Patents Assigned to University of Maryland
  • Patent number: 11228039
    Abstract: The disclosure relates to solid oxide fuel cell (SOFC) anode materials that comprise various compositions of chromate based oxide materials. These materials offer high conductivity achievable at intermediate and low temperatures and can be used to prepare the anode layer of a SOFC. A method of making a low- or intermediate-temperature SOFC having an anode layer comprising a chromate based oxide material is also provided.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: January 18, 2022
    Assignee: University of Maryland, College Park
    Inventors: Mohammed Hussain Abdul Jabbar, Eric D. Wachsman, Ke-Ji Pan
  • Publication number: 20220002746
    Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 6, 2022
    Applicants: University of Maryland, College Park, The Regents of the University of California
    Inventors: Anne Elizabeth Simon, Jingyuan Liu, Georgios Vidalakis, Sohrab Bodaghi
  • Publication number: 20220002399
    Abstract: Gastrin-releasing peptide (GRP) is a neuroendocrine peptide that acts as a novel contributor to the inflammatory response to influenza infection. Thus, inhibition of GRP or antagonizing the GRP receptor (GRPR) during influenza infection represents a novel therapeutic approach to mitigating lung damage. The present invention encompasses methods of treatment based on these novel findings and observations.
    Type: Application
    Filed: September 10, 2019
    Publication date: January 6, 2022
    Applicants: University of Maryland, Baltimore, The United Stated of America, as represented by the Secretary, Departmnet of Health and Human Servic
    Inventors: Stefanie N VOGEL, Kari Ann SHIREY, Frank CUTTITTA
  • Patent number: 11208571
    Abstract: A method termed “superacid-surfactant exchange” (S2E) for the dispersion of carbon nanomaterials in aqueous solutions. This S2E method enables nondestructive dispersion of carbon nanomaterials (including single-walled carbon nanotubes, double-walled carbon nanotubes, multi-wall carbon nanotubes, and graphene) at rapidly and at large scale in aqueous solution without a requirement for expensive or complicated equipment. Dispersed carbon nanotubes obtained from this method feature long length, low defect density, high electrical conductivity, and in the case of semiconducting single-walled carbon nanotubes, bright photoluminescence in the near-infrared.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: December 28, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: YuHuang Wang, Peng Wang, Mijin Kim, Chiyu Zhang
  • Publication number: 20210399333
    Abstract: Solid-state lithium ion electrolytes of lithium zinc chloride derivative compounds having a crystal morphology in the Pmn21 space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.15 to 0.40 eV and conductivities are from 0.01 to 15 mS/cm at 300 K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 23, 2021
    Applicants: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Yifei MO, Yunsheng LIU, Chen LING
  • Publication number: 20210399334
    Abstract: Solid-state lithium ion electrolytes of metal lithium chloride derivative compounds having a crystal morphology in the P21/c space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.15 to 0.40 eV and conductivities are from 0.01 to 3 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 23, 2021
    Applicants: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Yifei Mo, Yunsheng Liu, Chen Ling
  • Publication number: 20210399335
    Abstract: Solid-state lithium ion electrolytes of lithium aluminum chloride derivative compounds having a crystal morphology in the Pnma space group are provided as materials for conducting lithium ions. An activation energy of the lithium aluminum chloride derivative compounds is from 0.2 to 0.45 eV and conductivities are from 0.01 to 10 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes and electrodes containing the lithium aluminum chloride derivative compounds are also provided.
    Type: Application
    Filed: June 23, 2020
    Publication date: December 23, 2021
    Applicants: TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Yifei MO, Yunsheng LIU, Xingfeng HE, Chen LING
  • Publication number: 20210393214
    Abstract: An apparatus for generating a blood pressure estimation model includes: a signal acquirer configured to receive input a first signal and a second signal from a user; and a processor configured to obtain a pulse transit time (PTT) as a first predictor variable value based on the first signal and the second signal, to extract at least one feature from the second signal, to obtain a second predictor variable value based on the extracted at least one feature, and to generate a blood pressure estimation model based on the first predictor variable value and the second predictor variable value.
    Type: Application
    Filed: May 17, 2021
    Publication date: December 23, 2021
    Applicants: SAMSUNG ELECTRONICS CO., LTD., University of Maryland, College Park
    Inventors: Dae Geun JANG, Peyman Yousefian, Jin-Oh Hahn, Ui Kun Kwon, Youn Ho Ho Kim, Sungtae Shin
  • Publication number: 20210395682
    Abstract: Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of UCB and other transplant grafts, thereby significantly improving patient outcomes.
