Patents Assigned to University of Groningen
  • Patent number: 7994281
    Abstract: The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: August 9, 2011
    Assignees: European Molecular Biology Laboratory, National University of Ireland, University of Groningen
    Inventors: Vicente R. Tur, Albert Martinus Van der Sloot, Margaret M. Mullally, Robbert H. Cool, Eva E. Szegezdi, Afshin Samali, Gregorio Fernandez-Ballester, Luis Serrano, Wilhelmus J. Quax
  • Patent number: 6821779
    Abstract: The instant methods pertain to improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in medium lacking added buffer or added protein, other embodiments feature neural cells which are maintained at 4° C. prior to cryopreservation and have comparable viability and/or functionality to freshly harvest cells. In addition, methods for storing and/or transplantation of porcine neural cells are described.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: November 23, 2004
    Assignees: University Hospital Groningen, Inc., Diacrin, Inc.
    Inventors: Jan Koopmans, Douglas B. Jacoby, Jonathan Dinsmore
  • Patent number: 6713245
    Abstract: The instant methods pertain to an improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in medium lacking added buffer or added protein, other embodiments feature neural cells which are maintained at 4° C. prior to cryopreservation and have comparable viability and/or functionality to freshly harvested cells. In addition, methods for storing and/or transplantation of porcine neural cells are described.
    Type: Grant
    Filed: July 6, 1998
    Date of Patent: March 30, 2004
    Assignees: Diacrin, Inc., University Hospital Groningen
    Inventors: Jan Koopmans, Douglas B. Jacoby, Jonathan Dinsmore