Patents Assigned to University of College london
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Patent number: 8628584Abstract: A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.Type: GrantFiled: January 3, 2006Date of Patent: January 14, 2014Assignee: University College LondonInventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
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Patent number: 8586313Abstract: In particular aspects, stem-cell polycomb group (PcG) targets are more likely to have cancer-specific promoter DNA methylation than non-targets, indicating a stem-cell origin of cancer, where reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and predisposition to subsequent malignant transformation. Exemplary aspects provide methods for identifying preferred DNA methylation markers for a cellular proliferative disorder and/or cancer and markers for developmental lineages and/or stages, based on identifying PcG protein or PcG repressive complex genomic target loci within a precursor cell (e.g., stem or progenitor cell) population, and determining, in cells of the proliferative disorder and/or cancer or cell of the particular developmental lineages and/or stages, a characteristic methylation status of the PcG target loci. Additional aspects provide methods for validating and/or monitoring a precursor cell (e.g., stem cell) population.Type: GrantFiled: December 27, 2007Date of Patent: November 19, 2013Assignees: The University of Southern California, University College LondonInventors: Peter W. Laird, Martin Widschwendter
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Publication number: 20130274213Abstract: There is provided a method of glycosylating an aminocoumarin compound comprising conjugating a sugar to the 4?-OH position of the core of the aminocoumarin compound. Also provided is an aminocoumarin compound glycosylated at the 4?-OH position of the core of the aminocoumarin compound. Further aspects of this invention provide this compound for use in therapy, more particularly for use as an antibiotic, or in anticancer treatment.Type: ApplicationFiled: October 17, 2011Publication date: October 17, 2013Applicant: UNIVERSITY COLLEGE LONDONInventor: Min Yang
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Publication number: 20130203647Abstract: A composition comprises nanofibres for the delivery of a peptide across the blood brain barrier in a method of therapy of the human or animal body, wherein the nanofibres comprise a peptide conjugated to a lipophilic group. Further, a compound comprises a Dalargin or a derivative having one or more substituted, deleted or inserted aminoacyl units, and, conjugated to an aminoacyl group preferably via a side chain, a lipophilic group, optionally via a linker.Type: ApplicationFiled: July 11, 2011Publication date: August 8, 2013Applicant: UNIVERSITY COLLEGE LONDONInventors: Ijeoma Uchegbu, Andreas Schatzlein, Mariarosa Mazza
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Patent number: 8470371Abstract: Polymeric micellar clusters formed from amphiphilic carbohydrate polymers and their uses in formulating drugs is disclosed, and in particular the finding that amphiphilic carbohydrate polymers are capable of self assembling to form micellar clusters in which the carbohydrate amphiphiles aggregate into hierarchically organized micellar clusters of individual aggregates. The micellar clusters may be transformed into stable nanoparticles with drugs, especially hydrophobic drugs that have poor aqueous solubility, and may improve the transfer of hydrophobic drugs across biological barriers.Type: GrantFiled: August 8, 2007Date of Patent: June 25, 2013Assignee: University College LondonInventors: Ijeoma F. Uchegbu, Andreas G. Schatzlein, Xueliang Hou
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Publication number: 20130123356Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof,Type: ApplicationFiled: October 18, 2012Publication date: May 16, 2013Applicant: UNIVERSITY COLLEGE LONDONInventors: Masahiro Okuyama, David Selwood, Cristina Visintin, David Baker, Gareth Pryce
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Patent number: 8343545Abstract: A method of producing microparticles having a median diameter up to 100 ?m and the microparticles so produced are described. The method includes the steps of providing a solvent having a bioactive dispersed or dissolved therein and a vehicle dissolved therein, carrying out an emulsification in a non-solvent phase to produce an emulsion containing the bioactive and the vehicle in a solvent phase, and evaporating the solvent to leave the microparticles, wherein a mixture of at least two surfactants is employed to stabilize the emulsion and wherein the mixture has a hydrophilic-lipophilic balance (HLB) of up to 8.Type: GrantFiled: January 19, 2005Date of Patent: January 1, 2013Assignee: University College LondonInventors: Abdul Waseh Basit, Richard Andrew Kendall, Sudax Shina Murdan
