Patents Assigned to University of Chicago
  • Patent number: 11227385
    Abstract: Methods for classifying and measuring orientations of objects, as nonlimiting examples, implants utilizing two-dimensional radiographs. One such method determines a three-dimensional orientation of an object based on its area projected onto a two-dimensional image and known or measured geometry. Another such method provides an automated solution to computationally determine the orientation and characterizing features of an implant based on two-dimensional radiographs. Orientations and characteristics of one or more objects in the vicinity of an object of interest may also be determined.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: January 18, 2022
    Assignee: Loyola University Chicago
    Inventors: Michael Patrick Murphy, Cameron James Killen, Karen Wu
  • Publication number: 20220000977
    Abstract: Embodiments of the current invention provide a solution to the problems associated with balancing patient toxicity with broad efficacy of cancer therapy. In particular, embodiments are directed to anti-cancer peptides that demonstrate a broad anti-cancer efficacy with a limited toxicity to normal or non-cancer cells.
    Type: Application
    Filed: June 14, 2021
    Publication date: January 6, 2022
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Lev BECKER, Chang CUI
  • Patent number: 11214600
    Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 4, 2022
    Assignees: The University of Chicago, Janssen Pharmaceuticals, Inc.
    Inventors: Dominique Missiakas, Olaf Schneewind, Carla Emolo, Lena Thomer, Molly McAdow, Jeroen Geurtsen, Mark De Been
  • Patent number: 11213825
    Abstract: Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: January 4, 2022
    Assignees: Wisconsin Alumni Research Foundation, University of Leiden, University of Chicago
    Inventors: David Charles Schwartz, Kristy L. Kounovsky-Shafer, Juan Pablo Hernandez-Ortiz, Konstantinos Dimitrios Potamousis, Juan Jose De Pablo, Theo Odijk, Kyubong Jo
  • Patent number: 11204251
    Abstract: An embodiment may involve obtaining data representing a transportation map, a greenspace map, a noise map, and a crime map of a geographical location. The transportation map represents route segments within the geographical location, the greenspace map represents natural features within the geographical location, the noise map represents human-made noise within the geographical location, and the crime map represents reported crimes within the geographical location. The embodiment may also involve, for each of the route segments: (i) calculating a restorative score that is proportional to an amount of natural features associated with the respective route segment in the greenspace map, inversely proportional to an amount of human-made noise associated with the respective route segment in the noise map, and inversely proportional to an amount of crime associated with the respective route segment in the crime map.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: December 21, 2021
    Assignee: The University of Chicago
    Inventors: Kathryn E. Schertz, Omid Kardan, Marc G. Berman, Thomas N. Kompare
  • Patent number: 11205097
    Abstract: A computing device may receive a first set of training data for training an ANN to predict output data for a first task, and may train the ANN with the first set of training data by only adjusting values of weights associated with a first subset of neurons, the first subset selected based on an identity of the first task. The computing device may receive a second, different set of training data for training the ANN to predict output data for a second task, and may train the ANN with the second set of training data by only adjusting values of weights associated with a second subset of neurons, the second subset selected based on an identity of the second task. During training, adjusting of the value of any weight may entail weight stabilization that depends on whether there has been any training for one or more previous tasks.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: December 21, 2021
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Nicolas Y. Masse, Gregory D. Grant, David J. Freedman
  • Publication number: 20210386796
    Abstract: The current disclosure provides methods and compositions for treating food allergies, infections, autoimmune conditions, and other allergic conditions. Accordingly, the current disclosure relates to a method for treating an infectious, autoimmune, or allergic disease in a subject comprising administering a composition comprising bacterium Anaerostipes caccae to the subject. Further aspects relate to a method for treating a food allergy or for reducing an allergic response to an allergen or for treating or preventing an anaphylactic response in a subject comprising administering a composition comprising bacterium Anaerostipes caccae and a prebiotic to the subject.
