Patents Assigned to University of Illinois
  • Patent number: 12286407
    Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: April 29, 2025
    Assignees: The Board of Trustees of the University of Illinois, The Regents of the University of California
    Inventors: John A. Katzenellenbogen, Seema K. Tiwari-Woodruff, Sung Hoon Kim, Benita Katzenellenbogen
  • Publication number: 20250127729
    Abstract: Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.
    Type: Application
    Filed: February 1, 2023
    Publication date: April 24, 2025
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Hyunjoon Kong, Byoungsoo Kim, Lawrence B. Schook, Kyle Schachtschneider, Lobna Elkhadragy, Maximillian Carlino
  • Patent number: 12280492
    Abstract: Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: April 22, 2025
    Assignees: The Board of Trustees of the University of Illinois, Purdue Research Foundation
    Inventors: Hyunjoon Kong, Byoungsoo Kim, Jonghwi Lee, Chi Hwan Lee, Min Ku Kim
  • Patent number: 12277999
    Abstract: The disclosure relates to a re-writable DNA-based digital storage system with a random access feature. An example embodiment includes reading a physical nucleotide sequence of 2n+L bases to form a digital representation of the physical nucleotide sequence; dividing the digital representation of the physical nucleotide sequence into an address representation of n bases, followed by a data representation of L bases, followed by a further address representation of n bases; decoding the data representation into an integer value less than 3L that is a sum of a first addend and a second addend, wherein the data representation includes a first subsequence of bases encoding the first addend followed by a second subsequence of bases encoding the second addend; and storing, in a computer memory, the integer value.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: April 15, 2025
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Olgica Milenkovic, S. M. Hossein Tabatabaei Yazdi, Yongbo Yuan, Jian Ma, Huimin Zhao
  • Patent number: 12270821
    Abstract: Disclosed herein are instruments and related methods for measuring oxidative potential (OP) in airborne particulates, particularly PM2.5. The instrument is formed from three main components: a sample injector, a sample incubator and a measurement system. The instrument provides an automatic measure of five OP endpoints in a relatively rapid time frame of less than 3 hours. In this manner, additional parameters beyond the gross particle concentration or mass per unit volume is obtained, including the biologically-relevant OP associated with PM2.5.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 8, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Vishal Verma, Haoran Yu, Joseph Puthussery
  • Patent number: 12269900
    Abstract: Provided herein are compounds that inhibit a binding interaction between a ? integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: April 8, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventor: Xiaoping Du
  • Patent number: 12263351
    Abstract: This disclosure relates to methods for modulating activity of a cell capable of being activated by light and treating diseases with such methods. The disclosure also provides systems suitable for use in such methods, particularly systems having silicon nanostructures.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: April 1, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Bozhi Tian, Francisco Bezanilla, Erin Adams, Ramya Parameswaran, Yuanwen Jiang, João L. Carvalho-de-Souza, Kelliann C. Koehler, Michael G. Burke
  • Patent number: 12258511
    Abstract: The present invention provides methods for inhibiting the formation of ice on a surface, reducing contact line pinning at a water-solid interface, inhibiting the transition of water from a vapor state to a solid state (i.e., desublimation), and decreasing adhesion of a substance to a surface, which methods comprise, in various aspects, applying to a surface one or more phase change materials where the phase change materials have a melting point above a temperature at which ice formation occurs on the surface. Anti-icing compositions are further provided.
    Type: Grant
    Filed: September 1, 2021
    Date of Patent: March 25, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Sushant Anand, Rukmava Chatterjee, Hassan Bararnia
  • Patent number: 12235275
    Abstract: The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Disclosed herein is a substrate for monitoring PARG activity, TFMU-ADPr, which directly reports on total PAR hydrolase activity via release of a fluorophore; this substrate has excellent reactivity, generality, stability, and usability. A second substrate, TFMU-IDPr, selectively reports on PARG activity only from the enzyme ARH3. Use of these probes in whole-cell lysate experiments has revealed a mechanism by which ARH3 is inhibited by cholera toxin. TFMU-ADPr and TFMU-IDPr are versatile tools for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: February 25, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Bryon S. Drown
  • Patent number: 12234314
    Abstract: Provided herein are polymers having a polymer backbone including a zwitterionic precursor monomeric unit having a secondary or tertiary amine in the polymer backbone, as well as methods of making and using the same.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: February 25, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Gang Cheng, Huifeng Wang
  • Patent number: 12232996
    Abstract: The present application is directed to a method and system for restraining a patient before, during, or after surgery that increases efficiency of the surgical setup process and minimizes risk of musculoskeletal damage to the patient, particularly in surgeries requiring a patient to be in a Trendelenburg position (e.g., robotic or laparoscopic surgeries). One or more restraints can be worn by a patient prior to surgery', and may function to redistribute the patient's weight across the patient's torso to reduce strain on the patient's shoulders and back. The restraint(s) can be attached to a surgical table by way of an attachment mechanism coupled to the restraint(s) and the table. The attachment mechanism can secure the patient to the table by way of one or more straps, clips, and/or other intermediates. Optionally, the restraint(s) can fulfill other surgical needs, such as heat regulation and vascular compression.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: February 25, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Michael J. Young, Craig Niederberger, Stephan Peter Pfanner, Andrew Graham, Julissa Garcia, Sweta Shah, Leigha Covnot, Zahra Ahsan, Kimberlee Wilkens, Cristian Luciano
  • Patent number: 12234240
    Abstract: New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.
