Patents Assigned to University of Maryland
  • Publication number: 20250144199
    Abstract: The present disclosure relates generally to novel recombinant coronavirus-based fusion proteins (“RBDs-IgG Fc protein” and “RBDs protein”) and vaccine compositions using the same, in which the fusion proteins comprise tandemly arranged coronaviruses receptor binding domains (RBDs). The present disclosure further provides methods and kits for immunizing a subject using the compositions.
    Type: Application
    Filed: February 9, 2023
    Publication date: May 8, 2025
    Applicant: University of Maryland, College Park
    Inventors: Xiaoping Zhu, Weizhong Li, Tao Wang
  • Patent number: 12288132
    Abstract: Aspects of the present disclosure describe techniques that involve an active stabilization of coherent controllers using nearby qubits. In an aspect, a quantum information processing (QIP) system for stabilizing phase damping in qubits is described that provides a first and a second qubit ion, measuring magnetic field fluctuations using the second qubit ion, and generates one or more magnetic fields based on the measured magnetic field fluctuations, the one or more magnetic fields being applied near the first qubit ion to cancel the magnetic field fluctuations to stabilize the phase damping of the first qubit ion. Another such QIP system performs provides a first and a second qubit ion, locks a local oscillator to a frequency reference associated with the second qubit ion, and tracks, using the local oscillator, a frequency of the first qubit ion based on the frequency reference. Methods associated with these QIP systems are also described.
    Type: Grant
    Filed: June 29, 2021
    Date of Patent: April 29, 2025
    Assignees: University of Maryland, College Park, Duke University
    Inventors: Jungsang Kim, Kenneth Brown, Christopher Monroe
  • Patent number: 12288136
    Abstract: A method for detecting a two-qubit correlated dephasing error includes accessing a signal of a quantum system, where the quantum system includes a plurality of qubits. Every qubit has a nonzero rate of dephasing and some qubits have a nonzero rate of correlated dephasing. The signal further includes information about a matrix that includes diagonal elements and off-diagonal elements. The off-diagonal elements of the matrix are 2s-sparse. The method further includes performing randomized measurements of the off-diagonal elements of the matrix and recovering the matrix based on a direct measurement of the diagonal elements of the matrix.
    Type: Grant
    Filed: May 3, 2024
    Date of Patent: April 29, 2025
    Assignees: University of Maryland, College Park, Government of the United States of America, as Represented by the Secretary of Commerce
    Inventors: Seyed Alireza Seif Tabrizi, Mohammad Hafezi, Yi-Kai Liu
  • Patent number: 12287557
    Abstract: A quantum EIT-based optical switch includes a first waveguide, linear or nonlinear, a separate nonlinear waveguide evanescently coupled to the first waveguide, and a pump coupled to the nonlinear waveguide. A quantum STIRAP-based optical transduction device, which includes an auxiliary, intermediate spectral state for the quantum signal that aids efficient transduction of the quantum signal from the input spectral state to the output spectral state in a single device.
    Type: Grant
    Filed: February 20, 2024
    Date of Patent: April 29, 2025
    Assignees: University of Maryland, College Park, Government of the United States of America, as Represented by the Secretary of Commerce
    Inventors: Ivan A. Burenkov, Sergey V. Polyakov
  • Patent number: 12286633
    Abstract: Compositions and methods for modifying genomic DNA sequences of a plant cell are provided. The methods produce double stranded breaks at target sites in a genomic DNA sequence, resulting in mutation, insertion, and/or deletion of DNA sequences at the target site(s) in a genome. The compositions comprise DNA constructs comprising nucleotide sequences that encode a Cas12b protein. The DNA constructs can be used to direct the modification of genomic DNA at a target site. Methods to use these DNA constructs to modify genomic DNA sequences are described herein. Additionally, compositions and methods for modulating the expression of genes are provided.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: April 29, 2025
    Assignee: University of Maryland, College Park
    Inventor: Yiping Qi
  • Patent number: 12278740
    Abstract: This invention relates to methods and systems of procuring services in the cloud and specifically procurement where the requirements are defined by the consumer in a machine understandable knowledge representation language such as RDF and OWL using semantic web technology to establish a cloud agent for discovery of a service provider and effectuate the automatic generation of a contract, or service-level agreement, that can be monitored due to the coupling between the machine understandable knowledge representation language and the contract.
    Type: Grant
    Filed: September 20, 2022
    Date of Patent: April 15, 2025
    Assignee: University of Maryland, Baltimore County
    Inventors: Karuna Joshi, Timothy Finin, Yelena Yesha
  • Patent number: 12276624
    Abstract: Systems and methods of quantum sensing include depositing a sample volume onto an ensemble of quantum defects, hyperpolarizing spins in the sample volume, performing a sensing sequence, and reading out information regarding electronic spin states of the quantum defects in the ensemble of quantum defects, which sense the hyperpolarized spins in the sample volume.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: April 15, 2025
    Assignees: University of Maryland, College Park, The President and Fellows of Harvard College, North Carolina State University
    Inventors: Ronald Walsworth, Nithya Arunkumar, Dominik Bucher, Matthew Turner, David Glenn, Matthew S. Rosen, Thomas Theis
  • Patent number: 12269155
    Abstract: The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: April 8, 2025
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Thomas Jefferson University, University of Maryland, Baltimore
    Inventors: Reed F. Johnson, Matthias Schnell, Lisa E. Hensley, Christoph Wirblich, Christopher M. Coleman, Matthew S. Frieman
  • Publication number: 20250099075
    Abstract: A thermo-responsive ultrasound coupling gel that contains a thermo-responsive polymer such as poly (n-isopropyl acrylamide), the gel having a phase shift at a temperature in the range of 32 to 35° C. such that the gel has a loss factor G?/G? of >1 at <32° C. and a loss factor G?/G? of <1 at >35° C. The gel can also contain at least one of a solvent and gelling agent. Methods and uses for the thermo-responsive ultrasound coupling gel in an ultrasound and/or ultrasound guided procedure.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Applicant: University of Maryland
    Inventors: Paul E. BIGELEISEN, Kyle KENNY, Mark E. SHIRTLIFF
  • Publication number: 20250090133
    Abstract: Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. The adaptor mates with an ultrasound probe to provide the medical operator ultrasound feedback of the position of the member, thus allowing internal placement without the need for more specialized medical equipment.
