Patents Assigned to University of Exeter
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Patent number: 11684266Abstract: A probe comprising a body portion and a tip portion. The body portion comprises: a first mounting portion comprising a plurality of first carriers, each first carrier being arranged to support an elongate first waveguide, the first carriers being disposed in an equiangular arrangement around a longitudinal axis of the body portion; a plurality of first waveguides, each first waveguide being supported in a respective one of the plurality of first carriers; and a body end fitting at which first ends of the first waveguides are supported in the equiangular arrangement around the longitudinal axis of the body portion such that the first waveguides can transmit electromagnetic radiation signals from an energy source to the body end fitting and/or transmit electromagnetic radiation signals from the body end fitting to a receiver.Type: GrantFiled: March 15, 2018Date of Patent: June 27, 2023Assignees: The University of Bristol, The University of Exeter, Gloucestershire Hospitals NHS Foundation TrustInventors: Nicholas Stone, John Charles Clifford Day
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Patent number: 11567389Abstract: A display is described which comprises a plurality of pixels (12), wherein each pixel (12) comprises a plasmonic resonator (26) including first and second metallic material elements (16, 22) and incorporating a layer (18) of a phase change material, the plasmonic resonator (26) being arranged such that in one material state of the phase change material (18) the electric field coupling between the second metallic material element (22) and the phase change material layer (18) is strong and so strong absorption of selected wavelengths of the incident light occurs, whereas in another state of the phase change material (18) the electric field coupling between the metallic material elements (16, 22) and the phase change material layer (18), and between the first and second metallic material elements (16, 22) is weak and so re-radiation of incident light occurs, the pixel (12) being of high reflectance.Type: GrantFiled: August 24, 2018Date of Patent: January 31, 2023Assignee: University of ExeterInventors: Santiago Garcia-Cuevas Carrillo, Christopher David Wright
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Patent number: 11556312Abstract: A co-processor for performing a matrix multiplication of an input matrix with a data matrix in one step may be provided. The co-processor receives input signals for the input matrix as optical signals. A plurality of photonic memory elements is arranged at crossing points of an optical waveguide crossbar array. The plurality of memory elements is configured to store values of the data matrix. Input signals are connected to input lines of the optical waveguide crossbar array. Output lines of the optical waveguide crossbar array represent a dot-product between a respective column of the optical waveguide crossbar array and the received input signals, and values of elements of the input matrix to be multiplied with the data matrix correspond to light intensities received at input lines of the respective photonic memory elements. Additionally, different wavelengths are used for each column of the input matrix optical signals.Type: GrantFiled: July 10, 2020Date of Patent: January 17, 2023Assignees: International Business Machines Corporation, Oxford University Innovation Limited, University of Exeter, University of MuensterInventors: Abu Sebastian, Manuel Le Gallo-Bourdeau, Christopher David Wright, Nathan Youngblood, Harish Bhaskaran, Xuan Li, Wolfram Pernice, Johannes Feldmann
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Publication number: 20220174950Abstract: The invention provides an antifungal composition comprising an antifungal compound of formula R—S+(R?)2 or R—N+(R?)3 wherein R is C17-C32 straight chain or branched alkyl; and each R? is independently methyl, ethyl, propyl, isopropyl or butyl; and uses of said composition as antifungal agents.Type: ApplicationFiled: March 18, 2020Publication date: June 9, 2022Applicant: University of ExeterInventors: Gero Steinberg, Sarah Gurr, Mark Wood
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Patent number: 10995061Abstract: The present disclosure is concerned with N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)benzamide compounds that are capable of inhibiting SPAK kinase function, methods of treating hypoxic brain injuries due to, for example, ischemic stroke. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: GrantFiled: September 30, 2019Date of Patent: May 4, 2021Assignees: United States Government as Represented by the Department of Veterans Affairs, The University of Pittsburgh—of the Commonwealth of Higher Education, Xiamen University, University of ExeterInventors: Dandan Sun, Xianming Deng, Jinwei Zhang, Mohammad Iqbal Hossain Bhuiyan, Bradley J. Molyneaux
