Patents Assigned to University of Maryland
  • Publication number: 20200251779
    Abstract: The present invention is directed to aqueous solid state electrolytes that comprise a fluoride additive to stabilize the interface between the anode and aqueous electrolyte. The present invention is also directed to methods of making the solid state electrolyte materials and methods of using the solid state electrolyte materials in batteries and other electrochemical technologies.
    Type: Application
    Filed: August 24, 2018
    Publication date: August 6, 2020
    Applicants: University of Maryland, College Park, The United States of America as Represented by the Secretary of the Army
    Inventors: Kang XU, Chunsheng WANG, Chongyin YANG
  • Publication number: 20200251772
    Abstract: Solid-state lithium ion electrolytes of lithium metal sulfide based composites are provided which contain an anionic framework capable of conducting lithium ions. Composites of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium metal sulfide based materials and batteries with such electrodes are also provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 6, 2020
    Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei MO, Qiang BAI, Xingfeng HE, Chen LING
  • Publication number: 20200251770
    Abstract: Solid-state lithium ion electrolytes of lithium silicate based composites are provided which contain an anionic framework capable of conducting lithium ions. Composites of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium metal sulfide based materials and batteries with such electrodes are also provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 6, 2020
    Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei MO, Qiang Bai, Xingfeng He, Chen Ling
  • Publication number: 20200251771
    Abstract: Solid-state lithium ion electrolytes of lithium phosphate derivative compounds are provided which contain an anionic framework capable of conducting lithium ions. The activation energy of the lithium phosphate derivative compounds is from 0.2 to 0.45 eV and conductivities are from 0.01 to 10 mS/cm at 300K. Materials of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium phosphate derivative materials and batteries with such electrodes are also provided.
    Type: Application
    Filed: January 31, 2019
    Publication date: August 6, 2020
    Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei MO, Qiang BAI, Xingfeng HE, Chen LING
  • Patent number: 10732092
    Abstract: The present invention relates to a method and system for analyzing mechanical signatures of a plurality of cells for metastatic detection. Specifically, a data set characterized by at least one metric (such as Brillouin frequency shift and/or Brillouin linewidth) representing a cell mechanical signature is acquired for the plurality of cells by using a label-free Brillouin spectroscopy. A merit function is calculated based on one or more statistical characteristics of the data set, such as sensitivity and specificity. Then, the plurality of cells can be classified to detect metastatic cells based on mechanical signatures provided by the data set and an optimal metric value delivering maximum to the merit function.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: August 4, 2020
    Assignee: University of Maryland, College Park
    Inventors: Giuliano Scarcelli, Jitao Zhang
  • Patent number: 10730932
    Abstract: Stable immunogens comprising portions of the inner domain (ID) of the Human Immunodeficiency Virus (HIV-1) gp120 protein are provided. These ID immunogens selectively present the gp120 C1/C2 region in its CD4-bound state within a minimal structure. These ID immunogens can be used to vaccinate subjects against infection with HIV, the causative agent of Acquired Immunodeficiency Syndrome (AIDS). The immunogens can also be used as targets in screening to identify small molecule or peptide inhibitors that block HIV-1 viral entry and attachment steps, and as probes for identifying gp120 C1/C2 region-specific antibodies.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: August 4, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Marzena Pazgier, George Lewis, William Tolbert, Neelakshi Gohain
  • Patent number: 10724974
    Abstract: The present invention generally relates to a method of using NMR relaxation rates (R2) of water molecules as an indicator of the extent of aggregation of biopharmaceutical formulations. The biopharmaceutical can be evaluated nondestructively without the vial or container being opened or protective seal compromised (i.e., broken). The method is applicable to all biopharmaceuticals and the water signal obtained by magnetic resonance relaxometry is very strong and sensitive because water is used as the solvent and is present in high (>90%) concentrations in every biopharmaceutical formulation.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Yihua Bruce Yu, Marc Taraban, Yue Feng
  • Patent number: 10723763
    Abstract: The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: July 28, 2020
    Assignees: ALBA THERAPEUTICS CORPORATION, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Blake Paterson, Peter Ward, Alessio Fasano
  • Patent number: 10723715
    Abstract: Compounds and compositions are provided as inhibitors of the Wnt/?-catenin pathway for the treatment of diseases that implicate the same.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Fengtian Xue, Yan Shu
  • Patent number: 10726256
    Abstract: Various authentication systems may benefit from detection of counterfeits. More particularly, certain authentication systems may benefit from a counterfeit detection scheme applicable to paper surfaces that can employ mobile cameras, such as the cameras associated with mobile phones. A method, according to certain embodiments, can include illuminating a surface of an item with a lighting source of a device. The method can also include capturing a plurality of images of the surface by a camera of the device during the illumination of the surface. The method can further include authenticating the item based on the plurality of images.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Min Wu, Chau-Wai Wong
  • Publication number: 20200233051
    Abstract: An approach is presented to reconstruct image data for an object using a partial set of magnetic resonance (MR) measurements. A subset of data points in a data space representing an object are selected (e.g. through random sampling) for MR data acquisition. Partial MR data corresponding to the subset of data points is received and used for image reconstruction. The overall speed of image reconstruction can be reduced dramatically by relying on acquisition of data for the subset of data points rather than for all data points in the data space representing the object. Compressive sensing type arguments are used to fill in missing measurements, using a priori knowledge of the structure of the data. A compressed data matrix can be recovered from measurements that form a tight frame. It can be established that these measurements satisfy the restricted isometry property (RIP). The zeroth-order regularization minimization problem can then be solved, for example, using a 2D ILT approach.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 23, 2020
    Applicants: The United States of America, as represented by the Secretary, Dept. of Health and Human Services, University of Maryland, College Park
    Inventors: Peter J. Basser, Ruiliang Bai, Alexander Cloninger, Wojciech Czaja
  • Publication number: 20200229805
    Abstract: The present invention provides transseptal puncture devices configured to access structures on the left side of the heart from the right side of the heart without requiring open-heart surgery. The devices have adjustable stiffness to enter the vasculature in a flexible, atraumatic fashion, then become rigid once in place to provide a stable platform for penetration of the fossa ovalis. The devices are further configured to controllably and stably extend a needle to puncture the FO. The devices include an indwelling blunt stylus that can extend perpendicularly from the device to increase the accuracy of placement near the fossa ovalis.
