Patents Assigned to University of Bern
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Patent number: 11712468Abstract: The present invention provides combinations and methods using same for the treatment of malignancy, particularly a myeloid malignancy such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), and chronic myelomonocytic leukemia (CMML). The combination may comprise an antibody or antigen-binding fragment thereof that binds to CD70, and an inhibitor of BCL-2. In certain embodiments, the antibody is ARGX-110 (cusatuzumab). In certain embodiments, the BCL-2 inhibitor is venetoclax. In certain embodiments, the combination provides synergistic treatment of AML. The combination may additionally comprise at least one additional anti-cancer agent.Type: GrantFiled: December 18, 2019Date of Patent: August 1, 2023Assignees: ARGENX BV, University of BernInventors: Johannes De Haard, Samson Fung, Nicolas Leupin, Adrian Ochsenbein, Carsten Riether, Luc Van Rompaey
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Publication number: 20230235260Abstract: A microfluidic device for cell culture and screening, including a covering element with a plurality of openings configured for introducing and collecting fluids, and a central through hole; an intermediate element with a plurality of microchannels, a plurality of supply tanks and at least one waste tank, and a blind bottom cavity; a lower element, with a collecting tank and a recessed central portion; and a slide housed in a housing pocket. The intermediate element is interposed between the covering element and the lower element to form an upper optical window and at least one culture chamber. The plurality of microchannels puts in fluid communication the plurality of supply tanks, the at least one culture chamber and the waste tank.Type: ApplicationFiled: June 17, 2021Publication date: July 27, 2023Applicants: UNIVERSITA' DEGLI STUDI MAGNA GRAECIA DI CATANZARO, UNIVERSITY OF BERNInventors: Gerardo PEROZZIELLO, Francesco GUZZI, Elvira PARROTTA, Giovanni CUDA, Maria Laura COLUCCIO, Patrizio CANDELORO, Gina VALENTINO, Paola LUCIANI
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Patent number: 11571475Abstract: Provided are methods and compositions for the treatment of a BCR-ABL1 related disorder (e.g., chronic myelogenous leukemia) using a therapeutic combination of a WNT signaling pathway inhibitor and a BCR-ABL1 tyrosine kinase inhibitor.Type: GrantFiled: July 9, 2019Date of Patent: February 7, 2023Assignee: University of BernInventors: Carsten Riether, Christian Schürch, Adrian Ochsenbein, Karen Silence
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Publication number: 20230021982Abstract: The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided.Type: ApplicationFiled: August 25, 2022Publication date: January 26, 2023Applicants: KWS SAAT SE & Co. KGaA, UNIVERSITY OF ZURICH, UNIVERSITY OF BERNInventors: Bettina KESSEL, Milena OUZUNOVA, Daniela SCHEUERMANN, Beat KELLER, Simon KRATTINGER, Coraline PRAZ, Ping YANG, Matthias ERB
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Patent number: 11526994Abstract: Systems, methods, and computer program products are provided for segmenting a brain tumor from various MRI sequencing techniques. A plurality of MRI sequences of a head of a patient are received. Each MRI sequence includes a T1-weighted with contrast image, a Fluid Attenuated Inversion Recovery (FLAIR) image, a T1-weighted image, and a T2-weighted image. Each image of the plurality of MRI sequences is registered to an anatomical atlas. A plurality of modified MRI sequences are generated by removing a skull from each image in the plurality of MRI sequences. A tumor segmentation map is determined by segmenting a tumor within a brain in each image in the plurality of modified MRI sequences. The tumor segmentation map is applied to each of the plurality of MRI sequences to thereby generate a plurality of labelled MRI sequences.Type: GrantFiled: April 29, 2022Date of Patent: December 13, 2022Assignees: Neosoma, Inc., The University of BernInventors: Mauricio Reyes, Michael Müller, Aly Abayazeed
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Publication number: 20210366620Abstract: Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.Type: ApplicationFiled: May 31, 2019Publication date: November 25, 2021Applicants: CorFlow Therapeutics AG, Interstate University of Applied Sciences Buchs, University of BernInventors: Andre BERNARD, Peter HEEB, Cornelia NEF, Dominik OBRIST, Francesco CLAVICA, Sabrina FREY, Robert S. SCHWARTZ, Jon Helge HOEM, Oliver BLUDAU
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Publication number: 20200231984Abstract: The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided.Type: ApplicationFiled: August 22, 2018Publication date: July 23, 2020Applicants: KWS SAAT SE & co., KGaA, University of Zurich, University of BernInventors: Bettina KESSEL, Milena OUZUNOVA, Daniela SCHEUERMANN, Beat KELLER, Simon KRATTINGER, Coraline PRAZ, Ping YANG, Matthias ERB
