Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes Nat least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.

Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes at least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.

Abstract: Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue.

Abstract: The present invention provides an air filter comprising a polymer foam and an adsorbent material wherein said polymer foam comprises metal particles.

Abstract: Disclosed are methods and kits for producing a conformationally constrained peptide, such as a helix constrained peptide, in a cell. In some cases, the methods comprise contacting a cell comprising an intracellularly-localised recombinant peptide with a cross-linker and culturing the cell in the presence of the cross-linker, wherein the cross-linker forms thioether cross-links with at least two derivatisable amino acids located at anchoring positions in the recombinant peptide. The methods and kits and cells find application, for example, in the identification of inhibitors that can be used to disrupt protein-protein interactions.

Abstract: The invention relates to compounds capable of modulating the permeability of junctions between epithelial cells, and their use to facilitate delivery of substances such as therapeutic and diagnostic agents across epithelial surfaces.

Abstract: Disclosed are methods, kits and cells for screening an inhibitor of association between candidate binding partners, such as for screening antagonists of amyloid peptides. The methods, kits and cells employ a reporter expression cassette and hybrid proteins. The reporter expression cassette encodes a reporter and comprises at least one DNA binding site. Each hybrid protein comprises a candidate binding partner and a component of a DNA binding protein and, upon association, form a DNA-binding complex capable of binding to the at least one binding site and inhibiting expression of the reporter. The methods, kits and cells find application, for example, in the identification of inhibitors that may be useful in treating diseases associated with protein aggregation, such as Alzheimer's Disease and Parkinson's Disease.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack; drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: An apparatus for generating electrical energy comprises an oscillating heat pipe for transferring heat between a heat source and a heat sink, and a pyroelectric generator for generating electricity from thermal fluctuations generated by the oscillating heat pipe as the oscillating heat pipe transfers heat between the heat source and the heat sink.

Abstract: A peptide comprising a sequence for opening a tight junction of an epithelial surface and optionally a cell penetrating sequence; and related compositions, optionally comprising further pharmaceutical agents; and related methods.

Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.

Abstract: A method of forming an imaging fibre apparatus comprises arranging rods to form a plurality of stacks each comprising a respective plurality of rods, wherein: for each stack, the respective plurality of rods comprises rods having different core sizes, the rods of different core sizes being arranged in a selected arrangement, and the rods of different core sizes being arranged such that each stack has a respective selected shape; wherein the selected shape or shapes are such that the stacks stack together in a desired arrangement; the method further comprising: drawing each of the plurality of stacks; stacking together the plurality of drawn stacks together in the desired arrangement to form a further stack;drawing the further stack; and using the drawn further stack to form an imaging fibre apparatus, wherein the selected arrangement of the rods in each stack and the selected shape or shapes of the stacks are such that the further stack comprises a repeating pattern of rods of different core sizes.

Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.

Abstract: The present invention relates to opioid compounds, especially to C14 esters and ethers of naltrexone and analogs thereof. The present invention also relates to compositions, methods and medical uses that employ such compounds. More specifically, the present invention pertains to compounds of formula: and to their use in the treatment of diseases and disorders including pain, hyperalgesia, addiction, substance abuse disorders, stress, anorexia, anxiety, depression, cough, asthma, hypertension, gastrointestinal motility disorder, water retention, cognitive disorders, and locomotor disorders.

Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having formula 2: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.

Abstract: The invention provides a method of treating drug and alcohol abuse, depression, anxiety, or a compulsive disorder in a subject comprising administering to the subject a compound having the formula: or a pharmaceutically acceptable salt or solvate thereof, wherein R, R1, R2, R3, R4, R5, and X are as defined in the specification.

Abstract: The invention discloses compounds of the formula wherein A, B, X, Y and Z are defined. The compounds of the invention show activity against a range of bacteria, and are useful in the treatment or prophylaxis of a bacterial infection in an animal.