Patents Assigned to University of Leeds
  • Publication number: 20200165613
    Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.
    Type: Application
    Filed: May 31, 2018
    Publication date: May 28, 2020
    Applicants: The University of Leeds, The University of York
    Inventors: German Leonov, Simon White, Peter Stockley, Nikesh Patel, Emma Wroblewski, Dan Maskell, Reidun Twarock, Richard Bingham, Eva Weiss, Eric Dykeman
  • Publication number: 20200140451
    Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 7, 2020
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, Fundacio Institut Catala D'Investigacio Quimica, University of Delaware, University of Leeds, Universitat Rovira I Virgili
    Inventors: John A. Beutler, Antonio Echavarren, William Chain, David Beech, Zhenhua Wu, Jean-Simon Suppo, Fernando Bravo, Hussein Rubaiy
  • Patent number: 10604445
    Abstract: The present invention relates to a substrate comprising an ion-implanted layer, for example a cation, wherein the ion implanted layer has a substantially uniform distribution of the implanted ions at a significantly greater depth than previously possible, to a well-defined and sharp boundary within the substrate. The invention further comprises said sub-strate wherein the substrate is a silicon based substrate, such as glass. The invention also comprises the use of said material as a waveguide and the use of said material in measurement devices.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: March 31, 2020
    Assignee: UNIVERSITY OF LEEDS
    Inventors: Gin Jose, Toney Teddy Fernandez, Peter John Grant, Animesh Jha, Sikha Saha, David Paul Steenson
  • Patent number: 10508320
    Abstract: A process for recovering metal value-containing precipitates in consistently high concentrations from a metal-containing composition by combining selective roasting and leaching steps.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: December 17, 2019
    Assignee: UNIVERSITY OF LEEDS
    Inventors: Animesh Jha, Yotamu Stephen Rainford Hara, Stephen Parirenyatwa, Sergio Sanchez-Segado
  • Patent number: 10498450
    Abstract: A data center network, comprises a first group of optical ports for connection to respective servers of a first group of servers; a second group of optical ports for connection to respective servers of a second group of servers; a first lower passive optical routing element arranged to route optical communication signals between the first group of optical ports and a first lower optical communication path; a second lower passive optical routing element arranged to route optical communication signals between the second group of optical ports and a second lower optical communication path; an upper passive optical routing element arranged to: (i) route optical communication signals between the first lower optical communication path and an upper optical communication path, and (ii) route optical communication signals between the second lower optical communication path and the upper optical communication path.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: December 3, 2019
    Assignee: UNIVERSITY OF LEEDS
    Inventors: Jaafar Elmirghani, Taisir El-Gorashi, Ali Hammadi
  • Patent number: 10468009
    Abstract: An ultrasound generator having a signal generator; and to generate a pulsed drive signal from a modulating signal, the pulsed drive signal having at least a zero output level, a positive output level and a negative output level. The position and width of pulses are defined by at least first and second switching angles per half cycle of the modulating signal. In part of the range of the modulating signal one switching angle increases while the other switching angle decreases simultaneously such that the fundamental frequency of the pulsed drive signal increases or decreases with the modulating signal and such that a selected harmonic component of the generated pulsed drive signal is maintained below a first threshold. A transducer is arranged to generate ultrasound in response to the pulsed drive signal.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: November 5, 2019
    Assignee: The University of Leeds
    Inventors: Steven Freear, David Matthew Joseph Cowell, Peter Raymond Smith
  • Patent number: 10441643
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: October 15, 2019
    Assignees: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Jose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
  • Patent number: 10391159
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: August 27, 2019
    Assignees: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
  • Patent number: 10371656
    Abstract: Tomography apparatus comprises: a plurality of electrodes arranged around a perimeter of a cross section of a sample volume for containing a liquid or mixed-phase sample, each electrode being arranged to be in electrical contact with a sample contained in the sample volume; measurement means adapted to perform a set of measurements, each measurement comprising driving a current between a first respective adjacent pair of said electrodes and measuring a voltage developed across a second respective adjacent pair of said electrodes; and processing means adapted to generate a tomogram indicative of sample conductivity over said cross section from said set of measurements. The processing means is arranged to calculate sample conductivity values of a portion of said cross section from said set of measurements and generate said tomogram from said calculated sample conductivity values of said portion using an assumption of symmetry.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: August 6, 2019
    Assignee: UNIVERSITY OF LEEDS
    Inventors: Mi Wang, Bishal Karki, Qiang Wang
  • Patent number: 10350613
    Abstract: A method and apparatus for manipulating polarizable dielectric particles. The method includes positioning a liquid containing the particles above a surface of a piezoelectric material (2). The method also includes inducing a shear-horizontal surface acoustic wave in the piezoelectric material (2), thereby to form a time-varying non-uniform evanescent electric field extending into the liquid. The method further includes using the time-varying non-uniform evanescent electric field to apply a force to at least some of the particles (50, 52) by dielectrophoresis.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 16, 2019
    Assignee: UNIVERSITY OF LEEDS
    Inventors: Christoph Walti, Alban Josiah Smith, Richard O'Rorke, Alexander Giles Davies, Christopher David Wood
  • Publication number: 20190167773
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided.
