Abstract: The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.

Abstract: A composition comprising a mixture of a calcium orthophosphate and a bioactive glass comprising fluorine is useful in a non-aqueous toothpaste.

Abstract: The invention relates to a method of assembling a biosensor device comprising two or more biosensor units, wherein each unit comprises one or more biosensors comprising one or more carbon nanotubes (CNTs) coated with nucleic acid and one or more sensor molecules coupled to the nucleic acid, wherein each one of the one or more sensor molecules is capable of binding to a target molecule in a sample. Each biosensor unit is capable of detecting a different target molecule in a sample, and each unit comprises one or more biosensors each capable of detecting the same target molecule. The invention further relates to biosensor devices and methods for detecting target molecules in a sample using the same.

Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.

Abstract: The present invention relates to novel polypeptides, which are derived from a human agrin or a variant of a human agrin. The invention also concerns uses of the polypeptides and compositions comprising the polypeptides.

Abstract: A method of determining the safety and/or efficacy of a gene therapy vector prior to carrying out gene therapy on an individual includes infecting a culture of induced pluripotent stem cells obtained from the individual with a gene therapy vector. Ideally the cells are allowed to differentiate, and the infection is carried out at the start of culture and at least once during differentiation and/or after differentiation. Nucleic acids are extracted from the infected cells, and then analysed to measure and/or determine adverse effects of integration of nucleic acid from the vector and/or efficiency of expression of nucleic acid from the vector.

Abstract: A method is provided for forming an add-on component for an aerofoil which enable the structure of the aerofoil to be tuned in order to reduce the amplitude of sound produced at frequency fpeak when air flows in a flow direction from the leading edge over the trailing edge of an aerofoil. The method applies both to add-on components having a slitted formation and a Double-Rooted Trailing Edge Serration (abbreviated to “DRooTES”).

Abstract: A method of preparing a mixture of a metal or metal alloy and (NbxTi1-x)C (where 0<x?1) in which (NbxTi1-x)C in particulate form (either with or without metal powder) is formed into a preform and then if necessary added to the metal. The resulting (NbxTi1-x)C/metal mixture can then be heated to a temperature below the melting point of the (NbxTi1-x)C and optionally dispersed in liquid metal and/or casted and cooled to produce a solid product with improved physical properties.

Abstract: The present invention relates to anti-ROR2 inhibitors and uses thereof in treating and/or preventing cartilage loss.

Abstract: The present invention pertains to the field of cancer diagnosis. Specifically, it relates to a method for diagnosing pancreas cancer in a subject comprising the steps of determining in a sample of a subject suspected to suffer from pancreas cancer the amount of at least one biomarker selected from the biomarkers shown in Table 1 and comparing the said amount of the at least one biomarker with a reference, whereby pancreas cancer is to be diagnosed. The present invention also contemplates a method for identifying whether a subject is in need of a pancreas cancer therapy comprising the steps of the aforementioned methods and the further step of identifying a subject in need of a pancreas cancer therapy if said subject is to be diagnosed to suffer from pancreas cancer. Contemplated are, furthermore, diagnostic devices and kits for carrying out said methods.

Abstract: Disclosed herein is a sound synthesis system for generating a user defined synthesised sound effect, the system comprising: a receiver of user defined inputs for defining a sound effect; a generator of control parameters in dependence on the received user defined inputs; a plurality of sound effect objects, wherein each sound effect object is arranged to generate a different class of sound and each sound effect object comprises a sound synthesis model arranged to generate a sound in dependence on one or more of the control parameters; a plurality of audio effect objects, wherein each audio effect object is arranged to receive a sound from one or more sound effect objects and/or one or more other audio effect objects, process the received sound in dependence on one or more of the control parameters and output the processed sound; a scene creation function arranged to receive sound output from one or more sound effect objects and/or audio effect objects and to generate a synthesised sound effect in dependence o

Abstract: Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be provided directly as oligonucleotides or expression products of vectors that are administered to a subject. High rates of skipping can be achieved. High rates of skipping reduce the severity of a disease like Duchene Muscular Dystrophy so that the disease is more like Becker Muscular Dystrophy. This is a severe reduction in symptom severity and mortality.

Abstract: The present invention relates to glycolysis-activating agents. The present invention also relates to the treatment or prevention of diseases or medical conditions, in particular immune-related diseases or medical conditions. In particular, the present invention also relates to agents for use in the treatment or prevention of a disease or medical condition, which treatment or prevention is mediated via the trafficking of endogenous regulatory T cells (Tregs).

