Patents Assigned to University of Illinois
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Patent number: 12365816Abstract: An adhesive gripper for pick-and-place maneuvers comprises one or more legs, where each leg terminates in a foot rotatably connected to the respective leg. Each foot includes a SMP dry adhesive comprising a shape memory polymer, and a rigid backing layer attached to a back side of the SMP dry adhesive, such that a front side of the SMP dry adhesive is available for attachment and release of objects. The adhesive gripper further includes a handle portion connected to the one or more legs, a release mechanism comprising a release ring within the handle portion, and one or more releasing rods integrated with the one or more legs for release of an object onto a substrate.Type: GrantFiled: May 14, 2021Date of Patent: July 22, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Seok Kim, ChangHee Son
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Patent number: 12346410Abstract: Segmentation or other classification of digital pathology images with a deep learning model allows for sophisticated spatial features for cancer diagnosis to be extracted in an automated, fast, and accurate manner. A tiered analysis of tissue structure based in part on deep learning methods is provided. First, tissues depicted in a digital pathology image are segmented into cellular compartments (e.g., epithelial and stromal compartments). Second, the heterogeneity in the different cellular compartments are examined based on a clustering algorithm. Tissue can then be characterized in terms of inertia (or other spatial measures or features), which can be used to recognize disease. In some instances, multidimensional inertia (i.e., inertia computed in different cellular compartments or clustered components) can be used as an indicator of disease and its outcome.Type: GrantFiled: October 1, 2021Date of Patent: July 1, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Rohit Bhargava, Shachi Mittal
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Patent number: 12344666Abstract: Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided.Type: GrantFiled: June 9, 2022Date of Patent: July 1, 2025Assignees: Washington University, The Board of Trustees of the University of IllinoisInventors: Princess Imoukhuede, Erik Procko
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Patent number: 12348281Abstract: A system for co-transmitting discrete power and data over a common high frequency channel includes a power transmitting node, a power receiving node, a data transmitting node, a data receiving node, a power transmitting switch, a power receiving switch, a data transmitting switch, a data receiving switch, a primary power switch, a secondary power switch, a common high frequency channel, a first control unit, and a second control unit. When the primary power switch, power transmitting switch, and power receiving switch are in an activated state, a power signal is transmitted over the common high frequency channel from the power transmitting node to the power receiving node. When the secondary power switch, data transmitting switch, and data receiving switch are in an activated state, a data signal is transmitted over the common high frequency channel from the data transmitting node to the data receiving node.Type: GrantFiled: February 7, 2022Date of Patent: July 1, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Sudip K. Mazumder, Ankit Gupta
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Patent number: 12337347Abstract: A device includes a pair of substrate layer corresponding to a carrier substrate, an intermediary layer disposed on the pair of substrate layers, a cavity region disposed between the pair of substrate layers underneath the intermediary layer, a piezoelectric layer including a lithium-based film disposed on the intermediary layer, and a plurality of interdigital transducer electrodes disposed on the piezoelectric layer. The plurality of interdigital transducer electrodes includes an outer signal electrode, an inner signal electrode, an outer ground electrode and an inner ground electrode.Type: GrantFiled: November 17, 2021Date of Patent: June 24, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Songbin Gong, Ruochen Lu
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Patent number: 12342449Abstract: An apparatus includes a printed circuit board (PCB), a power component disposed on the PCB, the power component to generate heat, and a multilayered coating disposed over the power component and at least a portion of the PCB to dissipate heat from the power component, the multilayered including: an electrical insulation layer comprising a non-polar compound and disposed on the power component and the at least a portion of the PCB; a chromium layer disposed on the electrical insulation layer; and a copper layer disposed on the chromium layer that is at least 10 microns (?m) thick, the copper layer conformally adhered to a top of the power component and to the PCB.Type: GrantFiled: September 27, 2022Date of Patent: June 24, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Tarek Gebrael, Arielle R. Gamboa, Jiaqi Li, Nenad Miljkovic, Shayan Aflatounian
