Abstract: A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility and/or modifies drug release or other behaviour. The first segment may for example comprise a poly(dimethylsiloxane)-containing moiety. The second segment may for example resemble a drug molecule. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye.

Abstract: A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.

Abstract: The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.

Abstract: An ion guide electrode assembly (10) for an ion-mobility spectrometer is described. The electrode assembly (10) comprises a first sheet (100), having first and second surfaces (110, 120) comprising a plurality of corresponding regions (111, 112, 121, 122). The first sheet (100) comprises a set of N electrodes (130, 140), including a first electrode (130) and a second electrode (140), provided as tracks mutually spaced apart on the first surface (110) thereof. The electrode assembly (10) is arrangeable in a planar configuration and preferably in a tubular configuration. In the tubular configuration, a first part (131) of the first electrode (130), provided in a first region 111 of the first surface (110), overlays a second region (122) of the second surface (120).

Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a boundary is prepared. A space including the porous CAD volume is populated with unit cells. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. The space is populated with at least one elongated fixation element extending beyond the boundary to produce an interlocking feature enabling assembly or engagement with a mating structure.

Abstract: Aspects of the present disclosure relate generally to preparing models of three-dimensional structures. In particular, a model of a three-dimensional structure constructed of porous geometries is prepared. A component file including a porous CAD volume having a boundary is prepared. A space including the porous CAD volume is populated with unit cells. The unit cells are populated with porous geometries having a plurality of struts having nodes on each end. The space is populated with at least one elongated fixation element extending beyond the boundary to produce an interlocking feature enabling assembly or engagement with a mating structure.

Abstract: A transmitter for inductive charging of a device comprising a receiver is provided. The transmitter includes a set of coils, including a first coil having a first turn and a second turn. The first turn and the second turn are adjacent. The first turn has the first sense and the second turn has the second sense, opposed to the first sense; whereby, in use, current flows through the first turn and the second turn in opposed senses.

Abstract: A composition comprises: a base oil; an additive comprising a copolymer comprising hydrophobic and hydrophilic units; and a drug. The copolymer may for example have a comb structure in which the hydrophobic units and hydrophilic units are pendant chains on a backbone of the copolymer. The hydrophobic units and hydrophilic units may for example comprise polydimethylsiloxane moieties and ethylene glycol residues respectively. The composition may for example be used as a tamponade or as a component for a tamponade administered to the eye. The invention is useful for solubilising and/or releasing drugs.

Abstract: An embodiment of the present invention provides a method of creating a classifier indicative of a presence of a medical condition in a subject, comprising receiving chromatogram data indicative of a profile of volatile organic compounds in a sample from each of a first plurality of subjects having the medical condition and a second plurality of subjects without the medical condition, selecting one of the chromatogram data as reference chromatogram data, aligning the remaining chromatogram data in relation to the reference chromatogram data, extracting one or more features from the chromatogram data using a Mexican hat wavelet transform of one or more scales, selecting one or more features of the chromatogram data indicative of the medical condition, and constructing a classifier for determining a boundary between chromatogram data indicative of the medical condition and chromatogram data indicative of an absence of the medical condition.

Abstract: The present invention relates to novel sulfur-doped carbonaceous porous materials. The present invention also relates to processes for the preparation of these materials and to the use of these materials in applications such as gas adsorption, mercury and gold capture, gas storage and as catalysts or catalyst supports.

Abstract: There is provided an imaging device (100) for imaging a target, the imaging device (100) comprising a Scheimpflug imaging system (102) and an Optical Coherence Tomography, OCT, imaging system (104), where the Scheimpflug imaging system (102) comprises a camera (112) and a lens system (108), and the OCT imaging system (104) comprises an imaging optical element and a detector (122). The imaging device (100) further comprises a light source (106) adapted to provide a light beam suitable for operation of the Scheimpflug imaging system (102) and the OCT imaging system (104). The lens system (108) of the Scheimpflug imaging (102) system is configured to provide an adjustable focal length.

