Abstract: Various embodiments provide a robust backdoor attack on machine learning (ML)-based detection systems that can be applied to demonstrate and identify vulnerabilities thereof. In various embodiments, an artificial intelligence (AI)-based Trojan attack is generated and implanted inside a ML model trained for classification and/or detection tasks, and the AI-based Trojan attack can be triggered by specific inputs to manipulate the expected outputs of the ML model. Analysis of the behavior of an ML model having the AI-based Trojan implanted (and/or triggered) then enables identification of vulnerabilities of the ML model and further enables the design of ML models with improved security. Various embodiments of the present disclosure provide a fast and cost-effective solution in achieving 100% attack success rate that significantly outperforms adversarial attacks on ML models, thereby improving applicability and depth in testing ML-based detection systems.

Abstract: Provided herein are co-assembling peptides which may form granules under stimulating conditions. Also provided herein are protein carrying granules. Further provided herein, are methods of making each of the co-assembling peptides and granules.

Abstract: In one aspect, the disclosure relates to a super high frequency (SHF) or extremely high frequency (EHF) bulk acoustic resonator that includes a nanostructure, wherein the nanostructure includes a substrate, a three-dimensional structure disposed on the substrate, wherein the three-dimensional structure includes a planar structure including at least one nanocomponent and a matrix material contacting the nanocomponent on at least one side, the matrix material including an SiGe alloy or Ge. The disclosed bulk acoustic resonator operates at frequencies of from about 100 MHz to about 100 GHz, is capable of self-amplification upon application of direct current or voltage, and has a Q factor amplification exceeding 1. Also disclosed are methods for amplification of mechanical resonance in the disclosed bulk acoustic resonators and devices incorporating the bulk acoustic resonators.

Abstract: Embodiments of the present disclosure integrate magnetoelectric nanowire arrays within antenna assemblies to form ultra-compact antennas. An exemplary method comprises using a dielectrophoretic force to orient a magnetoelectric nanowire across an electrode gap separating a pair of electrodes; and transmitting or receiving electromagnetic waves through a magnetoelectric effect of the magnetoelectric nanowire. Other methods, apparatuses, and systems are also presented.

Abstract: The disclosure provides chimeric antigen receptors (CARs), T cells comprising such CARs, nucleic acids that encode such CARS, and methods of use thereof, e.g., to treat cancer such as B cell malignancies.

Abstract: In some aspects, the disclosure relates to compositions and methods useful for maintaining or improving retinal function and/or morphology. The disclosure is based, in part, on isolated nucleic acids encoding certain neurotrophic factors (e.g., leukemia inhibitory factor (LIF), etc.) and gene therapy vectors (e.g., recombinant adeno-associated virus (rAAV) vectors) encoding the same. In some embodiments, isolated nucleic acids and gene therapy vectors described by the disclosure are useful for treatment of certain diseases or disorders of the eye, for example retinal degeneration, retinitis pigmentosa (RP), age-related macular degeneration (AMD), glaucoma, etc.

Abstract: Disclosed herein are methods and uses of the polypharmacological modulator SR1903 and related compounds for inhibiting triggering receptor expressed on myeloid cells-1 (TREM-1) and treating diseases and conditions that are related to or mediated by TREM-1, such as inflammatory diseases, autoimmune diseases, metabolic disorders, and castration resistant prostate cancer (CRPC).

Abstract: Aspects of the disclosure relate to compositions and methods for the diagnosis and/or treatment of certain neurodegenerative diseases, for example those diseases associated with repeat-associated non-ATG (RAN) translation proteins, such as Alzheimer's disease (AD). In some embodiments, the disclosure relates to identifying a subject having a RAN protein-associated disease by detecting expression or activity of repeat-associated non-ATG (RAN) translation proteins (e.g., RAN proteins). In some embodiments, the disclosure relates to methods of treating a RAN protein-associated disease by administering to a subject in need thereof an agent that reduces expression or activity of RAN proteins.

Abstract: Methods and compositions for modulating repeat non-ATG protein (RAN protein) translation are provided. In some aspects, the disclosure relates to methods for treating a subject having a disease associated with RAN protein translation by administering the subject a modulator of eIF3 or an eIF3 subunit, or an antibody that bind to a RAN protein.

Abstract: Disclosed herein is a method for forming an anti-microbial layer on an apparatus. Also disclosed is a method for improving the anti-bacterial properties of a titanium device coated with titanium-nitride (TiN). Also disclosed is a medical apparatus comprising an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.

