Patents Assigned to University of Florida Research Foundation, Inc.
  • Patent number: 11505470
    Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. Described herein are methods of producing cerium-oxide nanoclusters. Described herein are cerium-oxide nanoclusters. Further described herein are cerium-oxide nanoclusters produced by methods as described herein. Methods as described herein can comprise providing a first cerium source, an organic acid, and a solvent; and mixing the cerium source and the organic acid in the presence of a solvent to create a reaction mixture at a temperature and a pressure for a period of time to create a composition of molecular cerium-oxide nanoclusters containing a plurality of molecular cerium-oxide nanoclusters.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: November 22, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: George Christou, Bradley Keith Russell-Webster
  • Patent number: 11497937
    Abstract: A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: November 15, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: James F. Dempsey
  • Patent number: 11491257
    Abstract: Embodiments of the present disclosure provide for structures including an alloy of calcium, strontium, and magnesium.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 8, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Michele Viola Manuel, Ida E. Svensson Berglund, Benjamin G. Keselowsky, Malisa Sarntinoranont, Harpreet Singh Brar, Hunter B. Henderson
  • Patent number: 11485704
    Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of terpenoid cores. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising a terpenoid core or scaffold, such as 6/7/5 tricycloalkanes. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to tunably and scalably assemble common terpenoid cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: November 1, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Alexander James Grenning, Sarah Scott
  • Publication number: 20220340557
    Abstract: The present disclosure provides compounds of Formula (I?), Formula (II), and Formula (III). The compounds described herein may useful in treating and/or preventing protozoan infections in a subject in need thereof, treating and/or preventing trypanosomal infections (e.g., Trypanosoma cruzi (T. cruzi) or Trypanosoma brucei infections) and/or plasmodial infections in a subject in need thereof, treating and/or preventing diseases in a subject in need thereof (e.g., Chagas disease, malaria, and/or sleeping sickness), and may be useful in treating and/or preventing infectious diseases in a subject in need thereof. Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including a compound described herein.
    Type: Application
    Filed: November 22, 2021
    Publication date: October 27, 2022
    Applicants: Memorial Sloan-Kettering Cancer Center, The Regents of the University of California, University of Central Florida Research Foundation, Inc., The Broad Institute, Inc.
    Inventors: Derek Shieh Tan, Corinne N. Foley, Gustavo Moura-Letts, James McKerrow, Sivaraman Dandapani, Rahul Edwankar, Alyssa Verano, Debopam Chakrabarti, Bracken Roberts
  • Patent number: 11480614
    Abstract: The present disclosure describes exemplary methods and systems that are applicable for hardware authentication, counterfeit detection, and in-field tamper detection in both printed circuit board and/or integrated circuit levels by utilizing random variations in boundary-scan path delay and/or current in the industry-standard JTAG-based design-for-test structure to generate unique device identifiers.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: October 25, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Swarup Bhunia, Shubhra Deb Paul
  • Patent number: 11480527
    Abstract: Described are chromogenic sensors, methods of use, and kits including sensors. The sensors can have a polymer structure with a waveform cross-section in a programmed state. Upon exposure to a first liquid, the polymer structure in the programmed state changes to polymer structure in an activated state. Methods for measuring the presence of a liquid using the sensor are described, as are kits including the sensors.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: October 25, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Peng Jiang, Zhuxiao Gu, Sin-Yen Leo
  • Patent number: 11480714
    Abstract: In one aspect, the present disclosure relates to a contact lens comprising a disclosed lubricious surface layer. In a further aspect, the lubricious surface layer comprises a polyacrylamide, e.g., a poly(N,N-dimethylacrylamide. In various aspects, the lubricious surface layer is formed at the surface of a contact lens. In a further aspect, the lens can be a hydrogel lens. In a further aspect, the lens can be a silicone hydrogel lens. The present disclosure also pertains to methods of forming the disclosed lubricious surface layers on a surface of a contact lens. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: October 25, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Kuan-Hui Hsu, Yifan Yu
  • Patent number: 11475168
    Abstract: Various examples are provided related to power side-channel vulnerability assessment. In one example, a method includes identifying target registers in an IC design; generating input patterns associated with a target function that can generate a power difference in the target registers when processing the target function; determining a side-channel vulnerability (SCV) metric using the power difference produced by the input patterns; and identifying a vulnerability in the IC design using the SCV metric. Identification of the vulnerability allows for modification of the IC design at an early stage, which can avoid power side-channel attacks (e.g., DPA and CPA) in the fabricated IC design. The method can be used for pre-silicon power side-channel leakage assessment of IC designs such as, e.g., cryptographic and non-cryptographic circuits.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: October 18, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mark M. Tehranipoor, Adib Nahiyan, Domenic J. Forte, Jungmin Park
  • Patent number: 11467094
    Abstract: Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: October 11, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Sin Yen Leo, Peng Jiang, Tianwei Xie
  • Patent number: 11466260
