Patents Assigned to University of Alberta
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Patent number: 11585777Abstract: The present disclosure provides a biosensor for detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, comprising: a support structure; at least two interdigitated electrodes coupled to the support structure, wherein at least one of the interdigitated electrodes is functionalized with a linker coupled to at least one biological component that recognizes the at least one fungal plant pathogen; and an impedance measurement circuit coupled to the at least two interdigitated electrodes. The present disclosure also provides methods of detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, methods of making the biosensor described herein, as well as methods and uses of using the herein described biosensor for detecting the presence of and/or amount of at least one fungal plant pathogen.Type: GrantFiled: April 25, 2019Date of Patent: February 21, 2023Assignees: InnoTech Alberta Inc., The Governors of the University of AlbertaInventors: Xiujie Li, Jie Chen, Jian Yang, Scott Mackay, Lian C. T. Shoute
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Patent number: 11576967Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.Type: GrantFiled: December 15, 2020Date of Patent: February 14, 2023Assignee: The Governors of the University of AlbertaInventors: Michael Houghton, John L. Law, Michael Logan, Darren Hockman, Abdolamir Landi
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Patent number: 11576968Abstract: The present disclosure provides immunogenic compositions comprising: a) hepatitis C virus (HCV) E1E2 heterodimers, HCV E2, or HCV E1; and b) an adjuvant, where the adjuvant is a cyclic dinucleotide or an archaeosome. The present disclosure provides methods of inducing an immune response in an individual to HCV, the methods comprising administering to an individual an effective amount of an immunogenic composition of the present disclosure.Type: GrantFiled: December 15, 2020Date of Patent: February 14, 2023Assignee: The Governors of the University of AlbertaInventors: Michael Houghton, Abdolamir Landi, Carlos A. Guzman, Thomas Ebensen, Darren Hockman, John L. Law, Michael Logan
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Patent number: 11566018Abstract: The present disclosure relates to 2-(3-indoyl)indolin-3-one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metallocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein the infection disease is caused by a virus, wherein the virus is from the family flaviviridae or paramyxoviridae.Type: GrantFiled: March 27, 2019Date of Patent: January 31, 2023Assignee: The Governors of the University of AlbertaInventors: Frederick Glenn West, David J. Marchant, Bren Jordan P. Atienza, Lionel D. Jensen
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Patent number: 11557337Abstract: An atomic orbital based memory storage is provided that includes a plurality of surface atoms forming dangling bonds (DBs) and a subset of the plurality of surface atoms passivated with spatial control to form covalent bonds with hydrogen, deuterium, or a combination thereof. The atomic orbital based data storage that can be rewritten and corrected as needed. The resulting data storage is also archival and capable of high data densities than any known storage as the data is retained in a binary storage or a given orbital being passivated or a dangling bond (DB). A method of forming and reading the atomic orbital data storage is also provided. The method including selectively removing covalent bonds to form dangling bonds (DBs) extending from a surface atom by hydrogen lithography and imaging the covalent bonds spatially to read the atomic orbital data storage.Type: GrantFiled: June 19, 2019Date of Patent: January 17, 2023Assignees: National Research Council of Canada, Quantum Silicon Inc., The Governors of the University of AlbertaInventors: Roshan Achal, Robert A. Wolkow, Jason Pitters, Martin Cloutier, Mohammad Rashidi, Marco Taucer, Taleana Huff
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Publication number: 20220396509Abstract: A system and method for treatment of wastewater, in which the system includes a blackwater reactor configured to receive a stream of blackwater influent, to contain the blackwater therein during treatment of the blackwater, to facilitate recovery of methane and nutrient precipitates therefrom, and to output partially treated blackwater, and a greywater reactor configured to receive a stream of greywater influent and the partially treated blackwater output from the blackwater reactor, to contain the greywater and the partially treated blackwater therein during greywater treatment, and to output greywater treatment discharge.Type: ApplicationFiled: June 10, 2022Publication date: December 15, 2022Applicant: The Governors of the University of AlbertaInventors: Yang Liu, Lei Zhang
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Patent number: 11518995Abstract: The disclosure relates to compositions comprising a nucleotide sequence having two domains: a locked nucleic acid (LNA) domain and a DNA gap domain, wherein nucleotide sequence binds to an endogenous DUX4 mRNA sequence disrupts DUX4 expression.Type: GrantFiled: September 19, 2018Date of Patent: December 6, 2022Assignees: Children's National Medical Center, The Governors of the University of AlbertaInventors: Yi-wen Chen, Toshifumi Yokota, Rika Yokota-Maruyama, Yusuke Echigoya
