Patents Assigned to UNIVERSITY OF HELSINKI
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Patent number: 10345093Abstract: An arrangement for determining four-dimensional properties of an interface of an object, including a light source includes: a unit for forming photonic jets, a unit for performing large field of view interferometric imaging of the interface and their combination, a unit for passing the light being close to the interface and direct the light to the interface, and an image unit. The arrangement includes a unit for performing phase shifting interferometric imaging of the interface, imaging a unit for receiving light from the interface modulated by e.g. microspheres for forming super-resolution image information by combining light interferometry with the photonic jets, and a processor unit for determining four-dimensional properties of the interface on the basis of the image information formed by the phase shifting interferometric imaging by utilizing effect of the photonic jets. The arrangement also can also include a unit to carry out the measurement using polarized light.Type: GrantFiled: December 11, 2015Date of Patent: July 9, 2019Assignee: UNIVERSITY OF HELSINKIInventors: Ivan Kassamakov, Edward Haeggström
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Patent number: 10160791Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite outgrowth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.Type: GrantFiled: September 28, 2017Date of Patent: December 25, 2018Assignee: UNIVERSITY OF HELSINKIInventors: Heikki Rauvala, Mikhail Paveliev, Juha Kuja-Panula, Ari Rouhiainen, Natalia Kulesskaya
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Patent number: 9916972Abstract: A device for ionizing sample particles of a sample gas flow comprises a first flow tube for providing the sample gas flow, and an introducing means for providing H2SO4 molecules to an interaction region. In addition the device comprises a generator for producing reagent primary ions from particles of candidate reagent gas flow essentially in a primary ion production region. The device is configured to introduce said reagent primary ions with H2SO4 molecules in said interaction region in order to arrange interaction between the reagent primary ions and the H2SO4 molecules, thereby producing HSO4? ions and again to produce HSO4? ion clusters comprising HSO4? ions and at least two H2SO4 molecules via interactions of HSO4? with other H2SO4 molecules in said interaction region.Type: GrantFiled: June 11, 2014Date of Patent: March 13, 2018Assignee: UNIVERSITY OF HELSINKIInventors: Mikko Sipilä, Heikki Junninen, Douglas Worsnop
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Publication number: 20180066027Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite outgrowth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.Type: ApplicationFiled: September 28, 2017Publication date: March 8, 2018Applicant: UNIVERSITY OF HELSINKIInventors: Heikki RAUVALA, Mikhail PAVELIEV, Juha KUJA-PANULA, Ari ROUHIAINEN, Natalia KULESSKAYA
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Patent number: 9896488Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.Type: GrantFiled: June 18, 2014Date of Patent: February 20, 2018Assignee: UNIVERSITY OF HELSINKIInventors: Heikki Rauvala, Mikhail Paveliev, Juha Kuja-Panula, Ari Rouhiainen, Natalia Kulesskaya
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Publication number: 20170247409Abstract: The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating surfaces, preventing, reducing or inhibiting bacterial biofilm formation, and treating or preventing disorders caused by microbial growth and viability as well as bacterial colonization.Type: ApplicationFiled: July 9, 2015Publication date: August 31, 2017Applicant: UNIVERSITY OF HELSINKIInventors: Vãnia M. MOREIRA, Adyary FALLARERO, Jari YLI-KAUHALUOMA, Pia VUORELA, Mikko VAHERMO
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Publication number: 20160331807Abstract: The present invention relates to therapeutic methods, uses and compositions for treating glaucoma or ocular hypertension. More specifically, the present invention relates to methods, uses and compositions utilizing VEGFR-3 activating ligand VEGF-C.Type: ApplicationFiled: January 20, 2015Publication date: November 17, 2016Applicant: UNIVERSITY OF HELSINKIInventors: Kari ALITALO, Aleksanteri ASPELUND, Tuomas TAMMELA, Ilkka IMMONEN
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Publication number: 20160272689Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.Type: ApplicationFiled: June 18, 2014Publication date: September 22, 2016Applicant: UNIVERSITY OF HELSINKIInventors: Heikki RAUVALA, Mikhail PAVELIEV, Juha KUJA-PANULA, Ari ROUHIAINEN, Natalia KULESSKAYA
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Publication number: 20140302616Abstract: Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions. Also a dopant is introduced into the sample gas flow to arrange proton transfer reaction between the dopant and the interfering ions thereby forming dopant ions and electrically neutral interfering constituents. For determination the gas flow with the sample ions to be determined is introduced together with the dopant ions to a mass spectrometer in order to determine the properties of the gas phase bases or acids.Type: ApplicationFiled: November 15, 2012Publication date: October 9, 2014Applicant: UNIVERSITY OF HELSINKIInventors: Mikko Sipila, Heikki Junninen
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Publication number: 20130056165Abstract: The invention relates to a process for fibrillating lignocellulosic material wherein the process comprises treating lignocellulosic material with ionic liquid and recovering basically intact fibres of said lignocellulosic material. Another object of the invention is to provide an activated and/or basically intact fibre wherein the lignocellulosic material is treated with ionic liquid and a basically intact fibre of said lignocellulosic material is recovered. The invention further relates to the use of the basically intact fibre of the invention in the production of bio-based materials, preferably bio-plastics, more preferably conductive polymers, stimuli-responsive polymers, bio-based polymer composites, ceramics, fabrics, or elastomers. A process for producing paper, board, pulp or the like from fibers of lignocellulosic material which have been treated with ionic liquid and recovered as basically intact fibres is also enclosed.Type: ApplicationFiled: March 18, 2011Publication date: March 7, 2013Applicant: UNIVERSITY OF HELSINKIInventors: Ilkka Kilpelainen, Alistair King, Pirkko Karhunen, Jorma Matikainen
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Publication number: 20110261347Abstract: The invention relates to a method for imaging a microfabricated device comprising at least one oscillating component. The method comprises stroboscopically illuminating in an interferometric setup said component in synchronized relationship with the excitation of the device, and detecting interference light in synchronized relationship with the illumination and excitation. According to the invention the component is illuminated at a wavelength band which is at least partly transmissible by the component, and the positions of at least two separate surfaces of the component of interest are determined based on the interference light detected at least at two temporal phases of excitation of the device. The invention provides an efficient method for in-depth characterization of micromechanical structures that provide only one-sided access during operation.Type: ApplicationFiled: December 9, 2009Publication date: October 27, 2011Applicant: UNIVERSITY OF HELSINKIInventors: Ivan Kassamakov, Juha Aaltonen, Heimo Saarikko, Edward Haeggstrom, Kalle Hanhijärvi