Abstract: A computer-implemented method of processing audio data, the method comprising receiving input audio data (x) comprising a time-series of amplitude values; transforming the input audio data (x) into an input frequency band decomposition (X1) of the input audio data (x); transforming the input frequency band decomposition (X1) into a first latent representation (Z); processing the first latent representation (Z) by a first deep neural network to obtain a second latent representation (Z{circumflex over (?)}, Z1{circumflex over (?)}); transforming the second latent representation (Z{circumflex over (?)}, Z1{circumflex over (?)}) to obtain a discrete approximation (X3{circumflex over (?)}); element-wise multiplying the discrete approximation (X3{circumflex over (?)}) and a residual feature map (R, X5{circumflex over (?)}) to obtain a modified feature map, wherein the residual feature map (R, X5{circumflex over (?)}) is derived from the input frequency band decomposition (X1); processing a pre-shaped frequency band

Abstract: A flywheel assembly 10 comprising: at least one flywheel mass support 14, the or each said support having a shaft 19 that extends along a rotational axis 18 about which the support 14 can rotate in use, the or each said support 14 comprising a plurality of openings 24 that are each offset from said rotational axis 18, a flywheel mass 12 comprising a plurality of openings 16 that are each arranged to align with a corresponding opening in said support; and means 23 for coupling said flywheel mass 12 to the or each said support 14 so that the mass 12 can rotate with the or each support 14 in use, said coupling means 23 being configured to extend through the aligned openings in the or each support 14 and said flywheel mass 12; wherein said flywheel mass 12 comprises a plurality of generally planar flywheel mass elements sandwiched together to form a stack of elements, each said element including a plurality of openings 16 that align with the openings 24 in the or each said support 14 and with openings in neighbou

Abstract: A heat pipe system including a heat pipe having a first end and a second end for transferring working fluid from the first to the second end, a first reservoir in fluid communication with the first end for holding working fluid in liquid form, a first heat exchanger for transmitting thermal energy from a heat source to working fluid in the first reservoir to vaporize the fluid, a second heat exchanger for transmitting thermal energy from vaporized working fluid to a heat sink thereby condensing the fluid, a return conduit and a pump for pumping the condensed working fluid along the return conduit, where the heat pipe, the return conduit and the first reservoir form a hermetically sealed circuit. A method of transferring thermal energy using a heat pipe system is also disclosed.

Abstract: A store (1) for thermal energy, the store comprising: a housing (5) defining an internal chamber having an inlet and an outlet; and a plurality of receptacles (7) provided within the internal chamber and spaced from one another so that heat transfer fluid can flow over and around the receptacles (7) as the fluid moves from the inlet to the outlet; wherein each said receptacle (7) defines an internal cavity (9) for the storage of phase change material (PCM) so that thermal energy can transfer between the stored PCM material and the heat transfer fluid as the fluid passes over and between the receptacles.

Abstract: The present invention provides a crystalline salt of chlorhexidine chloride having a spherical morphology under Scanning Electron Microscopy (SEM) comprising a chloride anion and a cation selected from the group consisting of calcium, sodium, potassium, magnesium, zinc, strontium or iron, processes for the preparation of the salt, compositions, pharmaceutical compositions and uses thereof in medicine. Also provided are crystalline forms of the salt and fibres comprising the same.

Abstract: A method of predicting the likelihood of success of a gene therapy procedure includes inducing DNA damage in a cell sample from an individual. The ability of the individual's cells in the sample to repair the DNA damage is then assessed to determine whether the individual could tolerate DNA damage caused by a gene therapy vector. In preferred embodiments, the ability of the individual's cells to repair DNA damage is assessed by detecting, and monitoring the subsequent disappearance of, a marker of DNA damage repair (such as gamma H2AX or phosphorylated 53BP1) in the sample.

Abstract: EL The present invention provides a system for electrodepositing a plurality of electrolytes onto a substrate in a single deposition chamber to form an article, in which the system comprises a removable substrate; a deposition chamber containing the substrate in which the chamber has an inlet and an outlet and in which the chamber comprises at least one anode with connection to a source of electrical current; a plurality of electrolyte reservoirs for an electrolyte solution connected to the deposition chamber through the inlet; and a rinse medium reservoir connected to the deposition chamber through the inlet. Also provided is a system comprising a cradle to form an article, methods using the systems of the invention, and composite materials and devices prepared by the methods of the invention.