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Publication number: 20120283295Abstract: The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1, R2, R3 and R4 are as defined herein. The indazole derivatives are capable of blockading voltage dependent sodium channels and they are useful in the treatment or prevention of normal tension glaucoma, multiple sclerosis, a motorneurone disease, stroke, spinal cord injury, Alzheimer's disease, Parkinson's disease or pain.Type: ApplicationFiled: September 30, 2010Publication date: November 8, 2012Applicant: University College LondonInventors: Cristina Garcia Posada, David Selwood, John Garthwaite, David Baker, Lisa Clutterbuck
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Patent number: 8293796Abstract: The present invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is OR1 or NR1R2 wherein each of R1 and R2 is independently H, or a hydrocarbyl group; X is an alkylene, alkenylene, or alkynylene group, each of which may be optionally substituted by one or more substituents selected from alkyl, COOH, CO2-alkyl, alkenyl, CN, NH2, hydroxy, halo, alkoxy, CF3 and nitro; Y is a polar functional group selected from OH, NO2, CN, COR3, COOR3, NR3R4, CONR3R4, SO3H, SO2—R3, SO2NR3R4 and CF3, where each of R3 and R4 is independently H or a hydrocarbyl group; A is an aryl or heteroaryl group, each of which may be optionally substituted; and B is (CH2)n where n is 0, 1, 2, 3, 4 or 5; with the proviso that: (i) when A is phenyl, n is 0, and Z is OH, X—Y is other than meta-C?—C—(CH2)2CO2H, meta-C?—C—(CH2)2OH, meta-C?C—(CH2)2CO2Me, meta-(CH2)4CO2H, ortho-CH2CO2H, ortho-(CH2)2CO2H and ortho-(CH2)4CO2H; and (ii) when A is phenyl, n is 0, and Z is OMe, X—Y is other than meta-C?Type: GrantFiled: February 18, 2010Date of Patent: October 23, 2012Assignee: University College LondonInventors: Masahiro Okuyama, David Selwood, Cristina Visintin, David Baker, Gareth Pryce
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Patent number: 8278277Abstract: Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.Type: GrantFiled: April 9, 2009Date of Patent: October 2, 2012Assignee: University College LondonInventors: Ijeoma Uchegbu, Aikaterini Lalatsa, Andreas Schatzlein
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Patent number: 8268011Abstract: The present invention provides an apparatus (1) for attaching a prosthetic limb to the bone of a patient, the apparatus comprising a proximal component (2) to mount to a bone implant, a distal component (3) to mount to a prosthetic limb, and a coupling body (4, 5) coupling together the proximal and distal components (2,3) with freedom to articulate when, in use, a bending and/or torsional force is applied to the prosthetic limb, only when the force exceeds a threshold level, whereby the force may be accommodated by articulation within the attachment apparatus (1). The attachment apparatus (1) thus functions as a fail-safe articulation mechanism protecting the bone of the patient.Type: GrantFiled: March 9, 2005Date of Patent: September 18, 2012Assignee: University College LondonInventors: Lindsay K. Newcombe, Michael E. Dewar
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Publication number: 20120229130Abstract: Apparatus for determining magnetic properties of materials comprises a portable probe, an equipment trolley holding cryogenics and electronics and connecting cables. The probe comprises a drive coil and a correction coil, the drive coil being disposed symmetrically with respect to an inner second-order gradiometer sensor coil. Electrical connectors in the form of 2-metre long Belden (1192A) microphone cables are used to connect the apparatus on the equipment trolley to the drive coil, the correction coil and the sensor coil. The drive coil is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop, a SQUID controller, a data acquisition module, which captures and processes the signals and computer. A liquid-nitrogen dewar is supported on the equipment trolley and houses a sensitive SQUID detector and a transfer coil made from copper.Type: ApplicationFiled: April 6, 2012Publication date: September 13, 2012Applicants: UNIVERSITY COLLEGE LONDON, UNIVERSITY OF HOUSTONInventors: Simon Richard Hattersley, Quentin Andrew Pankhurst, Audrius Brazdeikis
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Patent number: 8174259Abstract: Apparatus for determining magnetic properties of materials comprises a portable probe (1), an equipment trolley (2) holding cryogenics and electronics and connecting cables (3). The probe (1) comprises a drive coil (4) and a correction coil (5), the drive coil (4) being disposed symmetrically with respect to an inner second-order gradiometer sensor coil (8). Electrical connectors in the form of 2-meter long Belden (1192A) microphone cables (3) are used to connect the apparatus on the equipment trolley (2) to the drive coil (4), the correction coil (5) and the sensor coil (8). The drive coil (4) is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop (9), a SQUID controller (10), a data acquisition module (11), which captures and processes the signals and a computer (12). A liquid-nitrogen dewar (13) is supported on the equipment trolley (2) and houses a sensitive SQUID detector (14) and a transfer coil (15) made from copper.Type: GrantFiled: April 28, 2006Date of Patent: May 8, 2012Assignees: University of Houston, University College LondonInventors: Simon Richard Hattersley, Quentin Andrew Pankhurst, Audrius Brazdeikis