    Type: Grant
    Filed: December 16, 2022
    Date of Patent: February 25, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Paul J. Hergenrother, Timothy M. Fan, Riley L. Svec
  • Publication number: 20250061693
    Abstract: Embodiments are provided for determining simulated optical microscopy images of formalin-fixed paraffin embedded (FFPE) stained tissue samples from stimulated Raman scattering microscopy (SRSM) images of frozen tissue samples. These embodiments include applying the SRSM images to a first generative model to generate simulated optical microscopy images of thawed, stained tissue samples corresponding to the SRS imaged tissue samples. The simulated optical microscopy images are then applied to a second generative model to generate simulated FFPE microscopy images of the frozen tissue samples.
    Type: Application
    Filed: August 15, 2024
    Publication date: February 20, 2025
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Rohit Bhargava, Kianoush Falahkheirkhah, Sudipta S. Mukherjee
  • Patent number: 12229641
    Abstract: Embodiments described herein relate to training, by a computing system, a gamma mixture hurdle model. The model may characterize a functional relationship between: output data specifying food flows between zones, and input variables representing food production and food consumption in the zones. The training involves: (i) using binary logistic regression to estimate whether corresponding food flows exist between zone pairs, and (ii) for pairs in which corresponding food flows exist, using a gamma mixture model to estimate amounts of the corresponding food flows. Based on the gamma mixture hurdle model, the computing system can estimate, where each zone includes a respective set of regions: (i) whether corresponding food sub-flows exist between region pairs, and (ii) for pairs in which the corresponding food sub-flows are estimated to exist, potentials of the corresponding food sub-flows. The computing system can also determine, using a linear programming framework, values for the corresponding food sub-flows.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: February 18, 2025
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Megan Konar, Xiaowen Lin
  • Patent number: 12214910
    Abstract: A structure for changing the attitude of a spacecraft is provided including an elongated member and a plurality of actuators coupled to the elongated member. The elongated member is coupled to the spacecraft. The elongated member has a length and an angular position relative to an axis. The plurality of actuators are configured to deflect the angular position of the elongated member relative to the axis and to alter the length of the elongated member.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: February 4, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Vedant, James T. Allison
  • Patent number: 12210473
    Abstract: A computing device includes a host processor to execute a host driver to create a host-side interface, the host-side interface emulating a first Ethernet interface, assign the host-side interface a first medium access control (MAC) address and a first Internet Protocol (IP) address. Memory components are disposed on a substrate. A memory channel network (MCN) processor is disposed on the substrate and coupled between the memory components and the host processor. The MCN processor is to execute an MCN driver to create a MCN-side interface, the MCN-side interface emulating a second Ethernet interface. The MCN processor is to assign the MCN-side interface a second MAC address and a second IP address, which identify the MCN processor as a MCN network node to the host processor.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: January 28, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Nam Sung Kim, Mohammad Alian
  • Patent number: 12201730
    Abstract: Provided herein are stimulus-responsive polymer microgelator particles that can activate fibrin fiber formation from their surfaces by actively ejecting thrombin to form an interconnected fibrin network with an increased elastic modulus and desirable microstructure. The use of the microgelators enables the decoupling of gelation rate and gel rigidity.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: January 21, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Hyunjoon Kong, Yu-Tong Hong, Yongbeom Seo
  • Patent number: 12201643
    Abstract: Provided herein are compositions and methods for mechanochemical dynamic therapy.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: January 21, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: King C. Li, Gun Kim, Qiong Wu, Jeffrey S. Moore, Yun-Sheng Chen
  • Patent number: 12196659
    Abstract: The disclosure provides example mass-sensing instruments and methods for use thereof. A mass-sensing instrument includes a mass sensor that includes a first terminal and a second terminal. The mass sensor has a natural oscillation frequency configured to correspond to a mass of a deposited material on the mass sensor. The mass-sensing instrument also includes a first driving circuit configured to control a first voltage of the first terminal and a second driving circuit configured to control a second voltage of the second terminal.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: January 14, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Igor Paprotny, Mehdi Azadmehr
  • Patent number: 12187662
    Abstract: Provided are compounds, or pharmaceutically acceptable salts thereof, which are useful for inhibiting FOXM1, inhibiting cancer growth, and/or treating cancer. In particular, these compounds and their corresponding quaternary ammonium salts may be used to treat various forms of breast cancer.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: January 7, 2025
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: John A. Katzenellenbogen, Benita Katzenellenbogen, Sung Hoon Kim, Noah Bindman