    Type: Application
    Filed: April 4, 2024
    Publication date: March 20, 2025
    Applicant: University of Maryland, Baltimore
    Inventor: Steven P. TROPELLO
  • Patent number: 12253522
    Abstract: Provided herein is a method for treating a cancer in a subject by quantitating the concentration of a soluble form of Semaphorin 4D (sSema4D) in a blood sample obtained from the subject and administering an immunotherapy when the blood concentration of sSema4D is below a threshold value of 155 ng/ml. Also provided is a method for determining the continued susceptibility of a tumor tissue to immunotherapy in a subject by identifying the inflammatory subtype of the tumor tissue from a blood sample from the subject and administering immunotherapy over at least one interval as long as the tumor tissue exhibits an inflamed subtype.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: March 18, 2025
    Assignee: University of Maryland, Baltimore
    Inventor: Rania H. Younis
  • Patent number: 12245761
    Abstract: A tissue anchor deployment device includes a needle having a slotted portion including a longitudinal slot that runs from a distal end of the needle and a suture having a first coil portion including a plurality of turns that wrap around a first portion of the slotted portion of the needle, a second coil portion including a plurality of turns that wrap around a second portion slotted portion of the needle that is proximal to the first portion of the slotted portion of the needle, and an internal coupling portion that runs within the first coil portion and the second coil portion and couples a distal end of the first coil portion to a proximal end of the second coil portion.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: March 11, 2025
    Assignee: University of Maryland, Baltimore
    Inventors: James S. Gammie, Rahul Patel, Mehrdad Ghoreishi
  • Patent number: 12244687
    Abstract: Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: March 4, 2025
    Assignees: NTT Research Inc., University of Maryland, College Park, Cornell University
    Inventors: Dana Dachman-Soled, Ilan Komargodski, Rafael N Pass
  • Publication number: 20250062379
    Abstract: The present invention relates to a doped cubic bismuth oxide that is phase stable in a temperature range of from about 550° C. to about 700° C. The doped cubic bismuth oxide comprises a mixture of a first dopant and a second dopant.
    Type: Application
    Filed: November 4, 2024
    Publication date: February 20, 2025
    Applicant: University of Maryland, College Park
    Inventors: Eric D. Wachsman, Adam Jolley
  • Patent number: 12227734
    Abstract: A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The parent's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: February 18, 2025
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa Croucher, Kevin Tran, Monohar Pilli, Michael Tolosa, Chandrasekhar Gurramkonda, David Burgenson
  • Publication number: 20250055009
    Abstract: The present invention relates to rhomboidal phase bismuth oxide that maintains electric conductivity of at least about 1×10?2 S/cm at temperature of about 500° C. for at least about 100 hours. In particular, the bismuth oxides of the invention have stable conductivity at a temperature range from about 500° C. to about 550° C.
    Type: Application
    Filed: April 1, 2024
    Publication date: February 13, 2025
    Applicant: University of Maryland, College Park
    Inventors: Eric D. Wachsman, Adam Jolley
  • Patent number: 12221603
    Abstract: A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.
    Type: Grant
    Filed: June 6, 2023
    Date of Patent: February 11, 2025
    Assignee: University of Maryland, Baltimore County
    Inventors: Govind Rao, Yordan Kostov, Leah Tolosa, Xudong Ge, Douglas Frey
  • Patent number: 12220432
    Abstract: Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: February 11, 2025
    Assignee: University of Maryland, Baltimore
    Inventor: Sunjay Kaushal
  • Patent number: 12216776
    Abstract: A system for noise-resistant quantum communication using hyperentanglement includes a quantum system that includes a plurality of qubits, a processor, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the quantum system to access a signal of a quantum system that includes a plurality of qubits and obtain hyperentanglement of the plurality of qubits via an entanglement source. The hyperentanglement of the plurality of qubits is in at least two dimensions, including a first dimension and a second dimension. The instructions, when executed, further cause the quantum system to transmit the hyperentangled plurality of qubits via a communication channel; perform a communication of the signal with the first dimension of the at least two dimensions; and filter results of the communicated signal based on the second dimension of the at least two dimensions.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: February 4, 2025
    Assignees: University of Maryland, College Park, POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
    Inventors: Giuliano Scarcelli, Yoon-Ho Kim, Jin-Hun Kim
  • Publication number: 20250030486
    Abstract: Aspects of the present disclosure describe techniques for controlling coherent crosstalk errors that occur in multi-channel acousto-optic modulators (AOMs) by applying cancellation tones to reduce or eliminate the crosstalk errors. For example, a method and systems are described that include applying a first radio frequency (RF) tone to generate a first acoustic wave in a first channel of the multi-channel AOM, wherein a portion of the first acoustic wave interacts with a second channel to cause a crosstalk effect, and applying a second RF tone to generate a second acoustic wave in the second channel, wherein the second acoustic wave reduces or eliminates the crosstalk effect caused by the portion of the first acoustic wave.
    Type: Application
    Filed: November 11, 2022
    Publication date: January 23, 2025
    Applicant: University of Maryland, College Park
    Inventors: Kristin M. BECK, Marko CETINA, Michael Lurie GOLDMAN