Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.

Abstract: The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.

Abstract: The lack of clear predictors of prostate cancer progression leads to subjective decision-making regarding courses of treatment. The identification of new biomarkers that are predictive of recurrence after radical prostatectomy would advance the field of prostate cancer treatment. Disclosed are miRNAs that can be used as molecular biomarkers to detect or predict the progression of prostate cancer and to adjust a treatment plan accordingly. Furthermore, kits are included for the detection of these miRNAs.

Abstract: The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.

Abstract: A method for the precise measuring operating of a micro-mechanical rotation rate sensor, including at least one seismic mass, at least one drive device for driving the seismic mass in the primary mode (q1) and at least three trimming electrode elements which are jointly associated directly or indirectly with the seismic mass. An electric trimming voltage (u1, u2, u3, u4) is set respectively between the trimming electrode elements and the seismic mass. Each of the electric trimming voltages (u1, u2, u3, u4) are adjusted in accordance with a resonance frequency variable (?T, ?T,0), a quadrature variable (?c, ?C,0) and a restoring variable (?S).

Abstract: To carry out satisfactory object recognition in a short time. An object recognition method in accordance with an exemplary aspect of the present invention is an object recognition method for recognizing a target object by using a preliminarily-created object model. The object recognition method generates a range image of an observed scene, detects interest points from the range image, extracts first features, the first features being features of an area containing the interest points, carries out a matching process between the first features and second features, the second features being features of an area in the range image of the object model, calculates a transformation matrix based on a result of the matching process, the transformation matrix being for projecting the second features on a coordinate system of the observed scene, and recognizes the target object with respect to the object model based on the transformation matrix.

Abstract: A method for the precise measuring operating of a micro-mechanical rotation rate sensor, including at least one seismic mass, at least one drive device for driving the seismic mass in the primary mode (q1) and at least three trimming electrode elements which are jointly associated directly or indirectly with the seismic mass. An electric trimming voltage (u1, u2, u3, u4) is set respectively between the trimming electrode elements and the seismic mass. Each of the electric trimming voltages (u1, u2, u3, u4) are adjusted in accordance with a resonance frequency variable (?T, ?T,0), a quadrature variable (?c, ?C,0) and a restoring variable (?S).

Abstract: To carry out satisfactory object recognition in a short time. An object recognition method in accordance with an exemplary aspect of the present invention is an object recognition method for recognizing a target object by using a preliminarily-created object model. The object recognition method generates a range image of an observed scene, detects interest points from the range image, extracts first features, the first features being features of an area containing the interest points, carries out a matching process between the first features and second features, the second features being features of an area in the range image of the object model, calculates a transformation matrix based on a result of the matching process, the transformation matrix being for projecting the second features on a coordinate system of the observed scene, and recognizes the target object with respect to the object model based on the transformation matrix.