Patents Assigned to University of Florida Research Foundation, Inc.
  • Patent number: 11117810
    Abstract: Disclosed herein is a method comprising heating a strontium-containing compound using radiation in a first reactor; decomposing the strontium-containing compound into an oxide and carbon dioxide as a result of heat generated by the exposure to the radiation; reacting the oxide and the carbon dioxide in a second reactor; where the oxide and carbon dioxide react to produce heat; heating a working fluid using the heat produced in the second reactor; and driving a turbine with the heated working fluid to generate energy. Disclosed herein too is a composition comprising strontium carbonate; and strontium zirconate; where the mass ratio of strontium carbonate to strontium zirconate 2:8 to 8:2.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: September 14, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: James Klausner, Kelvin Fnu Randhir, Nicholas AuYueng, Like Li, Nathan Rhodes, Amey Anand Barde, Renwei Mei, David Worthington Hahn
  • Patent number: 11109808
    Abstract: Various examples are provided for intelligent mouthguards that can be used in fitness and sport activities. In one example, an intelligent mouthguard system includes a mouthguard including sensors and an internal module in communication with the sensors. The sensors can include a nine-axis inertial sensor comprising a three-axis magnetometer, a three-axis accelerometer and a three-axis gyroscope. The three-axis magnetometer can provide a reference plane in relation to the earth's magnetic field for the three-axis accelerometer and the three-axis gyroscope. The internal module can provide sensor data to an external processing unit when located in an oral cavity.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: September 7, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Yong Kyu Yoon, Justin M. Correll, Todd R. Schumann, Sheng-Po Fang, Fong Wong
  • Patent number: 11105498
    Abstract: Various embodiments relate to combined heat and power (CHP) systems. A CHP system can include a turbine system, a turbocharger system, and a refrigeration system. The refrigeration system can receive combustion products from the turbine system and compressed air from the turbocharger system. The refrigeration system can cool the combustion products and the compressed air to generate a cooled combustion product mixture that is provided to the turbine system.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: August 31, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: William E. Lear
  • Patent number: 11087058
    Abstract: Embodiments of systems and methods for an FIB-aware anti-probing physical design flow are described in the present disclosure. Such embodiments incorporate new and improved security-critical steps in a physical design flow, in which the design is constrained to provide coverage on asset nets through an internal shield.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: August 10, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Domenic J. Forte, Mark M. Tehranipoor, Qihang Shi, Huanyu Wang, Haoting Shen
  • Patent number: 11078380
    Abstract: A method of CMP includes providing a slurry solution including ?1 per-compound oxidizer in a concentration between 0.01 M and 2 M with a pH from 2 to 5 or 8 to 11, and ?1 buffering agent which provides a buffering ratio ?1.5 that compares an amount of a strong acid needed to reduce the pH from 9.0 to 3.0 as compared to an amount of strong acid to change the pH from 9.0 to 3.0 without the buffering agent. The slurry solution is exclusive any hard slurry particles or has only soft slurry particles that have throughout a Vickers hardness <300 Kg/mm2 or Mohs Hardness <4. The slurry solution is dispensed on a hard surface having a Vickers hardness >1,000 kg/mm2 is pressed by a polishing pad with the slurry solution in between while rotating the polishing pad relative to the hard surface.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: August 3, 2021
    Assignees: Entegris, Inc., University of Florida Research Foundation, Inc.
    Inventors: Rajiv K. Singh, Arul Arjunan, Deepika Singh, Chaitanya Ginde, Puneet N. Jawali
  • Patent number: 11077270
    Abstract: An article includes a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface. The first plurality of spaced features are arranged in a plurality of groupings. The groupings of features comprise repeat units, where the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 3, 2021
    Assignees: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., SHARKLET TECHNOLOGIES, INC.