    Type: Application
    Filed: February 11, 2020
    Publication date: July 23, 2020
    Applicants: University of Maryland, Baltimore, University of Maryland Medical System, LLC
    Inventors: James S. GAMMIE, Rachael QUINN, Chetan PASRIJA
  • Patent number: 10716839
    Abstract: Longer chain antigenic O-polysaccharide chains for use as a hapten in conjugate vaccines can be produced in a controlled manner using recombinant Gram-negative bacteria that overexpress native or heterologous genes of the wzz family, for example wzzB. Bacteria expressing a chosen wzz gene have modified O-polysaccharide chain lengths, allowing the bacteria to produce lipopolysaccharides having the longer O-polysaccharides. The LPS produced by the bacteria can be hydrolyzed to form core-O-polysaccharide molecules that can be conjugated to a carrier molecule, for example flagellin, to produce a vaccine. The invention also provides recombinant bacteria producing the longer chain O-polysaccharides, the polysaccharide molecules, themselves, conjugated vaccines comprising the O-polysaccharides, pharmaceutical compositions and kits.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: July 21, 2020
    Assignee: University of Maryland, Baltimore
    Inventors: Sharon M. Tennants, Raphael Simon, Myron M. Levine
  • Publication number: 20200222190
    Abstract: An implantable acellular polymeric scaffold device functionalized with aggrecan is provided. Also provided are methods of fabricating a polymeric scaffold device, including methods of fabricating the scaffold device via 3D printing. Methods of treating a cartilage defect in a subject in need thereof comprise application of the disclosed scaffold device in combination with microfracture procedures. A specialized lid for a centrifugation well plate is also provided.
    Type: Application
    Filed: January 15, 2020
    Publication date: July 16, 2020
    Applicant: University of Maryland, College Park
    Inventors: Ting Guo, John Patrick Fisher, Hannah Baker, Max Jonah Lerman, Robert Choe
  • Patent number: 10709119
    Abstract: Methods are provided for delivery of at least one agent into egg(s) from an egg-producing aquatic animal including contacting fertilized or unfertilized egg(s) from said egg-producing aquatic animal with the at least one agent in the presence of a guanidine-containing compound capable of enhancing the permeability of the chorion of the egg(s). Methods are provided for the drug screening and compound toxicity assays. Methods are also provided for the production of reproductively sterile fish and aquatic animals for aquaculture, the aquarium trade, and control of invasive species are described. The methods include disruption of gonadal development through the administration of agents that lead to the failure of fertile gonadal development. Agents may be delivered to the eggs directly before the fertilization or post fertilization by contacting eggs in an immersion medium including the agent of interest.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: July 14, 2020
    Assignee: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
    Inventors: Ten-Tsao Wong, Yonathan Zohar
  • Patent number: 10714788
    Abstract: Solid-state lithium ion electrolytes of lithium silicate based composites are provided which contain an anionic framework capable of conducting lithium ions. An activation energy for lithium ion migration in the solid state lithium ion electrolytes is 0.5 eV or less and room temperature conductivities are greater than 10?5 S/cm. Composites of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: July 14, 2020
    Assignees: UNIVERSITY OF MARYLAND, COLLEGE PARK, TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Yifei Mo, Xingfeng He, Chen Ling, Ying Zhang
  • Patent number: 10711043
    Abstract: The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are useful to stimulate an antigen-specific immune response and, in some embodiments, a protective immune response in an animal after challenge to pathogens. The compositions of the disclosure are also useful for treatment and prevention of disease in a subject such as cancer.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 14, 2020
    Assignees: University of Maryland, College Park, University of Maryland, Baltimore
    Inventors: Philip R. DeShong, Lenea Stocker, Daniel C. Stein, Stefanie N. Vogel, Katharina Richard
  • Patent number: 10710083
    Abstract: The present invention relates to a microfluidic system including a temperature controller and a thermoplastic microfluidic chip that enables rapid PCR in a PCR chamber of the microfluidic chip. Thermal control of the PCR chamber is achieved by applying voltage to heater electrodes patterned directly onto one layer of the microfluidic chip. The temperature controller adjusts the voltage applied to the heater electrodes by changing temperature controller parameters selected to minimize duration of each PCR cycle. Furthermore, simple operation of the microfluidic chip is provided through using an integrated passive capillary valve, requiring minimum operator intervention and eliminating the need for fluidic interfacing, pumping, or metering during chip loading.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 14, 2020
    Assignee: University of Maryland
    Inventors: Donald DeVoe, Eric Kendall, Alex Sposito
  • Publication number: 20200214661
    Abstract: Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. The adaptor mates with an ultrasound probe to provide the medical operator ultrasound feedback of the position of the member, thus allowing internal placement without the need for more specialized medical equipment.
    Type: Application
    Filed: August 19, 2019
    Publication date: July 9, 2020
    Applicant: University of Maryland, Baltimore
    Inventor: Steven P. TROPELLO
  • Patent number: RE48137
    Abstract: Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the treatment and prevention of Staphylococcus aureus infections in a subject.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: August 4, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Mark Shirtliff, Janette Harro, Jeffrey Leid