Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.

Abstract: Antimicrobial micro- or nanoparticles comprising a chlorhexidine salt and an anion, and a method of making the antimicrobial micro- or nanoparticle, are disclosed. The anion in the salt is selected form oxoanions and partially hydrogenated oxoanions of phosphorus, carbon, nitrogen, and sulfur.

Abstract: Aspects of the disclosure provide a method and system for power amplifier characterization and digital predistortion. The method includes receiving a test signal including K samples with a sampling rate fS, generating a synthetic test signal including the test signal and a sequence of (N-1) delayed versions of the test signal, generating an under-sampled signal including M samples by sampling, at a sampling rate fS/N, an output signal of a device-under-test (DUT) with the synthetic test signal as an input of the DUT, the M samples of the under-sampled signal including N segments each including K/N samples, and generating a reconstructed signal including the M samples of the under-sampled signal.

Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.

Abstract: This invention relates to protein structures, to methods of producing those protein structures, and to peptides used in the formation of the protein structures.

Abstract: The invention provides a method for delivering cells across the surface of a tissue, the method comprising distributing the cells on and/or within a sheet of biomaterial to form a cell bandage and applying the cell bandage to the surface, wherein, after application of the cell bandage to the surface of the tissue, the cells are released from the cell bandage. Further provided is a method for bonding two or more tissues, the method comprising providing a cell bandage in intimate contact with the surfaces to be joined, wherein the cell bandage comprises a sheet of biomaterial, said biomaterial having cells distributed on and/or within it. Also provided is a cell bandage for use in the methods of the invention.

Abstract: Homomorphic evaluations of functions are performed. The functions include operation(s). Variants of key switching and modulus switching are described and are performed prior to or after the operation(s). A key switching transformation converts a ciphertext with respect to a first secret key and a first modulus to a ciphertext with respect to a second secret key and a second modulus. A key switching transformation converts a first version of a ciphertext with respect to a first secret key and with some number r bits of precision to a second version of the selected ciphertext with respect to a second keys and with some other number r? bits of precision. The ciphertexts may be operated on as polynomials represented using evaluation representation, which has benefits for multiplication and automorphism. Further, ciphertexts are associated with an estimate of noise, which is used to determine when to perform modulus switching on the ciphertexts.

Abstract: A compound of formula (I): (I) wherein Y is, Z is OR10, NR11R11 SR11, S(O)R11 SO2R11, R10 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, CO—R11, or a protecting group, and R11 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or alkoxyl; a process for making a compound of formula (I); and a process for making a prostaglandin or a prostaglandin analog using a compound of formula (I).

Abstract: An integrated optical device and method for generating photons by manipulating path entanglement is provided. An integrated optical splitter splits pump light between two interferometer arms wherein each arm comprises a substantially identical photon pair source configured to be able to convert at least one pump light photon into a signal and idler photon pair. An integrated optical combiner device in optical communication with a first and a second optical output path interferes light from the first and second arms and outputs the signal and idler photons by bunching the signal and idler photons together in one of the optical output paths, or anti-bunching the signal photon in one output path and the corresponding idler photon in the other optical output path.

Abstract: This invention relates to polymer particles with surface functionality for charge retention, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new polymerisable dyes.

Abstract: Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.

Abstract: The invention relates to methods, devices, systems and uses of such systems for the generation and detection of electromagnetic fields carrying orbital angular momentum. An electromagnetic wave placed in a resonator having a closed-loop waveguide supporting a guided wave propagating at resonance with angular order, p, and with an angular grating patterned in the closed-loop waveguide, the angular grating having a integer number, q, of grating elements. The angular grating selectively couples the guided wave mode to a free space radiation mode having an OAM quantity, l, and out-of-plane wave vector component, krad,z, and wherein significant coupling to the grating occurs only when the following wave matching condition is satisfied: l=p?mq where: m is the diffraction order of the angular grating, m=1, 2, 3, . . . ,.

Abstract: The invention relates to methods, devices, systems and uses of such systems for the generation and detection of electromagnetic fields carrying orbital angular momentum. An electromagnetic wave placed in a resonator having a closed-loop waveguide supporting a guided wave propagating at resonance with angular order, p, and with an angular grating patterned in the closed-loop waveguide, the angular grating having a integer number, q, of grating elements. The angular grating selectively couples the guided wave mode to a free space radiation mode having an OAM quantity, l, and out-of-plane wave vector component, krad,z, and wherein significant coupling to the grating occurs only when the following wave matching condition is satisfied: l=p?mq where: m is the diffraction order of the angular grating, m=1, 2, 3, . . . ,.

Abstract: An apparatus for testing the quality of a fluid sample includes a chamber having an opening for receiving at least some of the fluid sample and a sealing element arranged to be movable to a sealing position. An insertion portion of the sealing element is received within an insertion space of the chamber to seal the opening One of the sealing element and container is arranged to define a displacement passage for enabling a portion of the fluid sample that is located within the insertion space to be displaced therefrom as the sealing element assumes the sealing position.

Abstract: An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ. ID NO. 1, or variants thereof.

Abstract: Encoding of a message is conducted using codewords selected from a codebook. The selected codewords are used to construct a corresponding plurality of waveforms, which are then weighted and added to form a signal for transmission. At a receiver, channel impulse response is used to determine which codewords from the known codebook have been used, and by which weights from a known constellation of weights the resultant waveforms have been weighted. A message embedded in a received signal can then be detected.

Abstract: A method of epitaxial growth of a material on a crystalline substrate includes selecting a substrate having a crystal plane that includes a plurality of terraces with step risers that join adjacent terraces. Each terrace of the plurality or terraces presents a lattice constant that substantially matches a lattice constant of the material, and each step riser presents a step height and offset that is consistent with portions of the material nucleating on adjacent terraces being in substantial crystalline match at the step riser. The method also includes preparing a substrate by exposing the crystal plane; and epitaxially growing the material on the substrate such that the portions of the material nucleating on adjacent terraces merge into a single crystal lattice without defects at the step risers.

Abstract: A probe, such as a spectroscopic probe, for enabling a fluid or tissue sample to be tested in situ. The probe includes a conduit, such as a hypodermic needle, that can be inserted into a test subject and a wave coupling arranged to direct electromagnetic radiation, such as light, from an energy source to the sample and/or from the sample to a receiver for analysis. The receiver may comprise a Raman spectroscope. The probe may include a carriage that can be used to move at least some of the optical coupling towards and away from the insertion tip of the conduit. The probe may include a pressure modifier that can be used to draw fluid into or expel fluid from the conduit.

Abstract: Methods for the determination of the molecular structures of compounds are disclosed, the methods comprising obtaining NMR spectroscopic measurements of compounds, determining internuclear distances from the NMR measurements, and inputting the distances to an algorithm to determine probable structures. Optionally, constraints may be added and the algorithm repeated. Usually, the methods do not require comparisons to databases of spectra during the generation of possible structures.

Abstract: A thermometer is described which is suitable as an indwelling thermometer to detect pyrexia or oestrus in a mammal. The thermometer provides a continued signal that a predetermined reference temperature has been exceeded, which temperature is selected to be indicative of pyrexia or oestrus in a given species and may change according to species.