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Patent number: 8137409Abstract: A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion. The method includes attaching the first component to a bone such that a transition from the second component to the third component is essentially at the surface of the skin and the third component extends from the skin surface when the first component is attached to a bone.Type: GrantFiled: September 13, 2010Date of Patent: March 20, 2012Assignee: University College LondonInventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
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Publication number: 20110262585Abstract: Disclosed are newborn infant formulas comprising fat, carbohydrate, and from 0.5 to 2.5 g of protein per 100 ml of formula, wherein the formula has a caloric density of from 25 to 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to provide newborns with optimal nutrition, to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of atherosclerosis or coronary artery disease in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.Type: ApplicationFiled: July 5, 2011Publication date: October 27, 2011Applicant: UNIVERSITY COLLEGE LONDONInventors: Atul Singhal, Alan Lucas
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Patent number: 8034766Abstract: The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a prion contaminated entity with a prion-degrading composition comprising an effective amount of an oxidizing agent, an effective amount of at least one protease, and an effective amount of a surfactant. The components of the composition may be contacted with a prion-contaminated entity sequentially or simultaneously using an aqueous composition. Typically at least two different proteases are used for optimal efficacy. Preferably the oxidizing agent comprises peracetyl ions or a source thereof. The invention also relates to kits comprising the various reagents.Type: GrantFiled: October 26, 2007Date of Patent: October 11, 2011Assignees: E I du Pont de Nemours and Company, University College LondonInventors: Vincent Brian Croud, John Collinge, Graham Jackson
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Patent number: 7998501Abstract: Disclosed are newborn infant formulas comprising fat, carbohydrate, and from 0.5 to 2.5 g of protein per 100 ml of formula, wherein the formula has a caloric density of from 25 to 50 kcal per 100 ml of formula. Also disclosed are methods of administering the infant formulas to provide newborns with optimal nutrition, to reduce the occurrence or extent of insulin resistance in an individual later in life, to reduce the occurrence or extent of atherosclerosis or coronary artery disease in an individual later in life, or combinations thereof, by feeding newborn infants the newborn infant formula described herein.Type: GrantFiled: July 2, 2007Date of Patent: August 16, 2011Assignee: University College LondonInventors: Atul Singhal, Alan Lucas
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Publication number: 20100331996Abstract: A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells and a third component adapted for location to extend from the skin surface and the third component having an outer surface. The outer surface of the third component has a surface energy that is lower than a surface energy of at least the first component and which is low enough to deter bacterial adhesion.Type: ApplicationFiled: September 13, 2010Publication date: December 30, 2010Applicant: University College LondonInventors: Gordon Blunn, Justin Cobb, Allen Goodship, Paul Unwin
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Patent number: 7790761Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.Type: GrantFiled: December 21, 2005Date of Patent: September 7, 2010Assignee: University College LondonInventors: Giti Garthwaite, David Selwood, Marcel Kling, Grant Wishart
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Publication number: 20100149545Abstract: Apparatus and method for measuring the deformation of a tethered or untethered cantilever by projecting a radiation beam onto the cantilever, detecting an interference pattern reflected from or transmitted through the cantilever, and calculating the deformation of the cantilever by measuring the intensity variation within at least a portion of the interference pattern.Type: ApplicationFiled: April 17, 2008Publication date: June 17, 2010Applicant: University College LondonInventors: Gabriel Aeppli, Benjamin Dueck