Patents Assigned to University of Leicester
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Publication number: 20240246905Abstract: Compounds of formula (I) or formula (II) are disclosed: Wherein Y1, Y2 and Y3 are independently selected from C—R1 or N. Such compounds find use as antibiotics and antifungals.Type: ApplicationFiled: May 10, 2022Publication date: July 25, 2024Applicant: University of LeicesterInventors: Steven D. Bull, Liam J. Stephens
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Patent number: 12005117Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.Type: GrantFiled: June 30, 2020Date of Patent: June 11, 2024Assignees: University of Leicester, Omeros CorporationInventors: Nigel John Brunskill, Gregory A. Demopulos, Thomas A. Dudler, Hans-Wilhelm Schwaeble
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Patent number: 11981748Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.Type: GrantFiled: November 17, 2020Date of Patent: May 14, 2024Assignees: Omeros Corporation, University of LeicesterInventors: Gregory A. Demopulos, Hans-Wilhelm Schwaeble, Thomas Dudler, Larry Tjoelker
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Patent number: 11896621Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.Type: GrantFiled: April 9, 2021Date of Patent: February 13, 2024Assignees: Omeros Corporation, University of LeicesterInventors: Gregory A. Demopulos, Thomas Dudler, Hans-Wilhelm Schwaeble
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Patent number: 11884742Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.Type: GrantFiled: October 2, 2019Date of Patent: January 30, 2024Assignees: Omeros Corporation, University of LeicesterInventors: Hans-Wilhelm Schwaeble, Clark E. Tedford, James B. Parent, Thomas Dudler, Gregory A. Demopulos
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Publication number: 20230120211Abstract: The disclosure provides compounds of formula (I). The compounds may be used to degrade the Histone Deacetylase (HDAC) family of enzymes, particularly HDAC1, 2 and 3 that exist in corepressor complexes. Accordingly, the compounds may be used to treat cancer. The invention extends to pharmaceutical compositions comprising these compounds, and the use of these compounds in therapy.Type: ApplicationFiled: January 22, 2021Publication date: April 20, 2023Applicant: University of LeicesterInventors: Shaun Cowley, James Hodgkinson, Jasmine M. Cross, John Schwabe, Joshua Smalley, Grace Adams, Chris Millard
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Patent number: 11389086Abstract: A method of assessing the effect of viewing varying colours of light on a subject's perception of tinnitus, comprising the steps of: presenting a display in at least part of the subject's field of view; illuminating the display with coloured light in the visible spectrum using one or more variable sources, varying measurable values of the coloured light illuminating the display; and recording the measurable values of the coloured light illuminating the display at which the subject indicates a change in their perception of tinnitus.Type: GrantFiled: December 26, 2019Date of Patent: July 19, 2022Assignees: University of Leicester, Orthoscopics LimitedInventors: Michael Mulheran, John Anderson, Graham Street, Ian Jordan
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Patent number: 11013772Abstract: In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.Type: GrantFiled: August 14, 2018Date of Patent: May 25, 2021Assignees: Omeros Corporation, University of LeicesterInventors: Gregory A. Demopulos, Thomas Dudler, Hans-Wilhelm Schwaeble
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Patent number: 10987046Abstract: A method for assessing the electrical function of a heart that includes: (1) for each of a plurality of leads of an ECG, determining a value derived from the output of that lead and which corresponds to an action potential duration; (2) for each of the plurality of leads of the ECG, determining a value derived from the output of that lead and which corresponds to a diastolic interval; (3) for each of the plurality of leads of the ECG, determining a relationship between the determined values for action potential duration and for diastolic interval; and (4) assessing the differences between the determined relationships for each of the plurality of leads. The invention further relates to apparatus and a computer program that may be used in the method.Type: GrantFiled: January 26, 2018Date of Patent: April 27, 2021Assignee: University of LeicesterInventors: William Nicolson, G. Andre Ng
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Patent number: 10933119Abstract: The invention relates to aortopathy, and in particular, to compositions and methods for the diagnosis and treatment of aortopathy.Type: GrantFiled: February 19, 2016Date of Patent: March 2, 2021Assignee: University of LeicesterInventor: Toru Suzuki
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Patent number: 10870708Abstract: In one aspect, the present invention provides methods for preventing, treating, reverting and/or delaying angiogenesis in a mammalian subject suffering from, or at risk for developing, an angiogenesis-dependent disease or condition, comprising administering to the subject an amount of a MASP-2 inhibitory agent effective to inhibit angiogenesis. In some embodiments of these aspects of the invention, the MASP-2 inhibitory agent is a MASP-2 antibody or fragment thereof.Type: GrantFiled: March 31, 2017Date of Patent: December 22, 2020Assignee: University of LeicesterInventors: Gregory A. Demopulos, Hans-Wilhelm Schwaeble, Thomas Dudler, Larry Tjoelker
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Patent number: 10736960Abstract: In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.Type: GrantFiled: January 5, 2017Date of Patent: August 11, 2020Assignees: Omeros Corporation, University of LeicesterInventors: Nigel John Brunskill, Gregory A. Demopulos, Tom Dudler, Hans-Wilhelm Schwaeble
