Abstract: A heterogeneous energy storage device and a method for controlling a heterogeneous energy storage device are provided. In one implementation, a heterogeneous energy storage device is provided. The heterogeneous energy storage device includes a first energy storage device, a second energy storage device and a capacitive device. The first energy storage device has a first energy capacity and a first power to energy ratio (P/E). The second energy storage device has a second total energy capacity and a second P/E ratio different from the first P/E ratio. The capacitive device is coupled in series with the first energy storage device, wherein the second energy storage device is coupled in parallel with the series combination of the capacitive device and the first energy storage device. In another implementation, a method of controlling a heterogeneous energy storage device including a first energy storage device and a second energy storage device is provided.

Abstract: The present disclosure provides formulations for a drug product comprising a PEGylated CBS protein having the amino acid sequence of SEQ ID NO: 1. Dosages and dosing regimens are provided for treatment of homocystinuria in a subject in need thereof. Additionally, the dosages and dosing regimens are also provided to reduce the level of homocysteine (Hcy) or increase the levels of cysteine (Cys) and/or cystathionine (Cth) in a subject in need thereof.

Abstract: The system and methods of the present invention involve estimating model parameters for non-linear systems of Differential Equations (DEs). This includes receiving data from these systems and applying Weak-form Estimation of Nonlinear Dynamics methods to the data. These methods are robust to instances of large measurement noise. The system and methods also involve converting strong form representations of a model to weak forms, solving regression problems to perform parameter inference, and using Errors-In-Variables frameworks and iteratively reweighted least squares algorithms. The system and methods of the present invention can be applied to various models from different fields such as population biology, neuroscience, and biochemistry. The system and methods are highly robust and exhibit computational efficiency when used to estimate parameters in some common models including logistic growth, Lotka-Volterra, FitzHugh-Nagumo, Hindmarsh-Rose, a Protein Transduction Benchmark model and Kuramoto-Sivashinsky.

Abstract: Methods of treating, preventing, delaying, or reversing presbyopia in a subject involve administering a pharmaceutically effective amount of an aggrelyte to the subject. The aggrelyte may be one or more of N,S-diacetyl-L-cysteine methyl ester, S-acetyl-N-(3,3,-dimethylbutanoyl)-L-cysteinate, or N-acetyl cysteine methyl ester. The aggrelyte may be administered topically.

Abstract: A high-frequency inverter architecture is provided that compensates for coupling variations in wireless power transfer (WPT) systems, while adapted to operate at a fixed frequency and maintaining high efficiency. This implementation, termed a variable compensation inverter (VCI), includes a plurality of high-frequency inverters feeding a lossless resonant network, with the inputs of the inverters fed by controllable voltages. By appropriately controlling the input voltages of the individual inverters and their relative phase-shift, the VCI can maintain near-resistive, and slightly but sufficiently inductive, loading of the inverters even as the reactance of the WPT coupler changes; hence, providing compensation while maintaining zero-voltage and near-zero-current switching. The VCI also ensures that the output power of the WPT system is maintained at a fixed level even during coupling variations.

Abstract: The invention provides compositions and methods allowing for rapid, accurate, robust, and low-cost diagnosis of infectious diseases via extraction-free, direct PCR techniques.

Abstract: Dynamic windows with adjustable tint give users greater control over flow of light and heat. Reversible metal electrodeposition dynamic windows include (i) a transparent or translucent conductive electrode; (ii) an electrolyte solution in contact with the electrode, the electrolyte solution comprising metal cations that are reversibly electrodeposited onto the transparent electrode upon application of a cathodic potential; and (iii) a counter electrode. The electrolyte solution advantageously includes a small amount of an additive (e.g., an inhibitor, an accelerator, a leveler, or an organic or inorganic molecule that similarly serves to enhance the surface morphology of the metal cations during reversible metal electrodeposition onto the transparent electrode). Such enhancement of surface morphology during the reversible electrodeposition of the metal tinting layer over the electrode enhances one or more of color neutrality, transmittance characteristics of visible wavelengths (e.g.

Abstract: A novel combinatorial and high-throughput platform that enables rapid screening of complex and heterogeneous copolymer brushes as enzyme immobilization supports named Combinatorial High-throughput Enzyme Support Screening (CHESS). Using a 384 well-plate format, we synthesized arrays of three-component polymer brushes in the microwells using photo-activated surface-initiated polymerization, and immobilized enzymes in situ. The utility of CHESS to identify optimal immobilization supports under thermally and chemically denaturing conditions was demonstrated using Bacillus subtilis Lipase A (LipA). The identification of supports with optimal compositions was validated by immobilizing LipA on polymer-brush modified biocatalyst particles. We further demonstrated that CHESS could be used to predict the optimal composition of polymer brushes a priori for the previously unexplored enzyme, alkaline phosphatase (AlkP).

