Abstract: The thermal management system for in-slot cooling of electric motors includes separating structures, either in the form of a scaffolding structure or a monolithic winding structure which is placed in between the adjacent winding turns to physically separate the winding turns to define coolant fluid passages for circulation of a coolant fluid in direct contact with the lateral surfaces of the winding turns. The scaffolding and monolithic winding structures are made from an electrically insulating material and are filled with a dielectric fluid that serves both the coolant and the electrical insulator between the winding turns. An end-winding organizer may be positioned at two end regions of each stator tooth to provide a curved surface for the winding turns to be held in tension throughout the 180° winding end turns and is formed with grooves to define the passage for the coolant flow to ensure that the flowing coolant reaches the surface of the innermost winding turns.

Abstract: The present invention provides tumor-targeting nanoplexes. Generally, a tumor-targeting nanoplex is a chemotherapeutic agent DNA conjugate with a first tumor-targeting agent and an optional second tumor-targeting agent linked thereto, such as a doxorubicin plasmid DNA conjugate and a linear histidine-lysine peptide with an optional cRGD-PEG-H3K4b second targeting agent. Also provided are methods for treating a cancer in a subject and for decreasing growth of a tumor in a cancer in a subject in need thereof in which the tumor targeting nanoplex is administered.

Abstract: Compounds and compositions are provided as inhibitors of the Wnt/?-catenin pathway for the treatment of diseases that implicate the same.

Abstract: The present disclosure provides a conformal solid-state battery (SSB) and methods for producing and using the same. The SSBs produced using a method of the disclosure have a higher energy and power compared to similar solid-state batteries without conformal electric cells. Due to avoidance of using any liquid electrolytes, SSBs of the disclosure have increased safety, especially in cases of medical implants and/or during catastrophic failures, where reactions of liquid electrolytes with air and/or water can produce toxic and/or poisonous by products.

Abstract: Antibodies and antigen binding fragments that specifically bind to IL-7R? are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7R? using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7R?, such as acute lymphoblastic leukemia.

Abstract: A method and apparatus for radiation therapy using functional measurements of branching structures. The method includes determining a location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that indicate a tissue type at each voxel. The method further includes determining a subset of the voxels based on an anatomical parameter of a respective branching structure of a set of branching structures indicated by the measurements. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure at each voxel. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function based on a computed dose delivered to each voxel and the utility measure for that voxel summed over all voxels.

Abstract: An apparatus for light delivery to magneto-optical trap (MOT) system utilizes only planar optical diffraction devices including a planar-integrated-circuit PIC and a metasurface MS. When MOT is based on the use of a diffraction grating, a grating chip is additionally employed to launch and manipulate light for laser cooling. Bridging the gap between the sub-micrometer-scale guided mode on the PIC and the centimeter-scale beam needed for laser cooling, a magnification of the mode area by about 1010 is demonstrated using an on-chip extreme-mode-converter to launch a Gaussian mode into free space from a PIC-waveguide and a beam-shaping, polarization-dependent MS to form a diverging laser beam with a flat-top spatial profile, which efficiently illuminates the grating chip without loss of light.

Abstract: Methods are provided that allow global access to redox-based molecular information by coupling electrochemical measurements with signal processing approaches. More specifically, the disclosure provides methods that rely on the use of redox probes to assay samples for redox activities that act to exchange electrons with the probe thereby generating detectable optical and electrochemical signature signals that can then be assigned to a sample feature of interest. In particular embodiments, the disclosed assay methods are useful for diagnosis and prognosis of disorders, such as schizophrenia, that are found to be associated with a specific redox-based signature within a subject sample.

Abstract: Systems and methods of analyzing user-entered or machine-generated values in data for determining defective entries are disclosed. According to an aspect, a system includes a data entry analyzer comprising at least one processor and memory configured to receive data including a plurality of user-entered or machine-generated values, wherein each user-entered or machine-generated value is organized in at least one predetermined entry format. The data entry analyzer is also configured to determine an entry constraint for each of the at least one predetermined entry formats. Further, the data entry analyzer is configured to analyze each user-entered or machine-generated value based on the determined entry constraint associated with the predetermined entry format of that user-entered or machine-generated value. The system also includes a user interface configured to present notification of the one or more defective entries.

Abstract: A method and apparatus for monitoring collection of subject condition data is provided. The method includes receiving a value of a parameter of subject condition data and a value of a sample time, for each of a plurality of sample times. The method also includes storing the subject condition data in a data structure including a first field for holding data indicating a current sample time and a second field for holding data indicating the value of the parameter. The method also includes determining a time gap defined by a duration between the current sample time and a most recent sample time and determining whether the time gap exceeds a time gap threshold and causing an apparatus to perform remedial action. A method for presenting the subject condition data on a display is also provided.

