Patents Assigned to University of Bern
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Patent number: 12165330Abstract: Systems, methods, and computer program products are provided for segmenting a brain tumor from various MRI sequencing techniques. A plurality of MRI sequences of a head of a patient are received. Each MRI sequence includes a T1-weighted with contrast image, a Fluid Attenuated Inversion Recovery (FLAIR) image, a T1-weighted image, and a T2-weighted image. Each image of the plurality of MRI sequences is registered to an anatomical atlas. A plurality of modified MRI sequences are generated by removing a skull from each image in the plurality of MRI sequences. A tumor segmentation map is determined by segmenting a tumor within a brain in each image in the plurality of modified MRI sequences. The tumor segmentation map is applied to each of the plurality of MRI sequences to thereby generate a plurality of labelled MRI sequences.Type: GrantFiled: November 22, 2022Date of Patent: December 10, 2024Assignees: Neosoma, Inc., The University of BernInventors: Mauricio Reyes, Michael Müller, Aly Abayazeed
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Patent number: 11712468Abstract: The present invention provides combinations and methods using same for the treatment of malignancy, particularly a myeloid malignancy such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), chronic myeloid leukemia (CML), and chronic myelomonocytic leukemia (CMML). The combination may comprise an antibody or antigen-binding fragment thereof that binds to CD70, and an inhibitor of BCL-2. In certain embodiments, the antibody is ARGX-110 (cusatuzumab). In certain embodiments, the BCL-2 inhibitor is venetoclax. In certain embodiments, the combination provides synergistic treatment of AML. The combination may additionally comprise at least one additional anti-cancer agent.Type: GrantFiled: December 18, 2019Date of Patent: August 1, 2023Assignees: ARGENX BV, University of BernInventors: Johannes De Haard, Samson Fung, Nicolas Leupin, Adrian Ochsenbein, Carsten Riether, Luc Van Rompaey
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Patent number: 11571475Abstract: Provided are methods and compositions for the treatment of a BCR-ABL1 related disorder (e.g., chronic myelogenous leukemia) using a therapeutic combination of a WNT signaling pathway inhibitor and a BCR-ABL1 tyrosine kinase inhibitor.Type: GrantFiled: July 9, 2019Date of Patent: February 7, 2023Assignee: University of BernInventors: Carsten Riether, Christian Schürch, Adrian Ochsenbein, Karen Silence
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Patent number: 11526994Abstract: Systems, methods, and computer program products are provided for segmenting a brain tumor from various MRI sequencing techniques. A plurality of MRI sequences of a head of a patient are received. Each MRI sequence includes a T1-weighted with contrast image, a Fluid Attenuated Inversion Recovery (FLAIR) image, a T1-weighted image, and a T2-weighted image. Each image of the plurality of MRI sequences is registered to an anatomical atlas. A plurality of modified MRI sequences are generated by removing a skull from each image in the plurality of MRI sequences. A tumor segmentation map is determined by segmenting a tumor within a brain in each image in the plurality of modified MRI sequences. The tumor segmentation map is applied to each of the plurality of MRI sequences to thereby generate a plurality of labelled MRI sequences.Type: GrantFiled: April 29, 2022Date of Patent: December 13, 2022Assignees: Neosoma, Inc., The University of BernInventors: Mauricio Reyes, Michael Müller, Aly Abayazeed
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Publication number: 20210366620Abstract: Systems, methods and apparatus are included that are configured to model microvascular obstruction (MVO) in patients. According to one aspect of the present disclosure, a multi-scale model is configured to mimic myocardial microcirculation of coronary vessels. The model includes collaterals configured to provide alternative pathways possibly bypassing the MVO, and configured to model coronary artery compliance for spatially resolved fluid transport through the coronary vessels. The model is configured to simulate the MVO by increasing flow resistance in at least one of the modelled coronary vessels, or by blocking the at least one of the modelled coronary vessels completely. The model is also configured to mimic behavior of fluid transport in the coronary vessels during diagnostics or treatment, to design and optimize therapy protocols for the MVO.Type: ApplicationFiled: May 31, 2019Publication date: November 25, 2021Applicants: CorFlow Therapeutics AG, Interstate University of Applied Sciences Buchs, University of BernInventors: Andre BERNARD, Peter HEEB, Cornelia NEF, Dominik OBRIST, Francesco CLAVICA, Sabrina FREY, Robert S. SCHWARTZ, Jon Helge HOEM, Oliver BLUDAU
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Publication number: 20200231984Abstract: The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided.Type: ApplicationFiled: August 22, 2018Publication date: July 23, 2020Applicants: KWS SAAT SE & co., KGaA, University of Zurich, University of BernInventors: Bettina KESSEL, Milena OUZUNOVA, Daniela SCHEUERMANN, Beat KELLER, Simon KRATTINGER, Coraline PRAZ, Ping YANG, Matthias ERB