Abstract: A portable computed tomography (CT) system is provided herein. In an example, the portable CT system includes an O-shaped gantry defining an opening, an x-ray source operably coupled to the O-shaped gantry, a flat panel detector (FPD) coupled to the O-shaped gantry, and an antiscatter grid (ASG) operably coupled to a side of the FPD facing the opening of the O-shaped gantry. The FPD includes an x-ray absorbing sensor layer and a detector pixel array. The ASG includes a plurality of vertical walls defining open-ended channels and formed of a radiation-absorbing material. The open-ended channels are arranged in a geometric pattern pointed toward the x-ray source to receive x-rays in an x-ray emission path from the x-ray source.

Abstract: Various embodiments of the present technology are generally related to a multimedia distraction system for patients receiving external beam radiation therapy. More specifically, some embodiments relate to a system for providing a video image to a patient while undergoing a treatment to avoid the need to anesthetize. The system comprises a video image source, a projector communicatively coupled to the video image source, abeam expander coupled to the projector, and a screen transparent to the radiation beam used in a radiation therapy treatment. The present technology can be used to distract a patient during multiple types of external beam radiation therapy including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, volumetric modulated arc therapy, and non-coplanar arcs, without interfering with the treatment.

Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.

Abstract: A compound, or a pharmaceutically acceptable salts or prodrugs thereof, having the chemical structure: and methods of using these compounds to inhibit WEE1 kinase and treat cancer in a subject.

Abstract: A liquid crystal elastomer (LCE) formed from liquid crystalline monomers having 4-(6-(acryloyloxy)n-oxy)phenyl-4-(6-(acryloyloxy)m-oxy)benzoate (CnBAPE) as the mesogenic core. The LCEs have improved thermotropic characteristics, including lower thermotropic activation temperatures. The LCEs may also incorporate azobenzene to thereby also enhance the phototropic properties of the LCE.

Abstract: A photonic-crystal resonator (PhCR) and associated methods of design and manufacture. The PhCR includes spontaneous optical-pulse generation and includes a ring whose geometry is correlated to a mode structure or dispersion of the PhCR while also taking into account a desired type of nonlinear optical output from the PhCR, such as an optical frequency comb, or a particular type of pulse. The PhCR includes a periodic nanopatterning on an inner radial wall of its ring and is able to spontaneously generate a nonlinear optical output. The nanopatterning of the inner radial wall is designed to form a desired output, such as one of a classic soliton pulse that has a sech type temporal profile, or a gaussian profile, or a sink pulse profile.

Abstract: The systems and methods disclosed herein provide inventive means for repurposing wind turbine blades. In an embodiment, a derivative of a decommissioned wind turbine blade may be positioned and anchored for use in soil retention installations (e.g., slope stabilization, land building, etc.). In another embodiment, a derivative of a decommissioned wind turbine blade may be implemented in infrastructure installations (e.g., bridge decking). In yet another embodiment, a derivative of a decommissioned wind turbine blade may be positioned and anchored to mitigate snow drifts (e.g., as a snow break). Additional uses of wind turbine blades are considered and disclosed herein.

Abstract: A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

Abstract: A compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof, having the chemical structure of formula I as defined in the text and methods of using these compounds to inhibit topoisomerase II? and treat or prevent metastasis of cancer in a subject.

Abstract: Disclosed is a tongue strengthening device that includes a handle on one end and a bulb structure on the other end. The bulb is resiliently flexible, and enables a user to exercise their tongue by repeatedly compressing and releasing the bulb. Provided is a system or kit that includes multiple tongue strengthening devices having different compression specifications that allow a patient to graduate to devices which are harder to compress as the patient gains tongue strength.

Abstract: A novel treatment method is disclosed, wherein a patch configured to be placed on a patient's skin is activated, before placement, to deliver localized radiotherapy to a diseased area of the skin. The disclosed devices and methods minimize or prevent collateral damage to the neighboring tissues. In most cases, the disclosed devices and methods include coating a contoured, solid, flexible or conformal substrate with one or more lanthanide elements and then activating (e.g. neutron irradiation) the elements such that its resulting radioisotope emits beta-particles into the diseased skin surface when applied to the patient's skin. Novel processes are described for fabricating and irradiating the lanthanide-based skin patch, for example a holmium-based skin patch.

Abstract: Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.