Abstract: Disclosed are novel compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.
Type:
Grant
Filed:
May 3, 2021
Date of Patent:
January 2, 2024
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Paul J. Hergenrother, Michelle Richter, Andrew Riley, Bryon S. Drown, Martin Chavez, Sarah Tasker, Alfredo Garcia
Abstract: Provided herein are complexes comprising amphotericin B (AmB) or derivatives and sterols. Also provided herein are methods of treating cystic fibrosis using AmB or complexes comprising AmB or derivatives and sterols.
Type:
Grant
Filed:
June 1, 2021
Date of Patent:
December 26, 2023
Assignee:
The Board of Trustees of the University of Illinois
Abstract: Plasma-Activated liquids and methods of using the same are described. In one aspect, a method of manufacturing an integrated circuit includes activating a photolithography liquid with a plasma; and treating a device component with the activated photolithography liquid. In one example, the photolithography liquid is a photoresist. Activating the photoresist liquid may impart reactive species to the photoresist.
Type:
Application
Filed:
November 8, 2021
Publication date:
December 21, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
David RUZIC, Mohan SANKARAN, Christian WILLIAMS
Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
Type:
Grant
Filed:
December 22, 2020
Date of Patent:
December 19, 2023
Assignees:
The Board of Trustees of the University of Illinois, Vanquish Oncology, Inc., The Johns Hopkins University
Inventors:
Paul J. Hergenrother, Rachel C. Botham, Timothy M. Fan, Mark J. Gilbert, Michael K. Handley, Avadhut Joshi, Gregory J. Riggins, Theodore M. Tarasow
Abstract: Provided are methods and related devices for preparing a cell and tissue culture, including a hanging drop culture. Microwells are specially loaded with cell mixtures using a removable reservoir and forcing cells into the underlying microwells. The removable reservoir is removed and the cells partitioned into the individual microwells and covered by an immiscible layer of fluid. The microwells and immiscible layer is inverted and the cells in the microwells cultured. The microwells may have shape-controlling elements to control the three-dimensional shape of the culture.
Type:
Grant
Filed:
May 4, 2021
Date of Patent:
December 19, 2023
Assignees:
The Board of Trustees of the University of Illinois, Mayo Foundation for Medical Education and Research
Inventors:
Anurup Ganguli, Rashid Bashir, Panagiotis Z. Anastasiadis, George Vasmatzis
Abstract: The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds.
Type:
Grant
Filed:
January 8, 2021
Date of Patent:
December 5, 2023
Assignees:
Vanquish Oncology, Inc., The Board of Trustees of the University of Illinois
Inventors:
Paul J. Hergenrother, Rachel C. Botham, Timothy M. Fan, Mark J. Gilbert, Michael K. Handley, Howard S. Roth, Theodore M. Tarasow
Abstract: A method includes receiving data including a plurality of data items, each data item of the plurality of data items including a three-dimensional (3D) radar heat map of an object and a corresponding two-dimensional (2D) image of the object captured by a stereo camera, inputting the training dataset into a machine learning model including a neural network (NN) that generates, from the 3D radar heat map, a 2D depth map for the object and outputs a probability that the 2D depth map is the corresponding 2D image of the object, and training the machine learning model based on a training dataset to generate a trained machine learning model that iteratively learns to generate an updated 2D depth map that approximates the corresponding 2D image. The training dataset includes the plurality of data items, the 2D depth map and the probability.
Type:
Grant
Filed:
December 17, 2020
Date of Patent:
December 5, 2023
Assignee:
Board of Trustees of the University of Illinois
Inventors:
Junfeng Guan, Seyedsohrab Madani, Suraj S. Jog, Haitham Al Hassanieh, Saurabh Gupta
Abstract: Improved heat exchangers according to several embodiments are provided. The heat exchangers provide improved heat transfer for air flow in wet and dry operating conditions, while minimizing pressure drop across the heat exchanger in some applications. According to one embodiment, an improved heat exchanger includes a plurality of metal foam fins between adjacent heat exchange conduits, the heat exchange conduits being arranged parallel to each other to define parallel flow paths between an inlet header and an outlet header. The metal foam fins occupy a cross-flow region between adjacent conduits, the fins having a fixed angular orientation or being rotatable in unison to vary the thermal capacitance of the heat exchanger.
Type:
Grant
Filed:
July 30, 2020
Date of Patent:
November 28, 2023
Assignees:
UT-BATTELLE, LLC, Board of Trustees of the University of Illinois
Abstract: Photoredox catalysis has emerged as a powerful strategy for C—O cross-coupling reactions. We herein report a new class of tridentate pyridinophane ligands RN3 that allow for detailed mechanistic studies of the photocatalytic C—O coupling reaction. The derived (RN3)Ni complexes are active C—O cross-coupling photocatalysts under mild conditions and without an additional photocatalyst. We also utilized the RN3 ligands to study the essential but so far putative steps involving paramagnetic Ni species in a proposed catalytic cycle: the oxidative addition of an aryl bromide to a Ni(I) species, the ligand exchange at a Ni(III) center, and the C—O reductive elimination from a Ni(III) species.
Type:
Grant
Filed:
June 6, 2022
Date of Patent:
November 28, 2023
Assignee:
The Board of Trustees of the University of Illinois
Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.
