Abstract: A static optical system, for use with a phase modulator, configured to expand (at least up to 4? steradian) the solid angle range within which a light beam can propagate from and after interacting with the phase modulator. A specific embodiment includes a first holographic disperser (a layer with at least one hologram recorded therein, a lens element configured as a large spherical cap, and a second holographic disperser (a layer with at least one hologram in it) shaped as a shell against second optical surface of the lens element. Holographic dispersers carry/contain angularly-selective multiplexed volume holograms.

Abstract: Freeform waveguide prism and use with head-mounted light field display with integral imaging and relay group.

Abstract: Provided herein are compositions and methods for treating bone fractures. In particular, provided herein are systems comprising carbon fiber sleeves and biocompatible polymers and the use of such systems in treating or preventing bone fractures.

Abstract: A fuel cell system with a stack that includes at least one high temperature membrane electrode assembly and a bipolar plate laminated with an electrically conducting layer to form a structure that contains a liquid cooling chamber inside the structure and gas flow channels on an outer side of the structure. Preferably, a membrane of the membrane electrode assembly contains a composite of inorganic and organic proton-conducting particles and is structurally supported at an anode of the assembly with a porous layer of metallic material. Methodologies of manufacture and used of such fuel cell system. An electrical generation system employing such fuel cell system.

Abstract: Optical imaging includes: configuring a spatial mode sorter to provide, in response to a received input optical signal, a separate output optical signal for each spatial mode in a set of target spatial modes: receiving a set of output optical signals from the spatial mode sorter during a detection interval of time: processing information based at least in part on the set of output optical signals received in the detection interval of time: and providing an estimated measurement for discriminating among a first set of two or more predetermined target images based at least in part on information derived from the processing. During the detection interval of time, a total number of the output optical signals is greater than two and less than ten.

Abstract: A flame retardant composition includes a polymers that is the reaction product of a mixture of a chalcogenide halide and one or more organic compounds comprising an unsaturated carbon-carbon bond under reaction conditions sufficient to produce the polymer, wherein the chalcogenide halide comprises a sulfur monohalide, a sulfur dihalide, a selenium monohalide, a selenium dihalide, a selenium tetrahalide, or a combination of any two or more thereof.

Abstract: Devices and methods that use a perceptual-driven approach to foveated displays with the goal of offering elegant degradation of image resolution with the increase of eccentricity and eye movements. As a result, the implementation leads to minimally perceivable image artifacts and image resolution discontinuity, and may further eliminate or limit the need for an eyetracker or scanning mechanism. Hereby we refer this approach as perceptual-driven continuous foveated display in contrast to the multi-level discrete foveation approach used previously.

Abstract: A method and system are provided for using induction heating to shape a work piece panel into a preselected shape. The method includes positioning a work piece panel near or in abutment with at least a first induction coil. Alternating current (AC) having a preselected amplitude and frequency can be passed through at least the first induction coil while the work piece panel is subjected to at least one preselected shaping condition. An alternating electromagnetic field produced by the AC current, can cause eddy current in the work piece panel that can heat it to a preselected temperature for a preselected period of time while subjected to the preselected shaping condition, thereby causing the work piece panel to attain the preselected shape. The alternating electromagnetic field can also create a repelling electromagnetic force between the coil and the work piece panel, which could be a shaping condition.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: Systems featuring two or more encapsulation devices stacked together. The encapsulation devices house cells, such as but not limited to islet cells or stem cell derived beta cells or the like. e.g., for regulating blood glucose, or other cells or spheroids that can produce and release a therapeutic agent that is useful in the body, etc. The system may feature oxygen delivery, or in some cases no exogenous oxygen is delivered and vascularization of the device can help provide oxygen and other needed nutrient to the cells. The system of the present invention may be used in conjunction with other therapies such as an artificial pancreas. Stacking the devices with blood vessel formation around and in between them may allow for a decrease in the footprint that would be needed for implantation.

Abstract: A tubular pulsatile ventricular assist device (PVAD) system for providing forward flow of blood in a pulsatile, peristaltic, and non-hemolytic manner to help reduce the amount of blood clotting associated with current ventricular devices on the market. The system can encircle a portion of a blood vessel, and the system can sequentially apply a pressure through each port in a particular pre-determined patter so as to selectively occlude the lumen, thereby creating a pulsatile, peristaltic movement along a length of system. Said movement causes blood to flow through the portion of the blood vessel.

