Abstract: Provided herein are methods of site-specific integration of a heterologous sequence into a host genome (e.g., by administering a recombinant adeno-associated virus (rAAV) to a host cell in the presence of a Rep protein), and methods for treating diseases and disorders by delivering an rAAV that comprises a nucleic acid vector comprising a Rep protein. Also provided herein are methods and compositions for producing rAAV particles with improved titer and transduction efficiencies.

Abstract: The present disclosure relates to systems and methods for tunable electrodynamic wireless power receivers. In some examples, a wireless power receiver electromechanically converts energy from a magnetic field using an oscillating or continuously rotating magnet. A sensing device detects an operational parameter of the receiver, and a tuning device initiates a tuning action based on the operational parameter.

Abstract: A universal insect trap having multiple points of entry is described being capable of capturing various types and sizes of insects. The universal insect trap may be used to capture and preserve target species such that genomes can be analyzed for specimens, which is beneficial in determining infection rates, strains of a vector or a pathogen, identifying associated microorganisms, determining or monitoring natural enemies, etc. The universal insect trap can include a base having a cone-shaped body, where the base includes a sloped surface. Further, the universal insect trap can include a dome portion and a trap portion. The trap portion can include an annular ring, a mounting portion, a vial, and an aggregation pheromone positioned in the trap portion, where the aggregation pheromone is one that emits a predetermined amount of pheromones over time to attract at least one predetermined type of insect.

Abstract: Various examples are provided related to electrochemical phosphate/pH (P/pH) sensors, systems and related methods. In one example, a P/pH sensor includes a substrate and collocated phosphate (P) electrode and pH electrode formed on a surface of the substrate. The P electrode includes a cobalt (Co) sensing window disposed on a first copper (Cu) sensor pad; and the pH electrode includes an antimony (Sb) sensing window disposed on a second Cu sensor pad. The P/pH sensor can include a reference electrode, and may also include other sensor electrodes such as, e.g., a nitrate electrode.

Abstract: Disclosed herein are compositions, devices, and methods for isolating human Adipose-derived stem cells (ASCs) without either electricity or enzymatic digestion. In particular, a paramagnetic immunobead (PIB) for isolating human ASCs is disclosed. In some embodiments, the PIB displays on its surface one or more antibodies that selectively bind ASC-specific antigens. Also disclosed is a method for isolating human ASCs using the disclosed PIBs.

Abstract: Disclosed herein are compositions and methods for treating obesity involving satiation gut peptide administration to the mouth of a subject for a predetermined dose and frequency. In other embodiments, materials and methods of treating certain psychological disorders are disclosed involving satiation gut peptides. In exemplary embodiments, the satiation gut peptide pertains to PYY.

Abstract: Embodiments of the present disclosure provide for lubricious structures (also referred to simply as “structure”), methods of making lubricious structures, methods of using lubricious structures, and the like.

Abstract: In some embodiments according to the present disclosure, calibrated pneumatic otoscopes and retrofit calibration devices are described. In certain aspects of the present disclosure, methods of using calibrated pneumatic otoscopes are described. In certain aspects according to the present disclosure, kits containing pneumatic otoscopes are described. In certain aspects according to the present disclosure, retrofit calibration devices are described.

Abstract: The present disclosure provides for porous polymer materials that include an ordered array of voids separated by a polymer framework. The porous polymer material can have a recovery state where the voids are in an uncollapsed state and iridescent color, and a deformed state having voids in a collapsed state that is non-iridescent or substantially transparent. The materials can have regions of both states simultaneously. Also described are methods for fabricating a polymer material as above, as well as chromogenic sensors including the polymer material. The sensors can have hidden anti-counterfeiting patterns, hydrophobic/oleophobic properties, and chromogenic transformation can be triggered by various stimuli such as solid target compounds, light energy, and more.

Abstract: Disclosed herein are materials and methods for the treatment of stress-related disorders and cancer. The disclosure provides an antibody, or antigen binding fragment thereof, that specifically binds to a region of corticotropin-releasing hormone (CRH). The disclosure also provides methods of treating a disorder associated with HPA axis activation, such as a stress-related disorder or cancer, comprising administering to a subject in need thereof an antibody or antigen binding fragment thereof described herein in an amount effective to treat the disorder.

