Abstract: The present invention relates to a method and apparatus that can predict the visible-infrared band images of a region of the Earth's surface that would be observed by an Earth Observation (EO) satellite or other high-altitude imaging platform, using data from radar reflectance/backscatter of the same region. The method and apparatus can be used to predict images of the Earth's surface in the visible-infrared bands when the view between an imaging instrument and the ground is obscured by cloud or some other medium that is opaque to electromagnetic (EM) radiation in the visible-infrared spectral range, approximately spanning 400-2300 nanometres (nm), but transparent to EM radiation in the radio-/microwave part of the spectrum. Regular, uninterrupted monitoring of the Earth's surface is important for a wide range of applications, from agriculture to defence.

Abstract: An apparatus, buffer solutions and a method are provided for pH control of in vitro dissolution tests used to monitor the drug release rate from solid unit dosage forms which are used to predict their in vivo effects or for quality control purposes. A method of preparing a continuous condition and a clear bicarbonate ion based solution for in vitro dissolution testing of pharmaceutical products is also provided. An enclosure device is also provided for use in the provision of pH control and stabilization to a bicarbonate based solution used in the in vitro dissolution testing of pharmaceutical products.

Abstract: Methods are provided for coating particles characterised by the addition of a powdered excipient, typically during coating. Typically, the coating method comprises Wurster fluidized bed coating. The method provides for coating particles in a coater comprising a coating processing chamber, wherein the particles comprise an active pharmaceutical ingredient. The coated particles are preferably for use in a method of administering an active pharmaceutical ingredient or for use in a method of treating or preventing a disease or condition. The invention further provides a pharmaceutical composition comprising coated particles obtainable by the method of the invention, preferably as part of a liquid formulation for oral administration.

Abstract: A compound of the general formula (A) or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof, in which: X is independently NO2 or H; and Y is selected from H, amino, amide, ester, carboxy and its esters and amides, alkyl, alkenyl, alkynyl, cycloalkyl, alkaryl, aryl, heterocyclic or heteroaryl groups, all of which can be substituted with heteroatoms and/or side groups, and wherein any chains can be straight or branched is disclosed.

Abstract: A compound of the general formula (A) or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, stereoisomer or mixture thereof, in which: X is independently NO2 or H; and Y is selected from H, amino, amide, ester, carboxy and its esters and amides, alkyl, alkenyl, alkynyl, cycloalkyl, alkaryl, aryl, heterocyclic or heteroaryl groups, all of which can be substituted with heteroatoms and/or side groups, and wherein any chains can be straight or branched is disclosed.

Abstract: An apparatus for the detection of a fluid-borne particle (10) in an optically defined particle sensing zone, the apparatus comprising: i) a scattering chamber (40); ii) a means for providing a sample of fluid (34), containing the fluid-borne particle, in the form of a flow through the optically defined particle sensing zone; iii) A means for generating a beam of radiation (12) through the optically defined particle sensing zone; iv) a single reflector or refractor (14) means having a primary focus (16) within the optically defined particle sensing zone and a secondary focus (20) located outside the beam of radiation; v) a detector means comprising a first photosensitive detection area (26) a second photosensitive detection area (29); vi) a means for deriving area from the radiation detected by the first photosensitive detection area and second photosensitive detection area of the detection means wherein the single reflector or refractor means is adapted to direct radiation scattered from the fluid borne parti