Patents Assigned to University of Leeds
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Publication number: 20250078290Abstract: There is provided a computer-implemented method for synthesising magnetic resonance angiography (MRA) images from other types of inputted magnetic resonance (MR) images, in a subject-specific manner, the method comprising providing a conditional generative adversarial network (cGAN) that learns a combined latent representation of the inputted magnetic resonance images for each subject and learns to transform this combined latent representation to a magnetic resonance angiography image corresponding to that subject, providing a plurality of magnetic resonance (MR) images as input into the cGAN, and outputting a plurality of MRA images from the cGAN based on the plurality of inputted MR images.Type: ApplicationFiled: September 6, 2023Publication date: March 6, 2025Applicant: University of LeedsInventors: Yan Xia, Nishant Ravikumar, Alejandro Federico Frangi
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Patent number: 12209241Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.Type: GrantFiled: May 31, 2018Date of Patent: January 28, 2025Assignees: The University of Leeds, The University of YorkInventors: German Leonov, Simon White, Peter Stockley, Nikesh Patel, Emma Wroblewski, Dan Maskell, Reidun Twarock, Richard Bingham, Eva Weiss, Eric Dykeman
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Publication number: 20240327975Abstract: The invention relates to tribological composites comprising diamond-like carbon and carbonaceous multi-layered nanoparticulate, e.g. graphene nanoplatelets, and methods for their preparation.Type: ApplicationFiled: July 12, 2022Publication date: October 3, 2024Applicant: University of LeedsInventors: Liuquan Yang, Nik Roselina BINTI NIK ROSELEY, Robbie Nathan BRITTAIN, Tomasz Witold LISKIEWICZ, Anne NEVILLE
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Patent number: 12082991Abstract: A three-dimensional (3D) dental scanning system (1) for scanning a dental object (D) includes a scanning surface (124a) to support the dental object (D); a scanning section (130) to capture a 3D scan of the dental object (D); a motion section (120) to move the scanning surface (124a) and scanning section (130) relative to each other in five axes of motion, whilst retaining the scanning surface (124a) in a substantially horizontal plane, and a control unit (140) configured to control the motion section (120) and the scanning section (130) to obtain a 3D scan of the dental object (D).Type: GrantFiled: September 17, 2020Date of Patent: September 10, 2024Assignee: University of LeedsInventor: Andrew James Keeling
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Patent number: 12053475Abstract: Described herein are inhibitors Transient Receptor Potential Canonical (TRPC) ion channels comprising TRPC4 protein and/or TRPC5 protein for use in combating obesity and other medical conditions including insulin resistance associated with Type II diabetes or development of Type II diabetes (pre-diabetes), metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Also disclosed is the use of the inhibitors for cosmetic purposes, such as cosmetic weight loss.Type: GrantFiled: October 15, 2021Date of Patent: August 6, 2024Assignee: University of LeedsInventors: David John Beech, Richard James Foster, Sin Ying Cheung, Baptiste Michel Rode
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Patent number: 12017284Abstract: The present application relates to a method for the production of a noble metal nanomaterial comprising: (A) adding an aqueous solution of a source of noble metal ions and a reducing agent to an aqueous solution of an organic compound to form a reaction mixture, wherein the organic compound is capable of undergoing 2D planar stacking in aqueous solution; and (B) separating the noble metal nanomaterial from the reaction mixture. The present application also relates to a noble metal nanomaterial manufactured according to said method.Type: GrantFiled: November 19, 2019Date of Patent: June 25, 2024Assignee: University of LeedsInventors: Stephen Derek Evans, Sunjie Ye, Alexander Fred Markham, Patricia Louise Coletta
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Patent number: 11964944Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.Type: GrantFiled: June 2, 2022Date of Patent: April 23, 2024Assignees: The University of Chicago, J. Craig Venter Institute, Inc., The University of Sheffield, Institute for Systems Biology, The University of Leeds, The University of Strathclyde, The Government of the United StatesInventors: Rima McLeod, Martin McPhillie, Colin W. G. Fishwick, Hernan Alejandro Lorenzi, Kai Wang, Taek-Kyun Kim, Yong Zhou, Leroy E. Hood, Ying Zhou, Kamal El Bissati, Mark Hickman, QiGui Li, Craig Roberts