    Inventors: Chelsea Marie Magin, Shravanthi T. Reddy, Anthony B. Brennan, Rhea Marie May, Ethan Eugene Mann, Michael Ryan Mettetal
  • Patent number: 11066545
    Abstract: Embodiments of the present disclosure provide for lubricious structures (also referred to simply as “structure”), methods of making lubricious structures, methods of using lubricious structures, and the like.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: July 20, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Scott S. Perry, Alexander Rudy, Wallace Gregory Sawyer, Thomas Ettor Angelini
  • Patent number: 11069033
    Abstract: Various embodiments for image denoising using a convolutional neural network (CCN) are described. A system may include at least one computing device and program instructions stored in memory and executable in the at least one computing device that, when executed, direct the at least one computing device to implement a genetic algorithm (GA) routine that identifies and optimizes a plurality of hyperparameters for use in denoising an image using the convolutional neural network. An image may be denoised using the convolutional neural network, where the image is denoised using the hyperparameters identified and optimized in the genetic algorithm routine.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: July 20, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Ruogu Fang, Peng Liu
  • Patent number: 11065266
    Abstract: The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-? and/or PKC-?. Non-limiting examples of an inhibitor of PKC-? and/or PKC-? include ICA-1 and ACPD. The invention also provides PKC-? and/or PKC-? as biomarkers for identifying a melanoma in a subject as likely to be responsive or non-responsive to a therapy using an inhibitor of PKC-? and/or PKC-?. Accordingly, a method of identifying a subject having a melanoma as being responsive or non-responsive to a melanoma therapy with an inhibitor of PKC-? and/or PKC-? based on the levels and/or activity of PKC-? and/or PKC-? mRNA or protein in the melanoma cells from the subject are also provided.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: July 20, 2021
    Assignees: UNIVERSITY OF SOUTH FLORIDA, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Mildred Enid Acevedo-Duncan, Wishrawana Sarathi Ratnayake, David A. Ostrov
  • Patent number: 11051976
    Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 ?m and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 ?m.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Kuan-Hui Hsu
  • Patent number: 11053572
    Abstract: Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Michele Manuel, Josephine Allen, Jordan P. Ball, Harpreet Singh Brar, Ida Svensson Berglund
  • Patent number: 11055614
    Abstract: Disclosed are various embodiments of memristive devices comprising a number of nodes. Memristive fibers are used to form conductive and memristive paths in the devices. Each memristive fiber may couple one or more nodes to one or more other nodes. In one case, a memristive device includes a first node, a second node, and a memristive fiber. The memristive fiber includes a conductive core and a memristive shell surrounding at least a portion of the conductive core along at least a portion of the memristive fiber. The memristive fiber couples the first node to the second node through a portion of the memristive shell and at least a portion of the conductive core.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: July 6, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Juan Claudio Nino, Jack Kendall
  • Patent number: 11051702
    Abstract: Various examples are provided for non-contact vital sign acquisition. Information can be provided regarding vibrations of a target using a radar signal such as, e.g., non-contact vital sign measurement. Examples include estimation of heart rate, change in heart rate, respiration rate, and/or change in respiration rate, for a human or other animal. Implementations can produce one or both rates of vibration and/or change in one or both rates of vibration for a target other than an animal or human experiencing two vibrations at the same time, such as a motor, a vehicle incorporating a motor, or another physical object. Some implementations can estimate the respiration movement in the radar baseband output signal. The estimated respiration signal can then be subtracted from radar signals in the time domain and, optionally, can be further enhanced using digital signal processing techniques, to produce an estimate of the heartbeat pulses.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: July 6, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jenshan Lin, Changyu Wei
  • Patent number: 11043142
    Abstract: Methods, systems, and computer instructions for virtual radiation oncology training are provided. The methods can allow for screening of many virtual patients in a clinical setting for radiation oncology training. The methods, system, and computer instructions can include receiving a medical record for a virtual patient, presenting the medical record to a trainee, receiving a treatment plan for the virtual patient from the trainee indicating an area to be treated and dose constraints, and computing one or more comparison metrics for the treatment plan.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 22, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Frank J. Bova, Sanford L. Meeks, Twyla R. Willoughby
  • Patent number: 11033457
    Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: June 15, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Phillip J. Dixon, Poorvajan Sekar
  • Patent number: 11027483
    Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: June 8, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Joshua Muse, Meghan Hughes, Carl David Crane, Thomas Ettor Angelini, Kyle D. Schulze, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Curtis Taylor
  • Patent number: 11021724
    Abstract: The subject invention concerns materials and methods for alkene reduction of compounds, such as levoglucosenone (LGO) and (S)-?-hydroxymethyl-?,?-butenolide (HBO), using an alkene reductase enzyme. In one embodiment, a method of the invention comprises alkene reduction of a target compound by reacting the compound with an Old Yellow Enzyme (OYE) that reduces alkene bonds. In one embodiment, the OYE is OYE 2.6 from Pichia stipites and comprises the amino acid sequence of SEQ ID NO: I. In a specific embodiment, the enzyme is an Old Yellow Enzyme (OYE) 2.6 mutant having an amino acid substitution at position 78 in the sequence, wherein the tyrosine at position 78 is substituted with a tryptophan amino acid (Y78W) and is designated as OYE 2.6 Y78W (SEQ ID NO:2).