Type:
Grant
Filed:
May 31, 2023
Date of Patent:
November 21, 2023
Assignees:
VedaBio, Inc., The Board of Trustees of The University of Illinois
Abstract: A component with a reflective substrate, a photoresist layer disposed on the reflective substrate, and a light diffusing layer sandwiched between the reflective substrate and the photoresist layer is provided. The light diffusing layer includes an outer metal oxide layer with an outer rough surface configured to diffuse laser light during laser interference lithography of the photoresist layer. The outer metal oxide is also configured to be reduced to a conductive metallic layer during electroplating of the substrate. The outer metal oxide layer includes a plurality of elongated light diffusing elements extending in an outward direction from the substrate such that the outer rough surface diffuses at least 90% of laser light during the laser interference lithography of the photoresist layer.
Type:
Grant
Filed:
March 25, 2022
Date of Patent:
November 14, 2023
Assignees:
Toyota Motor Engineering & Manufacturing North America, Inc., The Board of Trustees of the University of Illinois
Inventors:
Shailesh N. Joshi, Gaurav Singhal, Paul Vannest Braun, Kai-Wei Lan, Nenad Miljkovic
Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
Type:
Grant
Filed:
June 3, 2019
Date of Patent:
November 14, 2023
Assignees:
Northwestern University, The Board of Trustees of the University of Illinois
Inventors:
Michael Christopher Jewett, Joongoo Lee, Jeffrey S. Moore, Kenneth E. Schwieter, Kevin Jerome Schwarz
Abstract: Here we show that P. ananatis produces at least three phosphonates, two of which were purified and structurally characterized. The first, designated pantaphos, was shown to be 2-(hydroxy(phosphono)methyl)maleate; the second, a probable biosynthetic precursor, was shown to be 2-(phosphonomethyl)maleate. Purified pantaphos is both necessary and sufficient for the hallmark lesions of onion center rot. Moreover, when tested against mustard seedlings, the phytotoxic activity of pantaphos was comparable to the widely used herbicides glyphosate and phosphinothricin. Pantaphos was also active against a variety of human cell lines.
Type:
Application
Filed:
September 2, 2021
Publication date:
November 9, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
William W. Metcalf, Alexander L. Polidore
Abstract: Staphylococcus nepalensis releases corisin, a peptide conserved in diverse Staphylococci, that induces apoptosis of lung epithelial cells. Therefore, methods and apparatus for detecting the presence of corisin in a biological sample of a patient are disclosed, as well as pharmaceutical compositions, such as antibodies, and methods for treating patents having or suspected of having fibrosis.
Type:
Application
Filed:
December 16, 2020
Publication date:
November 9, 2023
Applicants:
Mie University, The Board of Trustees of the University of Illinois
Inventors:
Esteban Gabazza, Corina D'Alessandro-Gabazza, Isaac Cann
Abstract: Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.
Type:
Application
Filed:
May 1, 2023
Publication date:
November 9, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Jeffrey S. Moore, Nancy R. Sottos, Benjamin A. Suslick, Diego M. Alzate-Sanchez, Nil A. Parikh
Abstract: Disclosed herein are methods of using spun synthetic fibers to model ligaments of a joint of an animal. Further disclosed are models of joints which comprise spun synthetic fibers used to model ligaments. In certain aspects, the models of joints can be used for instructional purposes, as phantom models for testing medical devices or as models for calibration of tools used in physiological and/or biomechanical measurement.
Type:
Grant
Filed:
February 4, 2021
Date of Patent:
October 24, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Mariana Elizabeth Kersh, Sam Walter Goldsmith, Sara Moshage, Roberto Alonso Pineda Guzman
Abstract: A CRISPR/Cas system and method for editing or regulating transcription of a genome of a cell are provided, wherein the system includes a Cas endonuclease fused with one or more degron sequences and at least one activatable cognate single guide RNA harboring an inactivation sequence in a non-essential region of the cognate sgRNA, wherein said inactivation sequence comprises one or more endonuclease recognition sites of, e.g., a ribozyme.
Type:
Grant
Filed:
September 21, 2018
Date of Patent:
October 17, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Ryan E. Clarke, Bradley J. Merrill, Matthew S. MacDougall, Hannah M. Pennington, Brian R. Shy
Abstract: A method of fabricating a power semiconductor device includes forming a bi layer mask on a semiconductor substrate, where the bilayer mask comprises a first dielectric layer on the semiconductor substrate and a second dielectric layer on the first dielectric layer. The first and second dielectric layers are through-etched to define an exposed portion of the semiconductor substrate. The first dielectric layer is selectively etched to form an undercut region of the bi layer mask. A crystalline semiconductor material is epitaxially grown on the exposed portion of the semiconductor substrate, and a polycrystalline semiconductor material is deposited on the second dielectric layer of the bilayer mask. After the epitaxial growth, the bilayer mask and the polycrystalline semiconductor material are removed from the semiconductor substrate, leaving behind a mesa comprising the crystalline semiconductor material on the semiconductor substrate.
Type:
Application
Filed:
July 30, 2021
Publication date:
October 12, 2023
Applicant:
The Board of Trustees of the University of Illinois
Inventors:
Kyekyoon Kim, Palash Sarker, Frank P. Kelly
Abstract: A system for providing intraoperative feedback to a user during the course of surgery. A core imaging unit provides low-coherence optical radiation coupled to a sampling device and generates optical coherence tomography (OCT) data based on combining scattered light received from the sampling device together with a reference signal. The sampling device is adapted to receive the low-coherence optical radiation from the core imaging unit and to illuminate the tissue, and to collect light scattered by the tissue and to return said light to the core imaging unit. A core software unit receives the OCT data from the core imaging unit provides real-time feedback, such as an image, to the user via an indicator.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
October 10, 2023
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk