Patents Assigned to University of Chicago
  • Publication number: 20200163958
    Abstract: Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.
    Type: Application
    Filed: October 29, 2019
    Publication date: May 28, 2020
    Applicants: Salix Pharmaceuticals, Inc., The University Of Chicago
    Inventors: Jonathan Moss, Lorin K. Johnson
  • Patent number: 10663450
    Abstract: Provided herein are Si-based materials, methods of making the Si-based materials, and methods for using the Si-based materials. In embodiments, a silicon-based material comprises an aggregate of particles, the particles comprising an ordered array of nanostructures, the nanostructures comprising amorphous silicon, wherein at least some pairs of adjacent nanostructures are connected by one or more bridges comprising amorphous silicon, the one or more bridges extending from the surface of one nanostructure of the pair to the surface of the other nanostructure in the pair.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: May 26, 2020
    Assignee: The University of Chicago
    Inventors: Bozhi Tian, Francisco Bezanilla, Yuanwen Jiang, João L. Carvalho-de-Souza
  • Publication number: 20200157127
    Abstract: The present invention relates to a compound having a structure according to formula (I) or a salt thereof, wherein: R1 is a branched or linear alkyl, acyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, or hydroxy-alkinyl residue comprising 6 to 30 carbon atoms, R2 is selected from the group consisting of: a) an alkyl residue comprising 1 to 10 carbon atoms and comprising a terminal or cyclic quaternary ammonium, b) an alkyl residue comprising 1 to 10 carbon atoms and comprising a terminal amino group and/or 1 to 3 hydroxyl groups, c) an amino acid residue, d) a five or six carbon sugar and e) H, R3 is a residue selected from the group consisting of an alkyl, alkenyl, prostanyl-dialkyl, furanyl-dialkyl, cyclobutyl-dialkyl, cycloalkyl and aryl group of 2 to 40 carbon atoms length and comprising at least one keto group, epoxy group, aldehyde group, peroxy group, hydroperoxy group, hydroxyl group or a free carboxyl group, L1 is selected from the group consisting of O, NH, S, CH2, (aa), (bb), (cc), (dd), (ee), (ff), (gg)
    Type: Application
    Filed: July 27, 2018
    Publication date: May 21, 2020
    Applicants: Karl-Franzens-Universitaet Graz, University of Chicago
    Inventors: Konstantin Birukov, Anna Birukova, Valery Bochkov, Olga Oskolkova
  • Patent number: 10647733
    Abstract: Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 12, 2020
    Assignee: The University of Chicago
    Inventors: Wenbin Lin, Kuntal Manna, Teng Zhang
  • Patent number: 10650514
    Abstract: A device and method integrates a lesion stager in a reporting tool. The method includes receiving a user input. The user input is image data including at least one variable value. The variable value is indicative of a variable parameter of the image data. The method includes associating each of the at least one variable value with a corresponding variable parameter to generate at least one variable-value pair. The method includes determining a computed output value as a function of select ones of the at least one variable-value pair.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: May 12, 2020
    Inventors: Merlijn Sevenster, Paul Joseph Chang
  • Patent number: 10640549
    Abstract: This disclosure is directed to compositions and methods for utilizing the boundaries of the C-terminal domains of Nucleoprotein from Zaire Ebola virus as highly stable recombinant protein antigens to generate antibodies for diagnosis and treatment of Ebola virus infection.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: May 5, 2020
    Assignees: University of Virginia Patent Foundation, The University of Chicago
    Inventors: Zygmunt S. Derewenda, Daniel A. Engel, Anthony Kossiakoff, Elena K. Davydova, Mateusz Jaskolowski
  • Patent number: 10626087
    Abstract: Indoline and tetrahydroquinoline sulfonyl compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (“MBLs”), such as NDM-1 are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the compounds disclosed herein.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: April 21, 2020
    Inventors: Daniel Paul Becker, Cory Reidl, Maxwell Moore, Tahirah K. Heath, Walter Fast
  • Patent number: 10610278
    Abstract: This disclosure includes embodiments of mallets with radiolucent heads to permit radiologic imaging of a device (e.g., needle) as the device is being positioned with the mallet, as well as methods of using such a mallet, and methods of imaging a device while it is being positioned with such a mallet.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: April 7, 2020
    Inventors: Seon-Kyu Lee, Victor Guarino
  • Patent number: 10596238
    Abstract: Embodiments of the invention are directed to fibrillar adjuvants. Epitopes assembled into nanofibers by a short synthetic fibrillization domain elicited high antibody titers in the absence of any adjuvant.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: March 24, 2020
    Assignee: The University of Chicago
    Inventors: Joel H. Collier, Jai Simha Rudra
  • Patent number: 10599551
    Abstract: A method for detecting distributed concurrency errors in a distributed cloud computing system includes tracing operations that access objects in functions involving inter-process messaging, applying a set of happens-before rules to the traced operations. Analyzing the traced operations to identify concurrent operations that access a common object to generate a list of potential distributed concurrency errors (DCbugs). Pruning the list of DCbugs to remove DCbugs having only local effect and that do not generate run-time errors.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: March 24, 2020
    Assignees: The University of Chicago, Futurewei Technologies, Inc.
