Patents Assigned to University of Louisville Research Foundation, Inc.
  • METHODS FOR APPLYING EPIDURAL ELECTRICAL STIMULATION
    Publication number: 20180229036
    Abstract: Embodiments of the present invention relate to methods for applying epidural electrical stimulation to improve motor function or physiological responses in paralyzed individuals. More particularly, the present invention relates to methods for creating and applying specific configurations of epidural stimulation to assist or cause a patient to perform a complex motor function or to mitigate one or more secondary consequences of paralysis including, but not limited to, cardiovascular, respiratory, bladder, temperature and sexual dysfunction.
    Type: Application
    Filed: August 18, 2016
    Publication date: August 16, 2018
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Susan J. Harkema, Yangshen Chen, Manikandan Ravi, Claudia Angeli, Charles Hubscher
  • Methods for making copper inks and films
    Patent number: 10047236
    Abstract: The presently-disclosed subject matter includes methods for making a copper ink. In some embodiments the methods comprise forming an aqueous solution that includes copper and adding an amount of a surfactant to the aqueous solution to thereby produce a copper ink that includes a dispersion of copper nanoparticles. In some embodiments the methods further include adding an amount of a reducing agent to the aqueous solution. In some instances the copper inks are formed from copper salts, and in some embodiments the copper inks do not include oxides of copper. The presently-disclosed subject matter also includes copper inks formed by the presently-disclosed methods as well as methods of forming a copper film from a copper ink.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: August 14, 2018
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Theodore Druffel, Ruvini Dharmadasa, Menaka Jha, Delaina Amos
  • Methods for fabricating dental prostheses
    Patent number: 10045839
    Abstract: Methods of fabricating dental prostheses are provided that include the steps of providing a powder of a dental material, and then selectively melting the powder of the dental material to produce a functionally graded layer of the dental material. Additional layers of functionally graded dental material are then built on top of the initial layer of dental material to thereby produce a three-dimensional dental prosthesis having a functionally graded structure and a desired physical geometry. Dental prostheses produced by the foregoing methods are also provided.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: August 14, 2018
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Wei-Shao Lin, Amirali Zandinejad, Dean Morton
  • Methods and kits for predicting a response to an erythropoietic agent
    Patent number: 10041956
    Abstract: Methods for predicting a response to an erythropoietic agent in a subject include providing a biological sample from the subject, and determining an amount in the sample of at least one peptide selected from the group consisting of SEQ ID NOS: 1-17. If there is a measurable difference in the amount of the at least one peptide in the sample, when compared to a control level of the same peptide, the subject is then predicted to have a good response or a poor response to the erythropoietic agent.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: August 7, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Michael L. Merchant, Jon B. Klein, Michael E. Brier, Adam E. Gaweda
  • SELECTIVE PFKFB4 INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20180214438
    Abstract: Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) and the treatment of cancer are described.
    Type: Application
    Filed: April 22, 2016
    Publication date: August 2, 2018
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Sucheta TELANG, Jason CHESNEY, John O. TRENT
  • Method for synthesizing self-assembling nanoparticles
    Patent number: 10022791
    Abstract: Embodiments disclosed herein relate to a method for synthesizing self-assembling nanoparticles with defined plasmon resonances. More particularly, certain embodiments disclosed herein relate to an improved method for synthesizing self-assembling gold nanoparticles by dialyzing samples during the self-assembly process or in presence of a surface to reduce certain subpopulations.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: July 17, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Dhruvinkumar Patel, Kurtis James, Martin G. O'Toole, Robert S. Keynton
  • NANOPARTICLES FOR DRUG DELIVERY
    Publication number: 20180185512
    Abstract: The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles.
