Patents Assigned to UNIVERSITY OF BREMEN
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Patent number: 11901512Abstract: An electrolyte includes at least one lithium salt, at least one first organic solvent having a dielectric constant of >90 at 40° C., at least one second organic solvent having a boiling point of <110° C., and at least one phosphite having the formula (I) R1 is selected from an n-propoxy group, an iso-propoxy group, a tert-butoxy group, an n-pentafluoropropoxy group, an n-trifluoropropoxy group, an iso-hexafluoropropoxy group, or a tert-nonafluorobutoxy group. R2, R3, R4, and R5 are each selected, independently of one another, from H, a trifluoromethyl group, or a C2-C6-alkyl group which is substituted with a trifluoromethyl group.Type: GrantFiled: July 5, 2019Date of Patent: February 13, 2024Assignees: FORSCHUNGSZENTRUM JUELICH GMBH, CONSTRUCTOR UNIVERSITY BREMEN GGMBHInventors: Volodymyr Kozel, Natascha Von Aspern, Gerd-Volker Roeschenthaler, Martin Winter, Olesya Stubbmann-Kazakova, Isidora Cekic-Laskovic, Christian Woelke
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Publication number: 20230293699Abstract: A method of using a boron cluster as a transmembrane carrier to transport a bioactive molecule across a membrane of a cell or a vesicle. The method includes providing a boron cluster having at least one hydrogen atom and/or at least one halogen atom, providing a bioactive molecule which is cationic, zwitterionic or not charged, so that the bioactive molecule is not negatively charged, and using the boron cluster as a transmembrane carrier to transport the bioactive molecule across the membrane of the cell or the vesicle.Type: ApplicationFiled: June 11, 2021Publication date: September 21, 2023Applicants: CONSTRUCTOR UNIVERSITY BREMEN GGMBH, UNIVERSIDADE DE SANTIAGO DE COMPOSTELAInventors: WERNER NAU, JAVIER MONTENEGRO
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Patent number: 11698375Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.Type: GrantFiled: July 1, 2019Date of Patent: July 11, 2023Assignee: CONSTRUCTOR UNIVERSITY BREMEN GGMBHInventors: Sebastian Hartmut Springer, Sunil Kumar Saini
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Publication number: 20230099524Abstract: An imidazolidinylide compound for use as a shut-down additive for a lithium-ion battery. The imidazolidinylide compound has a formula (I), wherein, R1 to R4, each independently the other, is a linear C1- to C16-alkyl group, a branched C1- to C16-alkyl group, a C2- to C16-alkenyl group, a C3- to C8-cycloalkyl group, or a C3- to C16-arene group, wherein at least one of R2 and R3 may also be H, R1 to R4, each independently of the other, is completely, partially or not fluorinated, and R1 to R3 may each also contain O as a heteroatom.Type: ApplicationFiled: February 9, 2021Publication date: March 30, 2023Applicants: JACOBS UNIVERSITY BREMEN GGMBH, FORSCHUNGSZENTRUM JUELICH GMBHInventors: GERD-VOLKER ROESCHENTHALER, ISIDORA CEKIC-LASKOVIC, NATASCHA VON ASPERN, MARTIN WINTER, MYKHAILO SHEVCHUK
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Publication number: 20220050104Abstract: A method for detecting T cells includes a first step of bringing a plurality of different antigenic peptides into contact with peptide-free MHC molecules which are arranged in an immobilized manner on a substrate in an array so that the plurality of different antigenic peptides bind to the peptide-free MHC molecules so as to form peptide-loaded MHC molecules, a second step of bringing a sample comprising the T cells into contact with the peptide-loaded MHC molecules on the substrate, and a third step of detecting the binding of the T cells to the peptide-loaded MHC molecules on the substrate.Type: ApplicationFiled: November 19, 2019Publication date: February 17, 2022Applicant: JACOBS UNIVERSITY BREMEN GGMBHInventors: CINDY DIRSCHERL, SEBASTIAN HARTMUT SPRINGER