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Publication number: 20180122063Abstract: There is disclosed a system for estimating the volume of food on a plate, for example meal, with a mobile device. The system uses a camera and a light pattern projector. Images of the food with and without a projected light pattern on it enable to compute the tridimensional shape and volume, while image segmentation and recognition steps estimate one or more food types in said images. By applying accessible knowledge databases, the carbs content is estimated and the associated insulin bolus doses are provided. Developments comprise coding of the light pattern, different light sources and associated wavelengths, motion compensations, additional optics, estimation of fat content and associated multi-wave boluses. The invention can be implemented in a glucometer or in an insulin pump controller provided with a test strip port or with a mobile phone.Type: ApplicationFiled: December 28, 2017Publication date: May 3, 2018Applicants: Roche Diabetes Care, Inc., University of BernInventors: Joachim Dehais, Alan Greenburg, Sergey Shevchick, Abhishek Soni, Marios Anthimpoulos, Stavroula Mougiakakou
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Patent number: 9892501Abstract: There is disclosed a system for estimating the volume of food on a plate, for example meal, with a mobile device. The system uses a camera and a light pattern projector. Images of the food with and without a projected light pattern on it enable to compute the tridimensional shape and volume, while image segmentation and recognition steps estimate one or more food types in said images. By applying accessible knowledge databases, the carbs content is estimated and the associated insulin bolus doses are provided. Developments comprise coding of the light pattern, different light sources and associated wavelengths, motion compensations, additional optics, estimation of fat content and associated multi-wave boluses. The invention can be implemented in a glucometer or in an insulin pump controller provided with a test strip port or with a mobile phone.Type: GrantFiled: December 22, 2015Date of Patent: February 13, 2018Assignees: Roche Diabetes Care, Inc., University of BernInventors: Joachim Dehais, Alan Greenburg, Sergey Shevchick, Abhishek Soni, Marios Anthimpoulos, Stavroula Mougiakakou
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Publication number: 20140228960Abstract: A cervical implant for dogs includes a plate section for connecting two adjacent vertebral bodies and an intervertebral section which replaces the vertebral disc between the two vertebral bodies, wherein the plate section has at least one receptacle for each vertebral body for fastening the implant.Type: ApplicationFiled: February 10, 2014Publication date: August 14, 2014Applicants: University of Bern, Rita Leibinger GmbH & Co. KGInventors: Franck Forterre, Rita Leibinger, Enrico Wirth
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Publication number: 20130316345Abstract: The invention concerns an in vitro method of determining a genotype relating to hereditary nasal parakeratosis (HNPK) in a dog. According to the invention the presence or the absence of a genetic variation in the SUV39H2 gene sequence is indicative of said disorder. The invention also concerns polypeptide based methods for determining said disorder. Further, nucleic acids, polypeptides and antibodies usable in said method are disclosed.Type: ApplicationFiled: May 21, 2013Publication date: November 28, 2013Applicant: University of BernInventor: Tosso Leeb
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Publication number: 20110165124Abstract: The present invention relates to in vitro methods of determining a susceptibility to non-response to a hepatitis C treatment or a susceptibility to spontaneous hepatitis C clearance in a subject infected with hepatitis C.Type: ApplicationFiled: July 29, 2010Publication date: July 7, 2011Applicants: Centre Hospitalier Universitaire Vaudois, University of BernInventors: Pierre-Yves Bochud, Andri Rauch
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Patent number: 7833536Abstract: The present invention relates i.a. to vaccines for combating Mycoplasma infection, to mycoplasmal L-?-glycerophosphate oxidase for use in such vaccines, to the use of mycoplasmal L-?-glycerophosphate oxidase for the manufacturing of such vaccines, to methods for the preparation of such vaccines and to diagnostic tests for the discrimination of animals vaccinated with said vaccines and animals vaccinated with whole cell vaccines or animals suffering from field infection.Type: GrantFiled: July 6, 2006Date of Patent: November 16, 2010Assignee: University of BernInventors: Joachim Frey, Edy M. Vilei, Paola Pilo
