Abstract: There is provided a computer-implemented method for synthesising magnetic resonance angiography (MRA) images from other types of inputted magnetic resonance (MR) images, in a subject-specific manner, the method comprising providing a conditional generative adversarial network (cGAN) that learns a combined latent representation of the inputted magnetic resonance images for each subject and learns to transform this combined latent representation to a magnetic resonance angiography image corresponding to that subject, providing a plurality of magnetic resonance (MR) images as input into the cGAN, and outputting a plurality of MRA images from the cGAN based on the plurality of inputted MR images.

Abstract: The disclosure relates to the assembly of Virus Like Particles [VLPs] using packaging native and artificial packaging signals and their use in vaccines and immunological compositions and the methods of vaccination or immunisation against human and animal viral pathogens.

Abstract: The invention relates to tribological composites comprising diamond-like carbon and carbonaceous multi-layered nanoparticulate, e.g. graphene nanoplatelets, and methods for their preparation.

Abstract: A three-dimensional (3D) dental scanning system (1) for scanning a dental object (D) includes a scanning surface (124a) to support the dental object (D); a scanning section (130) to capture a 3D scan of the dental object (D); a motion section (120) to move the scanning surface (124a) and scanning section (130) relative to each other in five axes of motion, whilst retaining the scanning surface (124a) in a substantially horizontal plane, and a control unit (140) configured to control the motion section (120) and the scanning section (130) to obtain a 3D scan of the dental object (D).

Abstract: Described herein are inhibitors Transient Receptor Potential Canonical (TRPC) ion channels comprising TRPC4 protein and/or TRPC5 protein for use in combating obesity and other medical conditions including insulin resistance associated with Type II diabetes or development of Type II diabetes (pre-diabetes), metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Also disclosed is the use of the inhibitors for cosmetic purposes, such as cosmetic weight loss.

Abstract: The present application relates to a method for the production of a noble metal nanomaterial comprising: (A) adding an aqueous solution of a source of noble metal ions and a reducing agent to an aqueous solution of an organic compound to form a reaction mixture, wherein the organic compound is capable of undergoing 2D planar stacking in aqueous solution; and (B) separating the noble metal nanomaterial from the reaction mixture. The present application also relates to a noble metal nanomaterial manufactured according to said method.

Abstract: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.

Abstract: A process for reducing microbial growth in solutions of sugars extracted from waste materials, the process comprising monitoring indicators of microbial growth in the solution in situ and administering an antimicrobial; a sugar substrate obtained by concentrating a solution of sugar treated using the process; an apparatus for extracting sugars from waste materials, the apparatus comprising a reaction vessel (10), one or more sensors (15,20) for monitoring indicators of microbial growth in the reaction vessel, a software for analysing signals from the sensor and a source of antimicrobial.

Abstract: The invention relates to a method of identifying a genomic target for a test stimulus that is capable of modulating a cell phenotype, comprising: a) providing a population of cells that are phenotypically negative in response to the test stimulus; b) modifying the population of cells by random insertion into the cell genome of a gain-in-function construct; c) contacting the modified cell population with the test stimulus; d) screening the exposed modified cell population to identify modified cells that are phenotypically positive in response to the test stimulus; and e) identify a gene or genes associated with said positive phenotype thereby identifying the genomic target of the test stimulus.

Abstract: Examples provide a multilevel switched-mode ultrasound transmitter comprising a first push-pull transistor arrangement comprising first and second drive transistors, third and fourth additional switched transistors, each arranged as a bidirectional load switch with a one of the first and second drive transistors, wherein the first drive transistor and associated third additional switched transistor operate in series as a first arm of the first push-pull transistor arrangement, and the second drive transistor and associated fourth additional switched transistor operate in series as a second arm of the first push-pull transistor arrangement, wherein each arm is coupled between a respective polarity instance of a first bipolar drive voltage supply and a common output.

