Abstract: Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.
Type:
Grant
Filed:
May 21, 1986
Date of Patent:
September 5, 1989
Assignees:
Eli Lilly and Company, University of Hawaii
Inventors:
Richard E. Moore, Eiichi Furusawa, Ted R. Norton, Gregory M. L. Patterson, Jon S. Mynderse
Abstract: A strain of yeast Saccharomyces cerevisiae has been developed which, when grown under defined culture conditions, will produce protein indistinguishable from wheat gluten protein. This new yeast strain was developed by introducing a specially constructed autonomously replicating extrachromosomal genetic element, gluten plasmid pAY31, into the parent yeast strain. This plasmid is a circular DNA molecule, constructed by enzymic fusion of the following elements: (1) the E.
Type:
Grant
Filed:
October 24, 1986
Date of Patent:
May 2, 1989
Assignees:
The United States of America as represented by the Secretary of the Agriculture, The University of Hawaii
Inventors:
Frank C. Greene, John I. Stiles, John D. Neill, Olin D. Anderson, James C. Litts
Abstract: A rapid stick test for the detection of ciguatoxin and other polyether toxins from fish tissue is disclosed. This is a relatively simple and rapid field test utilizing enzyme immunoassay technology for the detection of lipid toxin which can be assessed in ten minutes or less in the field. The invention is both a procedure and a kit for conducting the test. The kit includes a bamboo sampling stick, buffer reagent, anti-ciguatoxin horseradish peroxidase conjugate, substrate reagent, fixation reagent, blotter, filter paper, and medicine dropper.
Type:
Grant
Filed:
June 1, 1987
Date of Patent:
March 28, 1989
Assignee:
Research Corporation of the University of Hawaii
Abstract: New alkaloids called hapalindoles, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
Type:
Grant
Filed:
February 14, 1986
Date of Patent:
July 5, 1988
Assignee:
University of Hawaii
Inventors:
Richard E. Moore, Gregory M. L. Patterson
Abstract: The reddish pericarp color of whole fresh lychee fruit is preserved by applying a composition of a food acid, an edible reducing agent, and a carbohydrate thickener to the pericarp surfaces, and thereafter storing the coated fruit at a low temperature. After initial coating, the lychee fruit is preferably frozen and then recoated before storage in frozen condition.
Abstract: Monoclonal antibodies are provided capable of distinguishing DNA-RNA hybrid complexes from single stranded DNA and RNA and double stranded DNA and RNA. The antibodies find particular use in determining the presence of a specific nucleic acid sequence on a solid surface. Single stranded polynucleotide is fixed to a solid (gel) surface and then hybridized with the complementary probe. The hybrid complex specific monoclonal antibody is then added to bind to any hybrid complexes which have formed. By appropriate label, the hybrid complex may be visualized in a variety of ways.
Abstract: A method is disclosed for eliminating grease, sewage odor and hydrogen sulfide from restaurant grease traps and municipal sewage systems using xeronine. Xeronine works by stimulating the metabolism of the resident anaerobic and aerobic bacteria.
Type:
Grant
Filed:
January 4, 1985
Date of Patent:
May 19, 1987
Assignee:
The Research Corporation of the University of Hawaii
Abstract: A novel system to ensure that papaya are free of fruit flies so as to meet quarantine restrictions is described. Papaya are subjected to selection on the basis of color in combination with a two-stage heated fluid treatment wherein time and temperature of the treatment are maintained within narrowly defined parameters. With this system, excellent fruit quality is maintained. The system is suitable for commercial use.
Type:
Grant
Filed:
July 22, 1985
Date of Patent:
October 21, 1986
Assignees:
The United States of America as represented by the Secretary of Agriculture, The University of Hawaii
Abstract: Described herein are the composition, the characterization, the assay, the mode of action and the utility of a new alkaloid which may be isolated from a wide variety of natural materials by observing certain techniques and precautions herein set forth.
