Patents Assigned to University of California, San Diego
  • Patent number: 12280349
    Abstract: In various embodiments, the present invention is directed to a facile one-pot reverse emulsion process to assemble core-shell nanoparticles (CS-SMNPs) into bright and noniridescent photonic supraballs. In one or more embodiments, the present invention is directed to core-shell nanoparticles having an inner high refractive index (RI) core and an outer low RI shell. In one or more embodiment, the present invention includes core-shell nanoparticles using high RI (˜1.74) melanin cores and low-RI (˜1.45) silica shells. In various embodiments, these nanoparticles may be self-assembled into bright and noniridescent supraballs using a scalable one-pot reverse emulsion process. According to various embodiments of the present invention, it is possible to generate a full spectrum of structural colors with the combination of only two ingredients, synthetic melanin and silica.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: April 22, 2025
    Assignees: The University of Akron, University of California, San Diego
    Inventors: Ali Dhinojwala, Ming Xiao, Ziying Hu, Matthew Shawkey, Nathan Gianneschi
  • Publication number: 20210011103
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry acquires a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values. The processing circuitry extracts a signal related to water, a signal related to a first fat, and a signal related to a second fat, on the basis of the first piece of data, the second piece of data, and the third piece of data.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 14, 2021
    Applicants: University of California, San Diego
    Inventors: Mitsue MIYAZAKI, Christine CHUNG
  • Patent number: 8741883
    Abstract: The invention is in general directed to compounds and methods for diagnosing, preventing or alleviating the symptoms of amyloid-associated diseases, for example, neuronal diseases, such as, for example, Alzheimer's disease, methods of screening for compounds useful in preventing or alleviating the symptoms of amyloid-associated diseases, methods of diagnostic imaging of A-beta fibrils, and compounds and methods useful for studying normal or disease-associated cellular mechanisms relating to amyloid proteins.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: June 3, 2014
    Assignee: The Regents of the University of California—San Diego
    Inventors: Jerry Yang, Petra Inbar
  • Patent number: 8484146
    Abstract: The present invention provides an interaction device adapted for setting own controller for maximizing expectation of information defined between a hypothesis about an interaction object and own input/output. Thus, the social robot can judge by using only simple input/output sensor whether or not the human being is present or absent at the outside world.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: July 9, 2013
    Assignees: Sony Corporation, University of California, San Diego Regents of University of California
    Inventors: Javier R. Movellan, Fumihide Tanaka
  • Publication number: 20120148660
    Abstract: The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.
    Type: Application
    Filed: February 7, 2008
    Publication date: June 14, 2012
    Applicant: Regents of the University of California, San Diego UCSD Technology Transfer Office
    Inventors: Dennis A. Carson, Howard B. Cottam, Wolfgang Wrasidlo, Christina C.N. Wu, Gregory A. Daniels
  • Publication number: 20120041032
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Application
    Filed: August 15, 2011
    Publication date: February 16, 2012
    Applicant: The Regents of the University of California, San Diego
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Publication number: 20120028905
    Abstract: Novel antiproliferative compounds, compositions comprising the same, and methods of use thereof are disclosed.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 2, 2012
    Applicants: Smithsonian Tropical Research Institute, University of California, San Diego, Oregon State
    Inventors: Kerry Leigh McPhail, Rebecca Ann Medina, William Henry Gerwick, Douglas Eugene Goeger, Todd Leo Capson
  • Patent number: 7862807
    Abstract: Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: January 4, 2011
    Assignee: University of California, San Diego
    Inventors: Murray Goodman, Churl Min Seong, Guido Harms
  • Publication number: 20100210598
    Abstract: Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 19, 2010
    Applicant: Regents of the University of California, San Diego
    Inventors: Dennis A. Carson, Howard B. Cottam, Tomoko Hayashi, Michael Chan
  • Patent number: 7624076
    Abstract: A facial expression recognition system that uses a face detection apparatus realizing efficient learning and high-speed detection processing based on ensemble learning when detecting an area representing a detection target and that is robust against shifts of face position included in images and capable of highly accurate expression recognition, and a learning method for the system, are provided. When learning data to be used by the face detection apparatus by Adaboost, processing to select high-performance weak hypotheses from all weak hypotheses, then generate new weak hypotheses from these high-performance weak hypotheses on the basis of statistical characteristics, and select one weak hypothesis having the highest discrimination performance from these weak hypotheses, is repeated to sequentially generate a weak hypothesis, and a final hypothesis is thus acquired.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: November 24, 2009