    Type: Application
    Filed: November 3, 2017
    Publication date: July 5, 2018
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Ralph J. Knipp, Michael H. Nantz
  • Adipose stromal vascular fraction cell constructs
    Patent number: 10011820
    Abstract: Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 3, 2018
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Amanda J. LeBlanc, James B. Hoying, Stuart K. Williams
  • Cardiac progenitor cells and methods of use therefor
    Patent number: 9987310
    Abstract: Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (CPCs) and/or progeny cells thereof that are SSEA3-positive and c-kit-negative. Also provided are methods for preparing cells capable of repairing damaged myocardium, methods for isolating populations of SSEA3-positive/c-kit-negative CPCs from cardiac tissue samples, methods for preparing an isolated cell population enriched in post-natal SSEA3-positive/c-kit-negative CPCs, therapeutic methods for using the presently disclosed cells and populations of cells to treat subjects in need thereof, and cell cultures that contain the presently disclosed cells and populations of cells.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: June 5, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Matthew C. L. Keith, Marcin Wysoczynski, Roberto Bolli
  • COMBINATIONS OF PFKFB3 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS TO TREAT CANCER
    Publication number: 20180147198
    Abstract: Provided herein is a method of treating cancer and stimulating anti-tumor immunity in a subject in need thereof, the method including administering to the subject a synergistic, therapeutically effective amount of a PFKFB3 inhibitor, such as PFK-158, in combination with an immune checkpoint inhibitor. Also provided is a method of synergistically increasing activity of an immune checkpoint inhibitor, the method including administering to a subject in need thereof a combination therapy including PFK-158 and the immune checkpoint inhibitor. A pharmaceutical composition including PFK-158, at least one immune checkpoint inhibitor; and at least one pharmaceutically-acceptable carrier is also provided.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Jason CHESNEY, Sucheta TELANG, Kavitha YADDANAPUDI
  • Milk-derived microvesicle compositions and related methods
    Patent number: 9943482
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 17, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • Neurostimulator devices using a machine learning method implementing a gaussian process optimization
    Patent number: 9931508
    Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 3, 2018
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEURORECOVERY TECHNOLOGIES, INC.
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen
  • Substituted pyrrolo[2,3-b]quinoxalines for cancer therapy
    Patent number: 9931339
    Abstract: Compounds, including quinoxaline derivatives of formula I, for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors such as Kpn?, AP-1, P65, NFAT into the nucleus of a cell by inhibiting the nuclear import protein, Kpn?1. Cancer cells have elevated levels of Kpn?1 and the inhibition of their nuclear import activity induces cell apoptosis. The administration of an effective amount of any one of the compounds results in cell apoptosis in cancer cells, while non-cancer cells are substantially unaffected by the inhibition of Kpn?1's nuclear import activity.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: April 3, 2018
    Assignees: University of Cape Town, University of Louisville Research Foundation Inc.
    Inventors: Virna Drucille Leaner, Pauline Janet Van Der Watt, John Olaf Trent
  • Computer aided diagnostic system for classifying kidneys
    Patent number: 9928347
    Abstract: A computer aided diagnostic system and automated method to classify a kidney. Image data for a medical scan that includes image data of a kidney may be received. The kidney image data may be segmented from other image data of the medical scan. One or more iso-contours may be registered for the kidney image data, and renal cortex image data may be segmented from the kidney image data based on the one or more registered iso-contours. The kidney may be classified by analyzing one or more features determined from the segmented renal cortex image data using a learned model associated with the one or more features.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: March 27, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ayman S. El-Baz, Amy Dwyer, Rosemary Ouseph, Fahmi Khalifa, Ahmed Soliman, Mohamed Shehata
  • Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film
    Patent number: 9926194
    Abstract: A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: March 27, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Balaji Panchapakesan
  • High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
    Patent number: 9907958
    Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 6, 2018
    Assignees: The Regents of the University of California, California Institute of Technology, University of Louisville Research Foundation, Inc.
    Inventors: Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Joel W. Burdick, Susan J. Harkema, Jonathan Hodes, Yu-Chong Tai, Mandheerej S. Nandra, Claudia A. Angeli, Thomas Anthony Desautels
  • Compositions and methods for use in treating silicosis and lung cancer
    Patent number: 9873878
    Abstract: A method for treating an inflammatory disease is provided. The method comprises administering an effective amount of a BLT1 inhibitor to a subject in need thereof. The BLT1 inhibitor is selected from the group consisting of a BLT1 receptor antagonist, a small molecule, a polypeptide, an siRNA, or a combination thereof.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: January 23, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Haribabu Bodduluri, Shuchismita R. Satpathy, Venkatakrishna R. Jala
  • GRIFFITHSIN MUTANTS
    Publication number: 20180016307
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 18, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Nanoparticles for drug delivery
    Patent number: 9849193
    Abstract: The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: December 26, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ralph J. Knipp, Michael H. Nantz
  • System and method for personalized dosing of pharmacologic agents
    Patent number: 9852267
    Abstract: A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: December 26, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Adam E. Gaweda, Michael E. Brier, George R. Aronoff, Alfred A. Jacobs