Patents Assigned to University of Florida
  • Publication number: 20210108237
    Abstract: The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes.
    Type: Application
    Filed: March 21, 2019
    Publication date: April 15, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Yousong Ding, Ran Zuo
  • Publication number: 20210108226
    Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.
    Type: Application
    Filed: August 10, 2020
    Publication date: April 15, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Phillip A. Doerfler, Nathalie Clement
  • Publication number: 20210107943
    Abstract: Provided herein are charge complementary peptides that can be optionally coupled to a cargo polypeptide that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. Also provided herein are methods of using the charge complementary peptides provided herein.
    Type: Application
    Filed: December 16, 2020
    Publication date: April 15, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Gregory Allan Hudalla, Dillon T. Seroski
  • Patent number: 10974441
    Abstract: A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed in (e.g., continuously printed using a moving dispensing nozzle) a yield-stress support bath to form an intermediate article. The intermediate article may be liquid or only partially coagulated after being printed into the yield-stress support bath. The yield-stress support bath may be at least partially disposed within a container, and the container may be immersed in a post-treatment coagulation solution to remove some or all of the solvent, causing the build material to fully solidify to form a finished article from the intermediate article.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: April 13, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Yong Huang, Ashley M. Compaan, Kaidong Song
  • Patent number: 10978908
    Abstract: Various examples are provided for wireless power charging for versatile receiver positions. In one example, a three dimensional array of transmitter coils is positioned around a charging area. A control circuit causes the array of transmitter coils to generate a magnetic field that charges a device with any position and orientation in the charging area.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 13, 2021
    Assignees: University of Florida Research Foundation, Inc., Mediatek Singapore PTE. LTD.
    Inventors: Patrick Riehl, Jenshan Lin, Ron-Chi Kuo
  • Patent number: 10968474
    Abstract: Described herein are fluid-manipulation-based devices and methods of use. Fluid manipulations according to devices and methods as described herein can be configured to perform assays on biological samples. Devices and methods as described herein can manipulate and analyze nanoliter volumes of fluid, microliter volumes of fluid, milliliter volumes of fluid, or greater. Embodiments of the present disclosure can enable random biological assays and rapid, simultaneous analysis of multiple biological samples.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: April 6, 2021
    Assignee: University of Florida Research Foundation Inc.
    Inventor: Yunwei Charles Cao
  • Patent number: 10971292
    Abstract: Embodiments of the subject invention relate to an electropermanent magnet core (EPM core) having two permanent magnets (or two permanent magnet portions where each portion can have one or more permanent magnets), including a fixed permanent magnet portion and a switching permanent magnet portion, where a switching magnetic field is used to switch the magnetization of the switching permanent magnet portion, but not switch the magnetization of the fixed permanent magnet portion.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: April 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David P. Arnold, Camilo Velez Cuervo
  • Publication number: 20210099196
    Abstract: In an example, a system includes a plurality of acoustically coupled nodes. Each of the nodes includes a transducer, a communication circuit and a controller. The transducer is adapted to be mechanically coupled to a medium. The communication circuit is coupled to the transducer to send and receive acoustic signals via the medium according to at least one communication parameter. The controller is to adaptively configure the at least one communication parameter of the communication circuit based on an acoustic signal received from at least one other of the nodes.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Applicants: University of Florida Research Foundation, Inc., Virtual EM Inc.
