Abstract: A method achieves minimum limit cycle oscillation (LCO) amplitude of a digital low dropout regulator (D-LDO) by adding auxiliary unit power transistors in parallel with the main PMOS array with selected unit strength and LCO mode. An improved D-LDO with reduced LCO amplitude includes an auxiliary power transistor array in selected strength driven by an output of a comparator in parallel with a main power transistor array.

Abstract: Bromodomain-containing protein 4 (BRI)) has recently emerged as an attractive epigenetic target for anticancer therapy. Iridium(III) complexes are useful as irreversible inhibitor of BRD4. Complex 1a of the formula: is particularly useful.

Abstract: According to one aspect of the present disclosure, a digital microfluidic system is provided. The digital microfluidic system includes a device, a control electronics, a field programmed gate array (FPGA), and a computer. The device includes a droplet on an electrode array, where the electrode array includes a plurality of electrodes. The control electronics connects to the device and provides an actuation pulse to the electrodes, where the control electronics generates a capacitance-derived frequency signal. The FPGA connects to the control electronics and collects the capacitance-derived frequency signal. The computer connects to the FPGA, the computer uses a frequency of the capacitance-derived frequency signal to calculate a precise droplet position and generates a duration voltage signal.

Abstract: A compliant gripper with integrated position and force sensors dedicated to automated micro-assembly tasks. The gripper possesses a larger gripping range with a bidirectional drive, and is capable of detecting grasping force and environmental interaction forces in horizontal and vertical axes. The gripper has a compliant rotary flexure bearing. The gripper further has a compliant mechanism with two-stage stiffness designed to provide force sensing with dual sensitivities in two measuring ranges to accommodate the grasping of objects with different sizes. The dual-sensitivity, dual-range force sensor provides finer and coarser force sensing in a small and large ranges, respectively. Analytical models are derived to predict the grasping range, force sensing sensitivities, and force measuring ranges. These models are verified by conducting finite-element analysis simulations.

Abstract: A mixed signal controller for a power quality compensator includes an analog circuit, an analog-to-digital converter (ADC), and a digital circuit. The analog circuit amplifies an input signal from the power quality compensator by a gain factor and outputs an analog signal, which is converted to a digital signal by the ADC. The digital circuit receives the digital signal, calculates the reference compensating current of each phase and then generates a trigger signal via hysteresis PWM to the power quality compensator. The digital circuit includes an evaluation circuit that calculates a value of the system total harmonic distortion after the power quality compensator compensates power and adjusts the gain factor when the value of the system total harmonic distortion reaches a predetermined threshold.

Abstract: The present invention discloses a gain-boosted n-path passive-mixer-first receiver. According to another aspect of the present disclosure, a gain-boosted n-path passive-mixer-first receiver is provided. The receiver includes a number n of switch-capacitor (sc) sets, a resistor, and a transconductance amplifier. The sc sets connect in parallel, and the sc sets have a first node and a second node. The resistor connects to the first node. The transconductance amplifier connects to the resistor and the second node.

Abstract: According to another aspect of the present disclosure, a radio-frequency-to-baseband-function-reuse receiver with shared amplifiers for common-mode and differential-mode amplification is provided. The receiver includes two set networks connected in parallel. The set networks includes a first and a second input capacitors, a first and a second output capacitors, a first transconductance amplifier having an input terminal, a second transconductance amplifier having an input terminal, a first switch, and a second switch. The first and the second input capacitors connect to a first node. The first and the second output capacitors connect to a second node. The first transconductance amplifier connects between the first input capacitor and the first output capacitor. The second transconductance amplifier connects between the second input capacitor and the second output capacitor. The first switch connects between the input terminal of the first transconductance amplifier and the second node.

Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.

Abstract: A method for reversible image data hiding includes steps of encrypting an original image by an encryption process to generate an encrypted image, embedding a message into the encrypted image by an embedment process to generate an embedded image, and extracting the message and the original image from the embedded image by a decryption and extraction process. The encryption process includes generating a key stream by using a secret encryption key, and generating an encrypted image by XORing the original image with the key stream. The embedment process includes generating an embedded image by embedding the message via XORing the encrypted image with a predetermined public key set.

Abstract: A microfluidic system for separating an analyte from a sample fluid including a series of fluidic channels including at least one first region and at least one second region. The first region includes a plurality of L-nodes, which connects to each other in series. The second region includes a plurality of R-nodes, which connects to each other in series. The first region is configured to trigger at least about one lamination process cycle for both the sample fluid and the buffer fluid and the second region is configured to trigger at least about one reverse lamination process cycle for both the sample fluid and the buffer fluid, whereby the lamination process cycle and the reverse lamination process cycle causes the analyte to diffuse to the buffer fluid from the sample fluid. A method for separating the analyte is also disclosed.

