the optical system. By folding the optical path of the optical beam, the optical system and method of the present invention can in one instance minimize the over-all volume and mass of the optical system. Specifically, the present invention provides an optical amplifier that has a plurality of active and passive reflectors. The passive reflectors are oriented to fold the optical beam in a minimized volume and direct the optical beam repeatedly at the active reflectors to amplify the optical beam to a selected power level. The folding aspects of the optical reflectors may also decrease the operating temperature of the optical system.

Abstract: A method for treating diverse pulp and paper products to produce a homogenous cellulosic feedstock comprises the steps of feeding diverse pulp and paper products into a vessel, introducing steam into the vessel while agitating the products, purging the gases from the vessel while agitating the products, sealing the vessel so that the vessel is pressure tight, saturating the products with steam at sufficient temperature and pressure to expand molecular structure of the products, while agitating the products, depressurizing the vessel to further enhance the molecular expansion of the products, and discharging the processed products. Alternatively, the method can be performed without purging the gases, if the temperature in the range of about 287° F. to about 312° F., and the pressure is in the range of about 40 to 65 psig.

Abstract: The invention provides an apparatus for measuring microgravity acceleration that includes an elongate flow chamber having a first end and a second end and a liquid contained therein. Each end of the chamber is engaged by a plug member that is positioned to block the flow of the liquid through the ends of the container. Each plug member is maintained at a different known temperature such that a temperature gradient is created across the flow chamber. Temperature sensors are immersed in the liquid, the sensors being spaced apart along a line intersecting the axis of the flow chamber and normal thereto. Quasi-steady components of acceleration can be calculated based on the difference in the temperatures measured by the temperature sensors.

Abstract: An improved optical scanning spectroscopic method and apparatus is provided that alternately scans the posterior portion of an eye with laser signals emitted by different ones of a plurality of lasers such that a data frame can be constructed that includes interlaced portions formed from signals returning from the posterior portion of the eye in response to illumination by laser signals emitted by different ones of the plurality of lasers. As such, the same data frame includes data attributable to the reflection of laser signals from each of the plurality of lasers even though the subject's eye is not subjected to simultaneous illumination by each of the lasers, thereby protecting the subject's eye.

Abstract: The invention provides a brushite coating that is easily convertible to hydroxyapatite at mild conditions. The brushite coating is rapidly electrodeposited from an aqueous electrolyte solution of calcium phosphate, monobasic and salts having cations of ammonium, alkali metals and alkaline earth metals. About 1 to 5 percent of the calcium ions in the brushite coating are substituted with ammonium, alkali metals or alkaline earth metal cations. Hydroxyapatite can be formed by immersing the brushite coating in an animal or human body fluid or a simulated body fluid at from about 20 to 37.degree. C. Substantially stoichiometric calcium hydroxyapatite is formed.