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Patent number: 10674920Abstract: A method of imaging a region of interest of a body, the body having sites outside the region which can produce image clutter. The method includes: generating a first pattern of vibration within the body to produce a localised first displacement at the region and localised first displacements at the clutter-producing sites; while the body undergoes the first displacements, generating ultrasound signals from the region, and detecting the ultrasound signals to generate a first image of the region; generating a second pattern of vibration within the body to produce a localised second displacement at the region and localised second displacements at the clutter-producing sites; while the body undergoes the second displacements, generating ultrasound signals from the region, and detecting the ultrasound signals to generate a second image of the region; and combining the first and second images to produce a third image of the region.Type: GrantFiled: July 24, 2013Date of Patent: June 9, 2020Assignees: THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL, UNIVERSITY OF BERNInventors: Jeffrey Colin Bamber, Martin Frenz, Michael Jaeger
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Patent number: 10414721Abstract: Provided is a highly potent and selective endocannabioid cellular reuptake inhibitor represented by formula (I): or a pharmaceutically acceptable solvate or co-crystal thereof as well as to a formulation comprising this inhibitor, and to methods of treatment in which this inhibitor is used.Type: GrantFiled: June 4, 2018Date of Patent: September 17, 2019Assignee: UNIVERSITY OF BERNInventors: Andrea Chicca, Jurg Gertsch
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Patent number: 10391168Abstract: Provided are methods and compositions for the treatment of a BCR-ABL1 related disorder (e.g., chronic myelogenous leukemia) using a therapeutic combination of a WNT signaling pathway inhibitor and a BCR-ABL1 tyrosine kinase inhibitor.Type: GrantFiled: August 21, 2015Date of Patent: August 27, 2019Assignee: UNIVERSITY OF BERNInventors: Carsten Riether, Christian Schürch, Adrian Ochsenbein, Karen Silence
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Publication number: 20180122063Abstract: There is disclosed a system for estimating the volume of food on a plate, for example meal, with a mobile device. The system uses a camera and a light pattern projector. Images of the food with and without a projected light pattern on it enable to compute the tridimensional shape and volume, while image segmentation and recognition steps estimate one or more food types in said images. By applying accessible knowledge databases, the carbs content is estimated and the associated insulin bolus doses are provided. Developments comprise coding of the light pattern, different light sources and associated wavelengths, motion compensations, additional optics, estimation of fat content and associated multi-wave boluses. The invention can be implemented in a glucometer or in an insulin pump controller provided with a test strip port or with a mobile phone.Type: ApplicationFiled: December 28, 2017Publication date: May 3, 2018Applicants: Roche Diabetes Care, Inc., University of BernInventors: Joachim Dehais, Alan Greenburg, Sergey Shevchick, Abhishek Soni, Marios Anthimpoulos, Stavroula Mougiakakou
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Patent number: 9889023Abstract: An acetabular component alignment device for total hip arthroplasty comprises a calibration component allowing for aligning a main instrument axis (5) of the acetabular component depending on a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component, whereas the device is constructed in such a way that calibration parameters may be chosen such that a second parameter of the set of calibration parameters is adjustable independently from a first parameter of the set of calibration parameters by rotating the acetabular component around the main instrument axis (5) of the acetabular component.Type: GrantFiled: June 8, 2010Date of Patent: February 13, 2018Assignee: UNIVERSITY OF BERNInventors: Guoyan Zheng, Xiao Dong, Lutz-Peter Nolte
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Patent number: 9892501Abstract: There is disclosed a system for estimating the volume of food on a plate, for example meal, with a mobile device. The system uses a camera and a light pattern projector. Images of the food with and without a projected light pattern on it enable to compute the tridimensional shape and volume, while image segmentation and recognition steps estimate one or more food types in said images. By applying accessible knowledge databases, the carbs content is estimated and the associated insulin bolus doses are provided. Developments comprise coding of the light pattern, different light sources and associated wavelengths, motion compensations, additional optics, estimation of fat content and associated multi-wave boluses. The invention can be implemented in a glucometer or in an insulin pump controller provided with a test strip port or with a mobile phone.Type: GrantFiled: December 22, 2015Date of Patent: February 13, 2018Assignees: Roche Diabetes Care, Inc., University of BernInventors: Joachim Dehais, Alan Greenburg, Sergey Shevchick, Abhishek Soni, Marios Anthimpoulos, Stavroula Mougiakakou
