Patents Assigned to University of Florida
  • METHODS AND APPARATUSES FOR FREEFORM ADDITIVE MANUFACTURING OF ENGINEERING POLYMERS
    Publication number: 20230330917
    Abstract: A polymer three-dimensional (3D) printing methodology is disclosed for freeform fabrication of polymeric structures under ambient conditions without the use of printed support structures. The build material can be dissolved in a suitable solvent for 3D printing. The polymer solution can be printed in (e.g., continuously printed using a moving dispensing nozzle) a yield-stress support bath to form an intermediate article. The intermediate article may be liquid or only partially coagulated after being printed into the yield-stress support bath. The yield-stress support bath may be at least partially disposed within a container, and the container may be immersed in a post-treatment coagulation solution to remove some or all of the solvent, causing the build material to fully solidify to form a finished article from the intermediate article.
    Type: Application
    Filed: June 20, 2023
    Publication date: October 19, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Yong HUANG, Ashley M. COMPAAN, Kaidong SONG
  • Photo-redox titanium containing organic frameworks and methods of making and use thereof
    Patent number: 11786890
    Abstract: Disclosed herein are metal-organic frameworks and methods of making and use thereof.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 17, 2023
    Assignees: FLORIDA STATE UNIVERSITY, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Fernando Javier Uribe-Romo, Matthew W. Logan, Kenneth Hanson, Suliman Ayad
  • Induction of protective immunity against antigens
    Patent number: 11788056
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: October 17, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • Chimeric antigen receptor t-cells expressing interleukin-8 receptor
    Patent number: 11788093
    Abstract: An IL-8 receptor (e.g., CXCR1 or CXCR2) modified CAR T cell is provided, as well as a nucleic acid encoding the IL-8 modified CAR T cell and method of use.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: October 17, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jianping Huang, Linchun Jin
  • AMERICAN CHESTNUT LEAF COMPOSITIONS COMPRISING OXALATE OXIDASE AND METHODS FOR TREATMENT OF OXALATE-RELATED DISORDERS
    Publication number: 20230321202
    Abstract: The invention provides American chestnut leaf compositions comprising oxalate oxidase. The compositions reduce oxalate levels in dietary sources of oxalate and are useful in reducing oxalate levels and reducing stone disease in patients. The invention provides methods of extracting and purifying oxalate oxidase from American chestnut leaf. The invention provides methods of extracting oxalate from biological samples.
    Type: Application
    Filed: March 16, 2023
    Publication date: October 12, 2023
    Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED, The Research Foundation for The State University of New York (RFSUNY)
    Inventors: Paul R. Dominguez-Gutierrez, William L. Donelan, Tania Quesada, William A. Powell
  • Self-repairing metal alloy matrix composites, methods of manufacture and use thereof and articles comprising the same
    Patent number: 11781206
    Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.
    Type: Grant
    Filed: April 28, 2022
    Date of Patent: October 10, 2023
    Assignees: University of Florida Research Foundation, Inc., United States Of America As Represented By The Administrator of NASA
    Inventors: Michele Viola Manuel, Charles Robert Fisher, Maria Clara Wright
  • Method for producing nanoparticles and the nanoparticles produced therefrom
    Patent number: 11781199
    Abstract: Disclosed herein is a method comprising disposing a container containing a metal and/or ferromagnetic solid and abrasive particles in a static magnetic field; where the container is surrounded by an induction coil; activating the induction coil with an electrical current, to heat up the metallic or ferromagnetic solid to form a fluid; generating sonic energy to produce acoustic cavitation and abrasion between the abrasive particles and the container; and producing nanoparticles that comprise elements from the container, the metal and/or the ferromagnetic solid and the abrasive particles. Disclosed herein too is a composition comprising first metal or a first ceramic; and particles comprising carbides and/or nitrides dispersed therein. Disclosed herein too is a composition comprising nanoparticles comprising chromium carbide, iron carbide, nickel carbide, ?-Fe and magnesium nitride.
    Type: Grant
    Filed: February 23, 2023
    Date of Patent: October 10, 2023
    Assignees: University of Florida Research Foundation, Inc., UT-BATTELLE, LLC
    Inventors: Michele Viola Manuel, Hunter B. Henderson, Orlando Rios, Gerard M. Ludtka
  • Methods and sensors for detection
    Patent number: 11781993
    Abstract: Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.
    Type: Grant
    Filed: September 6, 2022
    Date of Patent: October 10, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Sin Yen Leo, Peng Jiang, Tianwei Xie
  • AAV delivery of shRNA for treatment of pancreatic cancer
    Patent number: 11781142
    Abstract: Aspects of the disclosure relate to methods and compositions for treating pancreatic cancer (e.g., islet cell tumors). In some aspects, adeno-associated virus (AAV) may be used to deliver an interfering RNA that targets thymidylate synthase (TS).
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: October 10, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Maria Zajac-Kaye, Kyungah Maeng
  • METHODS OF PACKAGING MULTIPLE ADENO-ASSOCIATED VIRUS VECTORS
    Publication number: 20230313230
    Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.