Abstract: The present disclosure presents systems, apparatuses, and methods of active flow controls for dissipating tip vortices. In this regard, a method comprises positioning one or more fan-shaped plasma actuators on an end surface of a tip of one or more airfoils of an aircraft, wherein the fan-shaped plasma actuators are surface compliant with the surface of the tip of the one or more airfoils; and activating the one or more fan-shaped plasma actuators during a flight of the aircraft, wherein at least one tip vortex generated by a flight of the aircraft is reduced by an introduction of one or more vortices generated by the one or more fan-shaped plasma actuators on the end surface of the tip of the one or more airfoils of the aircraft. Other systems, apparatuses, and methods are also presented.

Abstract: Provided herein are methods and compositions for expressing Otoferlin, e.g., utilizing adeno-associated viral (AAV) particles. Such methods and compositions may be useful for treatment of diseases such as Deafness, Autosomal Recessive 9 (DFNB9).

Abstract: Described herein are new dual sigma receptor and dopamine transporter small molecule antagonists. As these compounds are antagonists of both sigma receptors and dopamine transporters, these compounds dose-dependently antagonize stimulant self-administration and also diminish the effects of stimulant effects on dopamine level, thus indicating minimal abuse liability.

Abstract: Aspects of the disclosure relate to methods and compositions useful for treating retinitis pigmentosa. In some aspects, the disclosure provides compositions and methods for delivering an interfering RNA to a subject in order to reduce expression of one or both alleles of an endogenous RHO gene (for example a mutant rho allele associated with retinitis pigmentosa) in a subject. In some embodiments, a replacement RHO coding sequence that is resistant to the interfering RNA also is delivered to the subject.

Abstract: Embodiments of the present disclosure provide unmanned aerial vehicle-based measurement techniques for building envelope surfaces One such method comprises acquiring, by an unmanned aerial vehicle, an air velocity measurement at an external surface of the high-rise building at a point on the external surface; acquiring, by the unmanned aerial vehicle, an external temperature at the external surface of the high-rise building at the point on the external surface; acquiring, by an infrared camera sensor of the unmanned aerial vehicle, IR measurements at the external surface of the high-rise building at the point on the external surface; and transferring, by the unmanned aerial vehicle, the IR measurements and the external air velocity and temperature measurements to a remote base station, wherein a current thermal performance of the external surface of the high-rise building is determined using the external air velocity, temperature, and IR measurements.

Abstract: The present disclosure relates to compositions and methods for the treatment of cardiomyopathy. Several embodiments provided for herein relate to virally-mediated transfer of a gene to host cells to induce expression of an encoded polypeptide, protein or other product in order to ameliorate one or more symptoms of the cardiomyopathy in a subject. In several embodiments, the disclosed methods and compositions relate to recombinant adeno-associated virus particles encoding human RBM20 in order to treat cardiomyopathies, including dilated cardiomyopathy.

Abstract: Methods, apparatus, systems, and computer program products for providing patient predictions are provided in various embodiments. Responsive to receiving an indication of initiation of a patient interaction, a model for the patient is initiated by an assessment computing entity. The model has been trained using machine learning and the model is configured to generate a prediction for the patient. The prediction comprises at least one of an acuity score or a mortality prediction. Responsive to identifying a prediction trigger, the assessment computing entity updates the model for the patient based at least in part on medical data corresponding to the patient. The assessment computing entity generates the prediction using the updated deep learning model. The assessment computing entity provides at least a portion of the prediction such that the at least a portion of the prediction may be used to update an electronic health record corresponding to the patient and/or provided to a clinician for review.

Abstract: The present disclosure relates to compositions and methods for the treatment of cardiomyopathy. Several embodiments provided for herein relate to virally-mediated transfer of a gene to host cells to induce expression of an encoded polypeptide, protein or other product in order to ameliorate one or more symptoms of the cardiomyopathy in a subject. In several embodiments, the disclosed methods and compositions relate to recombinant adeno-associated virus particles encoding human TMEM43 in order to treat Arrhythmogenic cardiomyopathy.

Abstract: The present disclosure relates to compositions and methods for the treatment of cardiomyopathy. Several embodiments provided for herein relate to virally-mediated transfer of a gene to host cells to induce expression of an encoded polypeptide, protein or other product to host in order to ameliorate one or more symptoms of the cardiomyopathy. In several embodiments, the methods and compositions relate to recombinant adeno-associated virus particles encoding human TNNT2 in order to treat cardiomyopathies, including dilated cardiomyopathy or hypertrophic cardiomyopathy.