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Publication number: 20240124872Abstract: The invention relates to a method of identifying a genomic target for a test stimulus that is capable of modulating a cell phenotype, comprising: a) providing a population of cells that are phenotypically negative in response to the test stimulus; b) modifying the population of cells by random insertion into the cell genome of a gain-in-function construct; c) contacting the modified cell population with the test stimulus; d) screening the exposed modified cell population to identify modified cells that are phenotypically positive in response to the test stimulus; and e) identify a gene or genes associated with said positive phenotype thereby identifying the genomic target of the test stimulus.Type: ApplicationFiled: February 22, 2022Publication date: April 18, 2024Applicant: University of LeedsInventor: Viktor Lukacs
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Publication number: 20240050986Abstract: Examples provide a multilevel switched-mode ultrasound transmitter comprising a first push-pull transistor arrangement comprising first and second drive transistors, third and fourth additional switched transistors, each arranged as a bidirectional load switch with a one of the first and second drive transistors, wherein the first drive transistor and associated third additional switched transistor operate in series as a first arm of the first push-pull transistor arrangement, and the second drive transistor and associated fourth additional switched transistor operate in series as a second arm of the first push-pull transistor arrangement, wherein each arm is coupled between a respective polarity instance of a first bipolar drive voltage supply and a common output.Type: ApplicationFiled: December 9, 2021Publication date: February 15, 2024Applicant: University of LeedsInventors: Steven Freear, David Matthew Joseph Cowell, Thomas Michael Carpenter
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Patent number: 11890593Abstract: A catalytic converter including a catalyst, the catalyst comprising a material of olivine composition, an engine comprising this catalytic converter and an method of producing nitrogen from NOx comprising the catalytic reduction of NOx by a catalyst comprising of a material of olivine composition. In addition, the use of a material of olivine composition in a catalytic reduction of NOx and a method of manufacture of a catalytic converter comprising adding the catalyst to a wash coat, applying the catalyst containing wash coat to a substrate and annealing the coated substrate.Type: GrantFiled: January 13, 2020Date of Patent: February 6, 2024Assignee: University of LeedsInventors: John Maurice Campbell Plane, Hu Li, Alexander James
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Patent number: 11793394Abstract: A steerable endoscope system includes a continuum manipulator, a plurality of syringes, and a steerable tip. The continuum manipulator includes a plurality of spaced discs and a plurality of backbones each extending through all discs. A bending movement of the continuum manipulator changes a varying linear displacement of each backbone. Each backbone is further coupled to a different one of the syringes such that the linear displacement of each backbone pushes or pulls a piston of the corresponding syringe by a varying amount. The steerable tip includes a plurality of bellows each pneumatically coupled to a different syringe such that movement of the piston of a syringe causes the corresponding bellow to inflate or deflate. Because the distal end of each bellow is fixedly coupled to the same end effector, variations in the amount of inflation or deflation on each bellow causes a bending of the steerable tip.Type: GrantFiled: December 1, 2017Date of Patent: October 24, 2023Assignees: Vanderbilt University, University of LeedsInventors: Nicolo Garbin, Pietro Valdastri, Keith L. Obstein, Nabil Simaan, Piotr Robert Slawinski
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Patent number: 11788008Abstract: There is provided the use of an aligned nematic elastomer to form a material having auxetic properties wherein the aligned nematic material has a mechanical Fréedericksz transition. Also provided is a method of producing an aligned nematic elastomer for said use.Type: GrantFiled: March 21, 2022Date of Patent: October 17, 2023Assignee: University of LeedsInventors: Helen Frances Gleeson, Devesh Arvind Mistry
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Publication number: 20230317203Abstract: The present invention relates to method of identifying a selective BRISC inhibitor. The present invention also relates to a stable BRISC dimer. The present invention further relates to use of the stable BRISC dimer to generate cryo-Electron Microscopy (cryo-EM), crystallography, nuclear magnetic resonance and/or X-ray crystallography structures for structure guided drug design.Type: ApplicationFiled: March 31, 2023Publication date: October 5, 2023Applicant: University of LeedsInventors: Elton Zeqiraj, Miriam Walden, Francesca Chandler
