Abstract: Creating compatible anonymized data sets by performing with machine learning equipment that operates a machine learning model by defining data types of variables of a data set; identifying quasi-identifiers for the data set; defining reidentification sensitivity of all or any targeted subset of the individual variables and quasi-identifiers; defining missing data handling rules for the individual variables; defining allowed data transformations including generalization and use of synthesized data; optimizing quasi-identifier selection, use of synthesized data and a choice of data transformations to minimize information loss and maximize privacy metrics based on the data set; the allowed data transformations; and the missing data handling rules; training the machine learning model using the data set according to the defined data types; the optimized quasi-identifier selection; the optimized use of synthesized data; and the choice of data transformations; and anonymizing the data set using the training of the m

Abstract: The invention concerns a device for tumour antigen identification and a method for tumour antigen identification; a tumour antigen identified following use of said device and/or method; a pharmaceutical composition comprising said tumour antigen; a method of treating cancer using said device and/or said method; a method of stratifying patients for cancer treatment using said device and/or said method; a treatment regimen involving stratifying patients for cancer treatment using said device and/or method and then administering a cancer therapeutic; and a tumour antigen identified using said device and/or said method for use as a cancer vaccine or immunogenic agent or cancer therapy.

Abstract: Creating compatible anonymized data sets by performing with machine learning equipment that operates a machine learning model by defining data types of variables of a data set; identifying quasi-identifiers for the data set; defining reidentification sensitivity of all or any targeted subset of the individual variables and quasi-identifiers; defining missing data handling rules for the individual variables; defining allowed data transformations including generalization and use of synthesized data; optimizing quasi-identifier selection, use of synthesized data and a choice of data transformations to minimize information loss and maximize privacy metrics based on the data set; the allowed data transformations; and the missing data handling rules; training the machine learning model using the data set according to the defined data types; the optimized quasi-identifier selection; the optimized use of synthesized data; and the choice of data transformations; and anonymizing the data set using the training of the m

Abstract: A method and apparatus are disclosed for calibrating a first sensor in a changing operating environment by a calibration process. Sensor data are received from the first sensor and sensor values are received from a known calibrating sensor. A sensor specific model is maintained for the first sensor. Calibration needs are detected by estimating a drift and an error, taking into account a difference of sensor values to the known calibrating sensor and further taking into account a sensor profile of the first sensor. A correction factor or a correction model is estimated to the sensor data using said difference and used for calibrating the sensor. The correction factor or the correction model is derived from the sensor specific model.

Abstract: This invention relates to bioassay method wherein the presence of a specific soluble antibody in a sample of a bodily fluid, plasma or serum, of an animal, including human, is qualitatively and/or quantitatively determined. The method employs, a first group labelled with an energy donor and a second group labelled with an energy acceptor; the first group, or second group, comprising an antigen of the soluble antibody and the second group, or first group, respectively, comprising a Fab binding moiety capable of binding to a Fab region of antibodies of said animal. The donor and the acceptor form an energy transfer pair capable of energy transfer. The invention further comprises a kit for the bioassay method.

Abstract: The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.

Abstract: An arrangement for determining four-dimensional properties of an interface of an object, including a light source includes: a unit for forming photonic jets, a unit for performing large field of view interferometric imaging of the interface and their combination, a unit for passing the light being close to the interface and direct the light to the interface, and an image unit. The arrangement includes a unit for performing phase shifting interferometric imaging of the interface, imaging a unit for receiving light from the interface modulated by e.g. microspheres for forming super-resolution image information by combining light interferometry with the photonic jets, and a processor unit for determining four-dimensional properties of the interface on the basis of the image information formed by the phase shifting interferometric imaging by utilizing effect of the photonic jets. The arrangement also can also include a unit to carry out the measurement using polarized light.

Abstract: Method, computer program and apparatus are disclosed in which search phrases are arranged multi-dimensionally in a relevance map pointing which the user can define weights of the search phrases. Documents are correspondingly ranked based on the weights and a result list is formed and presented accordingly.

Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite outgrowth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.

Abstract: An apparatus for frequency comb generation comprises a component of second order nonlinearity, where the component is configured to interact with a laser beam or derivatives of the laser beam and thereby generate frequencies for the frequency comb. The apparatus comprises advantageously an optical manipulator, which both comprises the component but additionally is configured to introduce the beam or its derivatives in a repetitive or resonating manner to the component. The component is e.g. a monolithic or other solid optical resonator or microresonator comprising optical crystal and having said second order nonlinearity.

Abstract: A device for ionizing sample particles of a sample gas flow comprises a first flow tube for providing the sample gas flow, and an introducing means for providing H2SO4 molecules to an interaction region. In addition the device comprises a generator for producing reagent primary ions from particles of candidate reagent gas flow essentially in a primary ion production region. The device is configured to introduce said reagent primary ions with H2SO4 molecules in said interaction region in order to arrange interaction between the reagent primary ions and the H2SO4 molecules, thereby producing HSO4? ions and again to produce HSO4? ion clusters comprising HSO4? ions and at least two H2SO4 molecules via interactions of HSO4? with other H2SO4 molecules in said interaction region.

Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite outgrowth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.

Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.

Abstract: A search system configured to predict further search intents of a user and to perform exploratory further searches and produce a number of search features and associated relevances and divergence quantifiers for displaying by user equipment at least two-dimensional so as to allow the user to identify relationship of various diverging search terms and to rapidly direct the searching towards information the existence of which may have been previously unknown to the user. Some of the search features can be concealed and shown to the user only if the user magnifies the corresponding area on a display showing the search features returned by the search engine. Files matching to varying degree with the present and predicted further searches are shown to the user with respective lists of search features.

Abstract: The present invention relates to the field of wood rosin and resin acid derivatives and more particularly to abietane-type diterpenoids as well as different uses thereof. Furthermore, the present invention relates to methods of coating surfaces, preventing, reducing or inhibiting bacterial biofilm formation, and treating or preventing disorders caused by microbial growth and viability as well as bacterial colonization.

Abstract: This invention relates to bioassay method wherein the presence of a specific soluble antibody in a sample of a bodily fluid, preferably plasma or serum, of an animal, including human, is qualitatively and/or quantitatively determined. The method employs, a first group labelled with an energy donor and a second group labelled with an energy acceptor; the first group, or second group, comprising an antigen of the soluble antibody and the second group, or first group, respectively, comprising a Fab binding moiety capable of binding to a Fab region of antibodies of said animal. The donor and the acceptor form an energy transfer pair capable of energy transfer. The invention further comprises a kit for the bioassay method.

Abstract: The present invention relates to therapeutic methods, uses and compositions for treating glaucoma or ocular hypertension. More specifically, the present invention relates to methods, uses and compositions utilizing VEGFR-3 activating ligand VEGF-C.

Abstract: The disclosure relates to anti-viral agents that mimic or inhibit packaging singles of RNA viruses that function in viral capsid formation and their use in the control of viral infection.

Abstract: The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTP?) is disclosed.

Abstract: Properties, such as concentrations, of gas phase bases or acids of a gas sample are determined by providing a sample gas flow, which includes the bases or acids to be determined as sample constituents, as well as also interfering constituents, which are other constituents than the sample constituents. Reagent ions are provided and introduced into the sample gas flow to arrange proton transfer reaction and thereby forming sample ions. Also a dopant is introduced into the sample gas flow to arrange proton transfer reaction between the dopant and the interfering ions thereby forming dopant ions and electrically neutral interfering constituents. For determination the gas flow with the sample ions to be determined is introduced together with the dopant ions to a mass spectrometer in order to determine the properties of the gas phase bases or acids.