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Publication number: 20210273263Abstract: An electrolyte includes at least one lithium salt, at least one first organic solvent having a dielectric constant of >90 at 40° C., at least one second organic solvent having a boiling point of <110° C., and at least one phosphite having the formula (I) R1 is selected from an n-propoxy group, an iso-propoxy group, a tert-butoxy group, an n-pentafluoropropoxy group, an n-trifluoropropoxy group, an iso-hexafluoropropoxy group, or a tert-nonafluorobutoxy group. R2, R3, R4, and R5 are each selected, independently of one another, from H, a trifluoromethyl group, or a C2-C6-alkyl group which is substituted with a trifluoromethyl group.Type: ApplicationFiled: July 5, 2019Publication date: September 2, 2021Applicants: FORSCHUNGSZENTRUM JUELICH GMBH, JACOBS UNIVERSITY BREMEN GGMBHInventors: VOLODYMYR KOZEL, NATASCHA VON ASPERN, GERD-VOLKER ROESCHENTHALER, MARTIN WINTER, OLESYA STUBBMANN-KAZAKOVA, ISIDORA CEKIC-LASKOVIC, CHRISTIAN WOELKE
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Publication number: 20190331681Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.Type: ApplicationFiled: July 1, 2019Publication date: October 31, 2019Applicant: JACOBS UNIVERSITY BREMEN GGMBHInventors: SEBASTIAN HARTMUT SPRINGER, SUNIL KUMAR SAINI
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Patent number: 10386367Abstract: A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with an examination peptide.Type: GrantFiled: January 3, 2013Date of Patent: August 20, 2019Assignee: JACOBS UNIVERSITY BREMEN GGMBHInventors: Sebastian Hartmut Springer, Sunil Kumar Saini
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Patent number: 9905885Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.Type: GrantFiled: April 25, 2013Date of Patent: February 27, 2018Assignees: JACOBS UNIVERSITY BREMEN GGMBH, WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTERInventors: Nataliya Kalinovich, Gerd-Volker Roeschenthaler, Tanja Schedlbauer, Johannes Kasnatscheew, Katja Vlasov, René Schmitz, Raphael Wilhelm Schmitz, Romek Ansgar Mueller, Martin Winter, Stefano Passerini
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Patent number: 9494588Abstract: A protein produced by an expression system that includes a nucleic acid sequence that encodes an MHC class I heavy chain. The MHC class I heavy chain comprises an alpha-1 helix and an alpha-2 helix. The nucleic acid sequence has a disulfide bridge formed between the alpha-1 helix and the alpha-2 helix in the MHC class I heavy chain. Amino acid 139 is substituted by a cysteine so as to provide Cys-139. Amino acid 84 is substituted by the cysteine so as to provide Cys-84 or amino acid 85 is substituted by the cysteine so as to provide Cys-85. The disulfide bridge is formed between the alpha-1 helix and the alpha-2 helix in the MHC class I heavy chain between Cys-139 and Cys-84 or between Cys-139 and Cys-85. The protein comprises an anchor element selected from a natural biotinylation sequence, a polyhistidine sequence, or a polyarginine sequence.Type: GrantFiled: August 30, 2011Date of Patent: November 15, 2016Assignee: JACOBS UNIVERSITY BREMEN GGMBHInventors: Sebastian Springer, Martin Zacharias
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Patent number: 9472831Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.Type: GrantFiled: July 25, 2012Date of Patent: October 18, 2016Assignees: Westfalische Wilhelms Universitat Munster, Jacobs University Bremen GGMBHInventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
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Publication number: 20160237449Abstract: Provided are genetic material and nucleic acid sequences useful in increasing yield, biomass, growth rate, vigor, nitrogen use efficiency and/or abiotic stress tolerance, preferably tolerance to nutrient deficiency of a plant. Specifically, the improvement of nitrogen fixation properties in cultivated plants is described.Type: ApplicationFiled: September 15, 2014Publication date: August 18, 2016Applicant: University of BremenInventors: Barbara Reinhold-Hurek, Thomas Hurek, Liwei Hu, Qi Wang, Haiyuan Yang
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Publication number: 20150322100Abstract: A compound having general formula (I) wherein, R1 and R2 are, independently of each other, CN or NH2, or together form a substituted aromatic ring system or an unsubstituted aromatic ring system. R3 and R4 are, independently of each other, C1-C12-alkyl. R5 is H, a halogen, or CnF2n+1, wherein n=1-10.Type: ApplicationFiled: April 23, 2013Publication date: November 12, 2015Applicant: JACOBS UNIVERSITY BREMEN GGMBHInventors: GERD-VOLKER ROESCHENTHALER, BLAZEJ DUDA, SERGEY N. TVERDOMED
