Abstract: A new installment classifies particles by their aerodynamic size This installment produces a truly monodisperse aerosol, and can produce very narrow distributions over a wide range of sizes Particles suspended in a fluid are classified by supplying particles into suspension in a carrier flow of a fluid and providing an acceleration to the flow at an angle to the velocity of the flow to cause the particles to follow trajectories determined by the acceleration and drag on the particles caused by the fluid The particles are then classified according to their trajectories The installment has a flow channel and a source of particles to supply particles into suspension in a carrier fluid in the flow channel A drive is connected to the flow channel at an angle to the flow of fluid through the carrier flow channel, and a classification system classifies the suspended particles according to their trajectories.
Type:
Grant
Filed:
July 2, 2010
Date of Patent:
March 3, 2015
Assignee:
The Governors of the University of Alberta
Abstract: Novel polymeric rhodium catalysts having repeating subunits of Formula (I), wherein R1-R8, X, A, m, n and p are as defined in the application, are described along with methods of using these catalysts, as well as precursors therefor, in the chemical synthesis transformations.
Type:
Grant
Filed:
September 28, 2010
Date of Patent:
February 24, 2015
Assignee:
The Governors of the University of Alberta
Inventors:
Steven H. Bergens, Andrew Douglas Sullivan, Michael Hass
Abstract: The present application provides a method of quantifying an amount of a derivatized peptide displayed on a phage by phage display, the method comprising: providing a phage containing the target peptide thereon; reacting the phage containing the target peptide with a first reagent to derivatize the target peptide to form a derivatized peptide, reacting the derivatized peptide with a capture agent comprising a detection marker, thereby incorporating the detection marker within the derivatized peptide; and determining an amount of the detection marker, thereby quantifying the amount of the derivatized peptide displayed on the phage. A kit comprising a capture agent comprising a detection marker for quantifying the phage displayed derivatized peptides is also provided.
Type:
Application
Filed:
February 1, 2013
Publication date:
January 22, 2015
Applicant:
The Governors of the University of Alberta
Inventors:
Ratmir Derda, Simon Ng, Seyed Mohammadreza Jafari
Abstract: Provided herein are methods for identifying a subject with an increased likelihood of developing or having metastatic papillary thyroid cancer (PTC), or a subject with an increased likelihood of developing or having recurrent PTC, and the treatment of such a subject.
Type:
Application
Filed:
February 1, 2013
Publication date:
January 8, 2015
Applicant:
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Abstract: The invention provides compositions and methods for preventing a metabolic disorder or bacterial infection in a subject, the composition comprising a bacterial endotoxin.
Type:
Grant
Filed:
June 7, 2007
Date of Patent:
December 30, 2014
Assignee:
The Governors of the University of Alberta
Abstract: In some embodiments, the present invention pertains to methods of detecting a contamination of an environment by a fracture fluid that comprises magnetic particles. In some embodiments, such methods include: (1) collecting a sample from the environment; and (2) measuring a magnetic susceptibility of the sample in order to detect the presence or absence of the magnetic particles. Further embodiments of the present invention pertain to methods of tracing fracture fluids in a mineral formation. In some embodiments, such methods include: (1) associating the fracture fluids with magnetic particles; (2) introducing the fracture fluids into the mineral formation; and (3) measuring a magnetic susceptibility of the fracture fluids. Additional embodiments of the present invention pertain to fracture fluids containing the aforementioned magnetic particles, the actual magnetic particles, and methods of making said magnetic particles.
Type:
Application
Filed:
December 10, 2012
Publication date:
December 4, 2014
Applicants:
William Marsh Rice University, University of Alberta
Inventors:
Andrew Ross Barron, David Keith Potter, Samuel J. Maguire-Boyle, Emil Pena, Lauren Morrow
Abstract: Phosphoranimide-metal catalysts are disclosed. The catalysts comprise first row transition metals such as nickel, cobalt or iron. The hydrocarbon-soluble catalysts have a metal to anionic phosphoranimide ratio of 1:1, have no inactive bulk phase and no dative ancillary ligands, and are active for a range of commercially important reductive transformations. A method of synthesis of these catalysts by reduction of a precursor of these catalysts is also disclosed.