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Patent number: 12329794Abstract: A method for treating a subject with cancer by administering to the subject a therapeutically effective amount of a recombinant Herpes Simplex Virus-1 (HSV-1) that expresses only a C-terminal portion of ?134.5 protein (e.g., amino acid residues 147-263) with no wild-type or intact ?134.5 protein expression is provided. The recombinant HSV-1 of this invention instigates immune activation, selectively replicates in cancer cells, and resists clearance by interferon.Type: GrantFiled: June 7, 2019Date of Patent: June 17, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Bin He, Xing Liu
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Patent number: 12316611Abstract: Systems, methods, network devices, and machine-readable media disclosed herein perform chosen ciphertext attack secure encryption given any public key infrastructure that has been established with only chosen plaintext attack security. The resulting chosen ciphertext attack secure encryption makes black-box use of the chosen plaintext attack secure scheme and other underlying primitives, and specifically new public keys do not need to be created or distributed.Type: GrantFiled: August 1, 2021Date of Patent: May 27, 2025Assignees: NTT Research, Inc., The Board of Trustees of the University of IllinoisInventors: Dakshita Khurana, Brent Waters
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Patent number: 12295939Abstract: In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: August 3, 2023Date of Patent: May 13, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Gregory R Thatcher, Rui Xiong, Jiong Zhao, Yunlong Lu, Lauren Gutgesell, Carlo Ivan Rosales, Yangfeng Li
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Patent number: 12286407Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.Type: GrantFiled: April 12, 2023Date of Patent: April 29, 2025Assignees: The Board of Trustees of the University of Illinois, The Regents of the University of CaliforniaInventors: John A. Katzenellenbogen, Seema K. Tiwari-Woodruff, Sung Hoon Kim, Benita Katzenellenbogen
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Publication number: 20250127729Abstract: Patches configured to hold an oncogenic cargo and deliver the cargo in a controlled manner to a predetermined location of a specified tissue are disclosed. As one example, a patch can comprise a base layer configured to adhere to a predetermined location of a tissue and a hydrogel layer. The hydrogel layer can comprise a plurality of microchannels that are configured to store and release a gene-modifying vector over a time period and in a quantity sufficient to produce a somatic cell tumor through manipulation of the genome of somatic cells at the predetermined location.Type: ApplicationFiled: February 1, 2023Publication date: April 24, 2025Applicant: The Board of Trustees of the University of IllinoisInventors: Hyunjoon Kong, Byoungsoo Kim, Lawrence B. Schook, Kyle Schachtschneider, Lobna Elkhadragy, Maximillian Carlino
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Patent number: 12280492Abstract: Provided herein are manipulators for handling fragile layers and related methods of handling using the manipulators. The manipulators comprise a contact surface with thermally responsive recess features and a microelectric heater in thermal contact with the contact surface. In this manner, the manipulator is an electrothermal manipulator, with changes in temperature providing a contact force to pick-up a transferable layer material and a release force to facilitate release of the transferable from the manipulator.Type: GrantFiled: August 31, 2021Date of Patent: April 22, 2025Assignees: The Board of Trustees of the University of Illinois, Purdue Research FoundationInventors: Hyunjoon Kong, Byoungsoo Kim, Jonghwi Lee, Chi Hwan Lee, Min Ku Kim
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Patent number: 12277999Abstract: The disclosure relates to a re-writable DNA-based digital storage system with a random access feature. An example embodiment includes reading a physical nucleotide sequence of 2n+L bases to form a digital representation of the physical nucleotide sequence; dividing the digital representation of the physical nucleotide sequence into an address representation of n bases, followed by a data representation of L bases, followed by a further address representation of n bases; decoding the data representation into an integer value less than 3L that is a sum of a first addend and a second addend, wherein the data representation includes a first subsequence of bases encoding the first addend followed by a second subsequence of bases encoding the second addend; and storing, in a computer memory, the integer value.Type: GrantFiled: October 15, 2019Date of Patent: April 15, 2025Assignee: The Board of Trustees of The University of IllinoisInventors: Olgica Milenkovic, S. M. Hossein Tabatabaei Yazdi, Yongbo Yuan, Jian Ma, Huimin Zhao
