Patents Assigned to University of Louisville
  • NANOPARTICLES FOR DRUG DELIVERY
    Publication number: 20180185512
    Abstract: The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles.
    Type: Application
    Filed: November 3, 2017
    Publication date: July 5, 2018
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Ralph J. Knipp, Michael H. Nantz
  • Adipose stromal vascular fraction cell constructs
    Patent number: 10011820
    Abstract: Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 3, 2018
    Assignee: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Amanda J. LeBlanc, James B. Hoying, Stuart K. Williams
  • Cardiac progenitor cells and methods of use therefor
    Patent number: 9987310
    Abstract: Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (CPCs) and/or progeny cells thereof that are SSEA3-positive and c-kit-negative. Also provided are methods for preparing cells capable of repairing damaged myocardium, methods for isolating populations of SSEA3-positive/c-kit-negative CPCs from cardiac tissue samples, methods for preparing an isolated cell population enriched in post-natal SSEA3-positive/c-kit-negative CPCs, therapeutic methods for using the presently disclosed cells and populations of cells to treat subjects in need thereof, and cell cultures that contain the presently disclosed cells and populations of cells.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: June 5, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Matthew C. L. Keith, Marcin Wysoczynski, Roberto Bolli
  • COMBINATIONS OF PFKFB3 INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS TO TREAT CANCER
    Publication number: 20180147198
    Abstract: Provided herein is a method of treating cancer and stimulating anti-tumor immunity in a subject in need thereof, the method including administering to the subject a synergistic, therapeutically effective amount of a PFKFB3 inhibitor, such as PFK-158, in combination with an immune checkpoint inhibitor. Also provided is a method of synergistically increasing activity of an immune checkpoint inhibitor, the method including administering to a subject in need thereof a combination therapy including PFK-158 and the immune checkpoint inhibitor. A pharmaceutical composition including PFK-158, at least one immune checkpoint inhibitor; and at least one pharmaceutically-acceptable carrier is also provided.
    Type: Application
    Filed: May 27, 2016
    Publication date: May 31, 2018
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Jason CHESNEY, Sucheta TELANG, Kavitha YADDANAPUDI
  • Milk-derived microvesicle compositions and related methods
    Patent number: 9943482
    Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: April 17, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ramesh C. Gupta, Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan
  • Substituted pyrrolo[2,3-b]quinoxalines for cancer therapy
    Patent number: 9931339
    Abstract: Compounds, including quinoxaline derivatives of formula I, for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors such as Kpn?, AP-1, P65, NFAT into the nucleus of a cell by inhibiting the nuclear import protein, Kpn?1. Cancer cells have elevated levels of Kpn?1 and the inhibition of their nuclear import activity induces cell apoptosis. The administration of an effective amount of any one of the compounds results in cell apoptosis in cancer cells, while non-cancer cells are substantially unaffected by the inhibition of Kpn?1's nuclear import activity.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: April 3, 2018
    Assignees: University of Cape Town, University of Louisville Research Foundation Inc.
    Inventors: Virna Drucille Leaner, Pauline Janet Van Der Watt, John Olaf Trent
  • Neurostimulator devices using a machine learning method implementing a gaussian process optimization
    Patent number: 9931508
    Abstract: Neurostimulator devices are described comprising: a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are configured to stimulate a spinal cord; one or more sensors; and at least one processor configured to modify at least one complex stimulation pattern deliverable by the plurality of electrodes by integrating data from the one or more sensors and performing a machine learning method implementing a Gaussian Process Optimization on the at least one complex stimulation pattern. Methods of use are also described.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 3, 2018
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEURORECOVERY TECHNOLOGIES, INC.
    Inventors: Joel W. Burdick, Yu-Chong Tai, John F. Naber, Robert S. Keynton, Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Susan J. Harkema, Jonathan Hodes, Claudia A Angeli, Mandheerej S. Nandra, Thomas Anthony Desautels, Steven L. Upchurch, Douglas J. Jackson, Nicholas A. Terrafranca, Yangsheng Chen
  • Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film
    Patent number: 9926194
    Abstract: A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (CNT's). When antibodies are absorbed by the CNT's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. In many respects, the device functions as a Field Effect Transistor (FET) with the bodily source, e.g., blood, acting as a polyelectrolyte liquid gate electrode to create a varying electrostatic charge or capacitance in the thin film based upon the binding of cellular targets in the source to the antibodies present on the biofunctional pad.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: March 27, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventor: Balaji Panchapakesan
  • Computer aided diagnostic system for classifying kidneys
    Patent number: 9928347
    Abstract: A computer aided diagnostic system and automated method to classify a kidney. Image data for a medical scan that includes image data of a kidney may be received. The kidney image data may be segmented from other image data of the medical scan. One or more iso-contours may be registered for the kidney image data, and renal cortex image data may be segmented from the kidney image data based on the one or more registered iso-contours. The kidney may be classified by analyzing one or more features determined from the segmented renal cortex image data using a learned model associated with the one or more features.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: March 27, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ayman S. El-Baz, Amy Dwyer, Rosemary Ouseph, Fahmi Khalifa, Ahmed Soliman, Mohamed Shehata
  • Synthetic peptides and peptide mimetics
    Patent number: 9914750
    Abstract: The present invention provides Parotid Secretory Protein peptides, nucleic acids encoding the peptides, and methods of using the peptides, and methods of screening GL13 mimetics.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: March 13, 2018
    Assignee: University of Louisville Research Foundation
    Inventor: Sven-Ulrik Gorr
  • High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury
    Patent number: 9907958
    Abstract: Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal cord injury, brain injury, or neurological neuromotor disease are described.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: March 6, 2018
    Assignees: The Regents of the University of California, California Institute of Technology, University of Louisville Research Foundation, Inc.