    Type: Application
    Filed: November 5, 2019
    Publication date: December 16, 2021
    Applicants: The University of Chicago, ClostraBio
    Inventors: Cathryn R. NAGLER, Riyue BAO, Dionysios ANTONOPOULOS, John W. COLSON, Lauren Anders HESSER
  • Patent number: 11194059
    Abstract: Hermetically sealed electronic devices and methods for fabricating the hermetically sealed electronic devices are provided. The devices include a solder sealed vacuum housing. The solder seal is formed using a solder wick having an external solder reservoir. When the reservoir is filled with molten solder, the solder is drawn via capillary action into a precisely defined narrow gap between two components of the housing where it forms an airtight and vacuum-tight seal.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: December 7, 2021
    Assignee: The University of Chicago
    Inventors: Henry J. Frisch, Evan Angelico, Andrey Elagin, Eric Spieglan
  • Patent number: 11189699
    Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: November 30, 2021
    Assignees: Samsung Electronics Co., Ltd., Center for Technology Licensing at Cornell University, The University of Chicago
    Inventors: Minhyun Lee, Jiwoong Park, Saien Xie, Jinseong Heo, Hyeonjin Shin
  • Patent number: 11174162
    Abstract: Technologies for quantum sensing are disclosed. In the illustrative embodiment, a sensor system may be operated by coupling an electromagnetic wave from a measurement line to a first resonator. The sensor system includes a second resonator that is non-reciprocally coupled to the first resonator. In the absence or a perturbation, there is no reciprocal coupling between the first resonator and the second resonator, but a perturbation may cause reciprocal coupling between the first and second resonator. With appropriate selection of the non-reciprocal coupling, the signal at the output of the measurement line may allow for fast determination of whether the perturbation is present.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: November 16, 2021
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Aashish Clerk, Hoi-Kwan Lau
  • Publication number: 20210346495
    Abstract: The current disclosure describes the use of NFkB inhibitors as immune potentiators in vaccine compositions comprising adjuvants. Accordingly, aspects of the disclosure relate to a method for vaccinating a subject comprising administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Further aspects relate to a method for inhibiting an inflammatory reaction associated with an adjuvant in a subject, the method comprising co-administering a NFkB inhibitor and an adjuvant (or a composition of the disclosure comprising NFkB and an adjuvant) to the subject. Yet further aspects relate to a pharmaceutical composition comprising a NFkB inhibitor and an adjuvant.
    Type: Application
    Filed: June 3, 2021
    Publication date: November 11, 2021
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Aaron ESSER-KAHN, Brittany MOSER
  • Patent number: 11156553
    Abstract: An optical resonance imaging system includes a light emitting device to emit laser pulses onto a subject. The laser pulses include a first pulse and a second pulse to place the subject in an excited state. The laser pulses also include a third pulse to stimulate emission of one or more third order signals from the subject. The system also includes a spectrometer to receive the one or more third order signals and to generate spectrum signals commensurate with intensities of the one or more third order signals. The system may further include circuitry configured to analyze the spectrum signals, generate one or more images of the subject based on the analysis, and construct one or more maps of positions of the subject based on the one or more images.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: October 26, 2021
    Assignee: The University of Chicago
    Inventors: Gregory S. Engel, Marco Alberto Allodi
  • Publication number: 20210317506
    Abstract: Certain embodiments are directed to compositions and methods for capture of elements in physical proximity. In certain aspects the methods comprise (a) contacting a target with a functionalized scaffold or capture agent that comprises activatable cross-linking moieties to form a target/scaffold mixture; (b) exposing the target/scaffold mixture to an activator to activate the cross-linking moieties of the dendrimer and form a cross-linked target/scaffold complex; (c) isolating the target/scaffold complexes; and (d) identify portions of the target or targets that are cross linked with the scaffold.
    Type: Application
    Filed: May 8, 2019
    Publication date: October 14, 2021
    Applicant: The University of Chicago
    Inventors: Chuan HE, Qiancheng YOU
  • Publication number: 20210310062
    Abstract: The methods, compositions, and kits of the disclosure provide a novel approach for a whole genome, unbiased DNA analysis method that can be performed on limited amounts of DNA. can be used to analyze DNA to determine its modification status. Aspects of the disclosure relate to a method for amplifying bisulfite-treated deoxyribonucleic acid (DNA) molecules comprising: (a) ligating an adaptor to the DNA molecules, wherein the adaptor comprises a RNA polymerase promoter comprising bisulfite-protected cytosines; (b) treating the ligated DNA molecules with bisulfite; (c) hybridizing the bisulfite-treated DNA molecules with a primer; (d) extending the hybridized primer to make double stranded DNA; and (e) in vitro transcribing the double-stranded DNA to make RNA.