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Patent number: 12270821Abstract: Disclosed herein are instruments and related methods for measuring oxidative potential (OP) in airborne particulates, particularly PM2.5. The instrument is formed from three main components: a sample injector, a sample incubator and a measurement system. The instrument provides an automatic measure of five OP endpoints in a relatively rapid time frame of less than 3 hours. In this manner, additional parameters beyond the gross particle concentration or mass per unit volume is obtained, including the biologically-relevant OP associated with PM2.5.Type: GrantFiled: March 17, 2021Date of Patent: April 8, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Vishal Verma, Haoran Yu, Joseph Puthussery
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Patent number: 12269900Abstract: Provided herein are compounds that inhibit a binding interaction between a ? integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, comprising the same, and related kits. In some embodiments, the compound is an antibody or antibody analog, and, in other embodiments, the compound is a peptide or peptide analog. Also provided are methods of using the compounds, including methods of treating or preventing a medical condition, such as stroke, heart attack, cancer, or inflammation.Type: GrantFiled: August 7, 2020Date of Patent: April 8, 2025Assignee: The Board of Trustees of the University of IllinoisInventor: Xiaoping Du
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Patent number: 12263351Abstract: This disclosure relates to methods for modulating activity of a cell capable of being activated by light and treating diseases with such methods. The disclosure also provides systems suitable for use in such methods, particularly systems having silicon nanostructures.Type: GrantFiled: February 19, 2019Date of Patent: April 1, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Bozhi Tian, Francisco Bezanilla, Erin Adams, Ramya Parameswaran, Yuanwen Jiang, João L. Carvalho-de-Souza, Kelliann C. Koehler, Michael G. Burke
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Patent number: 12258511Abstract: The present invention provides methods for inhibiting the formation of ice on a surface, reducing contact line pinning at a water-solid interface, inhibiting the transition of water from a vapor state to a solid state (i.e., desublimation), and decreasing adhesion of a substance to a surface, which methods comprise, in various aspects, applying to a surface one or more phase change materials where the phase change materials have a melting point above a temperature at which ice formation occurs on the surface. Anti-icing compositions are further provided.Type: GrantFiled: September 1, 2021Date of Patent: March 25, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Sushant Anand, Rukmava Chatterjee, Hassan Bararnia
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Patent number: 12234240Abstract: New synthetic methods to provide access to previously unexplored functionality at the C8 position of substituted imidazo[5,1-d][1,2,3,5]tetrazines of Formula I. Through synthesis and evaluation of a suite of compounds with a range of aqueous stabilities (from 0.5 to 40 hours), a predictive model for imidazotetrazine hydrolytic stability based on the Hammett constant of the C8 substituent was derived. Promising compounds were identified that possess activity against a panel of GBM cell lines, appropriate hydrolytic and metabolic stability, and brain-to-serum ratios dramatically elevated relative to TMZ, leading to lower hematological toxicity profiles and superior activity to TMZ in a mouse model of GBM.Type: GrantFiled: December 16, 2022Date of Patent: February 25, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Paul J. Hergenrother, Timothy M. Fan, Riley L. Svec
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Patent number: 12234314Abstract: Provided herein are polymers having a polymer backbone including a zwitterionic precursor monomeric unit having a secondary or tertiary amine in the polymer backbone, as well as methods of making and using the same.Type: GrantFiled: April 19, 2019Date of Patent: February 25, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Gang Cheng, Huifeng Wang
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Patent number: 12232996Abstract: The present application is directed to a method and system for restraining a patient before, during, or after surgery that increases efficiency of the surgical setup process and minimizes risk of musculoskeletal damage to the patient, particularly in surgeries requiring a patient to be in a Trendelenburg position (e.g., robotic or laparoscopic surgeries). One or more restraints can be worn by a patient prior to surgery', and may function to redistribute the patient's weight across the patient's torso to reduce strain on the patient's shoulders and back. The restraint(s) can be attached to a surgical table by way of an attachment mechanism coupled to the restraint(s) and the table. The attachment mechanism can secure the patient to the table by way of one or more straps, clips, and/or other intermediates. Optionally, the restraint(s) can fulfill other surgical needs, such as heat regulation and vascular compression.Type: GrantFiled: April 26, 2019Date of Patent: February 25, 2025Assignee: The Board of Trustees of the University of IllinoisInventors: Michael J. Young, Craig Niederberger, Stephan Peter Pfanner, Andrew Graham, Julissa Garcia, Sweta Shah, Leigha Covnot, Zahra Ahsan, Kimberlee Wilkens, Cristian Luciano