Patents Assigned to UNIVERSITY OF BREMEN
  • Patent number: 11901512
    Abstract: An electrolyte includes at least one lithium salt, at least one first organic solvent having a dielectric constant of >90 at 40° C., at least one second organic solvent having a boiling point of <110° C., and at least one phosphite having the formula (I) R1 is selected from an n-propoxy group, an iso-propoxy group, a tert-butoxy group, an n-pentafluoropropoxy group, an n-trifluoropropoxy group, an iso-hexafluoropropoxy group, or a tert-nonafluorobutoxy group. R2, R3, R4, and R5 are each selected, independently of one another, from H, a trifluoromethyl group, or a C2-C6-alkyl group which is substituted with a trifluoromethyl group.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: February 13, 2024
    Assignees: FORSCHUNGSZENTRUM JUELICH GMBH, CONSTRUCTOR UNIVERSITY BREMEN GGMBH
    Inventors: Volodymyr Kozel, Natascha Von Aspern, Gerd-Volker Roeschenthaler, Martin Winter, Olesya Stubbmann-Kazakova, Isidora Cekic-Laskovic, Christian Woelke
  • Publication number: 20230293699
    Abstract: A method of using a boron cluster as a transmembrane carrier to transport a bioactive molecule across a membrane of a cell or a vesicle. The method includes providing a boron cluster having at least one hydrogen atom and/or at least one halogen atom, providing a bioactive molecule which is cationic, zwitterionic or not charged, so that the bioactive molecule is not negatively charged, and using the boron cluster as a transmembrane carrier to transport the bioactive molecule across the membrane of the cell or the vesicle.
    Type: Application
    Filed: June 11, 2021
    Publication date: September 21, 2023
    Applicants: CONSTRUCTOR UNIVERSITY BREMEN GGMBH, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: WERNER NAU, JAVIER MONTENEGRO
  • Patent number: 11698375
    Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: July 11, 2023
    Assignee: CONSTRUCTOR UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Hartmut Springer, Sunil Kumar Saini
  • Publication number: 20230099524
    Abstract: An imidazolidinylide compound for use as a shut-down additive for a lithium-ion battery. The imidazolidinylide compound has a formula (I), wherein, R1 to R4, each independently the other, is a linear C1- to C16-alkyl group, a branched C1- to C16-alkyl group, a C2- to C16-alkenyl group, a C3- to C8-cycloalkyl group, or a C3- to C16-arene group, wherein at least one of R2 and R3 may also be H, R1 to R4, each independently of the other, is completely, partially or not fluorinated, and R1 to R3 may each also contain O as a heteroatom.
    Type: Application
    Filed: February 9, 2021
    Publication date: March 30, 2023
    Applicants: JACOBS UNIVERSITY BREMEN GGMBH, FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: GERD-VOLKER ROESCHENTHALER, ISIDORA CEKIC-LASKOVIC, NATASCHA VON ASPERN, MARTIN WINTER, MYKHAILO SHEVCHUK
  • Publication number: 20220050104
    Abstract: A method for detecting T cells includes a first step of bringing a plurality of different antigenic peptides into contact with peptide-free MHC molecules which are arranged in an immobilized manner on a substrate in an array so that the plurality of different antigenic peptides bind to the peptide-free MHC molecules so as to form peptide-loaded MHC molecules, a second step of bringing a sample comprising the T cells into contact with the peptide-loaded MHC molecules on the substrate, and a third step of detecting the binding of the T cells to the peptide-loaded MHC molecules on the substrate.
    Type: Application
    Filed: November 19, 2019
    Publication date: February 17, 2022
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: CINDY DIRSCHERL, SEBASTIAN HARTMUT SPRINGER
  • Publication number: 20210273263
    Abstract: An electrolyte includes at least one lithium salt, at least one first organic solvent having a dielectric constant of >90 at 40° C., at least one second organic solvent having a boiling point of <110° C., and at least one phosphite having the formula (I) R1 is selected from an n-propoxy group, an iso-propoxy group, a tert-butoxy group, an n-pentafluoropropoxy group, an n-trifluoropropoxy group, an iso-hexafluoropropoxy group, or a tert-nonafluorobutoxy group. R2, R3, R4, and R5 are each selected, independently of one another, from H, a trifluoromethyl group, or a C2-C6-alkyl group which is substituted with a trifluoromethyl group.