Type:
Grant
Filed:
December 21, 2012
Date of Patent:
December 2, 2014
Assignee:
Governors of the University of Alberta
Inventors:
Jeffrey Camacho Bunquin, Jeffrey Mark Stryker
Abstract: Phosphoranimide-metal catalysts and their role in hydrodesulfurization and hydrogenation are disclosed. The catalysts comprise of first row transition metals such as nickel, cobalt and iron. The catalysts have a metal to anionic phosphoranimide ratio of 1:1 and have no inactive bulk phase and no dative ancillary ligands. In one embodiment, the catalysts comprise discrete mixed-valent precatalyst clusters, the electronic state of which can be adjusted to optimize catalytic activity. The catalysts catalyze the hydrodesulfurization of a range of sulfur-containing organic compounds under lower temperature and pressure conditions than those conditions commonly used in industrial hydrodesulfurization. The catalysts also catalyze the hydrogenation of substrates comprising at least one carbon-carbon double bond which is not present in an aromatic moiety, although the substrate itself may include an aromatic moiety.
Type:
Application
Filed:
May 21, 2013
Publication date:
November 27, 2014
Applicant:
GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventors:
Houston J.S. BROWN, Jeffrey Mark Stryker, Dominque M. Hebert
Abstract: Phosphoranimide-metal catalysts are disclosed. The catalysts comprise first row transition metals such as nickel, cobalt or iron. The hydrocarbon-soluble catalysts have a metal to anionic phosphoranimide ratio of 1:1, and have no inactive bulk phase and no dative ancillary ligands. The electronic state of the clusters can be adjusted to optimize catalytic activity for a range of commercially important reductive transformations, including hydrodesulfurization. A method of synthesis of these catalysts by anionic metathesis of a halide substituted precursor followed by oxidation is also disclosed.
Type:
Application
Filed:
May 21, 2013
Publication date:
November 27, 2014
Applicant:
GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventors:
Houston J.S. BROWN, Jeffrey Mark Stryker, Dominque M. Hebert
Abstract: There is disclosed a combined hydrothermal and activation process that uses hemp bast fiber as the precursor to achieve graphene-like carbon nanosheets, a carbon nanosheet comprising carbonized crystalline cellulose, a carbon nanosheet formed by carbonizing crystalline cellulose, a capacitative structure comprises interconnected carbon nanosheets of carbonized crystalline cellulose, a method of forming a nanosheet comprising carbonizing crystalline cellulose to create carbonized crystalline cellulose. The interconnected two-dimensional carbon nanosheets also contain very high levels of mesoporosity.
Type:
Application
Filed:
May 5, 2014
Publication date:
November 6, 2014
Applicant:
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventors:
David Mitlin, Huanlei Wang, Zhanwei Xu, Zhi Li, Chris Holt
Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
Type:
Application
Filed:
November 12, 2012
Publication date:
October 30, 2014
Applicants:
Massachusetts Institute of Technology, The Governrs of the University of Alberta
Inventors:
Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
Abstract: The invention is directed to a method for preparing a polymer derived from an animal protein, such as in a feedstock derived from animal by-products. The method involves hydrolyzing proteins present in a feedstock to obtain hydrolyzed proteins, wherein hydrolysis is conducted under conditions sufficient to digest the proteins and destroy pathogens; extracting a protein fraction from the hydrolyzed proteins; and treating the protein fraction with a crosslinking reagent to form the polymer. The crosslinking reagents may include epoxies. The polymer may be further processed to form a thermoset plastic. The polymer may be used as an adhesive, or in the preparation of a natural fiber composite material.
