Patents Assigned to University of Geneva
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Publication number: 20240085580Abstract: A Proton Computer Tomography (pCT) system comprising: a position tracker, able to reconstruct the proton trajectory within the body; an energy detector, able to reconstruct the proton energy; wherein, the position tracker is made up of four Depleted Monolithic Active Pixel Sensors (DMAPS) placed in pairs at either side of a phantom, and the energy detector is a Super Thin Range Telescope located downstream comprising a plastic-scintillator made of layers of thin polystyrene bars oriented in alternate axis, perpendicular to the proton beam.Type: ApplicationFiled: September 8, 2023Publication date: March 14, 2024Applicants: INSTITUT DE FISICA D'ALTES ENERGIES ( IFAE)-THE BARCELONA INSTITUTE OF SCIENCE AND, University of Geneva, Birmingham UniversityInventors: Thorsten Lux, Federico Joaquin Sanchez Nieto, Tony Price, César Jesús Valls, Marc Granado González
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Publication number: 20230242643Abstract: Chimeric antigen receptor (CAR) bridging protein are provided comprising a CAR-binding domain linked to an antigen-binding domain, which can be used to re-direct the targeting of CAR-T cells. The bridging protein may comprie an antigen-binding domain that targets any antigen of interest, such as, for example, a tumor antigen or viral antigen. Also provided are methods of using the bridging proteins in combination with CAR-T cells to treat a disease, such as, for example, a cancer or an infectious disease.Type: ApplicationFiled: May 27, 2021Publication date: August 3, 2023Applicants: ANTION BIOSCIENCES SA, GENEVA UNIVERSITY HOSPITALS, UNIVERSITY OF GENEVA, UNIVERSITY OF ZURICHInventors: Marco ALESSANDRINI, Karl-Heinz KRAUSE, Renier MYBURGH
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Patent number: 11654202Abstract: An iodinated CT contrast agent made of fatty acid derivatives for non-invasive visualisation and quantification of the brown and/or beige adipose tissue (BAT) or for imaging the heart and/or liver of a subject, to be taken orally which is a breakthrough in CT imaging. Image resolution by CT is significantly enhanced compared to PET.Type: GrantFiled: July 27, 2018Date of Patent: May 23, 2023Assignee: UNIVERSITY OF GENEVAInventors: Laurent Vinet, Andrej Babic, Eric Allemann
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Patent number: 11649455Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: May 16, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Patent number: 11613747Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Patent number: 11492333Abstract: Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transmigration, such as for example inflammatory diseases and disorders, autoimmune diseases and disorders, and cancers.Type: GrantFiled: August 30, 2018Date of Patent: November 8, 2022Assignees: BAR-ILAN UNIVERSITY, UNIVERSITY OF GENEVA, GENEVA UNIVERSITY HOSPITALSInventors: Arie Lev Gruzman, Paul Bradfield, Tamar Getter, Beat Imhof, Thomas Matthes, Hanoch Senderowitz
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Publication number: 20210330820Abstract: An iodinated CT contrast agent made of fatty acid derivatives for non-invasive visualisation and quantification of the brown and/or beige adipose tissue (BAT) or for imaging the heart and/or liver of a subject, to be taken orally which is a breakthrough in CT imaging. Image resolution by CT is significantly enhanced compared to PET.Type: ApplicationFiled: July 27, 2018Publication date: October 28, 2021Applicant: UNIVERSITY OF GENEVAInventors: Laurent VINET, Andrej BABIC, Eric ALLEMANN
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Publication number: 20210095278Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: ApplicationFiled: April 1, 2019Publication date: April 1, 2021Applicants: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz KRAUSE, Francis ROUSSET, Patrick SALMON, Marco ALESSANDRINI, Roberto SPECK, Simon BREDL, Tafadzwa MLAMBO, Renier MYBURGH
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Patent number: 10314913Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: GrantFiled: February 14, 2018Date of Patent: June 11, 2019Assignee: UNIVERSITY OF GENEVAInventors: Michael Moller, Thomas Trimaille, Robert Gurny
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Publication number: 20180271984Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: ApplicationFiled: February 14, 2018Publication date: September 27, 2018Applicant: UNIVERSITY OF GENEVAInventors: Michael Moller, Thomas Trimaille, Robert Gurny
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Patent number: 9925267Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: GrantFiled: May 27, 2016Date of Patent: March 27, 2018Assignee: University of GenevaInventors: Michael Moller, Thomas Trimaille, Robert Gurny