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Patent number: 10422947Abstract: The rolled photonic fibers presents two codependent, technologically exploitable features for light and color manipulation: regularity on the nanoscale that is superposed with microscale cylindrical symmetry, resulting in wavelength selective scattering of light in a wide range of directions. The bio-inspired photonic fibers combine the spectral filtering capabilities and color brilliance of a planar Bragg stack compounded with a large angular scattering range introduced by the microscale curvature, which also decreases the strong directional chromaticity variation usually associated with flat multilayer reflectors. Transparent and elastic synthetic materials equip the multilayer interference fibers with high reflectance that is dynamically tuned by longitudinal mechanical strain. A two-fold elongation of the elastic fibers results in a shift of reflection peak center wavelength of over 200 nm.Type: GrantFiled: October 19, 2018Date of Patent: September 24, 2019Assignees: President and Fellows of Harvard College, University of ExeterInventors: Joanna Aizenberg, Mathias Kolle, Peter Vukusic, Robert D. Howe
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Publication number: 20190227224Abstract: The rolled photonic fibers presents two codependent, technologically exploitable features for light and color manipulation: regularity on the nanoscale that is superposed with microscale cylindrical symmetry, resulting in wavelength selective scattering of light in a wide range of directions. The bio-inspired photonic fibers combine the spectral filtering capabilities and color brilliance of a planar Bragg stack compounded with a large angular scattering range introduced by the microscale curvature, which also decreases the strong directional chromaticity variation usually associated with flat multilayer reflectors. Transparent and elastic synthetic materials equip the multilayer interference fibers with high reflectance that is dynamically tuned by longitudinal mechanical strain. A two-fold elongation of the elastic fibers results in a shift of reflection peak center wavelength of over 200 nm.Type: ApplicationFiled: October 19, 2018Publication date: July 25, 2019Applicants: President and Fellows of Harvard College, University of ExeterInventors: Joanna AIZENBERG, Mathias KOLLE, Peter VUKUSIC, Robert D. HOWE
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Patent number: 10174086Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: GrantFiled: August 22, 2016Date of Patent: January 8, 2019Assignee: University of ExeterInventors: Richard W. Titball, Sergio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Patent number: 10149907Abstract: The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or a pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.Type: GrantFiled: February 7, 2018Date of Patent: December 11, 2018Assignee: University of ExeterInventors: Mark Elliott Wood, Paul Graham Winyard, Daniel Colin Jeremy Ferguson, Matthew Whiteman, Alison Curnow, Alexis Perry
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Patent number: 10146007Abstract: The rolled photonic fibers presents two codependent, technologically exploitable features for light and color manipulation: regularity on the nanoscale that is superposed with microscale cylindrical symmetry, resulting in wavelength selective scattering of light in a wide range of directions. The bio-inspired photonic fibers combine the spectral filtering capabilities and color brilliance of a planar Bragg stack compounded with a large angular scattering range introduced by the microscale curvature, which also decreases the strong directional chromaticity variation usually associated with flat multilayer reflectors. Transparent and elastic synthetic materials equip the multilayer interference fibers with high reflectance that is dynamically tuned by longitudinal mechanical strain. A two-fold elongation of the elastic fibers results in a shift of reflection peak center wavelength of over 200 nm.Type: GrantFiled: January 23, 2014Date of Patent: December 4, 2018Assignees: President and Fellows of Harvard College, University of ExeterInventors: Joanna Aizenberg, Mathias Kolle, Peter Vukusic, Robert D. Howe
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Patent number: 10058100Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.Type: GrantFiled: October 1, 2012Date of Patent: August 28, 2018Assignee: The University of ExeterInventors: Mark Wood, Matthew Whiteman, Alexis Perry
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Patent number: 10053772Abstract: Methods of producing a uniformly or substantially uniformly doped relatively large area multi-layered graphene element are described comprising the steps of placing the graphene element and a dopant under low pressure conditions, and holding the graphene element and dopant at an elevated temperature for a period of time while under the low pressure conditions. In one arrangement, openings are formed in a multi-layered graphene element of relatively large area prior to doping. In another arrangement, a relatively large area multi-layered graphene element formed by an epitaxial growth technique is used. The invention also relates to an element produced using the aforementioned techniques.Type: GrantFiled: September 26, 2014Date of Patent: August 21, 2018Assignee: University of ExeterInventors: Saverio Russo, Monica Craciun, Thomas Hardisty Bointon