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Patent number: 11590119Abstract: The present specification relates to (S)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid (AZD4017), or a pharmaceutically acceptable salt thereof, for oral use in the treatment or prophylaxis of wounds, for example in diabetic patients. Methods of treatment and prophylaxis and the use of the compound in the preparation of a medicament for the treatment and prophylaxis of wounds are also provided.Type: GrantFiled: November 11, 2020Date of Patent: February 28, 2023Assignee: University of LeedsInventors: Ana Tiganescu, Paul Stewart
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Publication number: 20220097026Abstract: A catalytic converter including a catalyst, the catalyst comprising a material of olivine composition, an engine comprising this catalytic converter and an method of producing nitrogen from NOx comprising the catalytic reduction of NOx by a catalyst comprising of a material of olivine composition. In addition, the use of a material of olivine composition in a catalytic reduction of NOx and a method of manufacture of a catalytic converter comprising adding the catalyst to a wash coat, applying the catalyst containing wash coat to a substrate and annealing the coated substrate.Type: ApplicationFiled: January 13, 2020Publication date: March 31, 2022Applicant: University of LeedsInventors: John Maurice Campbell Plane, Hu Li, Alexander James
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Patent number: 11130130Abstract: A micro-fluidic flow device and method. The device includes a conduit having an inlet and an outlet distal from the inlet. The conduit further includes a plurality of constrictions each having a reduction in a cross-sectional area of the conduit in a direction from the inlet to the outlet. The constrictions are arranged in series and the reduction in cross-sectional area at each of the constrictions is sufficient to induce extensional flow in a fluid travelling therethrough, such that the maximum strain rate in the extensional flow region is at least 500 s?1.Type: GrantFiled: February 6, 2018Date of Patent: September 28, 2021Assignee: University of LeedsInventors: Sheena Elizabeth Radford, Nikil Kapur, David John Brockwell
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Patent number: 11098054Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.Type: GrantFiled: July 5, 2018Date of Patent: August 24, 2021Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Sciences, Fundacio Institut Catala D'Investigacio Quimica, University of Delaware, University of Leeds, Universitat Rovira I VirgiliInventors: John A. Beutler, Antonio Echavarren, William Chain, David Beech, Zhenhua Wu, Jean-Simon Suppo, Fernando Bravo, Hussein Rubaiy
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Publication number: 20210147773Abstract: A device for supporting development of a cellular deposit comprising at least one of a cell or a tissue derived from an ovary. The device comprises an inlet well, an outlet well, and an enclosed culture chamber disposed between the inlet well and the outlet well. The device further comprises an inlet channel fluidly coupling the inlet well to the culture chamber and an outlet chamber and/or at least one outlet channel fluidly coupling the culture chamber to the outlet well. At least one of the outlet chamber and the at least one outlet channel is sized to prevent passage of the cellular deposit therethrough.Type: ApplicationFiled: April 18, 2019Publication date: May 20, 2021Applicant: University of LeedsInventors: Virginia PENSABENE, Helen Mary PICTON, Paul Joseph MCKEEGAN, Francesco COLUCCI
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Patent number: 10869652Abstract: The disclosed technology relates to imaging catheters. A method is provided that includes: receiving, from a plurality of transducers disposed on a catheter probe, a corresponding plurality of analog signals; selectively sampling the plurality of analog signals; multiplexing to produce a sequence of samples; and transmitting the sequence of samples to a receiver circuit. The receiver circuit includes a clock; an analog to digital converter (ADC) in communication with the clock; and a sampling phase correction circuit in communication with the clock and the ADC. The method further includes: determining optimum sampling times based on measured signal delays associated with the system; adjusting a phase of the clock based on the measured signal delays; and communicating the phase-adjusted clock to the transmitter circuit for the selective sampling of the analog signals. Certain embodiments of the disclosed technology may further be utilized in conjunction with beamforming.Type: GrantFiled: October 14, 2016Date of Patent: December 22, 2020Assignees: Georgia Tech Research Corporation, University of LeedsInventors: Thomas Carpenter, M. Wasequr Rashid, F. Levent Degertekin, Steven Freear, David Matthew Joseph Cowell
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Patent number: 10717754Abstract: Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing. Improved catalytic activity has been observed with certain metal complexes of the invention.Type: GrantFiled: December 19, 2016Date of Patent: July 21, 2020Assignee: University of LeedsInventors: Stephen Philip Marsden, Patrick Columba McGowan, Roberta Lanaro, Andrew John Blacker