    Type: Application
    Filed: July 26, 2019
    Publication date: October 7, 2021
    Applicant: The University of Chicago
    Inventors: Chuan HE, Ji NIE, Xiao-Long CUI
  • Publication number: 20210312612
    Abstract: A method and apparatus uses multi-material decomposition of three or more material components to generate material-component images from spectral images reconstructed from spectral computed tomography data. In three-component material decomposition e.g., the Mendonça method is used for multi-material decomposition when the attenuation values satisfy an assumed volume fraction condition (i.e., for a given voxel, the attenuation values are within a triangle having vertices given by unit volume fractions of three respective material components). However, when the volume fraction condition fails (e.g., the attenuation values are outside the triangle), either a shortest-Hausdorff-distance method or a closest-edge method is used for multi-material decomposition. For example, the attenuation values of the voxel are projected onto a lower-dimensional space (e.g., the space of a closest edge) and decomposed into a pair/single material component(s) of the lower-dimensional space.
    Type: Application
    Filed: April 3, 2020
    Publication date: October 7, 2021
    Applicants: The University of Chicago, CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Dimple MODGIL, Patrick La Riviere, Yan Liu, Zhou Yu
  • Patent number: 11139959
    Abstract: An embodiment involves receiving a request to write data to a memory unit. The memory unit is divided into one or more logical blocks, each subdivided into groups of sub-blocks encrypted in accordance with a stream cipher. The memory unit maintains a transaction journal that marks each sub-block as dirty or clean. The memory unit stores keycount values for each of the logical blocks. The embodiment also involves: determining that the request seeks to write a portion of the data to a particular sub-block marked as dirty in the transaction journal, decrypting the particular logical block in accordance with the stream cipher, writing the portion of the data to the particular sub-block, incrementing the keycount value of the particular logical block, encrypting the particular logical block using the stream cipher, a key, and the keycount value, and writing the particular logical block to the memory unit.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: October 5, 2021
    Assignee: The University of Chicago
    Inventors: Bernard Dickens, III, Haryadi Gunawi, Ariel Feldman, Henry Hoffmann
  • Patent number: 11136618
    Abstract: Described herein are nucleic acid molecules and complexes useful as i-switch pH reporters that have increased sensitivities as a pH reporter and have alternate pH reporting capacity ranges. Aspects of the disclosure relate to a method for determining pH comprising providing a nucleic acid complex comprising: a first single-stranded nucleic acid molecule comprising the sequence CnXCnYCnZCn (SEQ ID NO.
    Type: Grant
    Filed: May 18, 2016
    Date of Patent: October 5, 2021
    Assignees: The University of Chicago, The National Centre for Biological Sciences, Tata Institute of Fundamental Research
    Inventors: Yamuna Krishnan, Saheli Halder
  • Patent number: 11130991
    Abstract: Methods, compositions and kits are provided to amplify the amount of genomic methylated DNA can by subsequently analyzed and/or sequenced. It has particular use with small amounts of DNA, including, but not limited to cell free DNA samples. In some embodiments, the ratio of polymerase and methyltransferase is controlled in order to provide maximum yields. In some embodiments, a dual primase/polymerase is used.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: September 28, 2021
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Chuan He, Boxuan Simen Zhao, Pradnya Narkhede, Chang Liu, Xiaolong Cui
  • Patent number: 11116977
    Abstract: One aspect of the present disclosure relates to a method for controlling levels of perceived intensity of a sensory stimulus. The method includes configuring a stimulation signal with an activation charge rate (ACR) based on a predefined level of intensity by a subject during an action. The ACR is based on a strength of pulses in the stimulation signal parameter and a frequency of pulses in the stimulation signal parameter. The stimulation signal can be applied to neural tissue of a subject during the action. Based on the stimulation signal, the subject can be induced to perceive the predefined level of intensity during the action.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: September 14, 2021
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE UNIVERSITY OF CHICAGO
    Inventors: Dustin James Tyler, Emily Lauren Graczyk, Sliman Julien Bensmaia, Benoit Pierre Delhaye, Hannes Philipp Saal
  • Patent number: 11118233
    Abstract: Provided herein are mutations in Bruton's Tyrosine Kinase (BTK) that confer resistance to treatment with a BTK inhibitors, such as Ibrutinib, and compositions and methods for the treatment, diagnosis, and characterization of BTK-inhibitor-resistant cancers.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 14, 2021
    Assignee: The University of Chicago
    Inventor: Y. Lynn Wang