    Type: Application
    Filed: November 28, 2022
    Publication date: October 5, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Barry John Byrne, Phillip A. Doerfler, Nathalie Clement
  • Compositions, methods of treatment, and containers including compositions
    Patent number: 11771665
    Abstract: Compositions for treatment of cystinosis, products for administering eye drops, and products for storing contact lenses are provided. Compositions include solutions that can contain an effective amount of cysteamine to treat cystinosis, and an oil with a lower density than the solution. Also provided is a product including a bottle for containing a solution, the bottle being substantially free of O2. Also provided is a contact lens holder for storing one or more contact lenses in a solution, the holder including barrier layers reducing the amount of O2 entering the contact lens holder.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: October 3, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Phillip J. Dixon
  • Automatic sharpness adjustment for imaging modalities
    Patent number: 11776093
    Abstract: Systems and methods are configured to generate a frequency map representing a density of objects found in regions of a sample that may be used in setting parameters for imaging the regions. Various embodiments involve binarizing the pixels for a raw image of the sample to transform the image into binary data. Run-length encoded components are identified from the data for dimensions of the raw image. Each component is a length of a sequence of adjacent pixels found in a dimension with the same value in the binary data. A projection of the image is then generated from projection values for the dimensions. Each projection value provides a measure of the density of objects present in a dimension with respect to the components identified for the dimension. This projection is used to identify a level of density for each region of the sample from which the frequency map is generated.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: October 3, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Damon Woodard, Navid Asadizanjani, Domenic J. Forte, Ronald Wilson
  • Hardware trojan detection using path delay based side-channel analysis and reinforcement learning
    Patent number: 11775693
    Abstract: The present disclosure describes systems and methods for test pattern generation to detect a hardware Trojan using delay-based analysis. One such method comprises determining a set of initial test patterns to activate the hardware Trojan within an integrated circuit design; and generating a set of succeeding test patterns to activate the hardware Trojan within the integrated circuit design using a reinforcement learning model. The set of initial test patterns can be applied as an input to the reinforcement learning model. Further, the reinforcement learning model can be trained with a stochastic learning scheme to increase a probability of triggering one or more rare nodes in the integrated circuit design and identify optimal test vectors to maximize delay-based side-channel sensitivity when the hardware Trojan is activated in the integrated circuit design. Other methods and systems are also provided.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: October 3, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Prabhat Kumar Mishra, Jennifer Marie Sheldon, Zhixin Pan
  • TARGETED RNA DEGRADATION ALLOWS PRECISION REPURPOSING OF PROTEIN-TARGETED SMALL MOLECULE MEDICINES TO RNA
    Publication number: 20230302139
    Abstract: The protein targeted medicine, Dovitinib, has been repurposed to target a non-coding RNA by using selection and computational drug design via Inforna. Selectivity was achieved for pre-miR-21 by endowing the medicine with the ability to recruit RNA quality control enzymes to cleave the target.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 28, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventor: Matthew D. Disney
  • COMPOSITIONS AND METHODS OF DETECTION OF PRE-SYMPTOMATIC ALS
    Publication number: 20230304088
    Abstract: Aspects of the disclosure relate to methods and compositions (e.g., biomarkers) useful for diagnosing pre- symptomatic amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD), and for monitoring the progression of ALS/FTD in subjects diagnosed with the disease. Methods of treating neurodegenerative diseases (e.g., ALS/FTD) are also described.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 28, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Laura Ranum, Amrutha Pattamatta, Eric Tzy-Shi Wang, Hailey Olafson
  • Modified AAV capsid proteins and uses thereof
    Patent number: 11767346
    Abstract: Adeno associated viral (AAV) particles are emerging as a useful vehicle for gene delivery to various organs and tissues, one of them being the retina. Provided here are variant AAV (for example, variant serotype 2 (AAV2)) capsid proteins and variant capsid protein containing particles with enhanced ability to transduce retinal cells.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: September 26, 2023
    Assignees: University of Florida Research Foundation, Incorporated, The UAB Research Foundation
    Inventors: Sergei Zolotukhin, Sanford L. Boye, Shannon E. Boye, Damien Marsic, Paul D. Gamlin
  • Food safety vaccine to control and reduce in poultry
    Patent number: 11766475
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: September 26, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Soo-Young Wanda
  • High speed 3D printing system for wound and tissue replacement
    Patent number: 11766823
    Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: September 26, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
  • Lightweight and trust-aware routing in NoC based SoC architectures
    Patent number: 11770399
    Abstract: Various examples are provided related to software and hardware architectures that enable lightweight and trust-aware routing. In one example, among others, a method for trust-aware routing includes calculating trust values to represent how much a node can be trusted to route packets through its router. Each node can store the trust values of routers that are one hop and two hops away from it, which represent direct trust and delegated trust, respectively. When a router receives a packet, the router can update trust values and forward the packet to the next hop.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: September 26, 2023
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Thelijjagoda S N Charles, Prabhat Kumar Mishra
  • CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
    Publication number: 20230295319
    Abstract: Aspects of the disclosure relate to chimeric antigen receptors (CARs) comprising an antigen binding domain (e.g., anti-TSHR), transmembrane domain (e.g., CD28), and a cytoplasmic domain (e.g., CD27, CD-137, etc.) and a safety mechanism comprising an inducible apoptosis trigger. In some aspects, the disclosure relates to use of the CARs in T cells, compositions, kits and methods for the treatment of thyroid cancers.
    Type: Application
    Filed: March 6, 2023
    Publication date: September 21, 2023
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Scott A. Rivkees, Christopher Wendler, Lung-Ji Chang