Abstract: An apparatus, buffer solutions and a method are provided for pH control of in vitro dissolution tests used to monitor the drug release rate from solid unit dosage forms which are used to predict their in vivo effects or for quality control purposes. A method of preparing a continuous condition and a clear bicarbonate ion based solution for in vitro dissolution testing of pharmaceutical products is also provided. An enclosure device is also provided for use in the provision of pH control and stabilization to a bicarbonate based solution used in the in vitro dissolution testing of pharmaceutical products.

Abstract: Methods are provided for coating particles characterised by the addition of a powdered excipient, typically during coating. Typically, the coating method comprises Wurster fluidized bed coating. The method provides for coating particles in a coater comprising a coating processing chamber, wherein the particles comprise an active pharmaceutical ingredient. The coated particles are preferably for use in a method of administering an active pharmaceutical ingredient or for use in a method of treating or preventing a disease or condition. The invention further provides a pharmaceutical composition comprising coated particles obtainable by the method of the invention, preferably as part of a liquid formulation for oral administration.

Abstract: A compound of the general formula (A) or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof, in which: X is independently NO2 or H; and Y is selected from H, amino, amide, ester, carboxy and its esters and amides, alkyl, alkenyl, alkynyl, cycloalkyl, alkaryl, aryl, heterocyclic or heteroaryl groups, all of which can be substituted with heteroatoms and/or side groups, and wherein any chains can be straight or branched is disclosed.

Abstract: A compound of the general formula (A) or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof, in which: X is independently NO2 or H; and Y is selected from H, amino, amide, ester, carboxy and its esters and amides, alkyl, alkenyl, alkynyl, cycloalkyl, alkaryl, aryl, heterocyclic or heteroaryl groups, all of which can be substituted with heteroatoms and/or side groups, and wherein any chains can be straight or branched is disclosed.

Abstract: An apparatus for the detection of a fluid-borne particle (10) in an optically defined particle sensing zone, the apparatus comprising: i) a scattering chamber (40); ii) a means for providing a sample of fluid (34), containing the fluid-borne particle, in the form of a flow through the optically defined particle sensing zone; iii) A means for generating a beam of radiation (12) through the optically defined particle sensing zone; iv) a single reflector or refractor (14) means having a primary focus (16) within the optically defined particle sensing zone and a secondary focus (20) located outside the beam of radiation; v) a detector means comprising a first photosensitive detection area (26) a second photosensitive detection area (29); vi) a means for deriving area from the radiation detected by the first photosensitive detection area and second photosensitive detection area of the detection means wherein the single reflector or refractor means is adapted to direct radiation scattered from the fluid borne parti

Abstract: Quantum source coding apparatus for communication of quantum information comprising: a quantum state preparation device for converting input messages into block messages; a coding device for producing coded signals by compressing the block messages prepared by the quantum state preparation device; and an output device for outputting the coded signals produced by the coding device.

Abstract: A fibre detector assembly comprising: (i) a scattering chamber body; (ii) means for drawing airborne particles through said body chamber, said means being adapted such the the particles tend to travel in single file with the longitudinal axis of particles with elongate shape substantially aligned with the direction of the air flow; (iii) means for illuminating the particle stream within the chamber body; (iv) an optical detector adapted to intercept and collect a portion of the light scattered by particles passing through the illuminating beam; (v) data processing means adapted to capture and process the signals from the optical detector; characterised in that the optical detector comprises a photodiode array consisting of a central opaque area surrounded by two or more annular rings of detector elements.

Abstract: A method of producing a genetically transformed fluid-producing plant comprises:i) inserting into the plant tissue a gene or gene fragment controlling the expression of a target product, andii) regenerating a plant from said tissue, the genetically transformed plant being capable of expressing the target product in the fluid that it produces.There are also provided clones of genetically transformed fluid-producing plants which contain in their cells a chromosomal insert such that the target product is expressed in the fluids that the plants produce. There is further described a method of producing a protein or other target product which comprises:i) harvesting the fluid from a genetically transformed fluid-producing tree or plant, or a clone thereof, andii) recovering the target protein or other product from said fluid.

Abstract: A method of performing biorheological measurements on a suspension (4) of cells by causing some of the cells to pass through one or more microsize tunnels (3) in a solid medium (1, 2) under a pressure difference between the tunnel ends and monitoring (6) their passage through the tunnel or tunnels, characterized in that the pressure difference is monitored to produce a signal which is recorded or is utilized to provide feedback to regulate the biorheological measurements. Apparatus for performing this method may have such a pressure feedback control, or may have tunnels with at least partly transparent walls for transmitting optical information to a detector for the biorheological measurements.

Abstract: A microscope is provided with a supplementary means for producing a light spot in the object plane of the microscope objective lens. The supplementary means comprises a light source from which a collimated light beam is derived, a focusing lens receiving the collimated beam and a coupling lens disposed between the first lens and the objective lens. The supplementary means has the following features: the focal point of the focusing lens is in the plane of the image of a specimen in the object plane as obtained through the objective lens and the coupling lens, the light beam fills the clear aperture of the objective lens without substantial light loss and the light source and the focusing lens may be moved together to displace the light spot within or away from the object plane of the objective lens.