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: June 1, 2021
    Assignees: University of Florida Research Foundation, Inc., AfroParisTech
    Inventors: Jon Dale Stewart, Florent Allais, Louis Michel Marie Mouterde
  • Patent number: 11022615
    Abstract: The invention pertains to methods of isolating a Treg from a subject, the method comprising the steps of analyzing a sample of cells obtained from the subject to determine the level of expression of polypeptides and/or polynucleotides corresponding to proteins CD 127, CD4, CD25, and CD226 and isolating, as the Treg, a cell which expresses CD4 and CD25, expresses low levels of CD 127 or does not express CD 127, and expresses low levels of CD226 or does not express CD226. The Treg isolated from a subject can be proliferated in vitro. Accordingly, the invention also provides compositions comprising Treg isolated/proliferated according to the methods of the invention and pharmaceutically acceptable carrier and/or excipient. The pharmaceutical compositions can be used to treat and/or prevent inflammation mediated disease, for example, autoimmune diseases, such as, systemic lupus erythmatosus, rheumatoid arthritis, Multiple Sclerosis, type 1 diabetes, or inflammatory bowel disease.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 1, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Todd M. Brusko, Christopher Fuhrman, Howard R. Seay
  • Patent number: 11015237
    Abstract: Disclosed herein is a shape memory alloy comprising 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium. Disclosed herein too is a method of manufacturing a shape memory alloy comprising mixing together to form an alloy nickel, hafnium, aluminum and titanium in amounts of 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium; solution treating the alloy at a temperature of 700 to 1300° C. for 50 to 200 hours; and aging the alloy at a temperature of 400 to 800° C. for a time period of 50 to 200 hours to form a shape memory alloy.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: May 25, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Michele Viola Manuel, Derek Hsen Dai Hsu
  • Patent number: 11014876
    Abstract: Cancer is a disease for which there remains a great unmet medical need, and therefore the discovery and development of new antineoplastic agents is critically important. The present invention relates in part to new therapeutic compounds with antineoplastic activity. Provided herein are polyamine sulfonamides such as compounds of Formula (I), or pharmaceutically acceptable salts thereof, which may be used in the treatment and/or prevention of diseases such as cancer. Also provided herein are pharmaceutical compositions and kits comprising the inventive compounds. Furthermore, the present invention provides methods of treating and/or preventing diseases (e.g., cancer) using compounds of Formula (I), or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof. Other methods provided include methods for inducing apoptosis of a cell, as well as methods for inhibiting alpha-enolase enzymatic activity in vivo and in vitro.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: May 25, 2021
    Assignees: University of Florida Research Foundation, Inc., Torrey Pines Institute for Molecular Studies
    Inventors: Christopher R. Cogle, Amy M. Meacham, Peter P. Sayeski, Marcello A. Giulianotti, Richard A. Houghten, Gregory S. Welmaker