Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the consumption of alcohol in a patient. These compounds may be used in treat or prevent alcoholism or an alcohol abuse disorder and show an improved pharmaceutical profile relative to other commonly used compounds.
Type:
Application
Filed:
October 4, 2022
Publication date:
August 10, 2023
Applicants:
University of Health Sciences & Pharmacy in St. Louis, Purdue Research Foundation, The Trustees of Columbia University in the City of New York
Inventors:
Susruta MAJUMDAR, Richard M. VAN RIJN, Soumen CHAKRABORTY, Balazs VARGA, Anna M. GUTRIDGE, Dalibor SAMES
Abstract: In some aspects, the present disclosure provides compounds of the formula: wherein the variables are as defined herein. In some embodiments, these compounds may be used to reduce the pain of a patient. These compounds may be used in pain relief and show an improved pharmaceutical profile relative to other commonly used opiates and opioid derivatives.
Type:
Grant
Filed:
July 8, 2020
Date of Patent:
March 28, 2023
Assignees:
University of Health Sciences & Pharmacy in St. Louis, University of Southern California, The University of North Carolina at Chapel Hill, Memorial Sloan Kettering Cancer Center, University of Florida Research Foundation, Incorporated
Inventors:
Susruta Majumdar, Vsevolod Katritch, Bryan Roth, Jay McLaughlin, Saheem Zaidi, Gavril W. Pasternak, Rajendra Uprety