Abstract: The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
Type:
Grant
Filed:
December 6, 2004
Date of Patent:
August 9, 2011
Assignees:
European Molecular Biology Laboratory, National University of Ireland, University of Groningen
Inventors:
Vicente R. Tur, Albert Martinus Van der Sloot, Margaret M. Mullally, Robbert H. Cool, Eva E. Szegezdi, Afshin Samali, Gregorio Fernandez-Ballester, Luis Serrano, Wilhelmus J. Quax
Abstract: The instant methods pertain to improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in medium lacking added buffer or added protein, other embodiments feature neural cells which are maintained at 4° C. prior to cryopreservation and have comparable viability and/or functionality to freshly harvest cells. In addition, methods for storing and/or transplantation of porcine neural cells are described.
Type:
Grant
Filed:
August 17, 2001
Date of Patent:
November 23, 2004
Assignees:
University Hospital Groningen, Inc., Diacrin, Inc.
Inventors:
Jan Koopmans, Douglas B. Jacoby, Jonathan Dinsmore
Abstract: The instant methods pertain to an improved methods for storing neural cells, preferably dissociated neural cells, prior to their use in transplantation and to the cells obtained using such methods. One embodiment pertains to methods for storing the neural cells in medium lacking added buffer or added protein, other embodiments feature neural cells which are maintained at 4° C. prior to cryopreservation and have comparable viability and/or functionality to freshly harvested cells. In addition, methods for storing and/or transplantation of porcine neural cells are described.
Type:
Grant
Filed:
July 6, 1998
Date of Patent:
March 30, 2004
Assignees:
Diacrin, Inc., University Hospital Groningen
Inventors:
Jan Koopmans, Douglas B. Jacoby, Jonathan Dinsmore