    Inventors: Shan Lu, Haopeng Liu, Guangpu Li, Haryadi Gunawi, Chen Tian, Feng Ye
  • Patent number: 10597655
    Abstract: Methods for modulating T-type calcium channel activity without directly targeting the T-type calcium channels are provided that include modulating kelch-like protein 1 (KLHL1) levels in a subject by providing a small hairpin RNA (shRNA) that targets a KLHL1 gene, and then administering the shRNA to the subject in an amount sufficient to modulate KLHL1 gene expression. The KLHL1 level directly effects current activity in T-type calcium channels and therefore modulation of KLHL1 gene expression indirectly modulates current activity in T-type calcium channels. The methods may be implemented with, for example, an shRNA molecule suitable for modulating a KLHL1 level in the subject which may be provided as a plasmid encoding the shRNA molecule or an adeno-associated virus vector encoding the shRNA molecule. Methods of identifying compounds that modulate current activity in T-type calcium channels by determining an effect of the compound on KLHL1 gene expression are also provided.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: March 24, 2020
    Assignee: Loyola University Chicago
    Inventors: Erika Sofia Piedras-Renteria, Jody Lee Martin
  • Patent number: 10600865
    Abstract: Disclosed herein is an isolable colloidal particle comprising a nanoparticle and an inorganic capping agent bound to the surface of the nanoparticle, a method for making the same in a biphasic solvent mixture, and the formation of structures and solids from the isolable colloidal particle. The process can yield photovoltaic cells, piezoelectric crystals, thermoelectric layers, optoelectronic layers, light emitting diodes, ferroelectric layers, thin film transistors, floating gate memory devices, phase change layers, and sensor devices.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: March 24, 2020
    Inventors: Angshuman Nag, Dmitri V. Talapin
  • Patent number: 10585091
    Abstract: Provided herein are methods, compositions, and devices for the identification and quantification of analytes, such as nucleic acids, proteins, cells or other biological samples. The methods, compositions, and devices are suited for accurate, portable analysis of small amounts of analyte.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: March 10, 2020
    Assignees: The University of Chicago, California Institute of Technology
    Inventors: Rustem F. Ismagilov, Stephanie McCalla, Travis Schlappi, Toan Huynh, Justin Rolando, Weishan Liu, Shencheng Ge, Jason E. Kreutz
  • Patent number: 10562028
    Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: February 18, 2020
    Assignee: The University of Chicago
    Inventors: Rustem F. Ismagilov, Joshua David Tice, Helen Song Baca, Lewis Spencer Roach
  • Patent number: 10561708
    Abstract: Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more inhibitors of the JAK/STAT pathway which renders the cancer chemosensitive and/or radiosensitive.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: February 18, 2020
    Assignee: The University of Chicago
    Inventors: Nikolai Khodarev, Ravi Sood, Bernard Roizman, Ralph R. Weichselbaum
  • Patent number: 10561661
    Abstract: A method for treatment of disease by reduction in macrophages-mediated bacterial killing, including administration to patients in need a compound of formula (I): wherein A is N or CH; B is NO, or S; R1 is H, (C1-C4)alkyl group, methyl(C1-C6)cycloalkyl group or (C1-C6)cycloalkyl group; R2 is an aryl, arylmethyl group or methylheteroaryl group as methylpyridine and methylthiophene; R3 is absent when B is O or S, or is H or (C1-C4)alkyl group when B is N; R4 is (C1-C5)alkyl group or (C1-C4)cycloalkyl group, groups bearing a carboxylic acid group, and (C1-C5)alkyl group or (C1-C4)cycloalkyl substituted by hydroxyl group, halogen group or methoxy group, when B is N, R3 and R4 can together form a 5- or 6-membered heterocycle substituted by carboxylic acid group, substituted by a halogen atom, hydroxyl group, methoxy group or hydroxymethyl group, or pharmaceutically acceptable salt. Also provided are new compounds relating to this use.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: February 18, 2020