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Patent number: 7785849Abstract: The present invention relates to novel amino acid and nucleic acid sequences of cyclic nucleotide-specific phosphodiesterases from the parasite Leishmania major. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the amino acid and nucleic acid sequences. The invention further relates to the use of these sequences, and of antibodies directed against these sequences, in the diagnosis and treatment of disorders related to the infection of Leishmania major, including the identification of compounds that form complexes with the polypeptides and nucleic acids of the present invention.Type: GrantFiled: September 3, 2004Date of Patent: August 31, 2010Assignees: University of Bern, Otsuka Pharmaceutical Co., Ltd.Inventors: Thomas Seebeck, Andrea Johner, Yasmin Shakur
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Patent number: 7598067Abstract: The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.Type: GrantFiled: June 1, 2006Date of Patent: October 6, 2009Assignees: University of Bern, University of WashingtonInventors: Joseph A. Beavo, Thomas Seebeck, Scott Haydn Soderling, Ana Rascon, Roya Zoraghi, Stefan Kunz, Kewei Gong, Natalie Glavas
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Patent number: 7541018Abstract: In one embodiment, a method for treating a cancerous disease is provided which includes characterizing a disease by an overexpression of one or more somatostatin receptors, and exposing the one or more somatostatin receptors to a pharmaceutical composition comprising a somatostatin analogue which binds to the one or more somatostatin receptors.Type: GrantFiled: March 8, 2007Date of Patent: June 2, 2009Assignee: University of BernInventors: Helmut Robert Maecke, Jean Claude Reubi, Hans Rink, Klaus-Peter Eisenwiener
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Patent number: 7213443Abstract: The invention relates to a process and to an apparatus for providing gas for isotopic ratio analysis. According to the invention, a gas is generated from an eluate of a liquid chromatograph (LC). Subsequently, the gas is separated from the eluate. Finally, the gas is fed to an instrument (IRMS) for isotopic ratio analysis.Type: GrantFiled: April 16, 2003Date of Patent: May 8, 2007Assignee: University of BernInventors: Andreas Hilkert, Reinhold Pesch
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Patent number: 7192570Abstract: In one embodiment, a composition of somatostatin analogues having the general formula: is provided wherein Z may be absent or present and when present is selected from DOTA- and DTPA-based chelators, NOTA-based chelators, carbonyl compounds, hydrazino nicotinamide, N4-chelators, desferrioxamine, NxSy-chelators, optionally complexed or labeled with a radioisotope, tyrosine for halogenation, a fluorescent dye, or biotin. The composition further provides that L may or may not be present and when present is a linker molecule, X1 is glutamic acid or a symmetric or asymmetric diamino acid containing 3 or 4 consecutive C atoms, X2 is a positively charged natural or unnatural amino acid, an arginine mimic, citrulline, or a neutral amino acid, X3 is phenylalanine, Ala-[3-(2-thienyl)], ?-naphthylalanine, or ?-naphthylalanine, X4 is an aromatic amino acid, X5 is threonine or serine, and X6 is phenylalanine, Ala-[3-(2-thienyl)], ?-naphthylalanine, or ?-naphthylalanine.Type: GrantFiled: August 7, 2002Date of Patent: March 20, 2007Assignee: University of BernInventors: Helmut Robert Maecke, Jean Claude Reubi, Hans Rink, Klaus-Peter Eisenwiener
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Patent number: 7138259Abstract: The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.Type: GrantFiled: September 12, 2001Date of Patent: November 21, 2006Assignees: University of Washington, University of BernInventors: Joseph A. Beavo, Thomas Seebeck, Scott Haydn Soderling, Ana Rascon, Roya Zoraghi, Stefan Kunz, Kewei Gong, Natalie Glavas
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Patent number: 6171260Abstract: A biological evidence collection apparatus provides contact-free drying, storage, identification, and protection against sample switch and contamination of collected biological samples. The apparatus may include the described forensic evidence collection kit which provides a set of tools for the collection and storage of biological evidence. The collection apparatus may also be used as part of a sexual assault evidence collection kit, or a kit for the collection of buccal swabs, and the like.Type: GrantFiled: January 26, 1999Date of Patent: January 9, 2001Assignee: Institute of Legal Medicine, University of BerneInventors: Manfred N. Hochmeister, Henry C. Lee
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Patent number: 6085907Abstract: A biological evidence collection apparatus provides contact-free drying, storage, identification, and protection against sample switch and contamination of collected biological samples. The apparatus may include the described forensic evidence collection kit which provides a set of tools for the collection and storage of biological evidence. The collection apparatus may also be used as part of a sexual assault evidence collection kit, or a kit for the collection of buccal swabs, and the like.Type: GrantFiled: May 11, 1998Date of Patent: July 11, 2000Assignee: Institute of Legal Medicine, University of BernInventors: Manfred N. Hochmeister, Henry C. Lee