    Type: Application
    Filed: July 5, 2019
    Publication date: September 2, 2021
    Applicants: FORSCHUNGSZENTRUM JUELICH GMBH, JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: VOLODYMYR KOZEL, NATASCHA VON ASPERN, GERD-VOLKER ROESCHENTHALER, MARTIN WINTER, OLESYA STUBBMANN-KAZAKOVA, ISIDORA CEKIC-LASKOVIC, CHRISTIAN WOELKE
  • Publication number: 20190331681
    Abstract: A method for producing an examination reagent includes adding a helper ligand to a receptor protein which is unfolded in an initial solution so as to provide a pre-solution of the examination reagent with a receptor protein which is folded. The receptor protein which is folded comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 31, 2019
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: SEBASTIAN HARTMUT SPRINGER, SUNIL KUMAR SAINI
  • Patent number: 10386367
    Abstract: A method for producing an examination reagent includes adding a helper ligand to an unfolded receptor protein in an initial solution so as to provide a pre-solution of the examination reagent with a folded receptor protein. The folded receptor protein comprises a bonded helper ligand which can be exchanged with an examination peptide.
    Type: Grant
    Filed: January 3, 2013
    Date of Patent: August 20, 2019
    Assignee: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Hartmut Springer, Sunil Kumar Saini
  • Patent number: 9905885
    Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: February 27, 2018
    Assignees: JACOBS UNIVERSITY BREMEN GGMBH, WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
    Inventors: Nataliya Kalinovich, Gerd-Volker Roeschenthaler, Tanja Schedlbauer, Johannes Kasnatscheew, Katja Vlasov, René Schmitz, Raphael Wilhelm Schmitz, Romek Ansgar Mueller, Martin Winter, Stefano Passerini
  • Patent number: 9494588
    Abstract: A protein produced by an expression system that includes a nucleic acid sequence that encodes an MHC class I heavy chain. The MHC class I heavy chain comprises an alpha-1 helix and an alpha-2 helix. The nucleic acid sequence has a disulfide bridge formed between the alpha-1 helix and the alpha-2 helix in the MHC class I heavy chain. Amino acid 139 is substituted by a cysteine so as to provide Cys-139. Amino acid 84 is substituted by the cysteine so as to provide Cys-84 or amino acid 85 is substituted by the cysteine so as to provide Cys-85. The disulfide bridge is formed between the alpha-1 helix and the alpha-2 helix in the MHC class I heavy chain between Cys-139 and Cys-84 or between Cys-139 and Cys-85. The protein comprises an anchor element selected from a natural biotinylation sequence, a polyhistidine sequence, or a polyarginine sequence.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: November 15, 2016
    Assignee: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Springer, Martin Zacharias
  • Patent number: 9472831
    Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: October 18, 2016
    Assignees: Westfalische Wilhelms Universitat Munster, Jacobs University Bremen GGMBH
    Inventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
  • Publication number: 20160237449
    Abstract: Provided are genetic material and nucleic acid sequences useful in increasing yield, biomass, growth rate, vigor, nitrogen use efficiency and/or abiotic stress tolerance, preferably tolerance to nutrient deficiency of a plant. Specifically, the improvement of nitrogen fixation properties in cultivated plants is described.
    Type: Application
    Filed: September 15, 2014
    Publication date: August 18, 2016
    Applicant: University of Bremen
    Inventors: Barbara Reinhold-Hurek, Thomas Hurek, Liwei Hu, Qi Wang, Haiyuan Yang
  • Publication number: 20150322100
    Abstract: A compound having general formula (I) wherein, R1 and R2 are, independently of each other, CN or NH2, or together form a substituted aromatic ring system or an unsubstituted aromatic ring system. R3 and R4 are, independently of each other, C1-C12-alkyl. R5 is H, a halogen, or CnF2n+1, wherein n=1-10.