    Assignees: Sony Corporation, University of California, San Diego
    Inventors: Javier R. Movellan, Marian S. Bartlett, Gwendolen C. Littlewort, John Hershey, Ian R. Fasel, Eric C. Carlson, Josh Susskind, Kohtaro Sabe, Kenta Kawamoto, Kenichi Hidai
  • Publication number: 20090286987
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 19, 2009
    Applicant: Regents of the University of California, San Diego UCSD Technology Transfer Office
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Patent number: 7579486
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: August 25, 2009
    Assignee: Regents of the University of California, San Diego
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Publication number: 20090191275
    Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
    Type: Application
    Filed: November 12, 2008
    Publication date: July 30, 2009
    Applicant: The Regents of the University of California, San Diego
    Inventors: Ranjan Dohil, John Bastian, Seema Aceves, Elaine Phillips, Malcolm Hill
  • Publication number: 20090181099
    Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
    Type: Application
    Filed: November 12, 2008
    Publication date: July 16, 2009
    Applicant: The Regents of the University of California, San Diego
    Inventors: Ranjan DOHIL, John BASTIAN, Seema ACEVES, Elaine PHILLIPS, Malcolm HILL
  • Publication number: 20080285835
    Abstract: Systems and techniques for reducing distortions in magnetic resonance images. In one aspect, machine-implemented method for reducing image distortion in magnetic resonance imaging (MRI) includes receiving a first MRI image and a second MRI image, estimating displacements of voxels between the first MRI image and the second MRI image by minimizing a cost function expressing a cost of the displacements, reducing distortion in an MRI image using the estimated displacements, and making the MRI image having reduced distortion available. The first MRI image and the second MRI image were acquired using different gradient fields.
    Type: Application
    Filed: May 16, 2008
    Publication date: November 20, 2008
    Applicant: University of California, San Diego
    Inventors: Dominic Holland, Anders Dale
  • Publication number: 20080188641
    Abstract: The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting ?5?1 integrin in the tissue with an agent that interferes with specific binding of the ?5?1 integrin to a ligand expressed in the tissue; and methods of identifying angiogenesis in a tissue, by contacting the tissue with an agent that specifically binds ?5?1 integrin, and detecting specific binding of the agent to ?5?1 integrin associated with a blood vessel in the tissue. Also provided are methods of diagnosing a pathological condition characterized by angiogenesis in a tissue in an individual.
    Type: Application
    Filed: May 1, 2007
    Publication date: August 7, 2008
    Applicant: University of California San Diego
    Inventor: Judith A. Varner
  • Publication number: 20080161362
    Abstract: The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
    Type: Application
    Filed: April 28, 2005
    Publication date: July 3, 2008
    Applicant: Regents of the University of California, San Diego UCSD Technology transfer office
    Inventors: David T. Puerta, Seth M. Cohen, Jana A. Lewis
  • Publication number: 20070275367
    Abstract: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may be screened to identify one or more as binding a ligand of interest. Compositions comprising the binding proteins, as well as methods of using the binding proteins are also provided.
    Type: Application
    Filed: December 31, 2004
    Publication date: November 29, 2007
    Applicant: University of California, San Diego
    Inventors: Partho Ghosh, Stephen McMahon, Jason Miller, Jeffrey Lawton
  • Patent number: 7199285
    Abstract: The present invention provides methods of modulating abscisic acid signal transduction in plants. The method comprise introducing into the plant a recombinant expression cassette comprising a promoter operably linked to an ABH1 polynucleotide.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: April 3, 2007
    Assignee: University of California, San Diego
    Inventors: Julian Schroeder, Veronique Hugouvieux, June M. Kwak
  • Patent number: 7157623
    Abstract: The invention provides a fertile transgenic monocot, e.g., maize, plant encoding an endosperm specific prolamin box binding factor peptide (PBF) that is expressed so as to increase the methionine and/or lysine content of the seeds of said plant over said content in the seeds of the corresponding plant that lacks said gene, wherein said corresponding plant was used to prepare said transgenic plant, or an ancestor of said transgenic plant.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: January 2, 2007
    Assignee: Regents of the University of California, San Diego
    Inventors: Robert J. Schmidt, Stephen P. Moose, Jesus Vicente-Carbajosa