Type:
Application
Filed:
May 14, 2012
Publication date:
October 23, 2014
Applicant:
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Abstract: Transgenic plants with enhanced punicic acid accumulation result from over-expression of PgFADX and PgFAD2, and optionally, one or more of PgDGAT1, PgDGAT2, and PgPDAT1. The invention also relates to novel isolated Punica granatum diacylglycerol acyltransferases: type 1 (PgDGAT1), type 2 (PgDGAT2) and phospholipid:diacylglycerol acyltransferases (PgPDAT1); polynucleotide sequences encoding the DGATs and PDAT enzymes; polynucleotide constructs, vectors and host cells incorporating the polynucleotide sequences; and methods of producing and using same.
Type:
Application
Filed:
March 25, 2014
Publication date:
September 25, 2014
Applicant:
The Governors of The University of Alberta
Inventors:
Randall J. WESELAKE, Elzbieta MIETKIEWSKA
Abstract: The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis B virus (HBV) DNA; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting HBV DNA; methods of detecting a covalently closed circular DNA (cccDNA) form of HBV; and methods for treating HBV infection.
Type:
Application
Filed:
February 4, 2014
Publication date:
September 25, 2014
Applicant:
The Governors of the University of Alberta
Inventors:
Kimberley Zimmerman, Michael A. Joyce, Karl Fischer, D. Lorne Tyrrell
Abstract: A metal nanodot material is formed by ion-exchange with an ETS zeolite, followed by activation to form metallic nanodots. The nanodot may be formed from silver, nickel, copper, gold or a platinum group metal.
Type:
Grant
Filed:
February 21, 2012
Date of Patent:
September 9, 2014
Assignee:
The Governors of the University of Alberta
Abstract: The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject.
Type:
Application
Filed:
August 30, 2012
Publication date:
September 4, 2014
Applicant:
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Inventors:
Todd Lambert Lowary, Christopher Warren Cairo, Lori Jeanne West, Jillian Mary Buriak, Peter John Meloncelli, Mylvaganam Jeyakanthan, Anne Margaret Slaney
Abstract: The present disclosure describes operationally simple methods for the low temperature, catalytic activation of carboxylic acids for organic reactions, in particular for direct amidation reactions with amines. The methods involve the use of orthosubstituted arylboromc acids of the formula (I), wherein the groups R1 to R5 are as defined herein. In preferred embodiments R1 is halogen. The arylboromc acids catalyze nucleophilic 1,2-addition reactions, conjugate 1,4-addition reactions, and cycloaddition reactions, including Diels-Alder reactions involving ?,?-unsaturated carboxylic acids.
Type:
Grant
Filed:
September 5, 2008
Date of Patent:
September 2, 2014
Assignee:
The Governors of the University of Alberta
Inventors:
Dennis Hall, Olivier Marion, Raed Al-Zoubi
Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed therefrom.
Type:
Grant
Filed:
June 17, 2009
Date of Patent:
August 26, 2014
Assignees:
National Research Council of Canada, The Governors of The University of Alberta
Inventors:
Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
Abstract: Steam-Over-Solvent Injection in Fractured Reservoirs (SOS-FR) is carried out by treating a fractured hydrocarbon bearing formation penetrated by a well with a first phase of injecting a formation compatible aqueous fluid into the fractured hydrocarbon bearing formation through the well, a second phase of injecting a hydrocarbon solvent into the fractured hydrocarbon bearing formation through the well and at least a third phase of repeating the first phase after the second phase.
Type:
Grant
Filed:
October 5, 2009
Date of Patent:
August 26, 2014
Assignee:
The Governors of the University of Alberta
Abstract: The disclosure provides mutant ribonucleotide reductase strains of poxviruses including for example vaccinia viruses. The disclosure also provides methods and for the use of these mutant ribonucleotide reductase strains of vaccinia viruses in oncolytic virotherapy.
Type:
Application
Filed:
January 28, 2014
Publication date:
August 21, 2014
Applicant:
The Governors of the University of Alberta