Abstract: A method of providing an article having a set of directional channels, including a first directional channel, therein is described. The method comprises preparing a mixture including particles comprising a first material and a first binding agent. The method comprises providing an article precursor by surrounding a pattern comprising a second material with the mixture. The method comprises heating the article precursor thereby coalescing the particles to provide the article. The method comprises removing the pattern by reacting the second material to form a gaseous product, thereby providing the set of directional channels in the article, wherein the set of directional channels corresponds with the removed pattern. Such an article is also described.

Abstract: The present invention relates to compounds of Formulae (I) and (II) as defined herein, and salts and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formulae (I) and (II), and to the use of compounds of Formulae (I) and (II) in the treatment or prevention of filarial worm infection, as well as other diseases or conditions in which filarial worm infection is implicated.

Abstract: Embodiments of the present invention provide a phantom and radiation detection system (100) comprising a vessel for containing a tissue equivalent liquid and adapted to pass a beam of test radiation into the vessel (110), a detector (140) adapted to determine the intensity of the beam of test radiation, the detector (140) being supported within the vessel (110) and movable therein along an expected path of the beam of test radiation, wherein the detector (140) is a 2-dimensional detector adapted to determine the spatial intensity and energy deposition of the beam.

Abstract: The present invention relates to methods of preferentially sorbing, from a target mixture, one or more target substance(s) over one or more non-target substance(s). In particular, porous organic cages (POCs) may be deployed in the quantum sieving of mixtures of hydrogen isotopes to selectively sorb heavy hydrogen isotopes (e.g. diatomic deuterium) over lighter isotopes (diatomic protium).

Abstract: Embodiments of the present invention provide a method and apparatus for frequency-domain optical interferometry imaging. Embodiments of the invention include an apparatus comprising a line-shaping optical element for directing optical radiation into a line illumination, an imaging optical element for receiving optical radiation comprising radiation reflected from a target sample and a reference point associated with the target sample, and a detection unit for measuring common path interferences between a plurality of reflections from the target sample and the reference point. Embodiments of the invention include a method comprising directing radiation into a line illumination, directing the line illumination towards a target sample, receiving radiation reflected from the target sample at a detection unit, and measuring common path interferences between a plurality of reflections at the target sample and a reference point.

Abstract: A method of selecting wavelengths of radiation for discriminating a first cell or tissue type from a different cell or tissue type is described. First and second sets of absorption spectra are obtained, each set comprising spectra obtained at a plurality of different spatial regions of the first cell or tissue type and of the different cell or tissue type, respectively. Sets of corresponding metrics are defined for the first and second sets of absorption spectra for each spatial region. Each metric comprises information corresponding to the absorption for at least two different wavelengths. The metrics in each set comprise different combinations of wavelengths. A characteristic value is generated for each metric. Distributions are generated for each metric using corresponding characteristic values for the first cell or tissue type and for the different cell or tissue type and compared to determine an extent of similarity.

Abstract: The present disclosure relates to a diagnostic test for the early detection of pancreatic cancer [i.e. pancreatic ductal adenocarcinoma, ‘PDAC’] or pancreatitis in a cohort of patients selected for an increased risk of PDAC which is associated with diabetes mellitus (DM) and including treatment regimens for the treatment of subjects with PDAC and kits used in the method of the invention.

Abstract: A device for applying a compressive force to the uterus, the device comprising a contact portion for contacting the uterus and providing a compressive force thereto, and at least two elongate handles each extending from the contact portion along a respective longitudinal axis. The at least two elongate handles are configured to facilitate insertion of the device into the body and handling of the device from outside the body when inserted. At least a part of the contact portion is configured to be radially moveable relative to the longitudinal axes between a first radial position and a second radial position where the second radial position is radially outward of the first radial position.

Abstract: Responsive or degradable branched polymers may be prepared by the free radical polymerisation of a multivinyl monomer in the presence of a chain transfer agent, using a source of radicals, wherein the extent of propagation is controlled relative to the extent of chain transfer to prevent gelation of the polymer. The multivinyl monomer may comprise a cleavable group, for example an ester, or a multiplicity of such groups, between two vinyl groups. Said monomer may be a macromonomer containing multiple cleavage sites.