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Patent number: 11512848Abstract: A system and method for estimating steam quality for a steam generator is provided which involves obtaining raw measurement values for process variables of the steam generator from sensors coupled to the steam generator; receiving the raw measurement values and slow-rate steam quality samples in order to determine a steam quality estimate, using a measurement module to receive the raw measurement values and determine model input values and a robustness index; using an estimator module to determines a raw steam quality estimate using the model input values and a model that is selected from several models depending on reliability of some of the raw measurements; and using a corrector module to determine the steam quality estimate using the raw steam quality estimate, robustness index, and slow-rate steam quality samples. An output receives the steam quality estimate and can provide the steam quality estimate to another device.Type: GrantFiled: March 5, 2019Date of Patent: November 29, 2022Assignee: The Governors of the University of AlbertaInventors: Biao Huang, Yanjun Ma, Seraphina Kwak
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Publication number: 20220372212Abstract: The invention provides methods for the formation of thermo-reversible hydrogels from triblock copolymers of poly(ethylene glycol) and poly(?-benzyl carboxylate-?-caprolactone) (PBCL-PEG-PBCL) prepared by bulk and solution polymerization. PBCL-PEG-PBCLs prepared at fixed PBCL to PEG ratios but different polymerization times were characterized for their average molecular weights, molar-mass disparity and intrinsic viscosity using 1H NMR and gel permeation chromatography (GPC). The results indicated a copolymer of high molecular weight population with elevated intrinsic viscosity. The size and proportion of this population grew as a function of polymerization time. The formation of this high molecular weight PBCL-PEG-PBCL population can be attributed to non-linear architecture caused by partial cross-linking of the PBCL segment during the polymerization reaction.Type: ApplicationFiled: April 29, 2022Publication date: November 24, 2022Applicant: The Governors of the University of AlbertaInventors: Nasim GHASEMI, Mohammad Reza VAKILI, Afsaneh LAVASANIFAR
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Publication number: 20220347114Abstract: Amphiphilic copolymers and compositions including amphiphilic copolymers. The amphiphilic copolymers include modified maleimide subunits, for example, as illustrated by the structures of Formula IA and Formula IB. The compositions form water-soluble complexes upon association with biological material wherein such biological material can include lipids or membrane proteins. Methods for producing, purifying, analyzing, and using the compositions and complexes are provided.Type: ApplicationFiled: October 23, 2020Publication date: November 3, 2022Applicant: The Governors of the University of AlbertaInventors: Michael OVERDUIN, Mansoore ESMAILI
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Patent number: 11479477Abstract: The present application relates to copper-doped double perovskites, for example, copper-doped double perovskites of the formula (I) and to uses thereof, for example as low-bandgap materials such as a semiconducting material in a device. The present application also relates to methods of tuning the bandgap of a Cs2SbAgZ6 double perovskite (for example, wherein Z is Cl) comprising doping the double perovskite with copper.Type: GrantFiled: June 23, 2020Date of Patent: October 25, 2022Assignee: The Governors of the University of AlbertaInventors: Vladimir Michaelis, Abhoy Karmakar
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Publication number: 20220299544Abstract: A nano-positioning system for fine and coarse nano-positioning including at least one actuator, wherein the at least one actuator includes a high Curie temperature material and wherein the nano-positioning system is configured to apply a voltage to the at least one actuator to generate fine and/or coarse motion by the at least one actuator. The nano-positioning system being a stand-alone system, a scanning probe microscope, or an attachment to an existing microscope configured to perform a method of creepless nano-positioning that includes positioning a probe relative to a first area of a substrate using coarse stepping and interacting with the first area of the substrate using fine motion after less than 60 seconds of the positioning the probe. The movement of the scanning probe microscope is actuated by a high Curie temperature piezoelectric material that limits and/or eliminates creep, hysteresis and aging.Type: ApplicationFiled: August 31, 2020Publication date: September 22, 2022Applicants: National Research Council of Canada, The Governors of the University of AlbertaInventors: Robert A. Wolkow, Jason Pitters, Mark Salomons
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Patent number: 11385230Abstract: Methods for the diagnosis of CRC, colorectal polyps in general and adenomatous polyps in particular by measurement of metabolites in urine are described. In some embodiments, certain metabolites are identified as being elevated or reduced in concentration or quantity in subjects with CRC and/or colorectal polyps as compared with subjects without CRC or colorectal polyps. The measurement of these metabolites in urine can indicate the presence of CRC or colorectal polyps in general or adanomatous polyps in particular in a subject.Type: GrantFiled: March 6, 2019Date of Patent: July 12, 2022Assignee: The Governors of the University of AlbertaInventors: Richard Neil Fedorak, Haili Wang