    Abstract: The invention pertains to a PPA from a microorganism belonging to the family Halobacteriaceae (HPPA), for example, a PPA from Haloferax volcanii. The HPPA provided by the invention is soluble, thermostable and active at high concentrations of salt and/or organic solvent. An embodiment of the invention provides a method of increasing the rate of a reaction by adding an HPPA to the reaction mixture, wherein the reaction produces PPi, for example, an enzymatic reaction, and wherein the reaction is carried out at moderately high temperature and/or low water activity. Further embodiments of the invention provide an assay to detect the PPi released during a reaction which produces PPi by adding an HPPA to convert the PPi in to Pi and measuring the resultant Pi. The invention further pertains to an assay to monitor a reaction which produces PPi in the presence or the absence of an HPPA.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: October 11, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Julie A. Maupin-Furlow, Nathaniel L. Hepowit, Lana McMillan
  • Patent number: 11435333
    Abstract: Nanoparticles and compositions thereof are provided for detecting and/or preventing food spoilage. Methods of making the nanoparticles and compositions, and methods of using the nanoparticles and compositions, e.g. in food packaging, are also provided. The nanoparticles can have a hydrophobic core containing a hydrophobic active agent, e.g. a hydrophobic dye and/or an antimicrobial agent, for detecting and/or preventing food spoilage. The nanoparticles can also have a copolymer of a hydrophobic polymer repeat unit, e.g. styrene or lactic acid, and a pH responsive dendrimer repeat unit. The pH responsive dendrimer repeat unit can have a pH responsive amine core having a plurality of branched acrylate arms extending therefrom. The nanoparticles can be chemically stable at neutral pH, and then release the hydrophobic active agent at a pH range indicative of food spoilage. By releasing the hydrophobic dye and/or antimicrobial agent, the nanoparticles can detect and/or inhibit food spoilage.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 6, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Zhaohui Tong, Suguna Jairam
  • Patent number: 11434281
    Abstract: Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, phosphorylated tau epitopes. Also disclosed are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: September 6, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Benoit Giasson, Todd Eliot Golde, Yona Levites
  • Patent number: 11434195
    Abstract: Compounds, pharmaceutical compositions, and methods for treating cancer, in particular brain cancer, are provided, including amphiphilic fatty acid/alcohol ethers (AIPs) comprising endocannabinoid and FABP motifs covalently linked to a beta-adrenoreceptor antagonist motif in one molecule. The invention includes methods for inhibiting growth of brain cancer cells by contacting the compound(s) with brain cancer cells. The invention provides a method for treating both brain cancer and brain cancer metastases, and for suppression of regrowth of brain cancer cells after radiation, surgical treatment, or chemotherapy of brain cancer. The invention also comprises an optimized chemical synthesis of the AIP compounds and methods of using the compounds, alone or in combination with another agent, for suppressing the growth of brain cancer cells, and enhancing survival of normal CNS cells, or improving recuperation from radiation, surgical or chemotherapy.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: September 6, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventor: Stanislav Igorevich Svetlov
  • Patent number: 11424271
    Abstract: Various examples are provided related to hydrogen plasma treatment of hafnium oxide. In one example, a method includes depositing a monolayer of a precursor on a first oxide monolayer; forming a second oxide monolayer by applying an oxygen (O2) plasma to the monolayer of the precursor; and creating oxygen vacancies in the second oxide monolayer by applying a hydrogen (H2) plasma to the second oxide monolayer. In another example, a device includes a hafnium oxide (HfO2) based ferroelectric thin film on a first side of a substrate and an electrode layer disposed on the HfO2 based ferroelectric thin film opposite the substrate. The HfO2 film includes a plurality of oxide monolayers including at least one HfO2 monolayer, each of the plurality of oxide monolayers having oxygen vacancies distributed throughout that oxide monolayer.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: August 23, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Toshikazu Nishida, Saeed Moghaddam, Glen H. Walters, Aniruddh Shekhawat
  • Patent number: 11406594
    Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: August 9, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Russell Macoon
  • Patent number: 11406607
    Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: August 9, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Phillip J. Dixon
  • Patent number: 11390835
    Abstract: A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. Cells may be placed in the three-dimensional cell growth medium according to any shape or geometry, and may remain in place within the three-dimensional cell growth medium.
    Type: Grant
    Filed: May 7, 2016
    Date of Patent: July 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Wallace Gregory Sawyer, Thomas Ettor Angelini, Steven Craig Ghivizzani, Tapomoy Bhattacharjee, Glyn Daniel Palmer
  • Patent number: 11390840
    Abstract: Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication with the first portion and is configured to receive cells from the first portion; an electrode can be present in the first portion, second portion, or both; a porous membrane can separate the first and second portions, the porous membrane can have one or more pores, and the pores can have one or more interior surfaces configured to allow cells from the first portion to pass through to the second portion; an electric generating device in electrical communication with one or more electrodes, the membrane, or the one or more electrodes and the membrane, wherein the electric generating device is configured to deliver constant voltage or one or more electric pulses to the system.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Charles R. Martin, Juliette Experton, Aaron G. Wilson
  • Patent number: 11390847
    Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: July 19, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: John Hardy, Christine E. Schmidt