Patents Assigned to University of East Anglia
  • Patent number: 10259784
    Abstract: The present invention relates to methods of synthesizing aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compound in the presence of a phosphoramide or a phosphoramide-derived catalyst. The present invention also relates to aziridines, modified aziridines and aziridine-derived compounds preparable by the aforementioned methods, and to phosphoramide or phosphoramide-derived catalysts suitable for use in such methods.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: April 16, 2019
    Assignee: University of East Anglia
    Inventors: Sean Patrick Bew, Sean Michael Thurston, Paolo Pesce
  • Patent number: 9765077
    Abstract: A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: September 19, 2017
    Assignee: University of East Anglia
    Inventors: Michael J Stephenson, Lesley A Howell, Mark Searcey
  • Patent number: 9732034
    Abstract: The present invention relates to methods of synthesizing aziridines including isotopically labelled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compound in the presence of a phosphoramide or a phosphoramide-derived catalyst. The present invention also relates to aziridines, modified aziridines and aziridine-derived compounds preparable by the aforementioned methods, and to phosphoramide or phosphoramide-derived catalysts suitable for use in such methods.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: August 15, 2017
    Assignee: University of East Anglia
    Inventors: Sean Patrick Bew, Sean Michael Thurston, Paolo Pesce
  • Patent number: 9410888
    Abstract: We describe a method for detection of the presence of an invertebrate or an invertebrate component in a sample of substantially non invertebrate material, comprising impinging said sample with a source of electromagnetic radiation at a wavelength of at least 600 nm and detecting Raman scattering/fluorescence of said invertebrate or a component of said invertebrate at a wavenumber where the non-invertebrate components of said sample either do not fluoresce or fluoresce with sufficiently low intensity wherein the non invertebrate material is edible and/or living.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: August 9, 2016
    Assignees: University of East Anglia, SRUC
    Inventors: Upali Abhaya Jayasooriya, Kenneth Andrew Evans
  • Patent number: 9001214
    Abstract: A method, system and reference target for estimating spectral data on a selected one of three spectral information types is disclosed. Spectral information types comprise illumination of a scene, spectral sensitivity of an imager imaging the scene and reflectance of a surface in the scene. The method comprises obtaining a ranking order for plural sensor responses produced by the imager, each sensor responses being produced from a reference target in the scene, obtaining, from an alternate source, data on the other two spectral information types, determining a set of constraints, the set including, for each sequential pair combination of sensor responses when taken in said ranking order, a constraint determined in dependence on the ranking and on the other two spectral information types for the respective sensor responses and, in dependence on the ranking order and on the set of constraints, determining said spectral data that optimally satisfies said constraints.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: April 7, 2015
    Assignee: University of East Anglia
    Inventor: Graham Finlayson
  • Publication number: 20140243213
    Abstract: The present invention relates to methods for determining the sequence bias of a sequencing technique. Furthermore, the invention relates to methods to reduce or enhance sequence bias during sequencing of nucleic acids via techniques involving adaptor ligations. Specifically the method relates to use of a degenerate RNA sequence to analyse sequence bias when generating small RNA libraries, and to the use of modified adaptors for cloning of small RNAs with degenerate or specific sequences to reduce or enhance sequencing bias, as well as various nucleic acid molecules relating thereto or derived therefrom.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 28, 2014
    Applicant: University of East Anglia
    Inventors: Karim Sorefan, Tamas Dalmay, Vincent Moulton, Helio Ernesto Coronel M. Pais
  • Patent number: 8682093
    Abstract: A method and system for producing accented image data for an accented image is disclosed. The method includes decomposing each of a first and a second image into a gradient representation which comprises spectral and edge components. The first image comprises more spectral dimensions than the second image. The edge component from the first image is combined with the spectral component from the second image to form a combined gradient representation. Accented image data for the accented image is then generated from data including the combined gradient representation.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: March 25, 2014
    Assignee: University of East Anglia
    Inventors: David Connah, Mark S. Drew, Graham Finlayson
  • Publication number: 20130333074
    Abstract: The present invention relates to a polypeptide (BIG1) and variants thereof capable of enhancing the rate of cell-division of a microorganism or plant cell, as well as nucleic acid molecules encoding said polypeptides, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors and expressing said polypeptides. The BIG1 polypeptide which has been identified in the marine centric diatom Thalassiosira pseudonana, variants thereof and nucleic acids encoding these may be used in methods of enhancing the rate of cell-division of microorganisms, plant cells or plants which produce useful sub stances or exhibit useful properties, to increase the yield thereof.
    Type: Application
    Filed: February 10, 2012
    Publication date: December 12, 2013
    Applicants: University of Washington through its Center for Commercialization, University of East Anglia
    Inventors: Thomas Mock, Rachel Elizabeth Hipkin
  • Patent number: 7751639
    Abstract: In a method for the recovery of an invariant image from a 3-band colour image, information relating to the angle for an “invariant direction” in a log-chromaticity space is obtained on the basis that the correction projection is that which minimizes entropy in the resulting invariant image. The method is applied to remove shadows from unsourced imagery.