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Publication number: 20150188191Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.Type: ApplicationFiled: April 25, 2013Publication date: July 2, 2015Applicants: JACOBS UNIVERSITY BREMEN GGMBH, WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTERInventors: Nataliya Kalinovich, Gerd-Volker Roeschenthaler, Tanja Schedlbauer, Johannes Kasnatscheew, Katja Vlasov, René Schmitz, Raphael Wilhelm Schmitz, Romek Ansgar Mueller, Martin Winter, Stefano Passerini
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Publication number: 20140377667Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.Type: ApplicationFiled: July 25, 2012Publication date: December 25, 2014Applicants: JACOBS UNIVERSITY BREMEN gGMBH, WESTFALISCHE WILHELMS UNIVERSITAT MUNSTERInventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
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Patent number: 8828656Abstract: Provided are novel methods and compositions for the diagnosis, prognosis and treatment of tumor involving a chromosomal rearrangement, in particular a tumor or neoplasia of the thyroid gland. In addition, methods of identifying anti-tumor agents are described.Type: GrantFiled: August 31, 2010Date of Patent: September 9, 2014Assignee: University of BremenInventors: Joern Bullerdiek, Volkhard Rippe
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Publication number: 20140248294Abstract: Provided are novel methods and compositions for the diagnosis, prognosis and treatment of gynecological tumors, in particular uterine leiomyoma (UL). Furthermore, novel methods and compositions for the treatment of diseases characterized by an aberrant growth of mesenchymal stem cells and their descendants and for the treatment of pituitary and prostate tumors are described.Type: ApplicationFiled: October 5, 2012Publication date: September 4, 2014Applicant: UNIVERSITY OF BREMENInventors: Jörn Bullerdiek, Dominique N. Markowski
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Publication number: 20140162293Abstract: A gene coded for a MHC class I molecule. The MHC class I molecule comprises an ALPHA-1 helix and an ALPHA-2 helix. The gene is coded so that a bond is formed between the ALPHA-1 helix and the ALPHA-2 helix in the MHC class I molecule.Type: ApplicationFiled: August 30, 2011Publication date: June 12, 2014Applicant: JACOBS UNIVERSITY BREMEN GGMBHInventors: Sebastian Springer, Martin Zacharias
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Publication number: 20130112623Abstract: The invention describes a composite microfiber, which is comprising a polysaccharide polymer selected from the group consisting of cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, n-propyl cellulose, isopropyl cellulose, cellulose acetate and combinations of two or more of these substances, and combinations of two or more of these substances, thereby the polysaccharide polymer further comprising substituents comprising a given formula, wherein k is 1 or greater, and wherein each moiety R1 is independently selected from H and methyl, and wherein each moiety R2 is independently selected from —H, —OH, —NH2, —SH, —OR3, —NHR3 and —NR3R4, —SR3, and wherein each moiety R3 and R4 are chemical groups independently selected from C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy halide and C1-C4 heteroalkyl substituents, and is preferably selected from —CH3, —CH2—CH3, —CH2—OH, —CH2—CH2—OH, —CH2—CH2—NH2, —CH—CH(OH)—CH2—OH, —CH—CH(OH)—CH3, glycidyl, anhydride, sulfonic acid and hydroxysType: ApplicationFiled: November 20, 2012Publication date: May 9, 2013Applicant: JACOBS UNIVERSITY BREMEN GGMBHInventors: MARCELLO FERNANDEZ-LAHORE, MARIANO GRASSELLI
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Publication number: 20120191740Abstract: A method of comparing first and second documents, the method comprising determining criteria of the comparison, selecting comparison means based on the criteria from a plurality of comparison means, and performing the comparison of the first and second documents by using the selected comparison means.Type: ApplicationFiled: September 9, 2009Publication date: July 26, 2012Applicant: UNIVERSITY BREMENInventor: Martin G. Moehrle