Type:
Grant
Filed:
September 9, 1983
Date of Patent:
September 24, 1985
Assignee:
Research Corporation of the University of Hawaii
Abstract: Antibiotic albicidin, a non-peptide antibiotic, is produced by culturing chlorosis-inducing strains of Xanthomonas albilineans isolated from diseased sugarcane, and mutants thereof. The antibiotic is isolated from the culture medium by adsorption on resin and is purified by gel filtration and HPLC.
Abstract: Described herein are the composition, the characterization, the assay, the mode of action and the utility of a new alkaloid which may be isolated from a wide variety of natural materials by observing certain techniques and precautions herein set forth.
Type:
Grant
Filed:
December 11, 1981
Date of Patent:
October 11, 1983
Assignee:
Research Corporation of the University of Hawaii
Abstract: A platinum caffeine chloride anionic complex is formed by reacting K.sub.2 PtCl.sub.4 with caffeine in an aqueous solution at neutral pH under ambient conditions of temperature and pressure. This complex is particularly useful for cancer treatment.
Type:
Grant
Filed:
February 19, 1980
Date of Patent:
April 20, 1982
Assignee:
The Research Corporation of the University of Hawaii
Abstract: A subsurface sampler which obtains samples of sand from offshore deposits. A 27 foot tube within a tube is lowered to the ocean floor while suspended from flotation tanks. The sampler is free of suspension cables and thus is detached from boat motions. Surface sand is sucked up through the suction tube and pumped to a container on deck by a jet pump.A jet pump is actuated by high pressure drive water sent down a three inch hose to the top of the sampler, through the void between the two pipes, and to an annular jet nozzle. The nozzle directs the flow upward in the two-inch center pipe through a venturi-shaped throat piece. The throat piece causes sand to be sucked up the suction tube and transported in a slurry through the inner pipe and a two-inch slurry hose to the surface. A manifold valve in the inner pipe shuts off upward flow, jetting water from the lower intake and flowing away sand to let the sampler drop deeper into a deposit.
Type:
Grant
Filed:
February 24, 1978
Date of Patent:
August 19, 1980
Assignee:
The Research Corporation of the University of Hawaii
Abstract: The invention is an apparatus and method for cleaning outsides of heat exchange tubes mounted transversely to the vertical flow of seawater in Ocean Thermal Energy Conversion plants. The invention comprises a number of small floating objects circulating in the seawater flow which randomly clean outside surfaces of heat exchange tubes. The floating objects are made of buoyant plastic foam encased in polyethylene or other material selected to maximize cleaning but minimize wear on the outside surfaces of the tubes. The preferred shape of the floating objects is generally fusiform, altered to have erratic motion in seawater flow. Appendages may trail from the floating objects to increase the randomness of the cleaning action.The flow of seawater is arranged to provide a constantly circulating path for the floating objects to rise through slow downward flow and to fall with greater downward flow velocity. Screens located above and below the heat exchanger prevent the floating objects from escaping.
Type:
Grant
Filed:
May 15, 1978
Date of Patent:
June 17, 1980
Assignee:
The Research Corporation of the University of Hawaii
Abstract: A novel peptide designated anthopleurin-B, hereinafter also referred to as AP-B, obtained from the sea anemone Anthopleura xanthogrammica is found to possess cardiotonic activity.
Type:
Grant
Filed:
May 3, 1978
Date of Patent:
August 28, 1979
Assignee:
University of Hawaii
Inventors:
Ted R. Norton, Shoji Shibata, Midori Kashiwagi
Abstract: A novel peptide designated anthopleurin-C, hereinafter also referred to as AP-C, obtained from the sea anemone Anthopleura elegantissima is found to possess cardiotonic activity.
Type:
Grant
Filed:
August 29, 1977
Date of Patent:
July 25, 1978
Assignee:
University of Hawaii
Inventors:
Ted R. Norton, Midori Kashiwagi, Shoji Shibata
Abstract: A peptide designated anthopleurin-A, hereinafter also referred to as AP-A, obtained from the sea anemone Anthopleura xanthogrammica is found to possess cardiotonic activity.
Type:
Grant
Filed:
August 2, 1976
Date of Patent:
November 22, 1977
Assignee:
The University of Hawaii
Inventors:
Ted R. Norton, Shoji Shibata, Midori Kashiwagi