    Inventors: Laurent Meijer, Nassima Oumata, Hervé Galons, Aida Gabdoulkhakova, Vladimir Riazanski, Deborah Nelson
  • Patent number: 10551450
    Abstract: Techniques provide for passive Q switching in a bimodal resonator environment, where magnetic resonators are coupled for power transfer. A passive Q switch is responsive to a driving power from one magnetic resonator coupled to another magnetic resonator. After the driving power reaches a threshold, the passive Q switch shunts the receiving magnetic resonator, at least partially, to reduce the Q of that second resonator, which allows faster detection operation of the second resonator in some applications. The technique allows for fast Q switching in a bimodal resonator system, especially one having resonators having magnetic fields that are orthogonal to one another.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: February 4, 2020
    Inventors: Howard Halpern, Subramanian V. Sundramoorthy, Boris Epel
  • Patent number: 10550421
    Abstract: Methods and compositions for quantitative immunoassays are provided, in which ligand-conjugated probes are used to label samples and ligand-surfaced microspheres are used as quantitative reference standards. Certain embodiments provide a method of quantitative flow cytometry where ligands are oligonucleotides, and a sample comprising one or more cells is contacted with a hybridized antibody::fluorophore labeled targeting construct to label the cells, and the labeled cells are analyzed. In some embodiments, a population of quantitative labeled oligospheres labeled with the same fluorescent label as the cells is analyzed using the flow cytometer and used to create a quantitative standard curve of cytometer intensity versus molecules fluorescent label per oligosphere event. A standard curve trendline is established and used to determine the molecules of fluorescent label per cellular event for the antigen-positive cell populations.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 4, 2020
    Assignee: The University of Chicago
    Inventors: Amy Flor, Ryan Duggan, Stephen Kron
  • Patent number: 10543485
    Abstract: A device is described having a first surface having a plurality of first areas and a second surface having a plurality of second areas. The first surface and the second surface are opposed to one another and can move relative to each other from at least a first position where none of the plurality of first areas, having a first substance, are exposed to plurality of second areas, having a second substance, to a second position. When in the second position, the plurality of first and second areas, and therefore the first and second substances, are exposed to one another. The device may further include a series of ducts in communication with a plurality of first second areas to allow for a substance to be disposed in, or upon, the plurality of second areas when in the first position.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: January 28, 2020
    Assignee: University of Chicago
    Inventors: Rustem F. Ismagilov, Wenbin Du, Liang Li, Feng Shen, Kevin Paul Flood Nichols, Delai Chen, Jason Eugene Kreutz
  • Patent number: 10543185
    Abstract: Aspects of the disclosure relate to a method for treating idiopathic pulmonary fibrosis (IPF) in a patient with N-acetylcysteine (NAC) comprising administering NAC to a patient after a sample from the patient has been genotyped and determined to be any one of: a) homozygous or heterozygous for a thymine at the single nucleotide polymorphism rs3750920; b) homozygous or heterozygous for guanine at the single nucleotide polymorphism rs5743894; or c) homozygous or heterozygous for thymine at the single nucleotide polymorphism rs35705950.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: January 28, 2020
    Assignees: The University of Chicago, Cornell University
    Inventors: Imre Noth, Justin Oldham, Fernando Martinez