Abstract: Methods for treating diseases associated with toxicity of Apolipoprotein E (“apoE”). Specifically, the present invention relates to new methods for treating a mammal having a condition associated with toxicity of apolipoprotein E cleavage fragments containing residues 130-169, comprising administering to said mammal a pharmacologically effective amount of compound or a pharmaceutically acceptable sale, derivative or fragment thereof to interfere with the receptor-binding site associated with residues 130-169 of the apolipoprotein E molecule in said mammal.
Type:
Grant
Filed:
February 22, 1999
Date of Patent:
August 21, 2001
Assignee:
University of Cincinnati and Apologic, Incorporated
Inventors:
Keith A. Crutcher, Judith A. K. Harmony