Patents Assigned to University of Kentucky Research Foundation
  • METHOD OF TREATING NEUROPATHIC PAIN
    Publication number: 20160340335
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 6, 2013
    Publication date: November 24, 2016
    Applicants: University of Utah, University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
  • Bis-quaternary ammonium salts as pain modulating agents
    Patent number: 9499518
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: November 22, 2016
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. Holtman, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • COMPOSITIONS AND METHODS FOR PEST CONTROL MANAGEMENT
    Publication number: 20160330974
    Abstract: Disclosed are genetically modified nudiviruses capable of being sexually transmitted by an insect useful for controlling pest populations. The genetically modified nudiviruses are capable of causing sterility in a target population of insects. Also disclosed are insects infected with the disclosed genetically modified nudiviruses, methods of making the genetically modified nudiviruses, and methods of using the genetically modified nudiviruses to control an insect pest population.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 17, 2016
    Applicants: Lepidext LLC, University of Kentucky Research Foundation
    Inventors: Bruce Webb, Kendra Hitz Steele, Angelika Fath-Goodin
  • Proteasome inhibitors
    Patent number: 9493439
    Abstract: Compounds of formula (I) are useful for inhibiting a proteasome in a cell. Compounds, pharmaceutical compositions and methods of use are provided herein.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: November 15, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Kyung-Bo Kim, Vinod Kasam, Wooin Lee, Dong-Eun Kim, Zach Miller, Chang-Guo Zhan, Do-Min Lee
  • Method and system for producing triterpenes
    Patent number: 9487762
    Abstract: A method and system are provided for the production of triterpene including methylated triterpenes. The method and system include isolated nucleic acid sequences encoding triterpene methyltransferases such as triterpene methyltransferases 1, 2, 3. Advantageously, the method and system includes transgenic plant cells via an expression vector for triterpene methyltransferase and optionally various triterpene synthase and prenyltransferase all with tags directing these enzymes to the chloroplast of the transgenic plant cells for using the chloroplast methyl erythritol phosphate (MEP) pathway in the triterpene biogenesis.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 8, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Joe Chappell, Thomas D. Niehaus, Shigeru Okada, Timothy P. Devarenne, David S. Watt
  • Methods and systems for prognosis and diagnosis of brain damage
    Patent number: 9482675
    Abstract: The presently-disclosed subject matter includes methods and devices for diagnosing, prognosing, and treating brain damage in a subject, including brain damage caused by stroke or a traumatic brain injury (TBI). The methods can comprise providing a sample obtained from the subject, exposing the sample to an antibody selective for a visinin-like protein, detecting the presence of a complex that includes the antibody and the visinin-like protein, and diagnosing and/or prognosing the subject as having brain damage if there is the presence of the complex. Embodied methods can also comprise administering a treatment for brain damage if the subject includes the presence of the visinin-like protein.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: November 1, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Mark A. Lovell, Bert C. Lynn, Melissa A. Bradley-Whitman
  • Compact heat exchanger for veno-venous perfusion-induced systemic hyperthermia systems
    Patent number: 9468557
    Abstract: A compact heat exchanger for veno-venous perfusion-induced hyperthermia includes an integral pneumatic pump and a hollow tubule heat exchange array. A veno-venous perfusion-induced hyperthermia system incorporating the compact heat exchanger is described. The heat exchanger provides a compact, efficient design allowing a lesser heat exchanging surface area and lesser required pumping power compared to conventional systems. In turn, the system provides a shorter blood circuit compared to conventional systems, allowing maintaining a lower blood temperature than such conventional systems while supplying sufficiently heated blood to patient visceral organs to provide a therapeutic effect, such as in supplementing chemotherapy drugs.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: October 18, 2016
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Dongfang Wang, Joseph B. Zwischenberger
  • Microfabricated surfaces for the physical capture of insects
    Patent number: 9468203
    Abstract: Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the microstructures of the leaf surfaces of plants and the key features of those surfaces with respect to the capture and control of pests have been determined and engineered into a variety of microfabricated surfaces capable of reproducing the effectiveness of these physical capture methods.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: October 18, 2016
    Assignees: The Regents of the University of California, The University of Kentucky Research Foundation
    Inventors: Catherine Loudon, Robert Corn, Megan Szyndler, Kenneth Haynes, Michael F. Potter
  • Solvent and method for removal of an acid gas from a fluid stream
    Patent number: 9468883
    Abstract: A solvent for removal of an acid gas from a fluid stream includes a promoter amine with a pKa of between 6.5 and 10.5 and a tertiary amine with a pKa of between 8.5 and 10.5.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: October 18, 2016
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph E. Remias, Cameron A. Lippert, Kunlei Liu