    Type: Application
    Filed: December 5, 2018
    Publication date: June 6, 2019
    Applicants: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
  • Publication number: 20190059870
    Abstract: The present invention provides a retraction device comprising, a shaft, a plurality of arms supported by the shaft, the arms being configured to be moveable between a first orientation in which the device assumes an insertion profile for passage of the device through a surgical incision, and a second orientation in which the device assumes a retraction profile. At least one of the plurality of the arms is adapted to be adjustable between a first length and a second length.
    Type: Application
    Filed: January 20, 2017
    Publication date: February 28, 2019
    Applicant: University of Leeds
    Inventors: David G. Jayne, Peter Culmer, Mohammed Sanami, Richard Hall, Timothy Flood
  • Patent number: 10198295
    Abstract: A method of controlling a datacenter (1), for example a cloud datacenter, and a computer management system (3) for managing a datacenter comprising a plurality of servers (2) configured to execute a plurality of jobs is provided. The method comprises receiving a request to execute a job from a user (4), determining an allocated server (2) on which to execute the job, and executing the job on the allocated server (2). The determining the allocated server (2) on which to execute the job comprises: classifying the job according to its resource requirement, selecting a subset of the servers (2) that fulfill the resource requirements of the job, determining the allocated server (2) that can execute the job with a favorable energy efficiency, wherein a total resource estimate for all jobs running on the server (2) from time to time exceeds the resources of at least one of the servers (2).
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: February 5, 2019
    Assignee: University of Leeds
    Inventors: Ismael Solis Moreno, Paul Michael Townend, Peter Michael Garraghan, Jie Xu
  • Patent number: 10188713
    Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: January 29, 2019
    Assignees: Mayo Foundation for Medical Education and Research, University of Leeds
    Inventors: Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
  • Patent number: 10184941
    Abstract: The invention relates to use of ACY-1 as a biomarker for ischaemia-reperfusion injury.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 22, 2019
    Assignee: University of Leeds
    Inventors: Rosamonde Elizabeth Banks, Matthew Peter Welberry Smith, Peter John Selby, Andrew Lewington
  • Patent number: 10180397
    Abstract: A THz quantum cascade laser is used to investigate a target by directing a first beam of laser radiation from the laser at the target to thereby produce a second beam of laser radiation by interaction of the first beam with the target. Self-mixing of the first and second beams occurs within the laser and causes variations in a signal such as the operating voltage of the laser. An operating parameter of the laser that affects the interaction of the first beam with, the target is varied. The operating voltage is monitored and processed to determine phase and amplitude changes associated with material properties of the target. Consequently in one embodiment the invention provides for processing the variations in the signal to produce various images of the target.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: January 15, 2019
    Assignees: The University of Queensland, University of Leeds
    Inventors: Aleksandar D. Rakic, Paul Dean, Alexander Giles Davies, Dragan Indjin, Edmund Harold Linfield, Stephen James Wilson, Thomas Taimre, Karl Bertling, Yah Leng Lim
  • Publication number: 20180291529
    Abstract: A composite fibre comprising polyurethane and a particulate, wherein the particulate has mean particle diameter in the range 50 nm-100 ?m. A web comprising this fibre, and the use of the web for non-slip applications or antimicrobial applications, together with a method for making the fibre.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 11, 2018
    Applicant: UNIVERSITY OF LEEDS
    Inventors: Parikshit Goswami, Timothy Smith, Andrew Hebden, Stephen Russell
  • Patent number: 10080811
    Abstract: The present Invention relates to the monitoring of biological substances, such as non-invasive monitoring of such substances in animal, for examples biomarkers and metabolites. Specifically, the invention further relates to such monitoring using rare earth tagged marker compounds. The invention further relates to such monitoring using laser spectroscopy or Raman spectroscopy. The invention further relates to the use of such monitoring in disease states, such as stroke, neurological disorders and cardiovascular disorders.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: September 25, 2018
    Assignee: University of Leeds
    Inventors: Sikha Saha, Gin Jose, Animesh Jha
  • Patent number: 10046087
    Abstract: There are provided collagen based polymeric materials comprising collagen molecules and/or collagen derived molecules which have been functionalized by the addition of one or more ethylenically unsaturated moieties and which have been cross-linked via said moieties. Also provided are collagen based compositions and methods of producing collagen based polymeric materials.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: August 14, 2018
    Assignee: University of Leeds
    Inventors: Giuseppe Tronci, Stephen John Russell, David John Wood
  • Publication number: 20180223471
    Abstract: The invention provides a method for the application of a bleaching agent to a substrate, the method comprising the treatment of the substrate in an aqueous system comprising a liquid bleaching agent in a closed container, the treatment being carried out at a ratio of liquor to substrate which does not exceed 3:1. Typically, the method is applied to the bleaching of textile fibres and may optionally comprise a bleaching and scouring treatment. The invention also provides a method for the removal of surplus bleaching agents following the bleaching treatment, the method comprising not more than three aqueous wash-off treatments of the substrate. In addition to facilitating the use of much reduced liquor levels, the method also allows for significant reductions to be achieved in usage levels of bleaching agents, auxiliary agents and rinsing agents, thereby reducing generation of waste liquors requiring disposal.
    Type: Application
    Filed: September 7, 2015
    Publication date: August 9, 2018
    Applicant: University of Leeds
    Inventor: Stephen BURKINSHAW