Patents Assigned to University of Leicester
  • Publication number: 20240246905
    Abstract: Compounds of formula (I) or formula (II) are disclosed: Wherein Y1, Y2 and Y3 are independently selected from C—R1 or N. Such compounds find use as antibiotics and antifungals.
    Type: Application
    Filed: May 10, 2022
    Publication date: July 25, 2024
    Applicant: University of Leicester
    Inventors: Steven D. Bull, Liam J. Stephens
  • Patent number: 12005117
    Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: June 11, 2024
    Assignees: University of Leicester, Omeros Corporation
    Inventors: Nigel John Brunskill, Gregory A. Demopulos, Thomas A. Dudler, Hans-Wilhelm Schwaeble
  • Patent number: 11981748
    Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: May 14, 2024
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Gregory A. Demopulos, Hans-Wilhelm Schwaeble, Thomas Dudler, Larry Tjoelker
  • Patent number: 11896621
    Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: February 13, 2024
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Gregory A. Demopulos, Thomas Dudler, Hans-Wilhelm Schwaeble
  • Patent number: 11884742
    Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 2, 2019
    Date of Patent: January 30, 2024
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Hans-Wilhelm Schwaeble, Clark E. Tedford, James B. Parent, Thomas Dudler, Gregory A. Demopulos
  • Publication number: 20230120211
    Abstract: The disclosure provides compounds of formula (I). The compounds may be used to degrade the Histone Deacetylase (HDAC) family of enzymes, particularly HDAC1, 2 and 3 that exist in corepressor complexes. Accordingly, the compounds may be used to treat cancer. The invention extends to pharmaceutical compositions comprising these compounds, and the use of these compounds in therapy.
    Type: Application
    Filed: January 22, 2021
    Publication date: April 20, 2023
    Applicant: University of Leicester
    Inventors: Shaun Cowley, James Hodgkinson, Jasmine M. Cross, John Schwabe, Joshua Smalley, Grace Adams, Chris Millard
  • Patent number: 11389086
    Abstract: A method of assessing the effect of viewing varying colours of light on a subject's perception of tinnitus, comprising the steps of: presenting a display in at least part of the subject's field of view; illuminating the display with coloured light in the visible spectrum using one or more variable sources, varying measurable values of the coloured light illuminating the display; and recording the measurable values of the coloured light illuminating the display at which the subject indicates a change in their perception of tinnitus.
    Type: Grant
    Filed: December 26, 2019
    Date of Patent: July 19, 2022
    Assignees: University of Leicester, Orthoscopics Limited
    Inventors: Michael Mulheran, John Anderson, Graham Street, Ian Jordan
  • Patent number: 11013772
    Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: May 25, 2021
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Gregory A. Demopulos, Thomas Dudler, Hans-Wilhelm Schwaeble
  • Patent number: 10987046
    Abstract: A method for assessing the electrical function of a heart that includes: (1) for each of a plurality of leads of an ECG, determining a value derived from the output of that lead and which corresponds to an action potential duration; (2) for each of the plurality of leads of the ECG, determining a value derived from the output of that lead and which corresponds to a diastolic interval; (3) for each of the plurality of leads of the ECG, determining a relationship between the determined values for action potential duration and for diastolic interval; and (4) assessing the differences between the determined relationships for each of the plurality of leads. The invention further relates to apparatus and a computer program that may be used in the method.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: April 27, 2021
    Assignee: University of Leicester
    Inventors: William Nicolson, G. Andre Ng
  • Patent number: 10933119
    Abstract: The invention relates to aortopathy, and in particular, to compositions and methods for the diagnosis and treatment of aortopathy.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 2, 2021
    Assignee: University of Leicester
    Inventor: Toru Suzuki
  • Patent number: 10870708
    Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: December 22, 2020
    Assignee: University of Leicester
    Inventors: Gregory A. Demopulos, Hans-Wilhelm Schwaeble, Thomas Dudler, Larry Tjoelker
  • Patent number: 10736960
    Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: August 11, 2020
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Nigel John Brunskill, Gregory A. Demopulos, Tom Dudler, Hans-Wilhelm Schwaeble
  • Publication number: 20200205700
    Abstract: A method of assessing the effect of viewing varying colours of light on a subject's perception of tinnitus, comprising the steps of: presenting a display in at least part of the subject's Held of view; illuminating the display with coloured light in the visible spectrum using one or more variable sources, varying measurable values of the coloured light illuminating the display; and recording the measurable values of the coloured light illuminating the display at which the subject indicates a change in their perception of tinnitus.