Abstract: A catalytic converter including a catalyst, the catalyst comprising a material of olivine composition, an engine comprising this catalytic converter and an method of producing nitrogen from NOx comprising the catalytic reduction of NOx by a catalyst comprising of a material of olivine composition. In addition, the use of a material of olivine composition in a catalytic reduction of NOx and a method of manufacture of a catalytic converter comprising adding the catalyst to a wash coat, applying the catalyst containing wash coat to a substrate and annealing the coated substrate.

Abstract: A steerable endoscope system includes a continuum manipulator, a plurality of syringes, and a steerable tip. The continuum manipulator includes a plurality of spaced discs and a plurality of backbones each extending through all discs. A bending movement of the continuum manipulator changes a varying linear displacement of each backbone. Each backbone is further coupled to a different one of the syringes such that the linear displacement of each backbone pushes or pulls a piston of the corresponding syringe by a varying amount. The steerable tip includes a plurality of bellows each pneumatically coupled to a different syringe such that movement of the piston of a syringe causes the corresponding bellow to inflate or deflate. Because the distal end of each bellow is fixedly coupled to the same end effector, variations in the amount of inflation or deflation on each bellow causes a bending of the steerable tip.

Abstract: There is provided the use of an aligned nematic elastomer to form a material having auxetic properties wherein the aligned nematic material has a mechanical Fréedericksz transition. Also provided is a method of producing an aligned nematic elastomer for said use.

Abstract: The present invention relates to method of identifying a selective BRISC inhibitor. The present invention also relates to a stable BRISC dimer. The present invention further relates to use of the stable BRISC dimer to generate cryo-Electron Microscopy (cryo-EM), crystallography, nuclear magnetic resonance and/or X-ray crystallography structures for structure guided drug design.

Abstract: The present specification relates to (S)-2-(1-(5-(cyclohexylcarbamoyl)-6-(propylthio)pyridin-2-yl)piperidin-3-yl)acetic acid (AZD4017), or a pharmaceutically acceptable salt thereof, for oral use in the treatment or prophylaxis of wounds, for example in diabetic patients. Methods of treatment and prophylaxis and the use of the compound in the preparation of a medicament for the treatment and prophylaxis of wounds are also provided.

Abstract: The present invention relates to a ceramic, to a process for preparing the ceramic and to the use of the ceramic as a dielectric in a capacitor.

Abstract: A catalytic converter including a catalyst, the catalyst comprising a material of olivine composition, an engine comprising this catalytic converter and an method of producing nitrogen from NOx comprising the catalytic reduction of NOx by a catalyst comprising of a material of olivine composition. In addition, the use of a material of olivine composition in a catalytic reduction of NOx and a method of manufacture of a catalytic converter comprising adding the catalyst to a wash coat, applying the catalyst containing wash coat to a substrate and annealing the coated substrate.

Abstract: The present application relates to a method for the production of a noble metal nanomaterial comprising: (A) adding an aqueous solution of a source of noble metal ions and a reducing agent to an aqueous solution of an organic compound to form a reaction mixture, wherein the organic compound is capable of undergoing 2D planar stacking in aqueous solution; and (B) separating the noble metal nanomaterial from the reaction mixture. The present application also relates to a noble metal nanomaterial manufactured according to said method.

Abstract: The present invention relates to a substrate comprising an ion-implanted layer, for example a cation, wherein the ion implanted layer has a substantially uniform distribution of the implanted ions at a significantly greater depth than previously possible, to a well-defined and sharp boundary within the substrate. The invention further comprises said substrate wherein the substrate is a silicon based substrate, such as glass. The invention also comprises the use of said material as a waveguide and the use of said material in measurement devices.

Abstract: A micro-fluidic flow device and method. The device includes a conduit having an inlet and an outlet distal from the inlet. The conduit further includes a plurality of constrictions each having a reduction in a cross-sectional area of the conduit in a direction from the inlet to the outlet. The constrictions are arranged in series and the reduction in cross-sectional area at each of the constrictions is sufficient to induce extensional flow in a fluid travelling therethrough, such that the maximum strain rate in the extensional flow region is at least 500 s?1.