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Patent number: 9157114Abstract: The invention concerns an in vitro method of determining a genotype relating to hereditary nasal parakeratosis (HNPK) in a dog. According to the invention the presence or the absence of a genetic variation in the SUV39H2 gene sequence is indicative of said disorder. The invention also concerns polypeptide based methods for determining said disorder. Further, nucleic acids, polypeptides and antibodies usable in said method are disclosed.Type: GrantFiled: May 21, 2013Date of Patent: October 13, 2015Assignee: UNIVERSITY OF BERNInventor: Tosso Leeb
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Publication number: 20150190534Abstract: The present invention relates generally to compounds according to formula I that bind more specifically to mutated androgen receptors than to the wild type androgen receptors and therefore are useful as imaging agents for positron emission tomography (PET) used in the diagnosis and monitoring of prostate cancer.Type: ApplicationFiled: January 9, 2014Publication date: July 9, 2015Applicant: UNIVERSITY OF BERNInventors: Brigitte FREY, Reto BERTOLLINI
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Publication number: 20140228960Abstract: A cervical implant for dogs includes a plate section for connecting two adjacent vertebral bodies and an intervertebral section which replaces the vertebral disc between the two vertebral bodies, wherein the plate section has at least one receptacle for each vertebral body for fastening the implant.Type: ApplicationFiled: February 10, 2014Publication date: August 14, 2014Applicants: University of Bern, Rita Leibinger GmbH & Co. KGInventors: Franck Forterre, Rita Leibinger, Enrico Wirth
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Publication number: 20130316345Abstract: The invention concerns an in vitro method of determining a genotype relating to hereditary nasal parakeratosis (HNPK) in a dog. According to the invention the presence or the absence of a genetic variation in the SUV39H2 gene sequence is indicative of said disorder. The invention also concerns polypeptide based methods for determining said disorder. Further, nucleic acids, polypeptides and antibodies usable in said method are disclosed.Type: ApplicationFiled: May 21, 2013Publication date: November 28, 2013Applicant: University of BernInventor: Tosso Leeb
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Publication number: 20120172884Abstract: An acetabular component alignment device for total hip arthroplasty comprises a calibration component (9) allowing for aligning a main instrument axis (5) of the acetabular component depending on a set of two patient specific calibration parameters relating to rotational offsets of the acetabular component, whereas the device is constructed in such a way that calibration parameters may be chosen such that a second parameter of the set of calibration parameters is adjustable independently from a first parameter of the set of calibration parameters by rotating the acetabular component around the main instrument axis (5) of the acetabular component.Type: ApplicationFiled: June 8, 2010Publication date: July 5, 2012Applicant: UNIVERSITY OF BERNInventors: Guoyan Zheng, Xiao Dong, Lutz-Peter Nolte
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Publication number: 20110165124Abstract: The present invention relates to in vitro methods of determining a susceptibility to non-response to a hepatitis C treatment or a susceptibility to spontaneous hepatitis C clearance in a subject infected with hepatitis C.Type: ApplicationFiled: July 29, 2010Publication date: July 7, 2011Applicants: Centre Hospitalier Universitaire Vaudois, University of BernInventors: Pierre-Yves Bochud, Andri Rauch
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Patent number: 7833536Abstract: The present invention relates i.a. to vaccines for combating Mycoplasma infection, to mycoplasmal L-?-glycerophosphate oxidase for use in such vaccines, to the use of mycoplasmal L-?-glycerophosphate oxidase for the manufacturing of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the discrimination of animals vaccinated with said vaccines and animals vaccinated with whole cell vaccines or animals suffering from field infection.Type: GrantFiled: July 6, 2006Date of Patent: November 16, 2010Assignee: University of BernInventors: Joachim Frey, Edy M. Vilei, Paola Pilo