    Type: Application
    Filed: September 1, 2021
    Publication date: December 23, 2021
    Applicants: UNIVERSITY OF MARYLAND, BALTIMORE, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Curt I. CIVIN, James C. STURM, Robert H. AUSTIN
  • Patent number: 11197678
    Abstract: An apparatus (100) includes: a expandable structure (140) formable into three dimensional shapes including a range of diameters (D) and corresponding lengths (L); a movable component (106) moveable between a range of positions (124, 126) effecting the range of diameters; and a mechanical linkage (110) disposed between the movable component and the expandable structure. The expandable structure is configured to fit inside a working channel (204) of an endoscope (202) when the expandable structure is collapsed. The mechanical linkage is configured to move the collapsed expandable structure through the working channel to a selected location (400) past a distal end (404) of the endoscope and to increase and decrease a diameter of the expandable structure in response to changes in the position of the movable component when the expandable structure is at the selected location.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: December 14, 2021
    Assignee: University of Maryland, Baltimore
    Inventor: Jeffrey S. Wolf
  • Patent number: 11191493
    Abstract: A method is provided for predicting that a patient will require a blood transfusion during a treatment. The method includes obtaining, on a processor, first data that indicates values for one or more parameters of a characteristic of a continuous photoplethysmographic (PPG) waveform collected during the treatment. The method further includes applying, on the processor, coefficients to the values for the one or more parameters. The method further includes determining, on the processor, second data that indicates a prediction that the patient will require the blood transfusion during the treatment based on applying the coefficients to the values for the one or more parameters. An apparatus is also provided for predicting that the patient will require the blood transfusion during the treatment.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: December 7, 2021
    Assignee: The University of Maryland, Baltimore
    Inventors: Fu-Ming Hu, Colin Mackenzie, Shiming Yang, Hegang Chen
  • Patent number: 11195117
    Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: December 7, 2021
    Assignees: University of Maryland, Duke University, University of British Columbia
    Inventors: Christopher Monroe, Jungsang Kim, Robert Raussendorf
  • Patent number: 11196053
    Abstract: In various embodiments, a solid oxide fuel cell features a functional layer for reducing interfacial resistance between the cathode and the solid electrolyte.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 7, 2021
    Assignees: REDOX POWER SYSTEMS, LLC, UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Ke-Ji Pan, Mohammed Hussain Abdul Jabbar, Dong Ding, Eric Wachsman
  • Patent number: 11193191
    Abstract: A formation of multielement nanoparticles is disclosed that includes at least three elements. Each of the at least three elements is uniformly distributed within the multielement nanoparticles forming nanoparticles having a homogeneous mixing structure. At least five elements may form a high-entropy nanoparticle structure. A method for manufacturing a formation of multielement nanoparticles includes providing a precursor material composed of the at least three component elements in multielement nanoparticles; heating the precursor material to a temperature and a time; and quenching the precursor to a temperature at a cooling rate to result in a formation of multielement nanoparticles containing at least three elements and the heating and the quenching representing a multielement nanoparticle thermal shock formation process. A corresponding system for manufacturing the formation of multielement nanoparticles and a method of using the multielement nanoparticles are also disclosed.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Yonggang Yao, Liangbing Hu
  • Patent number: 11193155
    Abstract: The present invention provides for novel fucosidase mutants that server as fuco-ligases for core fucosylation of a range of biological glycopeptides and glycoproteins including intact therapeutic antibodies. Several mutants with mutation at the general acid/base residue E274 of the Lactobacillus casei ?1,6-fucosidase, including E274A, E274S, and E274G, were able to efficiently fucosylate a wide variety of complex N-glycopeptides and intact glycoproteins. The site specific mutants enable the transfer of fucose to a core GlcNAc-Asn residue and useful for drug delivery and vaccine development.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: December 7, 2021
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Lai-Xi Wang, Chao Li, Shilei Zhu
  • Patent number: 11186632
    Abstract: This description provides novel strategies and methods for treatment of hyperproliferation conditions such as keloids, lung fibrosis, and lung cancer with the use of bi-functional molecules that target growth factors. A bifunctional hepatoma-derived growth factor (HDGF)-specific antibody for these methods comprises at least one complementarity determining region (CDR) specific for HDGF, at least one receptor domain that specifically binds to a growth factor selected from vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF?).
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: November 30, 2021
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Li Mao, Hening Ren
  • Patent number: 11186626
    Abstract: This disclosure provides a method for preventing, treating, or managing an ebolavirus infection in a subject, where the method includes administering to a subject in need thereof an effective amount of at least one pan-ebolavirus internal fusion loop antibody or antigen-binding fragment thereof, wherein the binding domain specifically binds to the epitope on two or more ebolavirus species or strains.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: November 30, 2021
    Assignees: INTEGRATED BIOTHERAPEUTICS, INC., UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: Mohammad Javad Aman, Katie A. Howell, Frederick Wayne Holtsberg, Xuelian Zhao, Yuxing Li
  • Patent number: 11179050
    Abstract: Most automatic cuff blood pressure (BP) measurement devices are based on oscillometry. These devices estimate BP from the envelopes of the cuff pressure oscillations using fixed ratios. The values of the fixed ratios represent population averages, so the devices may be accurate only in subjects with normal BP levels. A patient-specific oscillometric BP measurement method was developed. The idea was to represent the cuff pressure oscillation envelopes with a physiologic model and then estimate the patient-specific parameters of the model, which includes BP levels, by optimally fitting it to the envelopes.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: November 23, 2021
    Assignees: Board of Trustees of Michigan State University, University of Maryland, College Park
    Inventors: Jiankun Liu, Mohsen Moslehpour, Jin-Oh Hahn, Ramakrishna Mukkamala
  • Publication number: 20210355499
    Abstract: The present disclosure relates to a single stranded RNA vector suitable for introducing a therapeutic agent, such as a peptide, a protein or a small RNA, into a host plant. The vector does not encode for any movement protein or coat protein, but is capable of capable of systemic and phloem-limited movement and replication within the host plant.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 18, 2021
    Applicant: University of Maryland, College Park
    Inventor: Anne Elizabeth Simon
  • Patent number: 11174478
    Abstract: The present invention relates to a method for concentrating a biological sample containing nucleic acids by using magnetic chitosan microparticles and subsequently performing a PCR reaction on the nucleic acids captured on the microparticles. The chitosan microparticles added to the biological sample at a PCR compatible pH are mechanically agitated to provide for cell lysis and simultaneous DNA capture, and then serve as a solid support for the nucleic acid template during the PCR reaction. As the chitosan microparticles are utilized for lysis and the nucleic acids do not need to be removed from the microparticles before PCR, the ease of the sample preparation procedure is dramatically improved.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: November 16, 2021
    Assignees: University of Maryland, College Park, Canon U.S.A., Inc.
    Inventors: Ian M. White, Srinivasa Raghavan, Kunal R. Pandit, Imaly Nanayakkara, Weidong Cao