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Patent number: 9841380Abstract: This invention concerns the field of sample identification, in particular a method and apparatuses for identifying or discriminating biological species from non biological species, both as individual particles and as components of a composition, by pump-probe fluorescence spectroscopy for time-resolved detection or imaging. The method uses the finding that the UV-induced fluorescence of biological molecules is varied, in particular is depleted, by the addition of visible radiation, whereas this does not occur with non-biological organic molecules. The invention discriminates the fluorescence signals of bio and non-bio particles or species using a differential approach, i.e. the comparison. of the total fluorescence recorded with and without additional visible radiation. This allows to discriminate biological particles comprising aromatic amino-acids (AA), like peptides, proteins, bacteria, viruses, pollens, spores, etc.Type: GrantFiled: August 15, 2016Date of Patent: December 12, 2017Assignee: University of GenevaInventors: Jean-Pierre Wolf, Luigi Bonacina, Gustavo Alexandre Subtil Sousa
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Patent number: 9650635Abstract: This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the steps of (a) contacting a test compound with a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity, and optionally with one or more NADPH oxidase subunits, under conditions allowing binding of said test compound to said protein or, if present, said subunit(s); (b) optionally determining whether said test comType: GrantFiled: April 7, 2014Date of Patent: May 16, 2017Assignee: University of GenevaInventors: Karl-Heinz Krause, Botond Banfi
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Publication number: 20160367680Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: ApplicationFiled: May 27, 2016Publication date: December 22, 2016Applicant: UNIVERSITY OF GENEVAInventors: Michael MOLLER, Thomas TRIMAILLE, Robert GURNY
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Patent number: 9468683Abstract: The present invention relates to compositions and pharmaceutical compositions having a hyaluronic acid; a chitosan; and at least one ionic compound in hydrogel form, their use in medical applications and methods of making same as well as medical devices comprising same.Type: GrantFiled: August 21, 2013Date of Patent: October 18, 2016Assignee: UNIVERSITY OF GENEVAInventors: Olivier Jordan, Sema Gwendolyn Kaderli, Robert Gurny
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Patent number: 9375482Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: GrantFiled: April 22, 2014Date of Patent: June 28, 2016Assignee: University of GenevaInventors: Michael Moller, Thomas Trimaille, Robert Gurny
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Publication number: 20150073060Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: ApplicationFiled: April 22, 2014Publication date: March 12, 2015Applicant: UNIVERSITY OF GENEVAInventors: Michael MOLLER, Thomas TRIMAILLE, Robert GURNY
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Publication number: 20140356457Abstract: This invention relates to a method of identifying a modulator of an NADPH oxidase, whereby said modulator is suitable as a lead compound and/or as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing, the method comprising the steps of (a) contacting a test compound with a protein, wherein said protein (i) comprises or consists of the amino acid sequence of any one of SEQ ID NO: 1, 3 or 5, or (ii) is encoded by a nucleic acid comprising or consisting of the sequence of any one of SEQ ID NO: 2, 4, 6, 23 or 24, or (iii) is a fragment of the protein according to (i) or (ii) and exhibits NADPH oxidase activity, or (iv) has a sequence at least 75% identical with the protein according to (i) or (ii) or with the fragment according to (iii) and exhibits NADPH oxidase activity, and optionally with one or more NADPH oxidase subunits, under conditions allowing binding of said test compound to said protein or, if present, said subunit(s); (b) optionally determining whether said test comType: ApplicationFiled: April 7, 2014Publication date: December 4, 2014Applicant: UNIVERSITY OF GENEVAInventors: Karl-Heinz KRAUSE, Botond BANFI
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Patent number: 8741877Abstract: The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.Type: GrantFiled: February 26, 2013Date of Patent: June 3, 2014Assignee: University of GenevaInventors: Michael Moller, Thomas Trimaille, Robert Gurny
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Patent number: 8729228Abstract: This invention relates to a method of producing a modified (poly)peptide, said method comprising the step of modifying in an organic solvent a crown ether-bound (poly)peptide at one or more carboxylic groups by esterification or thioesterification and/or at the amino group of the N-terminal amino acid by amidation or alkylation. Furthermore provided are (poly)peptides and antibodies obtainable with the method of the invention as well as medical uses thereof.Type: GrantFiled: September 28, 2006Date of Patent: May 20, 2014Assignee: University of GenevaInventor: Paolo Botti