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Patent number: 9919049Abstract: Compounds for use The invention relates to a combination comprising (i) a compound A comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulfide or a pharmaceutically acceptable salt thereof or a prodrug thereof, an inhibitor of the thioredoxin antioxidant system or pharmaceutically acceptable salt thereof or a prodrug thereof, and/or a nitroxide or a pharmaceutically acceptable salt thereof or a prodrug thereof; and (ii) a photosensitizer or photosensitizer precursor; for use in photodynamic therapy.Type: GrantFiled: June 2, 2015Date of Patent: March 20, 2018Assignee: University of ExeterInventors: Mark Elliott Wood, Paul Graham Winyard, Daniel Colin Jeremy Ferguson, Matthew Whiteman, Alison Curnow, Alexis Perry
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Patent number: 9865369Abstract: The present invention relates to a transparent chemically functionalized graphene with high electrical conductivity and which is stable in air. It also relates to a method of manufacturing a conductive and transparent graphene-based material.Type: GrantFiled: December 21, 2012Date of Patent: January 9, 2018Assignee: University of ExeterInventors: Saverio Russo, Monica Felicia Craciun
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Patent number: 9720151Abstract: A structure for broadband light funneling comprises a two-dimensional periodic array of connected ultrasubwavelength apertures, each aperture comprising a large sub-aperture that aids in the coupling of the incoming incident light and a small sub-aperture that funnels a significant fraction of the incident light power. The structure possesses all the capabilities of prior extraordinary optical transmission platforms, yet operates nonresonantly on a distinctly different mechanism. The structure demonstrates efficient ultrabroadband funneling of optical power confined in an area as small as ˜(?/500)2, where optical fields are enhanced, thus exhibiting functional possibilities beyond resonant platforms.Type: GrantFiled: October 8, 2013Date of Patent: August 1, 2017Assignees: National Technology & Engineering Solutions of Sandia, LLC, University of ExeterInventors: Ganapathi Subramanian Subramania, Igal Brener, Stavroula Foteinopoulou
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Publication number: 20170051023Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: ApplicationFiled: August 22, 2016Publication date: February 23, 2017Applicant: University of ExeterInventors: Richard W. Titball, Sergio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Patent number: 9573981Abstract: There is provided an epsilon toxin epitope polypeptide comprising a sequence of at least 10 contiguous amino acids from SEQ ID NO:3, the sequence comprising a mutation of at least one tyrosine residue compared to the equivalent sequence in SEQ ID NO:3, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:5 and having reduced toxicity compared with the toxicity of SEQ ID NO:5. The polypeptide is useful in a method of vaccinating a subject against developing a disease caused by clostridium perfringens and/or caused by (or associated with the presence of) active epsilon toxin.Type: GrantFiled: March 28, 2013Date of Patent: February 21, 2017Assignee: University of ExeterInventors: Richard W. Titball, Monika Bokori-Brown, Claire Naylor
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Patent number: 9422343Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.Type: GrantFiled: October 24, 2012Date of Patent: August 23, 2016Assignee: University of ExeterInventors: Richard W. Titball, Sérgio Paulo Fernandes Da Costa, Claire Naylor, Ajit Basak
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Publication number: 20160230273Abstract: Methods of producing a uniformly or substantially uniformly doped relatively large area multi-layered graphene element are described comprising the steps of placing the graphene element and a dopant under low pressure conditions, and holding the graphene element and dopant at an elevated temperature for a period of time whilst under the low pressure conditions. In one arrangement, openings are formed in a multi-layered graphene element of relatively large area prior to doping. In another arrangement, a relatively large area multi-layered graphene element formed by an epitaxial growth technique is used. The invention also relates to an element produced using the aforementioned techniques.Type: ApplicationFiled: September 26, 2014Publication date: August 11, 2016Applicant: University of ExeterInventors: Saverio Russo, Monica Craciun, Thomas Hardisty Bointon
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Publication number: 20150364614Abstract: A detector is described comprising a first graphene element (12), the first graphene element (12) comprising a few layer graphene element functionally doped with a dopant material and to which at least one electrode is connected.Type: ApplicationFiled: January 14, 2014Publication date: December 17, 2015Applicant: University of ExeterInventors: Freddie Withers, Thomas H. Bointon, Monica F. Craciun, Saverio Russo, Steven Martins