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Patent number: 11370822Abstract: The present disclosure relates to bioactive self-assembling peptides, nanofibers and hydrogels for activating human mast cells. The peptides, nanofibers and hydrogels comprise a self-assembling peptide that mediates self-assembly linked to a MrgX2 agonist peptide; for example, (RADA)4 linked to proadrenomedullin-12 (PAMP-12).Type: GrantFiled: May 25, 2018Date of Patent: June 28, 2022Assignees: The Governors of the University of Alberta, National Research Council of CanadaInventors: Larry D. Unsworth, Lei Lu, Marianna Kulka
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Publication number: 20220183828Abstract: A device for replacing a mitral valve includes a substantially cylindrically-shaped body having a top portion, a bottom portion, and a waist portion disposed therebetween and having ferromagnetic elements arranged circumferentially, and the top portion, waist portion, and bottom portion defining an aperture extending therethrough for allowing blood flow; and a clamping ring formed of a ferromagnetic material and supporting a plurality of ferromagnetic spheres thereon.Type: ApplicationFiled: March 10, 2020Publication date: June 16, 2022Applicant: The Governors of the University of AlbertaInventor: Keysun ALIZADEHRANJBAR
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Patent number: 11353764Abstract: An electrochromic (EC) device comprises a first electrode and a second electrode separated by an electrolyte. The first electrode comprises an electrochromic (EC) layer comprising a compound having the formula AiBjOk, where A comprises one or more elements selected from a group consisting of W, Mn, Mo, Co, Ni, Cs, and Zn, where B is different than A and comprises one or more elements selected from a group consisting of Mo, Ti, Nb, and V, where i and j have values that are greater than 0, and where k is a stoichiometric value that balances the formula. A is selected such that the EC layer has an improved optical contrast relative to BjOk and B is selected such that the EC layer has an improved specific charge capacity relative to AiOk.Type: GrantFiled: February 24, 2020Date of Patent: June 7, 2022Assignee: The Governors of the University of AlbertaInventors: Abdulhakem Elezzabi, Hai Zeng Li
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Publication number: 20220169684Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.Type: ApplicationFiled: February 10, 2022Publication date: June 2, 2022Applicants: Massachusetts Institute of Technology, The Governors of the University of AlbertaInventors: Nathan KLAPOETKE, Brian Yichiun CHOW, Edward BOYDEN, Gane KA-Shu WONG, Yongku Peter CHO
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Patent number: 11343910Abstract: The development of stretchable, mechanically and electrically robust interconnects by printing an elastic, silver-based composite ink onto stretchable fabric. Such interconnects can have conductivity of 3000-4000 S/cm and are durable under cyclic stretching. In serpentine shape, the fabric-based conductor is enhanced in electrical durability. Resistance increases only ˜5 times when cyclically stretched over a thousand times from zero to 30% strain at a rate of 4% strain per second due to the ink permeating the textile structure. The textile fibers are wetted with composite ink to form a conductive, stretchable cladding of the silver particles. The e-textile can realize a fully printed, double-sided electronic system of sensor-textile-interconnect integration. The double-sided e-textile can be used for a surface electromyography (sEMG) system to monitor muscles activities, an electroencephalography (EEG) system to record brain waves, and the like.Type: GrantFiled: June 7, 2019Date of Patent: May 24, 2022Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTAInventors: Hyun-Joong Chung, Jana Rieger, Thanh-Giang La, Shide Qiu, Dylan Scott
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Publication number: 20220155339Abstract: A method for assessing the quality of a tip of a scanning probe microscope (SPM) includes recording an SPM image, extracting a plurality of images of dangling bonds from the SPM image, feeding the extracted images of dangling bonds into a convolution neural network one image at a time, analyzing each of the plurality of images of dangling bonds using the convolution neural network, assigning each of the plurality of images of dangling bonds one of a sharp tip status or a double tip status, and determining whether the number of the plurality of images of dangling bonds of the SPM image assigned the double tip status exceeds a predetermined threshold. A method of automatically conditioning a tip of a scanning probe microscope (SPM) during imaging of a sample and a method of mass-producing atomistic quantum dots, qubits, or particular atom orbital occupation are also provided.Type: ApplicationFiled: January 22, 2022Publication date: May 19, 2022Applicants: Quantum Silicon Inc., The Governors of the University of AlbertaInventors: Mohammad Rashidi, Robert Wolkow
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Patent number: 11325905Abstract: There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.Type: GrantFiled: April 5, 2018Date of Patent: May 10, 2022Assignee: The Governors of the University of AlbertaInventors: Dennis Hall, Michael Weinfeld, Sylvain Bernard, Tristan Verdelet, Timothy Morgan, Vikie Lamontagne, Zahra Shire, Afsaneh Lavasanifar