  • Methods for diagnosing and treating alzheimer's disease (AD) using the molecules that stabilize intracellular calcium (Ca) release
    Patent number: 9464322
    Abstract: The subject technology relates, in part, to a method of treating Alzheimer's Disease (AD), early-stage AD, elevated risk of AD, mild cognitive impairment (MCI), or other forms of age-related cognitive decline in a subject in need thereof by administering to the subject a molecule that promotes calcium-release stabilization in ryanodine receptors (RyRs) and/or inosital triphosphate receptors (InsP3Rs) in brain cells. Diagnostic methods using calcium-release stabilizing immunophilins, junctophilins or calmodulin are also disclosed.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: October 11, 2016
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Philip W. Landfield, John Christopher Gant, Eric M. Blalock, Kuey-Chu Chen, Olivier Thibault, Nada Porter
  • Methods of inhibiting Alu RNA and therapeutic uses thereof
    Patent number: 9464289
    Abstract: The presently-disclosed subject matter includes methods of identifying an Alu RNA inhibitor, and methods and compositions for inhibiting Alu RNA. Methods and compositions can be used for the treatment of geographic atrophy and other conditions of interest.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: October 11, 2016
    Assignee: University of Kentucky Research Foundation
    Inventor: Jayakrishna Ambati
  • BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20160279119
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 13, 2010
    Publication date: September 29, 2016
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • Protection of cells from -RNA-induced degeneration and inhibitors for protecting cells
    Patent number: 9453226
    Abstract: A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NF?B of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NF?B can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: September 27, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Jayakrishna Ambati, Valeria Tarallo
  • Semi-synthetic mithramycin derivatives with anti-cancer activity
    Patent number: 9447135
    Abstract: Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or other cancer or neuro-disease associated with an aberrant erythroblast transformation-specific transcription factor.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: September 20, 2016
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Jurgen T. Rohr, Daniel Scott, Markos Leggas, Jhong-Min Chen, Oleg V. Tsodikov
  • Polymeric prodrug
    Patent number: 9433638
    Abstract: The presently-disclosed subject matter includes compounds that comprise an initiator and an active agent that is covalently bonded to the initiator through a ring-opening polymerization process, an atom-transfer radical polymerization process, a Michael addition reaction, or a ring-opening metathesis polymerization process. In some embodiments the active agent includes simvastatin. The presently-disclosed subject matter also includes methods for making the compositions and methods for using the compositions to treat tissue wounds.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: September 6, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: David Puleo, Thomas Dziubla, Theodora Asafo-Adjei
  • Enhancement of binding characteristics for production of an agglomerated product
    Patent number: 9428705
    Abstract: A method is provided for preparing a product from a precursor material. The method includes the steps of (a) mixing a particulate material and a binder to form a precursor material and (b) irradiating that precursor material with microwave radiation so as to activate the binder and form the product.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: August 30, 2016
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Darrell Taulbee, Robert Hodgen
  • High activity mutants of butyrylcholinesterase for cocaine hydrolysis
    Patent number: 9415092
    Abstract: Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (?)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (?)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: August 16, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Wenchao Yang
  • Hybrid flow battery and Mn/Mn electrolyte system
    Patent number: 9413025
    Abstract: An electrolyte system for a hybrid flow battery has a manganese based anolyte and a manganese based catholyte.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: August 9, 2016
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Stephen M. Lipka, Christopher R. Swartz
  • Glucan phosphatase variants for starch phosphorylation
    Patent number: 9410133
    Abstract: Glucan phosphatase nucleotide or polypeptide variants of the presently-disclosed subject matter can alter the biophysical properties of starch in vitro or in planta, as well as the total starch biomass production in planta as compared to plants expressing wild-type glucan phosphatases. Plants producing the polypeptide variants of the presently-disclosed subject matter can have increased starch accumulation, increased starched biomass, and/or starch having desired biophysical properties. A method of the presently-disclosed subject matter for producing altered starch includes providing a plant that produces a glucan phosphatase polypeptide variant that comprises an amino acid mutation and collecting starch from the plant.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: August 9, 2016
    Assignee: University of Kentucky Research Foundation
    Inventors: Matthew Gentry, Craig Vander Kooi
  • Method of increasing mass transfer rate of acid gas scrubbing solvents
    Patent number: 9409125
    Abstract: A method of increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are also disclosed.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: August 9, 2016
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph E. Remias, Cameron A. Lippert, Kunlei Liu