Abstract: A portable modular NMR-DMF system for performing chemical/biological assays. The system comprises a PCB having an NMR electronic circuit thereon, wherein the NMR electronic circuit includes a figure-8 shaped RF coil generating a plane-parallel magnetic field. A planar DMF chip comprises a platform comprising an array of electrodes, the array of electrodes including a sensing site located under the figure-8 shaped RF coil. A portable magnet is disposed parallel to the DMF chip and the RF coil. The array of electrodes is configured to receive a sample under detection, move the sample along the array, mix the sample with a probe in the form of at least one droplet with target-specific nanoparticles, and move the mixed sample to the sensing site. A magnetic field corresponding to the mixed sample under detection is produced at the sensing site. The figure-8 shaped RF coil acts to transduce the magnetic field produced at the sensing site to a voltage signal.

Abstract: A palm-size portable ?NMR relaxometer system for performing multi-step multi-sample chemical/biological assays, comprising a PCB having a CMOS ?NMR transceiver and a DMF device integrated thereon. A portable magnet has an inner gap configured to at least partially receive the DMF device. The DMF device comprises a platform of electrodes including a sensing site and receives one or more samples for analysis at an electrode and automatically transports the one or more samples on individual paths sequentially to the sensing site, for performing sensing on each sample sequentially. A Butterfly coil disposed on the PCB and underneath the DMF device and is at least partially received in the inner gap. The Butterfly coil excites the sample at the ?NMR sensing site by transducing a magnetic field produced at the sensing site to an electrical signal which is processed by the CMOS ?NMR transceiver to produce an analytical signal.

Abstract: A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.

Abstract: The present invention provides a method of using indole-ketone or indolidone such as SU4312, SU5416, SU11248 (Sunitinib), or indirubin-3-oxime to treat a neurodegenerative disease or disorder such as Parkinson's disease which is associated with excessive neuronal Nitric Oxide Synthase (nNOS) activity.

Abstract: A complex-pole load is configured as a parallel circuit, having 4 transistors arranged in pairs. Each pair of transistors has a transistor gated by a control voltage sources, and connected in parallel with a transistor diode connected for gating by the respective input. The control voltage sources result in the circuit synthesizing a first order complex pole at a positive IF (+IF) or a negative IF (?IF) for channel selection and image rejection, offering image rejection and channel selection concurrently.

Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.

Abstract: According to one aspect of the present disclosure, an ultra-low voltage current reused voltage-controlled oscillator and transconductance-capacitor filter is provided. The circuit includes a voltage-controlled oscillator stacked atop a transconductance-capacitor filter. The voltage-controlled oscillator includes a node one, a node two, a node three, a node four, an inductance, a variable capacitor, a first switched element, a second switched element, a third switched element, and a fourth switched element. The transconductance-capacitor filter includes a first resistor, a second resistor, a fifth switched element, a sixth switched element, a seventh switched element, and an eighth switched element.

Abstract: A multi-pinhole collimator is formed by calculating a projection size (D) for different pinhole numbers (n) for a predetermined field-of-view (FOV) (d) by arranging a plurality of projections into a pattern. A pattern is selected which utilizes a whole detector with maximized packing density, minimum truncation to provide a projection overlap below a predetermined limit. The number of pinholes is modified to calculate a collimator length, a corresponding acceptance angle and aperture size. Sensitivities for individual pinholes are added to obtain a total sensitivity for a given pinhole number, and an optimized multi-pinhole configuration is obtained by maximizing the total sensitivity for a predetermined target resolution (Rt) and field-of-view (FOV) (d).

Abstract: A stage assembly for supporting articles, the stage assembly uses one or more intermediate stage modules. Each module has a plurality of compound radial flexures (CRFs), extending radially from a base or an intermediate stage module, and allowing rotational movement about a center axis. The CRFs each have a flat profile, with a long side of the profile aligned perpendicularly to the direction of rotation of the stage modules so that the CRFs have more flexibility in the direction of rotation than obliquely to the direction of rotation. Movement of a last of the stage modules results in deflection of the CRFs between each successive stage module, with partial movement of each stage module between the base and the last of the stage modules, the last of the stage modules provided as a primary stage module.

Abstract: The present invention provides a method of reversible audio data hiding. The method of data hiding and restoring comprises the steps of: protecting audio by embedding information into the audio according to variance calculation associated to the audio, wherein the quality of the protected audio is degraded after embedding the information into the audio; publishing the protected audio widely as a trial for listen version; and decoding the protected audio for a user who purchased the copyright of the audio by extracting the original audio from the protected audio.