Abstract: Systems and methods of graph-based vehicular intrusion detection are disclosed. According to an aspect, an intrusion detection system includes a computing device configured to receive messages communicated on a vehicular communications network. The computing device also includes construct a set of graphs based on the received messages. Further, the computing device includes apply a graph-based anomaly detection technique to the set of graphs for identifying an anomaly among one or more of the received messages. The computing device also includes implement a predetermined action to mitigate an intrusion based on identification of the anomaly.

Abstract: Organic color center-tailored carbon nanotubes, particularly semiconducting single-walled carbon nanotubes, are of significant interest for imaging, sensing, and quantum information processing applications. A high-yield, simple, one-pot synthetic route for producing these materials exceeding the current ?g/mL scale is provided. Adding an acid solution of raw carbon nanotubes, nitrite, and an aniline derivative into a reactive solvent, such as water, results in covalently bonded organic color center-tailored nanotubes. No radical initiator or heating is required for the reaction. The chemistry works for all the nanotube chiralities investigated. The synthesized materials are neat solids that can be readily dispersed in either water or an organic solvent using a surfactant or polymer depending on the specific application. The OCC-products can also be further sorted into single chirality-enriched fractions with defect-specific photoluminescence that is tunable over approximately 1100 to approximately 1550 nm.

Abstract: An object of the present invention is to provide cells that express a membrane protein as an exogenous protein but can be stably transported without a complicated culture apparatus. Cells from Polypedilum vanderplanki expressing an exogenous membrane protein are able to stably transport the membrane protein without a complex culture apparatus.

Abstract: The present invention provides broadly neutralizing antibodies against HIV, compositions comprising the same and methods of use thereof.

Abstract: A video is classified as real or fake by extracting facial features, including facial modalities and facial emotions, and speech features, including speech modalities and speech emotions, from the video. The facial and speech modalities are passed through first and second neural networks, respectively, to generate facial and speech modality embeddings. The facial and speech emotions are passed through third and fourth neural networks, respectively, to generate facial and speech emotion embeddings. A first distance, d1, between the facial modality embedding and the speech modality embedding is generated, together with a second distance, d2, between the facial emotion embedding and the speech emotion embedding. The video is classified as fake if a sum of the first distance and the second distance exceeds a threshold distance. The networks may be trained using real and fake video pairs for multiple subjects.

Abstract: Proteins, nucleic acids encoding the proteins, compositions comprising the proteins, and methods are provided. The proteins have the ability to be self-targeted to ICAM-1 and, if desired, enzymatically-released at acidic pH. The ICAM-1-targeting peptides are provided as single copies or multiples repeats, and can be separated by linkers from the enzyme segment, from which the ICAM-1 targeting peptides can be released, if desired, at acidic pH. These fusion proteins enhance the activity of the enzyme segment within or liberated from the fusion protein, and provide increased recognition and targeting of diseased organs, transport from the bloodstream across the endothelium into said diseased organ, and intracellular uptake and lysosomal trafficking by cells in them, both in peripheral tissues and the central nervous system. Representative nucleotide and amino acid sequences of these fusion proteins, as well as in vitro, cellular, and in vivo animal data are provided.

Abstract: The present invention is directed to aqueous solid polymer electrolytes that comprise a lithium salt and battery cells comprising the same. The present invention is also directed to methods of making the electrolytes and methods of using the electrolytes in batteries and other electrochemical technologies.

Abstract: Provided herein are bioresorbable, bioregenerative composite materials and compositions to regenerate tissues or organs to repair tissue or organ defects and constructs printed from the same as 3D structures shaped and sized to fill a tissue or organ defect. The composite materials are bioresorbable polymers, for example, polycaprolactone, and a bioresorbable graft material, for example, demineralized bone matrix. Also provided are methods for making the composite materials and compositions and methods for regenerating tissues or organs and repairing a tissue or organ defect using the constructs.

Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.

Abstract: Disclosed are peptides comprising a monomeric Fc fragment of an immunoglobulin recognized by a neonatal receptor (FcRn); an influenza HA protein; and a trimerization domain. Disclosed are compositions comprising one or more of the peptides described herein. Disclosed are nucleic acid sequences capable of encoding any one of the peptides described herein. Disclosed are methods for eliciting a protective immune response against influenza comprising administering to a subject an effective amount of a composition comprising a monomeric Fc fragment of an immunoglobulin recognized by a FcRn; an influenza HA protein; and a trimerization domain, wherein the administering is to a mucosal epithelium.