Abstract: The invention relates to proteins that contain the CD4 domain 1 and the CD4 domain 2 (CD4 D1D2), wherein the CD4 D1D2 contains one or more mutations compared to wild-type human CD4 D1D2, and to methods of using the proteins for treating a human immunodeficiency virus (HIV) infection in a subject.

Abstract: Disclosed herein are recombinant AAV variant (e.g., variant serotype 5 (AAV5)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce adult stem cells and neurons. Viral particles containing these capsid variants are capable of enhanced transduction of mammalian mesenchymal stem cells and neurons. The recombinant AAV5 variant proteins and viral particles disclosed herein were identified from a variant AAV5 capsid library that was engineered by making substitutions in variable regions of the capsid. Compositions of these variant AAV5 particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as mesenchymal stem cells, and thus treat diseases and disorders pertaining to these cells.

Abstract: Described herein are antireflective layers, methods for forming antireflective layers, and structures including antireflective layers. Methods are included for forming a durable antireflective layer on the surface of a substrate, wherein the substrate has a complex three-dimensional shape, wherein the durable antireflective layer comprises a uniform monolayer of silica nanoparticles interconnected by SiO2, a uniform monolayer of silica nanoparticles bonded to the surface of the substrate, or a combination thereof.

Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.

Abstract: Methods and systems are directed to protect a target logic circuit against optical probing attacks and conceal a logic state in the target logic circuit. The method comprises designing a concealing logic circuit. The concealing logic circuit can be coupled to complement of input signals of the target logic circuit, inserted as neighbor logic circuit of the target logic circuit, and placed in close optical proximity to the target logic circuit. The concealing logic circuit can operate in the opposite operation mode or logic state of the target logic circuit in response to the complement of the input signals to the target logic circuit. The method can further comprise designing an evaluation circuit that generates the complement of the input signals and minimizes a path delay between the target logic circuit input and the concealing logic circuit input.

Abstract: An apparatus and method for the delivery and deposition of particles air-liquid-interface (ALI) cell cultures includes a sample inlet coupled to a growth tube having interior walls that are wet. The growth tube is configured to operate at a first temperature along a first length of the tube and a second temperature along a second length positioned between the first length and a growth tube outlet. The apparatus also includes a nozzle plate having a plurality of nozzles. The exposure chamber adapted to hold cell cultures at an air-liquid interface positioned underneath the plurality of nozzles and a temperature regulator adapted to control a temperature of the exposure chamber. The apparatus also includes a controller including instructions operable to cause the controller to maintain a relative humidity within the exposure chamber by controlling at least the second temperature of the growth tube and the temperature of the exposure chamber.

Abstract: Provided herein are compounds (e.g., compounds of Formula (I)), their mechanism of action, and methods of treating diseases and disorders (e.g., cancer) using the compounds provided herein (e.g., compounds of Formula (I)). Also disclosed herein are N methods of inhibiting and degrading kinases (e.g., CDK9, CDK10, or anaplastic lymphoma kinase).

Abstract: The present disclosure presents systems, methods, and non-transitory computer-readable media for transforming civil, architectural, or engineering drawings into Building Information Modeling (BIM) or Computer-Aided Design (CAD) models.

Abstract: The present disclosure describes various embodiments of systems, apparatuses, and methods for large-scale processing of weather-related data. For one such system, the system comprises a database of weather-related data providing from at least one weather monitoring station and at least one processor for coordinating a data processing job for processing a set of input weather-related data from the database. Accordingly, the input data comprises sensor data from the at least one weather monitoring station positioned on an open shoreline during a hydrodynamic event, weather model data for the hydrodynamic event, and at least one of air-craft reconnaissance data or satellite reconnaissance data regarding the hydrodynamic event, wherein the at least one processor is configured to assimilate the input data and generate, using machine learning, an improved weather prediction model for the hydrodynamic event. Other systems, apparatuses, and methods are also provided.

Abstract: Embodiments of the present disclosure provide systems and methods for wirelessly charging household batteries without having to remove the batteries from battery-powered user-devices, consumer electronics, or other applications to which the batteries are being deployed. In one embodiment, a wireless rechargeable battery system comprises an electrical energy storage element for a wireless rechargeable battery; a wireless receiver for the wireless rechargeable battery, wherein the wireless receiver is configured to supply electrical energy to the electrical energy storage element in a presence of a magnetic field from a charging base station; and an internal electronics circuitry for the wireless rechargeable battery, wherein the internal electronics circuitry couples the electrical energy storage element and the wireless receiver.