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Publication number: 20200205700Abstract: A method of assessing the effect of viewing varying colours of light on a subject's perception of tinnitus, comprising the steps of: presenting a display in at least part of the subject's Held of view; illuminating the display with coloured light in the visible spectrum using one or more variable sources, varying measurable values of the coloured light illuminating the display; and recording the measurable values of the coloured light illuminating the display at which the subject indicates a change in their perception of tinnitus.Type: ApplicationFiled: December 26, 2019Publication date: July 2, 2020Applicants: University of Leicester, Orthoscopics LimitedInventors: Michael MULHERAN, John ANDERSON, Graham STREET, Ian JORDAN
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Patent number: 10660317Abstract: Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19; such mammals may also lack MASP-2.Type: GrantFiled: November 10, 2016Date of Patent: May 26, 2020Assignee: University of LeicesterInventors: Teizo Fujita, Hans-Wilhelm Schwaeble, Cordula Margaret Stover
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Patent number: 10662540Abstract: There is provided an electrolyte for the electrodeposition of chromium comprising: (A) water; (B) at least one chromium salt; and (C) at least one complexing agent, wherein the molar ratio of components B:C is in the range of 1:1 to 1:50. There is also provided a method for electrodepositing chromium metal onto a conductive substrate.Type: GrantFiled: February 3, 2016Date of Patent: May 26, 2020Assignee: University of LeicesterInventors: Andrew Peter Abbott, Karl Scott Ryder, Robert Harris
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Patent number: 10626184Abstract: In various embodiments the invention provides anti-mucin-like protein (MLP) monoclonal antibodies, compositions and methods for detecting MLP as a biomarker for mucin-secreting type of cancer such as ovarian or pancreatic cancer.Type: GrantFiled: June 6, 2017Date of Patent: April 21, 2020Assignees: Omeros Corporation, University of LeicesterInventors: Hans-Wilhelm Schwaeble, Gregory A. Demopulos
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Publication number: 20200033356Abstract: The invention provides methods, compositions, and kits for the characterisation and analysis of proteins. Methods are provided for determining, on a protein, a binding site for a binding partner, the methods comprising: contacting a protein with a plurality of monomers, and polymerising the monomers to create a protein:polymer complex; digesting the protein in the complex to produce a peptide:polymer complex; isolating the peptide:polymer complex; and sequencing the peptide, wherein the peptide corresponds to a binding site for a binding partner.Type: ApplicationFiled: March 19, 2018Publication date: January 30, 2020Applicant: University of LeicesterInventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones
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Patent number: 10489634Abstract: A method including receiving an indication that a first classifier has identified that an image includes an object of a predetermined class of objects. Image data that relates to the image is processed using a second classifier with a first training state, which determines whether the image data includes the object of the predetermined class of objects. In response to the determining, data relating to the image data is transmitted to a remote system. Update data relating to the transmitted data is received from the remote system. The training state of the second classifier is updated to a second training state in response to the update data such that the second classifier with the second training state would make a different determination of whether future image data similar to the image data includes an object of the predetermined class of objects than the second classifier with the first training state.Type: GrantFiled: September 26, 2017Date of Patent: November 26, 2019Assignee: Apical Limited and University of LeicesterInventors: Ilya Romanenko, Alexander Gorban, Ivan Tyukin
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Patent number: 10456514Abstract: A device for providing assistance to ventricular systole, the device comprising a pressuriser and a driver, wherein the pressuriser is adapted to be able to apply localised pressure to only the external wall of one ventricle, or a portion thereof, and the driver is operatively linked to the pressuriser so as to be able to drive a cycle of increased and decreased pressure applied by the pressuriser. The invention also relates to a method of implanting the device and a method of treating cardiac pump failure in which the device is used.Type: GrantFiled: April 1, 2016Date of Patent: October 29, 2019Assignee: University of LeicesterInventors: David Adlam, Samara-Ratna Piyal
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Patent number: 10309912Abstract: Methods and apparatus are provided for performing back-reflection energy-dispersive X-ray diffraction (XRD). This exhibits extremely low sensitivity to the morphology of the sample under investigation. As a consequence of this insensitivity, unprepared samples can be analyzed using this method. For example, in a geological context, whole rock samples become amenable to analysis. A composite diffraction spectrum can be produced using information from different recorded spectra in different energy sub-ranges. The composite spectrum excludes fluorescence signals that would otherwise obscure the diffraction signals.Type: GrantFiled: March 13, 2018Date of Patent: June 4, 2019Assignee: University of LeicesterInventor: Graeme Mark Hansford