Patents Assigned to University of Central Florida Foundation, Inc
  • Detection of gene loci with CRISPR arrayed repeats and/or polychromatic single guide ribonucleic acids
    Patent number: 11390908
    Abstract: A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: July 19, 2022
    Assignees: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF CENTRAL FLORIDA FOUNDATION, INC.
    Inventors: Thoru Pederson, Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximilaan Huisman, Shaojie Zhang
  • Neuronal protection by cerium oxide nanoparticles
    Patent number: 9161950
    Abstract: A method of treating a subject with elevated levels of peroxynitrite includes administering a therapeutically effective amount of cerium oxide nanoparticles to the subject, wherein the cerium oxide nanoparticles reduce the level of peroxynitrite in the subject.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 20, 2015
    Assignee: University of Central Florida Foundation, Inc.
    Inventors: William T. Self, Ella Bossy-Wetzel, Sudipta Seal, Janet Dowding
  • Miniature high speed compressor having embedded permanent magnet motor
    Patent number: 7942646
    Abstract: A high speed centrifugal compressor for compressing fluids includes a permanent magnet synchronous motor (PMSM) having a hollow shaft, the being supported on its ends by ball bearing supports. A permanent magnet core is embedded inside the shaft. A stator with a winding is located radially outward of the shaft. The PMSM includes a rotor including at least one impeller secured to the shaft or integrated with the shaft as a single piece. The rotor is a high rigidity rotor providing a bending mode speed of at least 100,000 RPM which advantageously permits implementation of relatively low-cost ball bearing supports.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: May 17, 2011
    Assignee: University of Central Florida Foundation, Inc
    Inventors: Lei Zhou, Liping Zheng, Louis Chow, Jayanta S. Kapat, Thomas X. Wu, Krishna M. Kota, Xiaoyi Li, Dipjyoti Acharya
  • Matched optical waveforms for detection and identification of biological pathogens
    Patent number: 7755755
    Abstract: A method is provided for identifying a contaminant in a gaseous space. The method includes: generating a broadband optical waveform; shaping the optical waveform to match an expected waveform for a known contaminant; and transmitting the shaped optical waveform towards an unknown contaminant. Upon receiving a reflected optical waveform from the unknown contaminant, determining whether the unknown contaminant correlates to the known contaminant based on the reflected waveform.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: July 13, 2010
    Assignees: Harris Corporation, Lucents Technologies Inc., University of Central Florida Foundations, Inc.
    Inventors: John Richard DeSalvo, Geoffrey Lynn Burdge, Bruce W. FitzGerald, Young-Kai Chen, Andreas Leven, Peter Delfyett