    Type: Application
    Filed: December 26, 2019
    Publication date: July 2, 2020
    Applicants: University of Leicester, Orthoscopics Limited
    Inventors: Michael MULHERAN, John ANDERSON, Graham STREET, Ian JORDAN
  • Patent number: 10660317
    Abstract: Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 26, 2020
    Assignee: University of Leicester
    Inventors: Teizo Fujita, Hans-Wilhelm Schwaeble, Cordula Margaret Stover
  • Patent number: 10662540
    Abstract: There is provided an electrolyte for the electrodeposition of chromium comprising: (A) water; (B) at least one chromium salt; and (C) at least one complexing agent, wherein the molar ratio of components B:C is in the range of 1:1 to 1:50. There is also provided a method for electrodepositing chromium metal onto a conductive substrate.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: May 26, 2020
    Assignee: University of Leicester
    Inventors: Andrew Peter Abbott, Karl Scott Ryder, Robert Harris
  • Patent number: 10626184
    Abstract: In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: April 21, 2020
    Assignees: Omeros Corporation, University of Leicester
    Inventors: Hans-Wilhelm Schwaeble, Gregory A. Demopulos
  • Publication number: 20200033356
    Abstract: The invention provides methods, compositions, and kits for the characterisation and analysis of proteins. Methods are provided for determining, on a protein, a binding site for a binding partner, the methods comprising: contacting a protein with a plurality of monomers, and polymerising the monomers to create a protein:polymer complex; digesting the protein in the complex to produce a peptide:polymer complex; isolating the peptide:polymer complex; and sequencing the peptide, wherein the peptide corresponds to a binding site for a binding partner.
    Type: Application
    Filed: March 19, 2018
    Publication date: January 30, 2020
    Applicant: University of Leicester
    Inventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones
  • Patent number: 10489634
    Abstract: A method including receiving an indication that a first classifier has identified that an image includes an object of a predetermined class of objects. Image data that relates to the image is processed using a second classifier with a first training state, which determines whether the image data includes the object of the predetermined class of objects. In response to the determining, data relating to the image data is transmitted to a remote system. Update data relating to the transmitted data is received from the remote system. The training state of the second classifier is updated to a second training state in response to the update data such that the second classifier with the second training state would make a different determination of whether future image data similar to the image data includes an object of the predetermined class of objects than the second classifier with the first training state.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: November 26, 2019
    Assignee: Apical Limited and University of Leicester
    Inventors: Ilya Romanenko, Alexander Gorban, Ivan Tyukin
  • Patent number: 10456514
    Abstract: A device for providing assistance to ventricular systole, the device comprising a pressuriser and a driver, wherein the pressuriser is adapted to be able to apply localised pressure to only the external wall of one ventricle, or a portion thereof, and the driver is operatively linked to the pressuriser so as to be able to drive a cycle of increased and decreased pressure applied by the pressuriser. The invention also relates to a method of implanting the device and a method of treating cardiac pump failure in which the device is used.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: October 29, 2019
    Assignee: University of Leicester
    Inventors: David Adlam, Samara-Ratna Piyal
  • Patent number: 10309912
    Abstract: Methods and apparatus are provided for performing back-reflection energy-dispersive X-ray diffraction (XRD). This exhibits extremely low sensitivity to the morphology of the sample under investigation. As a consequence of this insensitivity, unprepared samples can be analyzed using this method. For example, in a geological context, whole rock samples become amenable to analysis. A composite diffraction spectrum can be produced using information from different recorded spectra in different energy sub-ranges. The composite spectrum excludes fluorescence signals that would otherwise obscure the diffraction signals.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 4, 2019
    Assignee: University of Leicester
    Inventor: Graeme Mark Hansford