Patents Assigned to University of Iowa Reseach Foundation
  • CRISPR-related methods and compositions with governing gRNAs
    Patent number: 10640788
    Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: May 5, 2020
    Assignees: Editas Medicine, Inc., The Broad Institute Inc., Massachusetts Institute of Technology, University of Iowa Reseach Foundation
    Inventors: Feng Zhang, Deborah Palestrant, Beverly Davidson, Jordi Mata-Fink, Edgardo Rodriguez, Alexis Borisy
  • TUMOR VACCINES AND METHODS OF USE THEREOF
    Publication number: 20150374809
    Abstract: The present invention provides a therapeutic agent comprising an antibody-recognition epitope (ARE) covalently bound to a tumor cell, wherein the ARE is bound to an antibody that is specific for the ARE, to form a tumor cell:ARE:antibody complex, and kits and methods of using these tumor cell:ARE:antibody complexes.
    Type: Application
    Filed: January 30, 2014
    Publication date: December 31, 2015
    Applicant: UNIVERSITY OF IOWA RESEACH FOUNDATION
    Inventors: Tony Vanden Bush, Gail Bishop
  • Bis(phosphonic acid) difluoromethane
    Patent number: 4330486
    Abstract: Fluorine-containing phosphonates and phosphonic acids are described. The method of preparation is a reaction of trialkylphosphites with dihalodifluoromethanes or a reaction of the salts of dialkylphosphites with halodifluoromethylphosphonates. The corresponding phosphonic acids are prepared by hydrolysis of the phosphonates.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: May 18, 1982
    Assignee: University of Iowa Reseach Foundation
    Inventors: Donald J. Burton, Richard M. Flynn