Abstract: The present disclosure provides a pharmaceutical composition comprising i) an A1 adenosine receptor (A1AR) agonist, ii) an A1AR antagonist, and iii) an anticholinergic. Kits utilizing i) an A1 adenosine receptor (A1AR) agonist, ii) an A1AR antagonist, and iii) an anticholinergic are also provided, as well as methods utilizing the described pharmaceutical compositions and kits.

Abstract: The invention generally relates an apparatus for generation of hydrogen and oxygen gases by utilizing seawater. The invention also relates to a method of making hydrogen and oxygen gas by utilizing anion exchange membranes and seawater. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A flow cell can comprise a high-pressure, fluidic, flow-through housing that encloses and auto-aligns a heavy-walled, internally reflective low-cost glass capillary for concentrating and amplifying laser-excited spectra. The containment housing that encloses the capillaries can optionally sustain operational pressures of at least 10,000 psi. The pressure housing can be fitted with transparent optical windows that can accommodate laser-safe injection and spectra collection. The flow-cell design can adaptably accommodate different optical sampling configurations such as transmissive (forward scattering), reflective (backward scattering), or multipass, combined scattering. The flow cell size is scalable (lengthwise) to accommodate different applications or installations such as benchtop (lab), permanent (industrial), and portable (field).

Abstract: A system and method for generating synthetic streamflow data for a malfunctioning streamgage is provided. The method uses both classification and regression techniques to accurately predict streamflow data for the malfunctioning streamgage based on measured streamflow data from other streamgages and based on correlations between the streamgages. The system and method may also provide a method of improved flood forecasting, by updating flood forecasts using synthetic streamflow data when measured streamflow data from one or more streamgages are unavailable. The system may generate flood forecast information and/or flood warning messages.

Abstract: Disclosed are compositions and methods for enriching a non-host sequence from a host sample. Also disclosed are compositions and methods for detecting a non-host sequence in a host sample. For example, a pathogen can be enriched and detected in a sample taken from a human without knowing what the pathogen is.

Abstract: Methods and systems are disclosed for remotely and/or automatically controlling a probe to measure signals.

Abstract: Methods and systems for correcting environmental distortion are disclosed. An example method can comprise receiving a first plurality of signals sampled in space at a first time and determining a first plurality of correction factors based on the first plurality of signals. The first plurality of correction factors can be configured to correct environmental distortion in the first plurality of signals. The first plurality of signals can be corrected by applying the first plurality of correction factors to the first plurality of signals thereby generating a corrected first plurality of signals. The corrected first plurality of signals can be provided. The method can be repeated for one or more additional pluralities of signals sampled in space at times subsequent to the first time with corresponding additional pluralities of correction factors. Each additional plurality of correction factors can be unique to a corresponding plurality of signals.

Abstract: Provided herein are devices, systems and methods for separating age and size matched nematodes from a mixed size population of nematodes and/or debris. The device and system use a filter membrane with a defined pore size located between an upper housing with a first chamber adapted to receive a liquid sample comprising the mixed size population nematodes and a lower housing with a second chamber. Use of the system, along with a sample vessel, provide the user a method for efficiently and effectively isolating an age and size synchronized population of nematodes.

Abstract: This monolithic reactor is an adaptable and scalable, flow-through reaction containment apparatus embodied as a one-piece monolithic block of material that retains re-configurability to improve reaction processing. This apparatus increases operational flexibility, adaptable design, and vastly simplifies construction of tubular reaction-containment configurations. Internally, the monolithic block comprises one or more closely spaced, functional voids which operate as fluid channels that can be configured in various geometric arrangements. The apparatus is widely scalable, provides high thermodynamic efficiency, manufacturing simplicity, and affordability for varied operations through additive manufacturing, and has a compact physical footprint.

Abstract: Methods and systems for assessing changes to a region are disclosed. An example method can comprise receiving elevation data indicative of a region. A method can comprise generating a spatial model of the region based on the elevation data. A method can also comprise identifying based on the spatial model a first representation of a portion the region. The first representation of the portion of the region can be indicative of the portion of the region at a first time. A method can further comprise determining a difference between the first representation of the portion of the region and a second representation of the portion of the region. The second representation of the portion of the region can be indicative of the portion of the region at a second time.

Abstract: Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.

Abstract: Methods and systems for detecting ambient aerosols are disclosed. An example method can comprise receiving an air sample comprising aerosol particles. A method can comprise determining at least one of concentration of the aerosol particles and size of an aerosol particle from the aerosol particles. A method can also comprise determining a composition of the air sample if at least one of the concentration exceeds a first predetermined threshold and the size exceeds a second predetermined threshold. A method can further comprise providing a notification indicating the presence of volcanic ash based on the determined composition of the aerosol.

Abstract: Disclosed are methods and systems of rapidly validating accuracy in particle cloud forecast transport and dispersion models. An example method can comprise accessing a forecast model of a volcanic ash cloud. An example method can comprise generating first data based at least on the forecast model. The first data can have at least one fewer spatial dimension than second data associated with the forecast model. An example method can comprise determining accuracy of the forecast model based at least on measurements of at least a portion of the volcanic ash cloud. An example method can comprise refining the forecast model based at least on the determined accuracy, thereby improving a representation of the volcanic ash cloud.

Abstract: Provided are methods, circuits and apparatuses for detecting pressure variations. The circuit can comprise at least two pressure sensors electrically coupled in parallel. At least one pressure sensor can have a differential input and a differential output. The circuit can also comprise a first switching mechanism electrically coupled to the differential input of the at least one pressure sensor. The first switching mechanism can be configured to electrically couple a first current source to the at least one pressure sensor according to a first reference signal. The circuit can also comprise a second switching mechanism electrically coupled to the differential output of the at least one pressure sensor. The second switching mechanism can be configured to electrically couple a second current source to the at least one pressure sensor according to a second reference signal.

Abstract: Disclosed herein are synthetic methods and compounds related to the compounds that are useful as or in the production of biologically active compounds. Stereoselective and stereospecific synthetic methods are disclosed to produce compounds, such as, for example, ?,?-unsaturated-?-hydroxyesters and aminated derivatives thereof, at high yields with desired stereochemistry. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Disclosed are compositions and methods for inducing therapeutic hypothermia in a subject.

Abstract: Provided are methods, circuits and apparatuses for detecting pressure variations. The circuit can comprise at least two pressure sensors electrically coupled in parallel. At least one pressure sensor can have a differential input and a differential output. The circuit can also comprise a first switching mechanism electrically coupled to the differential input of the at least one pressure sensor. The first switching mechanism can be configured to electrically couple a first current source to the at least one pressure sensor according to a first reference signal. The circuit can also comprise a second switching mechanism electrically coupled to the differential output of the at least one pressure sensor. The second switching mechanism can be configured to electrically couple a second current source to the at least one pressure sensor according to a second reference signal.

Abstract: Embodiments described herein describe the construction of frequency domain estimates of generalized power density and the filters that can be constructed from those estimates. Using the concept of the Stokes vector representation of the spectral matrix in an M-dimensional vector space, a generalization of the process in which the spectral matrix may be represented by a set of trace-orthogonal matrices that are based upon a particular signal state can be produced. One aspect of the process is as follows: given a particular signal, represented as by a state vector in the space, a complete, orthonormal set of vectors can be produced that includes the signal of interest. Then, a generalized set of matrices is constructed, based upon the developed vectors, that are trace-orthogonal and which serve as a basis set for the expansion of the spectral matrix. The coefficients of this expansion form a generalized Stokes vector that represents the power in the spectral matrix associated with the various state vectors.

Abstract: Methods and systems are provided herein for signal source tracking. A signal emitted over time from a moving source is a collection of small sub-signals that were emitted by the source at different positions along its path. If the source is traveling at a slower speed than the signal, the sub-signals will arrive at a given sensor in the same order that they were released. By identifying the locations and times of the releases of several of these sub-signals, the path and velocity of the moving source can be estimated.

Abstract: The invention relates to a droplet-based digital microdialysis method that utilizes discrete perfusate droplets marched through a microchannel in an intermittent manner. The droplets sequentially reside on a microdialysis membrane that is in contact with the test fluid, e.g., fluid in an extracellular space. The droplets remain stationary at the membrane site for a period of time for rapid equilibration with the test fluid, and is then marched to an outlet port for processing. The invention further relates to microdialysis probes and methods based on the droplet-based digital microdialysis.