Abstract: A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide is disclosed. The particular fungicide used is a benzimidazole derivative having the formula: wherein R is selected from the group consisting of H, carboxyl (—CO2H), hydroxyl, amino or esters (—CO2R?) wherein R? is selected from the group consisting of alkoxy, haloalkyl, alkenyl, and cycloalkyl wherein the alkyl groups have from 1-8 carbons or CH3CH2(OCH2CH2)n— or CH3CH2CH2(OCH2CH2CH2)n— or (CH3)2CH—(OCH(CH3)CH2)n— wherein n is from 1-3, the pharmaceutically acceptable salts thereof, or mixtures thereof.

Abstract: Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.

Abstract: Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.

Abstract: This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing an aldehyde 5-oxo-1,2,4-triazine hydrazide derivative.

Abstract: This invention is a method of treating cancer, both carcinomas and sarcomas, and viral infections, in particular HIV through the administration of a pharmaceutical composition containing a benzimidazole derivative. The composition is also claimed.

Abstract: Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm-blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.

Abstract: A pharmaceutical composition that can be used to treat HIV is disclosed.

Abstract: Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these compounds. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.

Abstract: Method of treating leukemia, inhibiting the growth or proliferation of leukemic cells or extending the life span of a animal having leukemia are disclosed. The methods comprise the step of treating the leukemia with an effective amount of a compound of the Formula I or a pharmaceutically acceptable salt or prodrug form thereof, wherein: X is hydrogen, halogen or alkyl of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; R is hydrogen or an alkyl group of from 1 to 8 carbon atoms, alkylcarbamyl; R2 is 4-thiazolyl or NHCOOR1; and R1 is an aliphatic hydrocarbon of less than 7 carbon atoms. A chemotherapeutic agent and/or potentiator can be used in conjunction with the compound of the Formula I.

Abstract: This invention is a method of treating cancer, including carcinomas and sarcomas through the administration of a pharmaceutical composition containing an aldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The aldehyde 5-oxo-1,2,4-triazine hydrazide derivative is selected from the group consisting of those with the formula: wherein R and R1 are independently selected from the group consisting of hydrogen, or alkyl wherein the alkyl group has up to 7 carbon atoms and wherein R3 is selected from the group consisting of alkyl having 1 to 7 carbon atoms, cycloalkyl having up to 7 carbon atoms, and substituted alkyl having up to 12 carbons wherein the alkyl group is substituted with one more halogen, hydroxy, amino, sulfhydryl or alkoxy having up to 10 carbon atoms, or wherein X is independently selected from hydrogen, alkyl of less than 7 carbons, halogen, amino, hydroxy and sulfhydryl and n is 4 or less, pharmaceutical salt, prodrug, metabolites and mixtures thereof.

Abstract: This application describes a method of determining the amount of organic polyamine in an aqueous solution to be assayed, which comprises (1) incubating a measured volume of said solution with a solution containing a protein with glutamine residues and a small, known amount of radiolabeled polyamine, in the presence of transglutaminase, (2) placing aliquots of the incubated solution on thin layer chromatographic strips treated with aqueous acid, (3) treating said strips with dilute aqueous acid solution to cause ascending chromatography, (4) cutting from the strips the sections where the aliquots had been applied thereto, (5) counting the radioactive scintillations of said sections, (6) carrying out steps (1) through (5) with the same volume of a standard solution containing a known amount of said polyamine, and (7) calculating the amount of polyamine in the solution to be assayed from the scintillation count made in the test procedure thereon in comparison to the scintillation count made in the test procedure

Abstract: The present invention relates to improved apparatus and improved methods for quickly and economically checking the functional performance of blood pressure monitoring systems of the hydraulic type, both prior to and during patient use of the system. More specifically, apparatus faults such as a faulty transducer, and the presence of gaseous bubbles, i.e. air, in the liquid column of such a system through which blood pressure variations of a patient are transmitted to the transducer, are detected and can be isolated as to location in the system by providing volume changing means for changing the volumetric size of a portion or all of the liquid volume containing capacity of the system by a predetermined amount, and indicating or sensing the change in liquid column pressure resulting from the predetermined change in the volumetric size of the liquid volume containing capacity of the system.