    Inventors: Victor Reggie Edgerton, Roland R. Roy, Yury Gerasimenko, Joel W. Burdick, Susan J. Harkema, Jonathan Hodes, Yu-Chong Tai, Mandheerej S. Nandra, Claudia A. Angeli, Thomas Anthony Desautels
  • Genetic determinants of prostate and breast cancer risk
    Patent number: 9879324
    Abstract: Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa) or aggressive PCa, or to developing breast cancer (BrCa).
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 30, 2018
    Assignees: University of Louisville Research Fondation, Inc., North Carolina Central University
    Inventors: La Creis Renee Kidd, Kevin Sean Kimbro
  • Compositions and methods for use in treating silicosis and lung cancer
    Patent number: 9873878
    Abstract: A method for treating an inflammatory disease is provided. The method comprises administering an effective amount of a BLT1 inhibitor to a subject in need thereof. The BLT1 inhibitor is selected from the group consisting of a BLT1 receptor antagonist, a small molecule, a polypeptide, an siRNA, or a combination thereof.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: January 23, 2018
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Haribabu Bodduluri, Shuchismita R. Satpathy, Venkatakrishna R. Jala
  • GRIFFITHSIN MUTANTS
    Publication number: 20180016307
    Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.
    Type: Application
    Filed: February 10, 2016
    Publication date: January 18, 2018
    Applicants: The United States of America, as represented by the Secretary, Department of Health and Human Serv, University of Louisville Research Foundation, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Barry R. O'Keefe, Tinoush Moulaei, Kenneth E. Palmer, Lisa C. Rohan, Joshua L. Fuqua, Lindsay F. Kramzer
  • Genetic determinants of prostate cancer risk
    Patent number: 9863002
    Abstract: Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their risk.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: January 9, 2018
    Assignees: North Carolina Central University, University of Louisville Research Foundation
    Inventors: La Creis Renee Kidd, Kevin Sean Kimbro
  • System and method for personalized dosing of pharmacologic agents
    Patent number: 9852267
    Abstract: A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: December 26, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Adam E. Gaweda, Michael E. Brier, George R. Aronoff, Alfred A. Jacobs
  • Nanoparticles for drug delivery
    Patent number: 9849193
    Abstract: The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles. An important attribute of a drug delivery system is its ability to allow for spatial and temporal regulated drug release, thereby minimizing side effects and improving therapeutic efficacy of conventional pharmaceuticals. Iron oxide nanoparticles (NPs), specifically Fe304 nanoparticles, possess many appropriate qualities that make them a viable choice for drug delivery.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: December 26, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Ralph J. Knipp, Michael H. Nantz
  • TROCAR FOR IMPROVED FLUID PRESSURE MANAGEMENT DURING ENDOSCOPIC SURGERY
    Publication number: 20170360476
    Abstract: A trocar for arthroscopy and other endoscopic surgeries is provided, including a diaphragm seal, in which the assembly as a whole provides adequate insufflation of the body compartment during a procedure, while limiting or eliminating the leakage of insufflation fluid from the rear of the trocar, thus maintaining adequate insufflation pressure management. The design, placement, and spacing associated with said diaphragm seal provides an enhanced interface between the diaphragm opening and a surgical instrument inserted through such opening to gain access to the body compartment of a surgical patient.
    Type: Application
    Filed: December 1, 2015
    Publication date: December 21, 2017
    Applicant: University of Louisville Research Foundation, Inc.
    Inventor: George M. Pantalos
  • Methods for treating an established myocardial infarction
    Patent number: 9844514
    Abstract: This application discloses methods for treating an established myocardial infarction, including treatment with an epicardial construct containing stromal vascular fraction (SVF) from adipose tissue which may be seeded onto a biocompatible substrate, which preserves microvascular function and LV contractile mechanisms.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: December 19, 2017
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Stuart K. Williams, James B. Hoying, Amanda J. LeBlanc
  • OPEN LOOP POLYPECTOMY SYSTEM
    Publication number: 20170348017
    Abstract: Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a means for securely closing the loop. In some embodiments, the open loop polypectomy system comprises a snare wire and a capture mechanism wherein, when the snare wire is advanced, the snare wire extends from a distal portion of the open loop polypectomy system along a path passing through the capture mechanism. After the snare wire has advanced through the plane of the capture mechanism, retraction of the capture mechanism secures the snare wire, creating a formed loop around a target tissue. Retraction of at least one of the snare wire and capture mechanism contracts the formed loop, resecting the target tissue.
    Type: Application
    Filed: August 22, 2017
    Publication date: December 7, 2017
    Applicant: University of Louisville Research Foundation, Inc.
    Inventors: Gerald W. Dryden, Joseph Watson Vicars, III, Guruprasad A. Giridharan, Lauren Elizabeth Allen, Megan C. Mann, John F. Naber