    Type: Application
    Filed: April 23, 2013
    Publication date: November 12, 2015
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: GERD-VOLKER ROESCHENTHALER, BLAZEJ DUDA, SERGEY N. TVERDOMED
  • Publication number: 20150188191
    Abstract: The present invention provides a compound with a general formula (I) or a salt thereof, wherein, R1 and R2, are, independently of each other, F or CnF2n+1 with n=1-10, and R3 and R4 are, independently of each other, C1-C10-alkyl.
    Type: Application
    Filed: April 25, 2013
    Publication date: July 2, 2015
    Applicants: JACOBS UNIVERSITY BREMEN GGMBH, WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
    Inventors: Nataliya Kalinovich, Gerd-Volker Roeschenthaler, Tanja Schedlbauer, Johannes Kasnatscheew, Katja Vlasov, René Schmitz, Raphael Wilhelm Schmitz, Romek Ansgar Mueller, Martin Winter, Stefano Passerini
  • Publication number: 20140377667
    Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.
    Type: Application
    Filed: July 25, 2012
    Publication date: December 25, 2014
    Applicants: JACOBS UNIVERSITY BREMEN gGMBH, WESTFALISCHE WILHELMS UNIVERSITAT MUNSTER
    Inventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
  • Patent number: 8828656
    Abstract: Provided are novel methods and compositions for the diagnosis, prognosis and treatment of tumor involving a chromosomal rearrangement, in particular a tumor or neoplasia of the thyroid gland. In addition, methods of identifying anti-tumor agents are described.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: September 9, 2014
    Assignee: University of Bremen
    Inventors: Joern Bullerdiek, Volkhard Rippe
  • Publication number: 20140248294
    Abstract: Provided are novel methods and compositions for the diagnosis, prognosis and treatment of gynecological tumors, in particular uterine leiomyoma (UL). Furthermore, novel methods and compositions for the treatment of diseases characterized by an aberrant growth of mesenchymal stem cells and their descendants and for the treatment of pituitary and prostate tumors are described.
    Type: Application
    Filed: October 5, 2012
    Publication date: September 4, 2014
    Applicant: UNIVERSITY OF BREMEN
    Inventors: Jörn Bullerdiek, Dominique N. Markowski
  • Publication number: 20140162293
    Abstract: A gene coded for a MHC class I molecule. The MHC class I molecule comprises an ALPHA-1 helix and an ALPHA-2 helix. The gene is coded so that a bond is formed between the ALPHA-1 helix and the ALPHA-2 helix in the MHC class I molecule.
    Type: Application
    Filed: August 30, 2011
    Publication date: June 12, 2014
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: Sebastian Springer, Martin Zacharias
  • Publication number: 20130112623
    Abstract: The invention describes a composite microfiber, which is comprising a polysaccharide polymer selected from the group consisting of cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, n-propyl cellulose, isopropyl cellulose, cellulose acetate and combinations of two or more of these substances, and combinations of two or more of these substances, thereby the polysaccharide polymer further comprising substituents comprising a given formula, wherein k is 1 or greater, and wherein each moiety R1 is independently selected from H and methyl, and wherein each moiety R2 is independently selected from —H, —OH, —NH2, —SH, —OR3, —NHR3 and —NR3R4, —SR3, and wherein each moiety R3 and R4 are chemical groups independently selected from C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkoxy halide and C1-C4 heteroalkyl substituents, and is preferably selected from —CH3, —CH2—CH3, —CH2—OH, —CH2—CH2—OH, —CH2—CH2—NH2, —CH—CH(OH)—CH2—OH, —CH—CH(OH)—CH3, glycidyl, anhydride, sulfonic acid and hydroxys
    Type: Application
    Filed: November 20, 2012
    Publication date: May 9, 2013
    Applicant: JACOBS UNIVERSITY BREMEN GGMBH
    Inventors: MARCELLO FERNANDEZ-LAHORE, MARIANO GRASSELLI
  • Publication number: 20120191740
    Abstract: A method of comparing first and second documents, the method comprising determining criteria of the comparison, selecting comparison means based on the criteria from a plurality of comparison means, and performing the comparison of the first and second documents by using the selected comparison means.
    Type: Application
    Filed: September 9, 2009
    Publication date: July 26, 2012
    Applicant: UNIVERSITY BREMEN
    Inventor: Martin G. Moehrle