Abstract: An energy-efficient disinfection or sterilisation of contaminated liquid, such as water contaminated with viruses or microbes includes an asymmetric configuration of a cavitation nozzle made from dielectric material that enables the formation of a single, stable cavitation bubble of a large volume. A low-pressure gaseous plasma is continuously formed inside the cavitation bubble by electrodes to prevent contact of the metallic electrode with liquid water and Ohmic heating of the contaminated water. The electrodes are connected to a high voltage power supply. The power supply enables formation of a continuous stable gaseous discharge inside the cavitation bubble and radicals and radiation useful for destruction of viruses to the levels below the current US EPA standard in few minutes, while the temperature of liquid water remains practically unchanged. Use is not only for hospitals and pharmaceutical companies but the food industry and agriculture as well.

Abstract: An energy-efficient disinfection or sterilisation of contaminated liquid, such as water contaminated with viruses or microbes includes an asymmetric configuration of a cavitation nozzle made from dielectric material that enables the formation of a single, stable cavitation bubble of a large volume. A low-pressure gaseous plasma is continuously formed inside the cavitation bubble by electrodes to prevent contact of the metallic electrode with liquid water and Ohmic heating of the contaminated water. The electrodes are connected to a high voltage power supply. The power supply enables formation of a continuous stable gaseous discharge inside the cavitation bubble and radicals and radiation useful for destruction of viruses to the levels below the current US EPA standard in few minutes, while the temperature of liquid water remains practically unchanged. Use is not only for hospitals and pharmaceutical companies but the food industry and agriculture as well.

Abstract: The present invention relates to microorganisms that express, or have attached to their surface, a TNF? binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNF? and therefore reducing the content of free TNF? and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.

Abstract: The present invention relates to microorganisms that express, or have attached to their surface, a TNF? binding polypeptide. Peptides expressed or attached on the surface of microorganism are more resistant to chemical and enzymatic degradation in the gastrointestinal tract. Such microorganisms are capable of binding TNF? and therefore reducing the content of free TNF? and alleviating its pro-inflammatory effects in the gut. The invention also relates to the use of such microorganisms as medicament in the treatment of inflammatory bowel disease.

Abstract: Novel thrombin inhibitors of the formula I (I)and pharmaceutically acceptable salts thereof are described wherein the substituents in the description have the specific meanings. The compounds are useful as thrombin inhibitors.

Abstract: The invention relates to compounds that are heterocyclic derivatives of dipeptides and dipeptides mimetics and pharmaceutically acceptable salts thereof.