    Inventors: Xinyao Tang, Soumyajit Mandal, Joel B. Harley, Tayfun Ozdemir
  • Patent number: 10957040
    Abstract: Embodiments of the present disclosure provide for methods and systems for preparing chromosomal spread for a selected cell so that chromosomal spreads and/or translocations can be correlated with the selected cell.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: March 23, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Tanmay P. Lele, Wallace Gregory Sawyer
  • Patent number: 10952674
    Abstract: Various examples of methods, systems, and apparatus are provided for monitoring using an improved mouth guard apparatus. In one example, a battery-free diagnostic mouth guard includes a biting force-voltage transducer comprising a piezoelectric film; a compact resonance tank comprising a wireless sensor; and a transmitting antenna for transmitting sensing data. A piezo-voltage from the biting force-voltage transducer can bias a varactor diode loaded on the wireless sensor whose response frequency is tuned due to a capacitance change of the varactor diode. In some implementations, an external processing equipment can wirelessly detect a frequency shift of the varactor diode integrated resonator. In another example, a method includes detecting a biting force via a biting force-voltage transducer; biasing a varactor diode with a voltage from the transducer; tuning a response frequency of a split ring resonator using a capacitance change of the varactor diode; and emitting sensing data at the response frequency.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: March 23, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Yong Kyu Yoon, Xiaoyu Cheng, Gloria Jung A. Kim
  • Patent number: 10946492
    Abstract: Various examples are provided for polishing techniques for flexible tubular workpieces. In one example, a method includes supporting a tubular workpiece on a rod that extends axially through it; positioning a turning wheel against an external surface of the tubular workpiece, where it is held by magnetic attraction; and rotating the tubular workpiece by rotating the turning wheel. The external surface of the tubular workpiece is polished by the abrasive particles during rotation of the tubular workpiece. In another example, a polishing system includes a workpiece holder including a rod configured to axially support a tubular workpiece; a turning wheel with abrasive particles distributed about an outer surface; a wheel support assembly configured to position the outer surface of the turning wheel against the an external surface of the tubular workpiece, where it is held by magnetic attraction. The external surface is polished during rotation of the tubular workpiece.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: March 16, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Hitomi Greenslet, Xueyu Du, Valens Nteziyaremye, Timothy Pham
  • Patent number: 10941412
    Abstract: The invention pertains to a plant cell or a plant having one or more mutations in the promoters of both the alleles for CsLOB1 gene, wherein the one or more mutations are in the promoter binding sites for PthA4 protein from Xanthomonas spp., and wherein the one or more mutations reduce or abolish the binding of the Xanthomonas spp. PthA4 protein on to the binding sites in the promoters of the CsLOB1 genes. Also, a plant cell or a plant having one or more mutations in the coding regions of both the alleles for CsLOB1 gene, wherein the one or more mutations reduce or abolish the binding of the function of CsLOB1 protein are provided. The invention further pertains to the methods of making the plant cell or the plant resistant to infection by Xanthomonas spp.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: March 9, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Nian Wang, Hongge Jia
  • Patent number: 10940137
    Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 9, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Sadasivan Vidyasagar, Paul Okunieff, Lurong Zhang
  • Patent number: 10940161
    Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: March 9, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Fatma Ayhan, Tao Zu
  • Publication number: 20210061814
    Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
    Type: Application
    Filed: July 8, 2020
    Publication date: March 4, 2021
    Applicants: St. Louis College of Pharmacy, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
    Inventors: Susruta MAJUMDAR, Vsevolod KATRITCH, Bryan ROTH, JAY MCLAUGHLIN, Saheem ZAIDI, Gavril W. PASTERNAK, Rajendra UPRETY
  • Publication number: 20210061863
    Abstract: Adeno associated viral (AAV) particles are emerging as a useful vehicle for gene delivery to various organs and tissues, one of them being the retina. Provided here are variant AAV (e.g., variant serotype 2 (AAV2)) capsid proteins and variant capsid protein containing particles with enhanced ability to transduce retinal cells.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 4, 2021
    Applicants: University of Florida Research Foundation, Incorporated, The UAB Research Foundation
    Inventors: Sergei Zolotukhin, Sanford L. Boye, Shannon E. Boye, Damien Marsic, Nicholas Muzyczka, Hector Ruben Mendez-Gomez, Paul E. Gamlin
  • Patent number: 10934327
    Abstract: Disclosed are next-generation multi-mutated capsid protein-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols. Also disclosed are large-scale production methods for the multi-mutated, capsid-modified rAAV expression vectors, viral particles, and infectious virions, as well as use of the disclosed compositions in the manufacture of medicaments for use in a variety of in vitro and/or in vivo therapeutic methodologies.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: March 2, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Arun Srivastava, Li Zhong, Sergei Zolotukhin, George Vladimirovich Aslanidi, Mavis Agbandje-McKenna, Kim M. Van Vliet, Chen Ling
  • Patent number: 10936928
    Abstract: Devices and methods for detecting credit card skimmers are provided herein. A device can include a printed circuit board having a pattern of electrical traces on its surface, and a computer readable medium comprising instructions that cause a processor to direct an electrical voltage to a trace and detect an electrical current between two points of the trace. A gap can be disposed between the two points across which a voltage is applied in order to detect a magnetic reader. A count of the detected magnetic readers within a credit card reading device may be indicative of the presence of a credit card skimmer.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: March 2, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Walter N. Scaife, Patrick G. Traynor, Christian Peeters
  • Publication number: 20210052260
    Abstract: Disclosed herein is a unique surgical device that assists medical practitioners to stabilize and support their hand while conducting a surgical procedure. Specifically exemplified is a hand stabilizing device that includes a stem, having a shaft, a bent portion, and a base portion. The device may also be flexible. The device serves to support and stabilize the hand during a surgical procedure.
    Type: Application
    Filed: March 11, 2019
    Publication date: February 25, 2021
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Abigail ESTELLE, Laurent GANRY
  • Patent number: 10927150
    Abstract: Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: February 23, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: George Vladimirovich Aslanidi, Kim M. Van Vliet, Mavis Agbandje-McKenna, Arun Srivastava