Abstract: Systems and methods for providing oxygenated blood to a patient, e.g., in a patient with inadequate or failing circulation, including a dual lumen cannula system for drawing blood from the heart and returning oxygenated blood therein. Methods may feature inserting the dual lumen cannula system through the left ventricle such that intake aperture are positioned entirely within the left ventricle and the tip of the cannula is positioned in the aorta of the patients heart. By fluidly connecting the cannula to a cardiac assistance device, deoxygenated blood may be drained from the left ventricle through the intake apertures and oxygenated blood may be pumped into the aorta thorough the tip.

Abstract: Devices and associated methods for measuring orientation using an optical gyroscope are disclosed. One example optical gyroscope includes a spherical component configured to allow propagation of light in one or more confined modes inside the spherical component. The spherical component includes a gain medium for enhancing a sustained confinement of light within the spherical component. The optical gyroscope also includes one or more detectors positioned outside of the spherical component to detect at least one characteristic of the light, or a change thereto, in response to a rotation of the optical gyroscope.

Abstract: Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein R1 is as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.

Abstract: Methods, systems, and devices for enhancing cancer immunotherapy featuring co-transplantation of encapsulated xenogeneic cells with separately encapsulated autologous or allogeneic cells, e.g., autologous or allogeneic tumor cells. For example, both a first cellular transplantation device housing a patient's own tumor cells and a second cellular transplantation device housing xenogeneic cells may be implanted into a patient. The presence of the xenogeneic cells elicits an enhanced immune response, e.g., the xenogeneic cells will draw in a large number of immune cells. Shed tumor antigens from the first cellular transplantation may then be taken up by the immune cells that were drawn to the xenogeneic cells. This will generate an anti-tumor immune response that is amplified relative to a response elicited by the encapsulated tumor cells alone.

Abstract: A microscopic technique for generating high-clarity, large volume 3D images of fluorescent tissue structure at subcellular resolution and capture transient activities. The technique includes capturing two orthogonal 2D projection of the sample volume by performing a projection scan with an excitation laser sweeping through the volume at up to 100 vps, tracking the scan depth using an electrically tuned lens to keep the emission image in focus and generate an xy plane volume projection image at the camera; and placing a PMT behind the excitation lens to collect emission passed through the excitation lens, wherein signals from the PMT form a focus scan projection at the yz plane; and then merging the xy and yz projections.

Abstract: A machine reading system is described herein that includes a framework in which grammar rules can be developed using a concise language that combines syntax and semantics. The resulting technology thus reduces the development time for new grammars in a new domain. An enormous amount of information appears in the form of natural language across millions of academic papers and other literature sources. For example, in the biological domain, there is a tremendous ongoing effort to extract individual chemical interactions from these texts, but these interactions are only isolated fragments of larger causal mechanisms such as protein signaling pathways. The proposed rule-based event extraction framework can model underlying syntactic representations of events in order to extract signaling pathway fragments. Though application to the biomedical domain is herein described, the framework is domain-independent and is expressive enough to capture most complex events annotated by domain experts.

Abstract: A redox flow battery including: a catholyte including a radical dication of a conjugated heterocyclic carbenium compound; and an anolyte including a neutral radical of a conjugated heterocyclic carbenium compound; wherein the conjugated heterocyclic carbenium compounds present in the catholyte and anolyte are the same compound; and the redox flow battery has an open circuit potential of greater than about 2 V. A redox flow battery including: a catholyte including a conjugated heterocyclic cationic compound in a first oxidation state; and an anolyte including a conjugated heterocyclic cationic compound in a second oxidation state; wherein the first oxidation state is a higher oxidation state than the second oxidation state.

Abstract: Methods involving analysis of pretreatment leukocyte expression profiles for prognostic assessment of seizure outcome following a treatment or medical procedure, such as stereotactic laser amygdalohippocampotomy (SLAH). In one aspect, RNA sequencing (RNA-Seq) on whole blood leukocyte samples is taken from a patient with intractable epilepsy prior to SLAH. Differential expression (DE) analysis revealed 24 significantly dysregulated genes (?2.0-fold change, p-value <0.05, and False Discovery Rate, FDR <0.05) useful in prognostic assessment.

Abstract: The present disclosure is directed to systems and methods of providing a secure quantum key distribution cryptosystem in which the quantum key data is exchanged between Alice and Bob using a quantum channel and the parity bits associated with the quantum key data are encrypted using a post-quantum computing (PQC) encryption method and communicated between Alice and Bob using a public channel.