Abstract: A two stage cooling system in which the first stage's cooling affect is transferred to the second stage through direct contact with an oil-like material. The oil-like material is cooled by direct contact with water which has been evaporatively cooled. The oil-like material is then utilized to cool the air stream prior to the second stage evaporative cooling. The use of an oil-like material in the first cooling stage of evaporative cooling allows a relatively dry air stream to be produced so as to fully capitalize upon the evaporative cooling affect of the second stage cooler.

Abstract: The present invention relates to improved apparatus and improved methods for quickly and economically checking the functional performance of blood pressure monitoring systems of the hydraulic type, both prior to and during patient use of the system. More specifically, apparatus faults such as a faulty transducer, and the presence of gaseous bubbles, i.e. air, in the liquid column of such a system through which blood pressure variations of a patient are transmitted to the transducer, are detected and can be isolated as to location in the system by providing volume changing means for changing the volumetric size of a portion or all of the liquid volume containing capacity of the system by a predetermined amount, and indicating or sensing the change in liquid column pressure resulting from the predetermined change in the volumetric size of the liquid volume containing capacity of the system.

Abstract: The present invention relates to algal cell growth, modification and harvesting, and more particularly to systems apparatus and methods for growing, enhancing the growth of and harvesting of motile swimming microorganisms, especially unicellular algae, such as Dunaliella, which multiply by cell division.

Abstract: A system for reducing the effects of background radiation on a desired signal includes a plurality of physically spaced phase shifters arranged in a two-dimensional array and disposed in the path of the desired signal for cancelling the background radiation while passing the desired signal without substantial attentuation. In a second embodiment, the desired signal is split into two beams which traverse different paths and passed through two complementary two-dimensional arrays of physically spaced attenuators, each array being disposed in one of the paths. A phase shifter is disposed in one or both of the paths and the signals from the two paths are recombined to cancel the background radiation. The two-dimensional arrays of physically spaced phase shifters may be integrated into the beam splitters.

Abstract: The acoustic wave generated by sudden thermal stress is used to obtain information non-invasively on the composition and structure of the stressed body. One or more acoustic transducers (1 and 1') are coupled with the surface of the body to intercept the acoustic wave and generate a corresponding electrical signal. The sudden thermal stress is induced by a pulse of radiation which deposits energy causing a rapid, but very small, rise of temperature. The radiation may be ionizing radiation, such as high energy electrons, photons (X-rays), neutrons, or other charged particles. The radiation may also be non-ionizing radiation, such as RF(2) and microwave electromagnetic radiation (3) and ultrasonic radiation (4). The electrical signal from the acoustic transducer (1) is amplified (5) and supplied to a digitizer (6), which provides a continuous stream of digital words corresponding to samples of the amplified signal.

Abstract: The present invention relates to systems, processes and apparatus for harvesting microorganisms, especially free swimming unicellular algae, such as algal cells of the Dunaliella variety.In accordance with one aspect of the invention, a material mass made up of fibrous or inert inorganic material in interposed between the liquid containing reservoir in which the algal cells are disposed for multiplication by cell division and the cell harvest zone to provide a preferred travel path for the migration of the cells from the reservoir to the harvest zone. This mass not only enhances cell travel from the reservoir to the harvest zone, but also acts as a cell collision mass to enhance cell division, thereby to decrease the time lag of cell division build-up in the early stages of generating an algal cell culture in the reservoir.

Abstract: A device for reducing the effects of scattered light in an optical instrument utilizes an interferometer for interfering the scattered light and placing the image of the desired object within a dark fringe of the scattered light interference pattern to increase the contrast between the image of the desired object and the background.

Abstract: A device for reducing the effects of scattered light in an optical instrument utilizes an interferometer for interfering the scattered light and placing the image of the desired object within a dark fringe of the scattered light interference pattern to increase the contrast between the image of the desired object and the background.