    Type: Grant
    Filed: April 20, 2005
    Date of Patent: July 6, 2010
    Assignee: University of East Anglia
    Inventors: Graham Finlayson, Mark S. Drew, Cheng Lu
  • Patent number: 7227586
    Abstract: A method of adjusting the N components of an N component color signal (such as the 3 components of an RGB color signal) with respect to color temperature of illuminating light when imaging a colored subject, comprising the step of computing the difference between each of the components of the color signal for different temperatures of illuminating light, using an algorithm based on the spectral sensitivity of the imaging means and Planck's equation defining black body illumination to obtain N components whose values are independent of the color temperature of the illuminating light. Normalisation of the adjusted values renders the values independent of intensity of illumination and can also reduce the processing time for further processing of the signals. A technique for compensating for gamma correction which is commonly built in cameras, is disclosed.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: June 5, 2007
    Assignee: University of East Anglia
    Inventors: Graham Finlayson, Stephen Hordley
  • Publication number: 20070009944
    Abstract: A method of determining activity of a nucleic acid ligase or a nucleic acid nuclease is described. This method comprises the steps of: (i) providing a nucleic acid molecule comprising a hairpin with a single-stranded loop and a double-stranded stem containing a target site for the nucleic acid ligase and/or the nucleic acid nuclease, wherein the nucleic acid molecule has a first end tethered to a surface and a second end remote from the first end, and wherein a detectable label is attached to the nucleic acid molecule either at the second end or between the target site and the second end; (ii) contacting the nucleic acid molecule with the nucleic acid ligase or the nucleic acid nuclease; and (iii) detecting the presence or absence of the detectable label, thereby determining activity of the nucleic acid ligase or the nucleic acid nuclease.
    Type: Application
    Filed: June 27, 2006
    Publication date: January 11, 2007
    Applicant: University of East Anglia
    Inventors: Richard Bowater, Julea Butt, Benjamin Scott
  • Patent number: 7046288
    Abstract: An image recording apparatus for processing an image includes a camera (10), or other optical sensor means, for recording a first digital optical image of at least part of a scene illuminated by an illuminant light and for recording a second digital optical image of at least a part of substantially the same scene under substantially the same illuminant light. The images may be recorded on respectively different sensor arrays (12a and 12b). The light producing the first and second images undergoes different optical processing in order to produce those images, and processing means (18) in communication with the optical sensor means is provided for processing information relating to the first and second images. By relating the two images, the processing means (18) is able to provide information regarding the color of the illuminate light or other physical properties of the illuminated scene.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: May 16, 2006
    Assignee: University of East Anglia
    Inventor: Graham Finlayson
  • Publication number: 20050226496
    Abstract: A colour image comprises colour values in each of one or more colour channels for each of a plurality of points, or pixels, within the image. The image is represented by rank ordering the values in the or each colour channel. The image representation generated in this way is usable for automated-vision or computer-vision tasks, for example.
    Type: Application
    Filed: May 2, 2003
    Publication date: October 13, 2005
    Applicant: University of East Anglia
    Inventor: Graham Finlayson
  • Patent number: 6630128
    Abstract: There is provided a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y1, Y2, Y3, Z, M, A-B and C-D have meanings given in the description, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Compositions, apparatus and methods of treatment of a medical condition for which a photodynamic compound is indicated are also disclosed.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: October 7, 2003
    Assignees: Destiny Pharma Limited, University of East Anglia
    Inventors: William Guy Love, Michael John Cook, David Andrew Russell
  • Patent number: 6509476
    Abstract: This invention relates to a method of making N-benzyl indoles, and to intermediates for use in the method, and to certain substantially optically pure N-benzyl indoles obtained by the method.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: January 21, 2003
    Assignees: The University of East Anglia, Eli Lilly and Company
    Inventors: Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart
  • Patent number: 6255338
    Abstract: The use of a calcium intracellular store inactivator for inhibiting cell growth is disclosed; for example, thapsigargin or a derivative may be used to inhibit intraocular lens cell growth. Formulations include an emulsion of the compound for coating an IOL, either ex vivo or in vivo.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: July 3, 2001
    Assignees: The University of East Anglia, The Norfolk & Norwich Health Care NHS Trust
    Inventors: George Duncan, Michael Wormstone, Peter Davies, Christopher Liu
  • Patent number: 6160120
    Abstract: This invention relates to a method of making N-benzyl indoles, and to intermediates for use in the method, and to certain substantially optically pure N-benzyl indoles obtained by the method.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: December 12, 2000
    Assignees: Eli Lilly and Company, University of East Anglia
    Inventors: Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart
  • Patent number: 5807866
    Abstract: A process for producing a compound of the formu5la ##STR1## comprising the step of reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## to form a compound of the formula ##STR4## wherein R.sup.2a is selected from the groups recited above for R.sup.2, or R.sup.2a --X-- is a protected hydroxyl group, and Z is a group of formula --Y--R.sub.5 recited above, or a group that can be converted into a group of said formula --Y--R.sup.5. Intermediates of formula IV and composition containing substantially optically pure enantiomers of Formula (I) are included within the scope of the invention.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: September 15, 1998
    Assignees: The University of East Anglia, Eli Lilly and Company
    Inventors: Nicholas James Bach, Stephen Richard Baker, Jeremy Gilmore, Russell Andrew Lewthwaite, Alexander McKillop, Jason Scott Sawyer, George Richard Stephenson, Michael William John Urquhart